• Journal of Pharmaceutical Investigation
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• 제41권5호
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• pp.309-315
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• 2011

A sensitive and specific liquid chromatographic method coupled with tandem mass spectrometry (LC-MS/MS) was developed for the analysis of ambroxol (active moiety of acebrophylline). After acetonitrile precipitation of proteins from plasma samples, ambroxol and the domperidone (internal standard, IS) were eluted on a C18 column. The isocratic mobile phase was consisted of 10 mM ammonium acetate and methanol (10 : 90, v/v), with flow rate at 0.2 mL/min. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z 379.2${\rightarrow}$264.0 and the m/z 426.2${\rightarrow}$175.1 transitions for ambroxol and the IS, respectively. Twenty four healthy Korean male subjects received two capsules (100 mg ${\times}$ 2) of either the test or the reference formulation of acebrophylline HCl in a 2 ${\times}$ 2 crossover study, this was followed by a 1week washout period between either formulation. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were acceptable range of log 0.8 to log 1.25 (e.g., log 0.8964 - log 0.9910 for $AUC_{0-t}$ log 0.8690 - log 1.0750 for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of Korea Food and Drug Administration for bioequivalence indicating that Acephyll$^{(R)}$ capsule (test) is bioequivalent to Surfolase$^{(R)}$ capsule (reference).

• Nutrition Research and Practice
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• 제6권2호
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• pp.120-125
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• 2012

The aim of this study was to investigate the influencing factors that characterize low density lipoprotein (LDL) phenotype and the levels of LDL particle size in healthy Korean women. In 57 healthy Korean women (mean age, $57.4{\pm}13.1$ yrs), anthropometric and biochemical parameters such as lipid profiles and LDL particle size were measured. Dietary intake was estimated by a developed semi-quantitative food frequency questionnaire. The study subjects were divided into two groups: LDL phenotype A (mean size: $269.7{\AA}$, n = 44) and LDL phenotype B (mean size: $248.2{\AA}$, n = 13). Basic characteristics were not significantly different between the two groups. The phenotype B group had a higher body mass index, higher serum levels of triglyceride, total-cholesterol, LDL-cholesterol, apolipoprotein (apo)B, and apoCIII but lower levels of high density lipoprotein (HDL)-cholesterol and LDL particle size than those of the phenotype A group. LDL particle size was negatively correlated with serum levels of triglyceride (r = -0.732, $P$ < 0.001), total-cholesterol, apoB, and apoCIII, as well as carbohydrate intake (%En) and positively correlated with serum levels of HDL-cholesterol and ApoA1 and fat intake (%En). A stepwise multiple linear regression analysis revealed that carbohydrate intake (%En) and serum triglyceride levels were the primary factors influencing LDL particle size ($P$ < 0.001, $R^2$ = 0.577). This result confirmed that LDL particle size was closely correlated with circulating triglycerides and demonstrated that particle size is significantly associated with dietary carbohydrate in Korean women.

• 한국철도학회논문집
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• 제12권1호
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• pp.144-150
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• 2009

환경 친화적인 철도 노선선정 예 관련된 전문가의 의견을 설문조사하여, 철도노선 환경에 영향을 미치는 주요 환경 영향인자를 연구하였으며, 주요 영향인자와 관련된 7개의 환경항목은 환경 친화적인 철도 노선의 대안 선정을 위한 6개 분야 20개 환경영향평가 항목에서 추출하였다. 최적의 철도노선을 선정하기 위해서는, 여러 대안은 비교되어야 하고 각 대안의 환경성 평가는 7개의 환경영향인자를 모두 고려하는 포괄적인 평가에 의해 행해져야 한다. 이 문제를 해결하기 위하여 본 연구에서는 계층구조를 이용하여 복잡한 문제를 간단하고 객관적으로 결론을 내리는데 용이한 AHP 기법을 이용하였다. 이에 따라 전문가에 의한 환경평가항목의 가중치를 기본 값으로 정하고 GUI를 활용한 정량화시스템을 개발하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.195-200
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• 2013

Secreted protein acidic and rich in cysteines-like protein 1 (SPARCL1), an extracellular matrix glycoprotein, has been implicated in the pathogenesis of several disorders including cancer. However, little is known about the expression and significance of SPARCL1 in human breast cancer. The aim of this study was to determine the expression pattern and clinicopathological significance of SPARCL1 in a Chinese breast cancer cohort. mRNA and protein expression of SPARCL1 in human breast cancer cell lines and breast cancer tissues was detected using the reverse transcription-polymerase chain reaction, real-time quantitative PCR, and Western blotting, respectively. Immunostaining of SPARCL1 in 282 Chinese breast cancer samples was examined and associations with clinicopathological parameters were analyzed. Compared to the positive expression in immortalized human breast epithelial cells, SPARCL1 was nearly absent in human breast cancer cell lines. Similarly, a significantly reduced expression of SPARCL1 was observed in human breast cancer tissues compared to that in normal breast epithelial tissues, for both mRNA and protein levels (P < 0.001). Immunohistochemical analysis showed that strong cytoplasmic immunostaining of SPARCL1 was observed in almost all normal breast samples (43/45) while moderate and strong immunostaining of SPARCL1 was only detected in 191 of 282 (67.7%) breast cancer cases. Moreover, down-regulation of SPARCL1 was significantly correlated with lymphatic metastasis (P = 0.020) and poor grade (P = 0.044). In conclusion, SPARCL1 may be involved in the breast tumorigenesis and serve as a promising target for therapy of breast cancer.

• Corrosion Science and Technology
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• 제12권6호
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• pp.280-287
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• 2013

Flow accelerated corrosion(FAC) of the carbon steel piping in pressurized water reactors(PWRs) has been major issue in nuclear industry. Severe accident at Surry Unit 2 in 1986 initiated the worldwide interest in this area. Major parameters influencing FAC are material composition, microstructure, water chemistry, and hydrodynamics. Qualitative behaviors of FAC have been well understood but quantitative data about FAC have not been published for proprietary reason. In order to minimize the FAC in PWRs, the optimal method is to control water chemistry factors. Chemistry factors influencing FAC such as pH, corrosion potential, and hydrazine contents were reviewed in this paper. FAC rate decreased with pH up to 10 because magnetite solubility decreased with pH. Corrosion potential is generally controlled dissolved oxygen (DO) and hydrazine in secondary water. DO increased corrosion potential. FAC rate decreased with DO by stabilizing magnetite at low DO concentration or by formation of hematite at high DO concentration. Even though hydrazine is generally used to remove DO, hydrazine itself thermally decomposed to ammonia, nitrogen, and hydrogen raising pH. Hydrazine could react with iron and increased FAC rate. Effect of hydrazine on FAC is rather complex and should be careful in FAC analysis. FAC could be managed by adequate combination of pH, corrosion potential, and hydrazine.

• 한국지반공학회논문집
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• 제16권4호
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• pp.63-70
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• 2000

불연속성 암반의 강도특성이나 변형특성에 대한 해석중 가장 중요한 점은 불연속면의 정량적인 파악과 조사방법에 있다. 그러나, 실질적으로 불연속면의 조사 인자들이 암반의 역학적인 특성과의 관계에 대하여는 분명한 해답을 내릴 수 없는 단계에 있다. 본 연구에서는 첫째로 불연속면의 현장 조사 항목 중 절리밀도, 절리길이, 절리 간격을 변화시키면서 암반의 탄성계수와의 상호관계를 밝히고 둘째로, 불연속성 암반의 탄성계수에 직접적인 관계를 가지며 불연속성 암반의 탄성계수를 정리할 수 있는 새로운 인자를 제안하는 것이 목적이다. 해석방법으로는 불연속성 암반의 기본모델로써 난수발생법에 의하여 불연속면을 발생시킨 기본단위구조를 가정하고 이를 균질화법과 유한요소법을 이용한다. 이들 방법을 통한 수치해석으로 불연속성 암반의 탄성계수를 구한다. 그 결과 불연속면의 조사항목과 탄성계수와의 상호관계성 뿐만 아니라 불연속성 암반의 탄성계수와 선형적인 관계를 가지는 새로운 파라메타로써 영향면적률을 제안한다.

• 한국환경과학회지
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• 제11권8호
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• pp.819-827
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• 2002

Laboratory scale experiments were conducted to evaluate the performance of a biofilter for eliminating dimethyl sulfide(DMS). A commercial compost/pine bark nugget mixture served as the biofilter material for the experiments. The gas flow rate and DMS concentration entering the filter were varied to study their effect on the biofilter efficiency. The operating parameters, such as the residence time, inlet concentration, pH, water content, and temperature, were all monitored throughout the filter operation. The kinetic dependence of the DMS removal along the column length was also studied to obtain a quantitative description of the DMS elimination. High DMS removal efficiencies(>95％) were obtained using the compost filter material seeded with activated sludge. DMS pollutant loading rates of up to 5.2 and 5.5 g-DMS/m$^3$/hr were effectively handled by the upflow and downflow biofilter columns, respectively. The macrokinetics of the DMS removal were found to be fractional-order diffusion-limited over the 9 to 25 ppm range of inlet concentrations tested. The upflow column had an average macrokinetic coefficient(K$\_$f/) of 0.0789 $\pm$ 0.0178 ppm$\^$$\sfrac{1}{2}$//sec, while the downflow column had an average coefficient of 0.0935 $\pm$ 0.0200 ppm$\^$$\sfrac{1}{2}$//sec. Shorter residence times resulted in a lower mass transfer of the pollutant from the gas phase to the aqueous liquid phase, thereby decreasing the efficiency.

• 천문학회지
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• 제29권1호
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• pp.63-73
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• 1996

The previous study of chemical evolution of the Galaxy is extended to the radial properties of the Galactic disk. The present model includes radial dependency of the time-dependent bimodal IMF, radial flow of material in the disk, and the change of type I supernova explosion rate with radial distance from the disk center as model parameters and observed gas and stellar density distributions and metallicity abundance gradient as observational constraints. The results of two models in this study explain the observed gas and stellar density distributions well, with the slope of the gas density gradient in the region of 4.5 kpc$Y_1$ and -0.123dex/kpc in model $Y_2$, respectively, which fit well the observed gradient of -0.l1dex/kpc. The abundance gradient reproduced in model $Y_1$ is getting flatter with decreasing radius, while that in model $Y_2$ is getting steeper, which fits better the observed abundance gradient. This result shows the necessity of exponentially increasing type I supernova explosion rate with decreasing radius in order to explain the observed abundance gradient in the disk. The fitness of observed density distribution and star formation rate distribution justifies the reliability of time-dependent bimodal IMF as a compound quantitative chemical evolution model of the Galaxy. The temporal variations of metallicity gradients for carbon, nitrogen and oxygen are also shown.

• 한국인터넷방송통신학회논문지
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• 제12권3호
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• pp.15-22
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• 2012

안전하고 쾌적한 도시 환경을 조성하기 위해 폐기물 매립 시설은 필요하며 폐기물 부피 관리의 신뢰성 및 용량 정보의 정확성을 파악하는 것이 필요하다. 본 연구에서는 쓰레기 매립장 환경 개선을 위해 매립된 쓰레기의 체적을 스테레오 비전 카메라를 이용하여 계산하고 매립량을 계산하기 위한 알고리즘을 개발 하였다. 스테레오(stereo)) 카메라를 이용하여 왜곡 파라메타 교정을 한 후에 쓰레기 매립지의 대상 표면 점들의 클라우드를 얻게 되며 이를 체적 알고리즘의 입력으로 하여 제시된 두 가지 방법의 체적계산 알고리즘을 통해 대상체의 체적을 계산하게 된다. 그리고 이 부피 값과 비교하고자 하는 지난 시간의 체적 값을 감산하여 매립된 체적을 계산한다. 이를 통해 주간 매립 체적, 월간 매립 체적 및 년간 매립 체적을 계산하여 쓰레기 매립 제어를 위한 정량적인 통계값을 얻을 수 있게 된다.

• 한국인터넷방송통신학회논문지
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• 제17권6호
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• pp.145-150
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• 2017

소프트웨어 유지보수는 소프트웨어 생명주기에서 전체 비용의 많은 부분을 차지하고 있다. 소프트웨어를 유지보수하기 위해서는 코드를 읽는 것이 필수적이고, 이는 유지보수 활동에서 가장 많은 시간이 소요되는 활동이다. 코드의 가독성은 사람이 소스코드를 이해하는데 드는 어려움의 정도를 측정하는 메트릭이다. 코드의 가독성이 좋을수록 사람이 소스코드를 이해하기 쉬워진다. 본 논문에서는 소스코드의 가독성을 이분법적으로 판단하는 기존의 연구보다 향상된 기법을 사용하여, 개발 중인 소스코드의 가독성 정도를 정량적으로 측정할 수 있는 새로운 소스코드 가독성 메트릭을 제안한다. 이를 평가하기 위해, 우리는 설문조사를 수행하고 가독성을 가장 잘 설명하는 척도를 찾을 수 있도록 회귀 분석 기법을 사용해 그 결과를 분석할 것이다.