• Journal of Communications and Networks
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• 제18권5호
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• pp.818-825
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• 2016

Network management and anomaly detection are challenges in high-speed networks due to the high volume of packets that has to be analysed. Flow-based analysis is a scalable method which reduces the high volume of network traffic by dividing it into flows. As sampling methods are extensively used in flow generators such as NetFlow, the impact of sampling on the performance of flow-based analysis needs to be investigated. Monitoring using sampled traffic is a well-studied research area, however, the impact of sampling on flow-based anomaly detection is a poorly researched area. This paper investigates flow sampling methods and shows that these methods have negative impact on flow-based anomaly detection. Therefore, we propose an efficient probabilistic flow sampling method that can preserve flow traffic distribution. The proposed sampling method takes into account two flow features: Destination IP address and octet. The destination IP addresses are sampled based on the number of received bytes. Our method provides efficient sampled traffic which has the required traffic features for both flow-based anomaly detection and monitoring. The proposed sampling method is evaluated using a number of generated flow-based datasets. The results show improvement in preserved malicious flows.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1994년도 Proceedings of the Korea Automatic Control Conference, 9th (KACC) ; Taejeon, Korea; 17-20 Oct. 1994
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• pp.747-752
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• 1994

Ussing's flux ratio theorem (1978) reflects a reciprocal relationship behavior between the unidirectional fluxes in asymmetric steady diffusion-convection in a membrane slab. This surprising result has led to many subsequent studies in a wide range of applications, in particular involving linear models of time dependent problems in biology and physiology. Ussing's theorem and its extensions are inherently linear in character. It is of considerable interest to ask to what extent these results apply, if at all, in situations involving, for example, nonlinear reaction. A physiologically interesting situation has been considered by Weisiger et at. (1989, 1991, 1992) and by McNabb et al. (1990, 1991) who studied the role of albumin in the transport of ligands across aqueous diffusion barriers in a liver membrane slab. The results are that there exist reciprocal relationships between unidirectional fluxes in the steady state, although albumin is chemically interacting in a nonlinear way of the diffusion processes. However, the results do not hold in general at early times. Since this type of study first started, it has been speculated about when and how the Ussing's flux ratio theorem fails in a general diffusion-convection-reaction system. In this paper we discuss the validity of Ussing-type theorems in time-dependent situations, and consider the limiting time behavior of a general nonlinear diffusion system with interaction.

• 대한한의학회지
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• 제32권6호
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• pp.10-17
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• 2011

Background: Vibration response imaging (VRI) is a new technology that records energy generated by airflow during the respiration cycle. Analysis of lung sound using VRI may overcome the limitations of auscultation. Objectives: To set a VRI standard for healthy Koreans, we conducted a clinical assessment to evaluate breath sound images and quantification in healthy subjects and compared the findings with reported breath sound characteristics. Methods: Recordings were performed using the VRIxp. Eighty subjects took a deep breath four times during a 12-second interval while sitting upright. The quantitative aspect was analyzed using the VRI quantitative lung data (QLD) for total left lung, total right lung and for six lung regions: left upper lung (LUL), left middle lung (LML), left lower lung (LLL), right upper lung (RUL), right middle lung (RML), right lower lung (RLL). The qualitative aspect was provided through image assessments by three reviewers. Results: In all regions the left lung had significantly higher QLD than the right lung (P<0.005, paired t-test). The inter-rater agreement was 0.78. 84% of the images were found normal by the final assessment. Among the 16% (n=13) of images with abnormal final assessment, the most common flawed features were dynamic image (77%, n=10) and maximum energy frame (MEF) shape (77%, n=10). No significant differences were found between males and females for QLD but there were significant differences in qualitative aspects including dynamic images, MEF shape, and missing LLL. Conclusion: The characteristics of healthy Koreans are similar to those of Western subjects reported previously. VRI is easy to use and objective, and so is helpful to diagnose patients with respiratory diseases and to monitor the progress of diseases after medical treatments.

• Bulletin of the Korean Chemical Society
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• 제34권2호
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• pp.437-442
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• 2013

A new series of 4-(2-(substituted)pyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazoles (4a-f) and their 1,2-isoxazole analogues (5a-f) has been rationally designed, synthesized and screened against both ROS and MAPK14 kinases. Compounds 4b, 4c and 4e showed moderate inhibitions against both ROS and MAPK14 kinases. Compound 4e has showed the strongest inhibitions with IC50 values of 1.25 ${\mu}M$ and 3.00 ${\mu}M$ against ROS and MAPK14 kinases, respectively. A brief structure-activity relationship study and a molecular modeling study were made revealing a group of essential structural features for good kinase inhibitory activity within this new class of kinase inhibitors.

• 한국토양비료학회지
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• 제27권3호
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• pp.201-208
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• 1994

밭토양(土壤) 심층(深層)에 용탈집적(溶脫集積)되어 있는 Nitrate를 작물(作物)이 이용(利用)할때 이의 흡수(吸收)를 저해(沮害)하는 토양성분(土壤成分)을 찾고자 검은연두(緣豆), 해바라기, 수수등 3가지 작물(作物)을 공시(供試)하여 이들 작물(作物)의 시용실소(施用室素)의 회수율(回收率)과 다른 토양성분(土壤成分)들의 관계를 구명(究明)하였다. 3가지 작물(作物)의 건물중(乾物重)과 질소규수량(窒素叫收量)은 토양(土壤)의 질소함량(窒素含量)이 높은 토양(土壤)에서 많았다. 염소흡수량(鹽素吸收量)은 해바리기와 수수에서는 염소농도(鹽素濃度)가 낮고 질소함량(窒素含量)이 높은 토양(土壤)에서, 검은연두(緣豆)에서는 질소함량(窒素含量)이 높은 토양(土壤)과 염소농도(鹽素濃度)가 높은 토양(土壤)에서 높았다. 3가지 작물의 시비질소(施肥窒素) 흡수비율(吸收比率)과 검은녹두(綠豆)의 고정질소(固定窒素) 비율(比率)은 질산태질소(窒酸態窒素) 함량(含量)이 가장 높은 토양(土壤)에서 낮았으며 토양질소(土壤窒素) 흡수비율(吸收比率)은 반대(反對)의 경향(傾向)을 보였다. 각종(各種) 양(陽)이온들의 흡수량(吸收量)이 증가(增加)할수록 3가지 작물(作物)의 시용질소(施用窒素) 회수율(回收率)이 증가(增加)하는 경향(傾向)이었다. 해바라기와 수수에서는 염소흡수량(鹽素吸收量)이 많아짐에 따라 시용질소회수율(施用窒素回收率)도 증가(增加)하였으나 검은녹두(綠豆)에서는 감소(減少)하는 경향(傾向)이었다. 검은연두(緣豆)의 시용질소(施用窒素) 회수율(回收率)은 토양(土壤)중 염소농도(鹽素濃度)가 높을수록 고도(高度)의 유의성(有意性)있는 감소(減少)를 보였다.

• 대한임상검사과학회지
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• 제36권2호
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• pp.163-172
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• 2004

Mast cells (MCs) have been implicated in the pathogenesis of tissue fibrosis. However, the role of MC in the development of liver fibrosis has not been fully elucidated. Stem cell factor (SCF) is known to recruit MCs to the liver following injury as it induces mast cell proliferation, survival and differentiation from resident tissue precursors. This study examines the interaction between activated hepatic stellate cells (HSCs) and MCs in rat fibrotic liver, and SCF production by HSCs during culture in vitro. Rats were studied 4, 7, 14 and 21 days after bile duct ligation (BDL). Fibrogenesis was assessed by a measurement of collagen stained with sirius red F3B. Activated HSCs and MCs were identified by ${\alpha}$-smooth muscle actin (${\alpha}-SMA$) immunohistochemical and alcian blue staining and measured by a computerized image analysis system. SCF production was determined in rat HSC cultures using Western blotting. Mild fibrotic changes were noted in BDL rat livers as early as 4 days after induction of cholestasis. Significant expansion and organization of fibrous tissue has occurred in day 14 BDL rats which progressed to bridging fibrosis by day 21. In BDL rats, both a large number of activated HSCs and MCs were detected in portal tracts and fibrous septa. Both area of activated HSCs infiltration and density of MCs were significantly higher in all BDL group compared with Shams. In BDL rats, both areas of activated HSCs infiltration and density of MCs were no significant difference between day 4 and 7 and were significantly higher in day 14. However, the areas of activated HSCs infiltration were significantly lesser in day 21 and the densities of MCs were significantly higher in day 21 compared with day14 BDL. In BDL rats, both areas of activated HSCs infiltration and density of MCs were highly correlated with areas of fibrosis. Western blotting showed that SCF protein was consistently produced in activated HSCs by culture on plastic and freshly isolated HSCs expressed relatively little 30kD SCF compared to late primary culture activated HSCs (day 14) and passaged HSCs. These results suggest that HSCs activated in vitro produce SCF, and may play an important role in recruiting mast cells to the liver during injury and fibrosis.