• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1397-1401
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• 2015

Background: To determine the expressions of Tbx3, a member of subgroup belonging to T-box family, and its prognostic value in pancreatic carcinoma. Materials and Methods: We determined the expression levels of Tbx3 on both mRNA and protein levels in 30 pairs of fresh tumor tissues and paratumor tissues by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting, respectively. In addition, protein level of Tbx3 were identified using immunochemistry in 80 pairs of paraffin-embedded specimen. The correlations between Tbx3 expression and various clinicopathological parameters as well as overall survival were evaluated. Results: Tbx3 mRNA and protein levels in tumor tissues were significantly higher than in the paratumor tissues by qRT-PCR ($0.05{\pm}0.007$ vs. $0.087{\pm}0.001$, p<0.001) and western blotting ($1.134{\pm}0.043$ vs. $0.287{\pm}0.017$, p<0.001). The statistical analysis based on immunohistochemical evaluation suggested that Tbx3 aberrant expression was significantly associated with several conventional clinicopathological variables, such as gender, age, tumor position, preoperative CA19-9 level, pathological T staging and N staging. Univariate and multivariate analyses revealed that Tbx3 expression was an independent prognostic factor for overall survival (<0.001). Conclusions: Our results suggest that overexpression of Tbx3 is associated with poor prognosis of pancreatic cancer patients. However, additional clinical trials are needed to accurately validate this observation.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.2851-2857
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• 2013

Objective: REPS2 plays important roles in inhibiting cell proliferation, migration and in inducing apoptosis of cancer cells, now being identified as a useful biomarker for favorable prognosis in prostate and breast cancers. The purpose of this study was to assess REPS2 expression and to explore its role in esophageal squamous cell carcinoma (ESCC). Methods: Protein expression of REPS2 in ESCCs and adjacent non-cancerous tissues from 120 patients was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patient outcome. Additionally, thirty paired ESCC tissues and four ESCC cell lines and one normal human esophageal epithelial cell line were evaluated for REPS2 mRNA and protein expression levels by quantitative RT-PCR and Western blotting. Results: REPS2 mRNA and protein expression levels were down-regulated in ESCC tissues and cell lines. Low protein levels were significantly associated with primary tumour, TNM stage, lymph node metastasis and recurrence (all, P < 0.05). Survival analysis demonstrated that decreased REPS2 expression was significantly associated with shorter overall survival and disease-free survival (both, P < 0.001), especially in early stage ESCC patients. When REPS2 expression and lymph node metastasis status were combined, patients with low REPS2 expression/lymph node (+) had both poorer overall and disease-free survival than others (both, P < 0.001). Cox multivariate regression analysis further revealed REPS2 to be an independent prognostic factor for ESCC patients. Conclusions: Our findings demonstrate that downregulation of REPS2 may contribute to malignant progression of ESCC and represent a novel prognostic marker and a potential therapeutic target for ESCC patients.

• Journal of Korean Neurosurgical Society
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• v.54 no.4
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• pp.280-288
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• 2013

Objective : Perfusion computed tomography (PCT) has the ability to measure quantitative value and produce maps of mean transit time (MTT), cerebral blood flow (CBF), and cerebral blood volume (CBV). We assessed cerebral hemodynamics by using these parameters and acetazolamide (ACZ) challenge for pre- and post-procedural evaluation in patients with unilateral cerebrovascular stenotic disease. Methods : Thirty patients underwent pre-procedural PCT with ACZ challenge, and 24 patients (80%) was conducted follow up PCT after angioplasty with same protocol. The mean MTT, CBF, and CBV were measured and compared in both middle cerebral arterial (MCA) territories before and after ACZ challenge. Hemispheric ratio and percent change after ACZ challenge were calculated before and after angioplasty. Results : The mean stenosis rate was 76.6%. Significant increases in MTT (32.6%, p=0.000) and significant decreases in CBF (-14.2%, p=0.000) were found in stenotic side MCA territories. After ACZ challenge, there were significant changes in MTT (37.4%, p=0.000), CBF (-13.1%, p=0.000), and CBV (-10.5%, p=0.001) in pre-procedural perfusion study. However, no significant increases were found in MTT, or decreases in CBF and CBV in post-procedural study. There were no significant changes after ACZ challenge also. In addition, the degrees of these changes (before and after ACZ challenge) were highly correlated with the stenotic degrees in pre-procedural perfusion study. Conclusion : PCT with ACZ challenge appears to be a useful tool to assess the cerebral perfusion status especially in patients with unilateral symptomatic stenotic disease.

• The KIPS Transactions:PartC
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• v.12C no.6 s.102
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• pp.855-864
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• 2005

In this paper, we propose an intrusion detection system(IDS) architecture which can detect and respond against the generation of abnormal traffic such as malicious code and Internet worms. We model the system, design and implement a simulator using OPNET Modeller, for the performance analysis on the response capacity of alert information in the proposed system. At first, we model the arrival process of alert information resulted from abnormal traffic. In order to model the situation in which alert information is intensively produced, we apply the IBP(Interrupted Bernoulli Process) which may represent well the burstiness of traffic. Then we perform the simulation in order to gain some quantitative understanding of the system for our performance parameters. Based on the results of the performance analysis, we analyze factors which may hinder in accelerating the speed of security node, and would like to present some methods to enhance performance.

• KSBB Journal
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• v.18 no.5
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• pp.347-351
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• 2003

The extraction of glycyrrhizic acid from licorice using supercritical carbon dioxide (SCCO$_2$) was investigated with respect to the effects of extraction parameters such as the kind and amount of modifier, temperature, pressure, and extraction time. The conventional organic solvent extraction was also conducted for a quantitative comparison. The content of glycyrrhizic acid in crude extracts was analyzed by HPLC and the yield of glycyrrhizic acid was computed as a weight percent recovery. The optimal pressure and temperature for SCCO$_2$ extraction were found to be 40 MPa and 80$^{\circ}C$, respectively, when SCCO$_2$ was modified with 70% aqueous ethanol. Under the same pressure and temperature, the highest recovery was attained to be 104.57% in the first 60 min when the concentration of 60%, aqueous ethanol in SCCO$_2$ was 15%.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.280-286
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• 2019

This study verified the difference in biomechanical variation and the pattern of the lower limb between using or not using functional insoles on the gait of elderly people. Ten females subjects were selected (age: 73.2 years, height: 152.1 cm, body mass: 59.4 kg) for testing their gait with using functional insoles and without using functional insoles. The gait motions were captured with the Qualisys system and the gait parameters were calculated with Visual-3D. As a result, the subjects' stride length and swing time were significantly increased (p<.05). Also, the lower limb's extension moment was significantly increased (p<.05) when using the insole. These differences suggest the functional insole used in the experiment increases the subjects' gait stability. However, to generalize the results of this study, it is necessary to accumulate more quantitative data with more subjects. Further studies to examine gait variables and changes of walking patterns need to be conducted by gathering and utilizing the results of those subjects who have used insoles for a long period of time.

• Journal of the Institute of Convergence Signal Processing
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• v.9 no.2
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• pp.112-120
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• 2008

This study aims to develop a system for diagnosing pulse and disease conditions based on oriental medical classics to collect objective quantitative information in the traditional pulse examination environment that uses fingers. For this purpose, the study suggested a thimble-type sensor unit as the most appropriate pulse analyzer and proposed a traditional method to measure the pulse pressure wave on the spots of cheok, gwan and chon by installing the pulse analyzer on the forefinger, middle finger and medical finger. Then, it was interpretively found that this pulse analyzer enables us to objectively recognize 28 pulses defined in Oriental medical classics including the yukjo pulse, described as the buchimjisak-heosil pulse, and the hong, yoo, hyeok and san pulses. Finally, the study proposed a method to extract key parameters essential to pulse condition diagnosis from the pulse pressure wave measured by this pulse analyzer.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.39 no.spc1
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• pp.214-222
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• 2006

Dominant species of macrobenthos were analyzed based on differentiation of three distinct methods: the density based method, the biomass based method and LeBris method, by considering the frequency of occurrence using quantitative data collected over 5 years (1993-1998) at 21 stations in Chonsu Bay. Sedimentary environments as well as species composition and diversity showed the spatial and temporal distribution patterns. The ranks of dominant species as determined by the density based method were more similar to the results by the LeBris method than to those from the biomass based method. Considering the temporal variation, LeBris method were more efficient than any other methods for the determination of dominant species in Chonsu Bay. Lumbrineris longifolia, Theora fragilis, and Moerella jedoensis were recognized by all three methods. A one-way analysis of variance indicated spatial distributions patterns among most of the dominant species. These species showed positive correlations to sedimentary parameters such as mean grain size. However, T. fragilis and Paraprinospio pinnata showed the temporal patterns in their distribution, and were also correlated to the benthic environment, organic content and dissolved oxygen. Some dominant species, e.g., T. fragilis, S. scutata, G. gurjanovae proved to be useful benthic indicators based on the environmental variations determinated by long-term benthic ecological monitoring in Chonsu Bay.

• Journal of the Korean Association of Geographic Information Studies
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• v.11 no.4
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• pp.150-160
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• 2008

The present domestic underwater and ocean facilities management depends on analysis with the naked eye. This study performs quantitative analysis to improve conventional methods, analyze spatial situation of underwater facilities. This research is divided into two steps; underwater image distortion correction and image mosaic step. First, underwater image distortion correction step is for the production of underwater target, calculates the correction parameters, and then developed the method that convert the original image point to whose distortion is corrected. Second step is for the obtaining pipe images installed in the underwater, corrects the distortion, and then transforms a coordinates of the correction pipe image. After coordinate transformation, we make the mosaic image using the singularities. As a result, when we measure the distance between pipe and underwater ground and compare with calculation value on mosaic image, it is showed that RMSE is 0.3cm.

• Journal of Korean Foot and Ankle Society
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• v.2 no.2
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• pp.71-75
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• 1998

The fact that, under similar training activities performed in the same environment, march fractures develop in only a certain percentage of the trainees indicates that intrinsic factors are affecting the prevalence of these fractures. Among these intrinsic factors, the relation between foot arch type and the occurance of march fractures was investigated in this study. From 1997 to 1998, at one infantry medical company of infantry corps in Korea, 15 march fracture patients were detected among infantry soldiers. Quantitative measures of the foot arch (longitudinal) structure of 15(30feet) march fracture patients were established and compared with those of 15(30feet) normal person. The results were as follows. 1. From the lateral X-ray film, three parameters (i.e. calcaneal angle, forefoot angle, height to length ratio)were defined to describe the structure of the longitudinal arch of the foot. 2. The mean value of the calcaneal angle of march fracture group and normal control group showed 16.4 degree, 20.5 degree respectively. The difference between two groups was statistically significant (P>0.006), but those of forefoot angle and height to length ratio were not. 3. In the calcaneal angle twenty-six feet(87%) of march fracture group were lower than 17 degrees but twenty-five feet(83%) of normal control group were more than 17 degrees. That is, march fracture were more prevalent in feet with low calcaneal angle. 4. In the low arch foot, the orthotic device might relieve the energy load carried by the foot, thus reducing the incidence of march fractures, and should be analyzed in further study.