• Proceedings of the IEEK Conference
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• 2004.06b
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• pp.407-410
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• 2004

This paper describes an embedded system to put a SoC actuator IP in motion and linux drivers. The If that a embedded linux among embedded OS is ported is implemented as linux driver. The actuator IP is controlled by application programming. To make users use this easily, a QT is ported on the system. Application program can operate the actuator IP device driver on TFT LCD.

• Proceedings of the Korea Multimedia Society Conference
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• 2002.11b
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• pp.780-785
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• 2002

오늘날 디지털 컨텐츠 시장의 급성장, 그리고 전자책이 갖는 장점들로 인하여 전세계적으로 전자책에 많은 관심을 집중시키고 있으며, 이에 전세계적으로 각국에서는 전자책 문서의 표준화를 위한 컨소시엄이 활동 중에 있다. 또한 전자책을 보기 위한 도구인 E-Book Viewer에 대한 여러 연구 및 서비스가 제공되고 있다. 이 중에서 주석 기능은 정보 공유 및 검색과 같은 다양한 활용을 위하여 반드시 필요한 기능이라 하겠다. 이에 본 연구에서는 주석을 지원하는 PDA용 E-Book Viewer의 설계를 위하여 Windows 환경에서 QT Labrary를 이용하였으며, 폰트의 크기와 스킨의 색상, 주석의 표현 여부 등을 설정할 수 있고, 특정 단어를 검색하는 기능을 지원한다.

• Proceedings of the KIEE Conference
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• 2006.07d
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• pp.2138-2139
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• 2006

본 논문에서는 인텔사의 PXA 255 프로세서에 내장형 운영 시스템을 실장하여 미디어 플레이어의 기능을 구현하고, Wireless LAN(IEEE 802.11b)망을 통한 다양한 멀티미디어 컨텐츠를 다운로드할 수 있는 시스템 구현을 보였다. 이를 위하여 리눅스 운영 시스템에 미디어 플레이어와 코덱을 크로스 컴파일하여 보드에 실장하고, 사용자의 편의를 위하여 USB 디바이스 지원과 저장용량 확대를 위한 Compact Flash 메모리 디바이스 지원을 보였다. 또한 사용자 인터페이스를 위하여 Qt/E를 이용하여 어플리케이션을 제작함으로서 사용자의 편의성을 도모하였다.

• 대한임상약리학회:학술대회논문집
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• 1999.12a
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• pp.52-52
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• 1999

• Proceedings of the Korean Biophysical Society Conference
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• 1999.06a
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• pp.64-64
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• 1999

Amitriptyline has been known to induce QT prolongation and ventricular arrhythmias such as torsades de pointes which causes sudden death. We studied the effects of amitriptyline on the human ether-a-go-go-related gene (HERG) channel expressed in Xenopus oocytes.(omitted)

• Annual Conference of KIPS
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• 2004.05a
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• pp.1663-1666
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• 2004

임베디드 리눅스를 상에서 수행되는 건물 정보 서비스를 구현하였다. 종래의 웹에서 제공하는 맵(map) 서비스 기능에 건물 내부의 정보를 조회하는 기능을 추가하였다. 건설교통부에서 제공하는 수치 지형도를 사용하였고, 이로부터 지리정보데이터베이스를 구축하기 위하여 파서 및 속성정보 입력기를 구현하였다. 건물 정보를 표현하기 위하여 OralceSpatial 컴포넌트를 사용하였다. 그리고 Qt-E을 사용하여 지리정보를 보기 위한 클라이언트 프로그램을 개발하였다.

• Journal of Ginseng Research
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• v.37 no.3
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• pp.283-292
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• 2013

Ginsenosides are divided into two groups based on the types of the panaxadiol group (e.g., ginsenoside-Rb1 and -Rc) and the panaxatriol group (e.g., ginsenoside-Rg1 and -Re). Among them, ginsenoside-Re (G-Re) is one of the compounds with the highest content in Panax ginseng and is responsible for pharmacological effects. However, it is not yet well reported if G-Re increases the hemodynamics functions on ischemia (30 min)/reperfusion (120 min) (I/R) induction. Therefore, in the present study, we investigated whether treatment of G-Re facilitated the recovery of hemodynamic parameters (heart rate, perfusion pressure, aortic flow, coronary flow, and cardiac output) and left ventricular developed pressure (${\pm}dp/dt_{max}$). This research is designed to study the effects of G-Re by studying electrocardiographic changes such as QRS interval, QT interval and R-R interval, and inflammatory marker such as tissue necrosis factor-${\alpha}$ (TNF-${\alpha}$) in heart tissue in I/R-induced heart. From the results, I/R induction gave a significant increase in QRS interval, QT interval and R-R interval, but showed decrease in all hemodynamic parameters. I/R induction resulted in increased TNF-${\alpha}$ level. Treatment of G-Re at 30 and $100{\mu}M$ doses before I/R induction significantly prevented the decrease in hemodynamic parameters, ameliorated the electrocardiographic abnormality, and inhibited TNF-${\alpha}$ level. In this study, G-Re at $100{\mu}M$ dose exerted more beneficial effects on cardiac function and preservation of myocardium in I/R injury than $30{\mu}M$. Collectively, these results indicate that G-Re has distinct cardioprotectective effects in I/R induced rat heart.

• Korean Journal of Clinical Pharmacy
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• v.25 no.2
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• pp.120-129
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• 2015

Objectives: Drug utilization review program in Korea has provided 'drug combinations to avoid (DCA)' alerts to physicians and pharmacists to prevent potential adverse drug events or inappropriate drug use. Seven hundred and six DCA pairs have been announced officially by the Ministry of Food and Drug Safety (MFDS) by March, 2015. Some DCA pairs could be grouped based on the drug interaction mechanism and its consequences. This study aimed to investigate the drug-drug interaction (DDI) pairs, which may be potential DCAs, generated by the drug class-drug class interaction method. Methods: Eleven additive/synergistic and one antagonistic drug class-drug class interaction groups were identified. By combining drugs of two interacting drug class groups, numerous DDI pairs were made. The status and severity of DDI pairs were examined using Lexicomp and Micromedex. Also, the DCA listing rate was calculated. Results: Among 258 DDI pairs generated by the drug class-drug class interaction method, only 142 pairs were identified as official DCA pairs by the MFDS. One hundred and four pairs were identified as potential DCA pairs to be listed. QT prolonging agents-QT prolonging agents, triptans-ergot alkaloids, tricyclic antidepressants-monoamine oxidase inhibitors, and dopamine agonists-dopamine antagonists were identified as drug class-drug class interaction groups which have less than 50 % DCA listing rate. Conclusion: To improve the clinicians' adaptability to DCA alerts, the list of DCA pairs needs to be continuously updated.

• Biomolecules & Therapeutics
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• v.18 no.4
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• pp.448-453
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• 2010

Drug-induced long QT syndrome is known to be associated with the onset of torsades de pointes (TdP), resulting in a fatal ventricular arrhythmia. QT interval prolongation can result from blocking the human ether-a-go-go-related gene (hERG) channel, which is important for the repolarization of cardiac action potential. Nicardipine, a Ca-channel blocker and antihypertensive agent, has been reported to increase the risk of occasional serious ventricular arrhythmias. We studied the effects of nicardipine on hERG $K^+$ channels expressed in HEK293 cells and Xenopus oocytes. The cardiac electrophysiological effect of nicardipine was also investigated in this study. Our results revealed that nicardipine dose-dependently decreased the tail current of the hERG channel expressed in HEK293 cells with an $IC_{50}$ of 0.43 ${\mu}M$. On the other hand, nicardipine did not affect hERG channel trafficking. Taken together, nicardipine inhibits the hERG channel by the mechanism of short-term channel blocking. Two S6 domain mutations, Y652A and F656A, partially attenuated (Y652A) or abolished (F656A) the hERG current blockade, suggesting that nicardipine blocks the hERG channel at the pore of the channel.

• Toxicological Research
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• v.22 no.2
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• pp.109-116
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• 2006

Safety pharmacology studies are conducted to investigated the potential undesirable pharmacodynamic effects of a substance on physiological functions in relation to exposure in the therapeutic range and above. In the International Conference on Harmonisation (ICH), the guideline 'S7A: Safety Pharmacology Studies for Human Pharmaceuticals' has been developed and reached Step 5 of the ICH process in 2001. Now the Korea Food and Drug Administration (KFDA) are going to transfer 'The Guideline for General Pharmacology' into 'The Guideline for Safety Pharmacology'. Safety pharmacology studies should be performed in compliance with Good Laboratory Practice (GLP). Thus, the present paper reviews the Japanese GLP guidelines for pharmaceuticals to help the conduct and inspection of safety pharmacology studies in compliance with GLP. We also reviewed the ICH guidelines 'S7B revised : The Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals' and 'E14 : The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-antiarrhythmic Drugs' to apply our drug approval systems.