• The Journal of Korean Medicine
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• v.34 no.3
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• pp.119-125
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• 2013

Objectives: Medically unexplained fatigue includes chronic fatigue syndrome (CFS) and idiopathic chronic fatigue (ICF). These disorders quite impair quality of life while no effective therapies exist. Therefore, patients with CFS or ICF frequently choose treatments based on traditional Korean medicine. The study aimed to analyze characteristic of patients visiting an Oriental clinic with CFS or ICF. Methods: Patients who met criteria for CFS or ICF were enrolled in this study, from March 2011 to Jun 2013. Clinical information focused on symptom differentiation and Sasang constitution was analyzed. Pearson's chi-square test was used to compare the frequency among sub-groups. Results: In total, 77 patients (49 male and 28 female) were diagnosed with CFS (17 male and 13 female) or ICF (32 male and 15 female). The symptom differentiation was 37.7%, 26.0%, 13.0%, and 23.3% for "Qi deficiency of both spleen and lung (脾肺氣虛)", "Yin deficiency of both liver and kidney (肝腎陰虛)", "Blood deficiency of both heart and spleen (心脾血虛)" and "Yang deficiency of both spleen and kidney (脾腎陽虛)", while Sasang constitutional distribution was 59.7%, 22.1% and 18.2% Soeumin, Taeumin and Soyangin, respectively. The fatigue severity was notably different between CFS ($63.7{\pm}12.1$) or ICF ($52.2{\pm}15.3$) according to the Chalder fatigue scale (10-point scale for eleven questions). There was statistical significance regarding symptom differentiation and Sasang constitution (p < 0.05). Conclusions: In the process of traditional Korean medicine-based development of therapeutics for patients with chronic fatigue or related conditions, this report can serve as reference data.

• Journal of Korean Medical classics
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• v.30 no.1
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• pp.167-184
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• 2017

Objectives : The paper attempted to analyze the contents found in the networks of five viscera in Yixuerumen's Zangfutiaofen published by Li Chan in 1575, and tried to reveal the body structure dealt in the contents through anatomical verification. Methods : Books such as Huataxianshengneizhaotu, Tushupian, and Shisijingfahui were used to compare, understand, and interpret the original texts and annotations of Yixuerumen in an attempt to verify these through anatomy reference texts and computer programs. Results : In Yixuerumen, some contents of the networks of five viscera were revised to see feixi as not one but two, and explained the relationship of intestinal organs through heart and lung. Anatomically speaking, the networks of five viscera has a vertical structure that unfolds top to bottom centering on aorta, and has many organs connected to it such as trachea, esophagus, splenic artery, pulmonary trunk, ureter, mesentery arteriovenous, gonadal artery, and ductus deferens. Conclusions : The networks of five viscera has a great significance in that it is the fruit of much efforts where oriental medicine tried to explain not only the functions of five viscera, but also the creation and circulation of qi, blood, and bodily fluids through anatomical observation.

• Journal of the Korea Convergence Society
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• v.7 no.1
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• pp.137-143
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• 2016

This study was understanding the application of Misutgaru in Diabetes mellitus. To address these concerns, this study was performed to provide basic ideas to further the understanding oriental medicinal cuisine and its application. Also this study designed to provide basic information applicable to promotion of health and medical cure for modern people through the Korean traditional dietary treatment. Basic data on the nutritional composition and oriental diet therapy area approach of Misutgaru was acquired to predict the usefulness of Misutgaru as tonify the liver and kidney. Thus nourish the blood through tonify the liver & kidney. Misutgaru energy was 309.76Kcal per 100g, crude protein was 39.27 g, crude fat was 4.40g, crude ash was 5.21g and carbohydrate was 28.27g per 100g. This study realize the value of functional effects on various foods with oriental theory. I want that many researchers concerning our traditional theory for dietary food effects.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1378-1382
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• 2008

This study is aim to evaluate pulse diagnosis as indicators for classification of the pattern identifications in stroke patients. To get the clinical information, we recruited the onset 1 month stroke patients through the multicenter network which consists of 13 oriental hospitals. The clinical informations about three pairs of pulse wave form and levels of their significancy based on the case report form (CRF) were collected and their distribution in each pattern identification were analyzed. The results are as follows Fire-Heat group shows high portions of floating pulse, rapid pulse and solid pulse. Qi Defficiency group has a greater portion of deep pulse, slow pulse, deficient pulse. The well-defined character of Phlegm-Retained Fluid, Yin Defficiency, Static Blood groups cannot be explained by pulse wave form. These results show a rough relationship between the pulse diagnosis and pattern identifications of stroke therefore, further studies are required to determine the pulse diagnosis as significant indicators of stroke pattern identification.

• Journal of Korean Medical classics
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• v.30 no.2
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• pp.45-57
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• 2017

Objectives : There exists a number of books that deal with curing diseases with foods. This includes Shennongbencaojing from Han Dynasty era, Zanyin's Shiloaoxingan and Mengxi's Shilaobencao from Tang Dynasty era, Husihui's Yinshanzhengyao from Won Dynasty era, and Feiboxiong's Sikgamboncho from Qing Dynasty era. This paper aims to delve into the food treatment revealed in Sikgamboncho, which is the latest book in the preceeding list, and studied its differences when compared to other medical books that deal with food treatment methods. Methods : The format and contents of Feiboxiong's Sikgamboncho were studied. For its format, Shilaoaoxingan, Yinshanzhengyao, Shikryochanyo, and Donguibogam were used to compare their formats with that of Sikgamboncho in order to discern the unique characteristics found in the book. For its contents, the paper studied food ingredients and food treatment separately, and then studied the historical significance of Feiboxiong's Sikgamboncho. Results : Sikgamboncho categorizes 12 types of grain, 22 types of vegetables, 7 types of cucumis calyx, 27 types of fruit, 9 types of flavor, 4 types of bird, 4 types of animal, 10 types of fish with scales, 4 types of carapace, and 2 types of worm. The book explains each ingredient's harvest period, its nature, potency, and taboos. The food treatment section explains 74 types of treatments that are divided between the wind, cold, summer heat, dampness, dryness category and the qi, blood phlegm, deficiency, and excess category. Each treatment contains its potency and recipe. Conclusions : Feiboxiong underlined the importance of ingredient through placing significance even to the order of ingredients. Out of the total 74 food treatments, 25 treatments were dedicated to deal with weakness. Feiboxiong attempted to prevent human body from becoming weak, which reflects his emphasis on the importance of food and wellness.

• Herbal Formula Science
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• v.28 no.4
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• pp.429-441
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• 2020

Objectives : Systemic sclerosis(SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs and vasculopathy. The purpose of this study was to investigate the trend in the research on SSc using herbal medicine. Methods : We searched for papers which had both systemic sclerosis and herbal medicine from Pubmed, KCI and NDSL. After searching papers, we classified according to the study design and analyzed selected studies. Results : 18 studies were searched. The types and numbers of study were as follows: 11 were in vitro or in vivo studies using herbal medicine or active components, and 7 were clinical research including case reports. 1. Herbal medicines include the therapeutic effects of "tonifying qi(補氣)" or "active blood(活血)" improved systemic sclerosis in vivo and in vitro studies. 2. Active components isolated from Herbal Medicine such as Astragalus membranaceus(黃芪), Zhizi(梔子), Salvia miltiorrhiza(丹蔘) have anti-fibrotic effects. 3. Clinical trials showed that herbal medicine can improve the symptom of systemic sclerosis including skin fibrosis, Raynaud's phenomenon, pain and gastric dysmotility. Conclusions : This study showed that herbal medicine can be effective for treating SSc. However, further studies are needed to develop novel medicine for SSc.

• Biomolecules & Therapeutics
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• v.25 no.5
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• pp.490-496
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• 2017

Imatinib resistance has become a major clinical problem for chronic myeloid leukemia. The aim of the present study was to investigate the involvement of MEG3, a lncRNA, in imatinib resistance and demonstrate its underlying mechanisms. RNAs were extracted from CML patients' peripheral blood cells and human leukemic K562 cells, and the expression of MEG3 was measured by RT-qPCR. Cell proliferation and cell apoptosis were evaluated. Western blotting was used to measure the protein expression of several multidrug resistant transporters. Luciferase reporter assay was performed to determine the binding between MEG3 and miR-21. Our results showed that MEG3 was significantly decreased in imatinib-resistant CML patients and imatinib-resistant K562 cells. Overexpression of MEG3 in imatinib-resistant K562 cells markedly decreased cell proliferation, increased cell apoptosis, reversed imatinib resistance, and reduced the expression of MRP1, MDR1, and ABCG2. Interestingly, MEG3 binds to miR-21. MEG3 and miR-21 were negatively correlated in CML patients. In addition, miR-21 mimics reversed the phenotype of MEG3-overexpression in imatinib-resistant K562 cells. Taken together, MEG3 is involved in imatinib resistance in CML and possibly contributes to imatinib resistance through regulating miR-21, and subsequent cell proliferation, apoptosis and expression of multidrug resistant transporters.

• The Journal of Internal Korean Medicine
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• v.28 no.4
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• pp.929-936
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• 2007

Tremor is a rhythmic, involuntary muscular contraction characterized by oscillations of a part of the body and is the most common movement disorder. Clinically, tremor isclassified into postural tremor, resting tremor, action tremor, or other kinds of tremor, and treated according to the causes. The appropriate treatment of tremor depends on accurate diagnosis of its cause. We have recently examined a number of tremor-patients diagnosed as cerebellar infarction. Based on traditional Korean medicine curative way, we diagnosed this patient as deficiency of Qi and blood(氣血兩虛). On this account, suitable treatment had been provided. Our results show the clinical symptoms had improved through treatment with herbal medicine (Palmultang-gamibang) and acupuncture, so we report it for better treatment.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.6
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• pp.717-729
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• 2013

Bioelectrical Impedance Analysis (BIA) is a non-invasive and low-cost technique that estimates body composition based on the distribution of water and electrolytes in the body by analyzing body's electrical responses to source voltages. In this work, we carried out a systematic literature review on BIA researches in traditional East Asian medicine (TEAM). For comparison, firstly we introduced the concept and principle of BIA, and offered a general overview of research trends in western medical perspectives. We searched through the databases of Oriental Medicine Advanced Searching Integrated System and DataBase Periodical Information Academic for the articles published between 1994 and 2013, with keywords such as 'BIA', 'bioelectrical impedance' and 'impedance'. Among the rough-searched 274 articles, we finally selected 21 articles appropriate to the intended research field. The selected articles were categorized into diagnosis in Sasang medicine, impedance analysis in meridian system, and change of body composition after taking herbal medicine. We found that most of BIA researches in TEAM were preliminary and remained in the peripheral levels which is far behind the western medical research activities. Therefore, more efforts are needed to study BIA in association with major subjects such as pattern identification or physiological/pathological phenomena. In addition, methodological breakthrough of BIA is possible by applying the diagnostic concepts of the TEAM in relation to the balance of Qi and Blood.

• The Journal of Pediatrics of Korean Medicine
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• v.29 no.3
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• pp.21-31
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• 2015

Objectives : The purpose of this study is to analyze Korean medicine treatment of guillain-barre syndrome based on TCM (Traditional Chinese Medicine) Journals. Methods : 12 control studies and 28 case studies in CNKI (China National Knowledge Infrastructure) were selected for analysis. Results and Conclusions : 1. In control studies, most studies have studied western medicine (Control) versus western medicine + TCM (Intervention group). The intervention group had significantly better results than that of the control group. 2. In case studies, syndrome differentiations related to dual deficiency of qi and blood are common. Every syndrome differentiations has deficiency syndrome. 3. The most commonly used acupoints are LI11, ST36, LI4 and GB34. 4. The most commonly used meridians are large intestine meridian and stomach meridian.