• Journal of Acupuncture Research
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• 제29권4호
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• pp.25-34
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• 2012

Objectives : This study was conducted to investigate the effects of fixed-intensity and varied-intensity electroacupuncture in pain and sensory threshold concerning parameters visual analogue scale(VAS), brief pain inventory(BPI) and quantitative sensory testing(QST), among chronic tension headache patients. Methods : Thirty patients with chronic tension headache were randomly assigned to three groups and received different kinds of electroacupuncture at $ST_{36}$ and $ST_{37}$. Group A received fixed-intensity electroacupuncture(fixed-EA), group B received varied-intensity electroacupuncture (varied-EA), and group C received only acupuncture treatment without electrical stimulation as a control group. The intervention was given three times per week, and continued in two weeks. All the experiments were conducted blindly. Results : Fixed-EA group showed a significant decrease of VAS and BPI compared to the baseline measurement, while both varied-EA and control group did not. Of the parameters of QST, subtraction of heat pain threshold(HPT) and cold pain threshold(CPT) slightly increased in all groups, but this was not significant. Conclusions : These results suggest that fixed-EA reduce pain and improve quality of life in patients with chronic tension headache and that acupuncture may regulate patient's pain sensitivity through changing sensory threshold.

• 터널과지하공간
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• 제18권6호
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• pp.465-479
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• 2008

저심도 터널 굴착시 예상되는 암반 거동을 정량적으로 파악하기 위해 계층 분석적 의사결정 방법과 암반 공학 시스템 방법을 적용하여 암반 거동 지수를 산정하였다. 복잡하고 조직화되지 않은 암반 거동을 효과적으로 결정하기 위해 쌍대 비교 매트릭스를 이용하는 계층 분석적 의사결정 방법과 상호 영향 매트릭스를 이용하는 암반 공학 시스템 방법을 적용하였고, 전문가 의견의 불확실성을 극복하고자 퍼지 델파이 방법을 적용하였다. 저심도 암반 터널 굴착 시 예상되는 암반 거동 유형으로 소성 변형, 낙반과 낙석을 제시하였다. 각각의 암반 거동 유형을 결정하기 위해 일축압축강도, 암질 지수와 절리 조건을 포함하는 암반 내생적 매개변수, 응력, 지하수와 지진 조건을 포함하는 암반 외생적 매개변수와 굴착 매개변수를 고하였다. 이를 서울 지하철 O호선 O공구 설계에 적용하여 예상되는 암반 거동 유형을 정량적인 암반 거동 지수로 제시하였다.

• 대한의용생체공학회:의공학회지
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• 제30권2호
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• pp.142-146
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• 2009

The purpose of this study is to investigate the angular velocity of forearm pronation/supination movement in Parkinson's disease patients, as a quantitative measure of the bradykinesia. Thirteen Parkinson's disease patients ($64{\pm}11.0$ yrs, male:6, female:7) participated in the experiments. The subjects' both right and left forearms were scored by a rater according to rapid alternating movement of hands category in the UPDRS (unified Parkinson's disease rating scale) and the angular velocity of forearm pronation/supination was measured at the same time. As analysis parameters, RMS (root mean square) angular velocity and RMS angle were used. The parameters showed negative correlation with the clinical score (RMS angular velocity: r= - 0.914, RMS angle: r= -0.749). The RMS angular velocity of all clinical scales were significantly different one another except for the non significant difference between those of scale 3 and 4. RMS angle of scale 0 was significantly different from those of scale 2, 3, 4 and that of scale 1 was significantly different from those of scale 3 and 4. This suggests that RMS angular velocity can be used for a quantitative measure of bradykinesia in motor examination.

• 대한후두음성언어의학회지
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• 제20권1호
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• pp.42-46
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• 2009

Background and Objectives : Vocal polyps and nodules are representative chronic benign laryngeal disease. Treatment options for vocal polyp and nodule in general include voice therapy or laryngeal microsurgery. The purpose of this study was to analyze voice results before and after laryngeal microsurgery. Materials and Method: Vocal polyp and vocal nodule patients were treated by laryngeal microsurgery from March 2004 to December 2006 at Kosin University Hospital. All were women. Voice analysis studies were done before and after laryngeal microsurgery. Five measurements were performed: MPT, Fo, jitter, shimmer and NHR. Results: There was significant improvement in the vocal polyp patients regarding MPT, jitter, shimmer and NHR. Also there was significant improvement in the vocal nodule patients regarding MPT, jitter and shimmer. Conclusion: MPT, jitter, shimmer and NHR will be effective acoustic parameters in documenting the quantitative changes in the vocal polyp patients. MPT, jitter and shimmer will be effective acoustic parameters in documenting the quantitative changes in the vocal nodule patients before and after laryngeal microsurgery.

• 한국산학기술학회논문지
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• 제17권4호
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• pp.59-73
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• 2016

지하 수송에 대한 수요가 증가함에 따라 도로터널 사용자와 운영자는 다양한 원인에 의한 위험에 노출되어 있으며, 주요 원인은 각각 사고 이벤트가 될 수 있는 교통상황이다. QRA(정량적 위험평가)의 중요성은 도로터널의 안전성을 정량화하고, 다수의 이해관계자들의 관점(용량, 신뢰성, 가용성, 유지보수 및 안전)에서의 요구조건에 밸런스를 유지하려는 의도에서 커지기 시작했다. 위험평가에 사용되는 고전적 방법은 ETA, FTA이지만, 변수의 다양함과 상호관계를 반영하지 못한다는 이유에서 이 방법들은 상대적으로 단순한 경우에만 적용할 수 있다. 특정위험평가에 필요한 객체, 이벤트, 결과 및 가정, 경계조건 등의 총체는 도로 터널시설 위험평가를 위해 필수적인 내용으로 관찰되어야 하는 시스템을 만들고, 정보, 데이터, 모델 등 관련 항목들이 그 시스템을 서술하게 된다. 시스템은 위험모델에 기반한 계층적 지표들을 사용하여 모델링되고 분석되며, 시스템의 모든 가능한 구성은 지표의 적절한 선택을 통하여 표현될 수 있다. 따라서 본 연구에서는 일반터널에서뿐만 아니라 복층터널 같은 복합적인 지하시스템 변수들간의 상호의존성을 고려하여 정량화할 수 있는 베이지안 네트워크를 근거로 한 정량적 위험평가방법을 소개한다.

• 한국게임학회 논문지
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• 제7권4호
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• pp.63-70
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• 2007

넓은 시야각을 갖는 전방향(omnidirectional) 카메라 시스템은 적은 수의 영상으로도 주변 장면에 대해 많은 정보를 취득할 수 있는 장점으로 감시, 3차원 해석 등의 분야에 널리 응용되고 있다. 본 논문에서는 어안(fisheye) 렌즈를 이용한 전방향 카메라로 입력된 영상으로부터 카메라의 이동 및 회전 파라미터를 자동으로 추정하는 새로운 자동보정 알고리즘이 제안되었다. 먼저, 카메라 위치를 임의의 각 도로 변환하여 얻어진 영상을 이용해 일차 매개변수로 표현된 카메라의 사영(projection)모델을 추정한다. 그리고 이후 다양하게 변환되는 카메라의 위치에 따라 에센셜(essential) 행렬을 구하며, 이 과정에서 대상 영상으로부터 적합한 인라이어(inlier) 집합을 구하기 위해 특징점이 영역 내에 분포 정도를 반영하는 표준편차(standard deviation)를 정량적(quantitative) 기준으로 이용한다. 다양한 실험을 통해 제안된 알고리즘이 전방향 카메라의 사영 모델과 회전, 이동 등의 변환 파라미터를 정확하게 추정함을 확인하였다.

• Journal of Preventive Medicine and Public Health
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• 제45권4호
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• pp.251-258
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• 2012

Objectives: The purpose of this paper was to elucidate the potential methylation levels of adjacent normal and cancer tissues by comparing them with normal colorectal tissues, and to describe the correlations between the methylation and clinical parameters in Korean colorectal cancer (CRC) patients. Methods: Hypermethylation profiles of nine genes (RASSF1, APC, $p16^{INK4a}$, Twist1, E-cadherin, TIMP3, Smad4, COX2, and ABCB1) were examined with 100 sets of cancer tissues and 14 normal colorectal tissues. We determined the hypermethylation at a given level by a percent of methylation ratio value of 10 using quantitative methylation real-time polymerase chain reaction. Results: Nine genes' hypermethylation levels in Korean CRC patient tissues were increased more higher than normal colorectal tissues. However, the amounts of $p16^{INK4a}$ and E-cadherin gene hypermethylation in normal and CRC tissues were not significantly different nor did TIMP3 gene hypermethylation in adjacent normal and cancer tissues differ significantly. The hypermethylation of TIMP3, Ecadherin, ABCB1, and COX2 genes among other genes were abundantly found in normal colorectal tissues. The hypermethylation of nine genes' methylation in cancer tissues was not significantly associated with any clinical parameters. In Cohen's kappa test, it was moderately observed that RASSF1 was related with E-cadherin, and Smad4 with ABCB1 and COX2. Conclusions: This study provides evidence for different hypermethylation patterns of cancer-associated genes in normal and CRC tissues, which may serve as useful information on CRC cancer progression.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권3호
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• pp.127-141
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• 2015

Silver-based systems activated by low intensity direct current continue to be investigated as an alternative antimicrobial for infection prophylaxis and treatment. However there has been limited research on the quantitative characterization of the antimicrobial efficacy of such systems. The objective of this study was to develop a semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model providing the quantitative relationship between the critical system parameters and the degree of antimicrobial efficacy. First, time-kill curves were experimentally established for a strain of Staphylococcus aureus in a nutrientrich fluid environment over 48 hours. Based on these curves, a modified PK/PD model was developed with two components: a growing silver-susceptible bacterial population and a depreciating bactericidal process. The test of goodness-of-fit showed that the model was robust and had good predictability ($R^2>0.7$). The model demonstrated that the current intensity was positively correlated to the initial killing rate and the bactericidal fatigue rate of the system while the anode surface area was negatively correlated to the fatigue rate. The model also allowed the determination of the effective range of these two parameters within which the system has significant antimicrobial efficacy. In conclusion, the modified PK/PD model successfully described bacterial growth and killing kinetics when the bacteria were exposed to the electrically activated silver-titanium implant system. This modeling approach as well as the model itself can also potentially contribute to the development of optimal design strategies for other similar antimicrobial systems.

• Korean Journal of Radiology
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• 제21권9호
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• pp.1095-1103
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• 2020

Objective: The present study aimed to investigate whether quantitative dual-energy computed tomography (DECT) parameters offer an incremental risk stratification benefit over the CT ventricular diameter ratio in patients with acute pulmonary embolism (PE) by using propensity score analysis. Materials and Methods: This study was conducted on 480 patients with acute PE who underwent CT pulmonary angiography (CTPA) or DECT pulmonary angiography (DE CT-PA). This propensity-matched study population included 240 patients with acute PE each in the CTPA and DECT groups. Altogether, 260 (54.1%) patients were men, and the mean age was 64.9 years (64.9 ± 13.5 years). The primary endpoint was all-cause death within 30 days. The Cox proportional hazards regression model was used to identify associations between CT parameters and outcomes and to identify potential predictors. Concordance (C) statistics were used to compare the prognoses between the two groups. Results: In both CTPA and DECT groups, right to left ventricle diameter ratio ≥ 1 was associated with an increased risk of all-cause death within 30 days (hazard ratio: 3.707, p < 0.001 and 5.573, p < 0.001, respectively). However, C-statistics showed no statistically significant difference between the CTPA and DECT groups for predicting death within 30 days (C-statistics: 0.759 vs. 0.819, p = 0.117). Conclusion: Quantitative measurement of lung perfusion defect volume by DECT had no added benefit over CT ventricular diameter ratio for predicting all-cause death within 30 days.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.457-460
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• 2002

The image quality of three-dimensional (3D) images has been widely investigated by the qualitative analysis method. A need remains for an objective and quantitative method to assess the image quality of 3D volume-rendered images. The purpose of this study was to evaluate the quantitative accuracy of distance measurements on 3D volume-rendered images of a dry human skull by using multi-detector computed tomography (MDCT). A radiologist measured five times the twenty-one direct measurement line items composed among twelve reference points on the skull surface with a digital vernier caliper. The water filled skull specimen was scanned with a MDCT according to the section thicknesses of 1.25, 2.50, 3.75, and 5.00 mm for helical (high quality; pitch 3:1) scan mode. MDCT data were reconstructed with its acquisition section thickness and with 1.25 mm section thickness for all scans. An observer also measured seven times the corresponding items on 3D volume-rendered images with measuring tools provided by volumetric analysis software. The quantitative accuracy of distance measurements on the 3D volume-rendered images was statistically evaluated (p-value < 0.05) by comparatively analyzing these measurements with the direct distance measurements. The accuracy of distance measurements on the 3D volume-rendered MDCT images acquired with 1.25, 2.50, 3,75 and 5.00 mm section thickness and reconstructed with its section thickness were 48%, 33%, 23%, and 14%, respectively. Meanwhile, there were insignificant statistical differences in accuracy of distance measurements among 3D volume-rendered images reconstructed with 1.25 mm section thickness for the each acquisition section thickness. MDCT images acquired with thick section thickness and reconstructed with thin section thickness in helical scan mode should be effectively used in medical planning of 3D volume-rendered images. The quantitative analysis of distance measurement may be a useful tool for evaluating the quantitative accuracy and the defining optimal parameters of 3D volume-rendered CT images.