• Title/Summary/Keyword: QR

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Effects of Natural Products on the Induction of NAD(P)H: Quinone Reductase in Hepa 1c1c7 Cells for the Development of Cancer Chemopreventive Agents

  • Kim, Young-Mi;Chang, Il-Moo;Mar, Woong-Chon
    • Natural Product Sciences
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    • v.3 no.2
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    • pp.81-88
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    • 1997
  • NAD(P)H:quinone reductase (QR) is one of the protective phase II enzymes against toxicity that accomplishes the capacity of detoxification by modulating the effects of mutagens and carcinogens. The detoxification mechanism is that quinone reductase promotes the 2-electron reduction of quinones to hydroquinones which are less reactive. This study is to search new inducers of quinone reductase from natural products, which can be used as cancer chemopreventive agents. Plant extracts were evaluated by using quinone reductase generating system With Hepa 1c1c7 murine hepatoma cell lines for enzyme inducing properties and crystal violet staining method for the measurement of cytotoxicity provoked. We have tested approximately 106 kinds of natural products after partition into n-hexane, ethyl acetate and aqueous layers from 100% methanol extracts of natural products. The ethyl acetate fractions of Vitex rotundifolia $(fruits,\;2FC:\;12.7\;{\mu}g/ml)$, Cnidium officinale $(aerial\;parts,\;2FC:\;10.5\;{\mu}g/ml)$, Chrysanthemum sinese $(flowers,\;2FC:\;17.4{\mu}g/ml)$ and the hexane fractions of Angelica gigas $(roots,\;2FC:\;13.2\;{\mu}g/ml)$, Smilax china $(roots,\;2FC:\;l1.9\;{\mu}g/ml)$, Sophora flavescens $(roots,\;2FC:\;16.3\;{\mu}g/ml)$ revealed the significant induction of quinone reductase in a murine hepatic Hepa 1c1c7 cell culture system.

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Core Factors Governing Manufacturing Procedures and Systems (의류 생산 시스템을 지배하는 핵심 요소들에 대한 고찰)

  • Lee, Duck-Weon;Lim, Ho-Sun;Shim, Woo-Sub
    • Journal of the Korean Society of Clothing and Textiles
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    • v.33 no.12
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    • pp.1910-1923
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    • 2009
  • This paper reviews four factors involved in apparel and textile manufacturing procedures under international economic fluctuation. This work will be helpful to evaluate the efficiency of global manufacturing systems. Production costs including direct costs related to material and labor costs, and indirect costs associated with manufacturing running ones are significantly correlated to diverse visible and invisible elements such as infrastructure and the labor skills of foreign manufacturing areas, which might create an apparent difference in production costs. Manufacturers can consider how to improve the efficiency of manufacturing systems through a review of the co-relationship between manufacturing procedures and four factors such as manufacturing systems, production outsourcing types, manufacturing locations, and production costs in detail. In addition, the four factors are the core parameters of determining or contributing to the efficiency of a production schedule that is ultimately associated with the supply chain management (SCM) to efficiently conduct Quick Response (QR).

Diagnostic value of two modes of cone-beam computed tomography in evaluation of simulated external root resorption: an in vitro study

  • Dalili, Zahra;Taramsari, Mehran;Mehr, Seyed Zoheir Mousavi;Salamat, Fatemeh
    • Imaging Science in Dentistry
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    • v.42 no.1
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    • pp.19-24
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    • 2012
  • Purpose : Field of view and voxel resolution of cone beam computed tomography (CBCT) might affect the diagnostic capability. This study was performed to compare between the standard and HiRes zoom modes in the diagnosis of external root resorption (ERR) using CBCT. Materials and Methods : Sixty three small cavities (0.25 mm depth and 0.5 mm diameter) were simulated on the buccal, lingual, and proximal surfaces at three different levels of 16 roots of teeth. After covering the root with nail varnish, the roots were inserted in the sockets and the model was placed in a water-containing lacuna. CBCT scans were taken in both standard and HiRes zoom modes using NewTom VG (QR srl Company, Verona, Italy). Then, an observer assessed the images to determine the presence or absence of the cavities. This process was repeated by increasing the size and depth of cavities to 0.5 mm depth and 1 mm diameter. Data were analyzed by McNemar test. The sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio in evaluation of the simulated cavities were calculated. Results : There was a significant difference between the two imaging modes in diagnosing the shallow cavities (p=0.02).The sensitivity of the standard zoom in detecting the shallow cavities was lower than that of the HiRes zoom. The likelihood ratio of the HiRes zoom was higher in the diagnosis of both cavity types. Conclusion : This study suggested that a smaller voxel size in the HiRes zoom mode of CBCT is preferred for diagnosis of ERR.

The Automatic Design of Optimal Systolic Arrays (최적 시스토릭 어레이의 자동설계)

  • Seong, Ki-Taek;Shin, Dong-Suk;Lee, Deok-Su
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.26 no.3
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    • pp.295-302
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    • 1990
  • In this paper, a methodology for the automatic design of the optimal systolic arrays is proposed. Algorithm transformation is the main mathematical tool on which this methodology is based. Also, technique for partitioning algorithm into systolic arrays is presented. Algorithm partitioning is essential when the size of the computational problem is larger than the size of the array. This study results in (a) reduction of the design time of systolic arrays for given algorithms, (b) CRT display of the structures of systolic arrays, and (c) automatic designing of the optimal systolic array by the criteria such as the number of processing elements, bands, and communication paths. The procedure for these results was programmed using HP BASIC language on HP-9836 computer.

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Vision-based Real-Time Two-dimensional Bar Code Detection System at Long Range (비전 기반 실시간 원거리 2차원 바코드 검출 시스템)

  • Yun, In Yong;Kim, Joong Kyu
    • Journal of the Institute of Electronics and Information Engineers
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    • v.52 no.9
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    • pp.89-95
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    • 2015
  • In this paper, we propose a real-time two-dimensional bar code detection system even at long range using a vision technique. We first perform short-range detection, and then long-range detection if the short-range detection is not successful. First, edge map generation, image binarization, and connect component labeling (CCL) are performed in order to select a region of interest (ROI). After interpolating the selected ROI using bilinear interpolation, a location symbol pattern is detected as the same as for short-range detection. Finally, the symbol pattern is arranged by applying inverse perspective transformation to localize bar codes. Experimental results demonstrate that the proposed system successfully detects bar codes at two or three times longer distance than existing ones even at indoor environment.

Efficient QRS Detection and PVC(Premature Ventricular Contraction) Classification based on Profiling Method (효율적인 QRS 검출과 프로파일링 기법을 통한 심실조기수축(PVC) 분류)

  • Cho, Ik-Sung;Kwon, Hyeog-Soong
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.17 no.3
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    • pp.705-711
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    • 2013
  • QRS detection of ECG is the most popular and easy way to detect cardiac-disease. But it is difficult to analyze the ECG signal because of various noise types. Also in the healthcare system that must continuously monitor people's situation, it is necessary to process ECG signal in realtime. In other words, the design of algorithm that exactly detects QRS wave using minimal computation and classifies PVC by analyzing the persons's physical condition and/or environment is needed. Thus, efficient QRS detection and PVC classification based on profiling method is presented in this paper. For this purpose, we detected QRS through the preprocessing method using morphological filter, adaptive threshold, and window. Also, we applied profiling method to classify each patient's normal cardiac behavior through hash function. The performance of R wave detection, normal beat and PVC classification is evaluated by using MIT-BIH arrhythmia database. The achieved scores indicate the average of 99.77% in R wave detection and the rate of 0.65% in normal beat classification error and 93.29% in PVC classification.

Divide and conquer kernel quantile regression for massive dataset (대용량 자료의 분석을 위한 분할정복 커널 분위수 회귀모형)

  • Bang, Sungwan;Kim, Jaeoh
    • The Korean Journal of Applied Statistics
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    • v.33 no.5
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    • pp.569-578
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    • 2020
  • By estimating conditional quantile functions of the response, quantile regression (QR) can provide comprehensive information of the relationship between the response and the predictors. In addition, kernel quantile regression (KQR) estimates a nonlinear conditional quantile function in reproducing kernel Hilbert spaces generated by a positive definite kernel function. However, it is infeasible to use the KQR in analysing a massive data due to the limitations of computer primary memory. We propose a divide and conquer based KQR (DC-KQR) method to overcome such a limitation. The proposed DC-KQR divides the entire data into a few subsets, then applies the KQR onto each subsets and derives a final estimator by aggregating all results from subsets. Simulation studies are presented to demonstrate the satisfactory performance of the proposed method.

Research on the Contents Construction for the Information-oriented Family Life and Development of Professional Occupations : Based on the Analysis of the Present Condition of Information Needs among the Human Ecology Majors (가정생활 정보화 콘텐츠 구성과 전문 직업 개발을 위한 연구 : 생활과학 전공자의 정보화 요구 실태분석을 통하여)

  • 윤소영
    • Journal of Families and Better Life
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    • v.21 no.3
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    • pp.75-85
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    • 2003
  • This study is aimed at sowing two purposes. The first is to analyze the real condition and demand of profession development from the human ecology majors. The second is to develop necessary methods in which ordinary people can collect necessary information about family life. Related questionnaire was distributed to 147 the human ecology majors, and analysis was performed on the several web sites providing with information related to family life. Web sites such as“www.yahoo.com”and“www.naver.com”were included in the analysis. Questionnaire consisted of questions about whether the students majoring in the human ecology were familiar with the information-related terms or futuristics-related books, and whether they have ever taken the related courses in college. The results of analysis are as follows: First, analysis shows that the present level of the human ecology majors' information orientation and networking experiences is extremely low. Secondly, according to the analysis on whether they have optimistic or pessimistic attitude toward the contemporay informatized society, the human ecology majors have rather optimistic attitude in group while having pessimistic one individually. As to their response to the question about whether informatized society is connected with industrial society or not, the human ecology majors are divided in neatly equal ratio. Thirdly, analysis of the human ecology majors' understanding of profession relevant to their major indicates that they have high level of perception and information about the professions of fashion designing, traditional garment designing, nutrition counselling or consumer counselling. On the other hand, they are not familiar with the information about professions such as professional QR Programming, eating habit-related information business and family welfare. Lastly, level of web sites supplying information about family life is fragmentary. Especially, probe into the directories providing with necessary information of family life subdivided into special areal of life shows that they lack systematic organization making more convenient consumer use.

Hybrid Detection Algorithm for Spatial Multiplexing MIMO-OFDM System (공간 다중화 MIMO-OFDM 시스템을 위한 Hybrid 검출 기법)

  • Won, Tae-Yoon;Kim, Seung-Hwan;Lee, Jin-Yong;Kim, Young-Lok
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.35 no.6C
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    • pp.539-546
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    • 2010
  • In next generation wireless communication systems based on OFDM, multiple-input multiple-output (MIMO) technique is adopted in order to achieve high data throughput with limited bandwidth. As one of MIMO techniques, spatial multiplexing scheme needs high performance data detection algorithm that can be performed with low computational complexity. In this paper, we propose an algorithm that can compute QRM-MLD with reduced complexity. Also, hybrid detection technique is proposed, which can reduce the complexity by selecting between MMSE and QRM-MLD according to the channel condition. The proposed algorithm provides the trade-off between performance and complexity. The computer simulations for downlink transmission in 3GPP LTE system show that less than 0.1dB performance degradation can be achieved at 0.1% BER with 59% reduction on computational complexity compared with the conventional QRM-MLD algorithm.

A new method for optimal selection of sensor location on a high-rise building using simplified finite element model

  • Yi, Ting-Hua;Li, Hong-Nan;Gu, Ming
    • Structural Engineering and Mechanics
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    • v.37 no.6
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    • pp.671-684
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    • 2011
  • Deciding on an optimal sensor placement (OSP) is a common problem encountered in many engineering applications and is also a critical issue in the construction and implementation of an effective structural health monitoring (SHM) system. The present study focuses with techniques for selecting optimal sensor locations in a sensor network designed to monitor the health condition of Dalian World Trade Building which is the tallest in the northeast of China. Since the number of degree-of-freedom (DOF) of the building structure is too large, multi-modes should be selected to describe the dynamic behavior of a structural system with sufficient accuracy to allow its health state to be determined effectively. However, it's difficult to accurately distinguish the translational and rotational modes for the flexible structures with closely spaced modes by the modal participation mass ratios. In this paper, a new method of the OSP that computing the mode shape matrix in the weak axis of structure by the simplified multi-DOF system was presented based on the equivalent rigidity parameter identification method. The initial sensor assignment was obtained by the QR-factorization of the structural mode shape matrix. Taking the maximum off-diagonal element of the modal assurance criterion (MAC) matrix as a target function, one more sensor was added each time until the maximum off-diagonal element of the MAC reaches the threshold. Considering the economic factors, the final plan of sensor placement was determined. The numerical example demonstrated the feasibility and effectiveness of the proposed scheme.