• Korean Journal of Construction Engineering and Management
• /
• v.8 no.4
• /
• pp.119-127
• /
• 2007

Cost and Schedule is the most important information, and how efficiently manage this information is the key issue for Construction Project Management. Domestically, systematic scheduling method such as CPM network is not only used widely but integration of time and cost information also is. In order to effectively integrate and use the time and cost information, it is suggested that WBS(Work Breakdown Structure) based QDB(Quantity Database) should be generated from the design phase and, WBS and QDB related system tool should be supported. It could be helpful to relate and integrate other construction project information.

• Construction Engineering and Management
• /
• v.13 no.2
• /
• pp.8-12
• /
• 2012

• Journal of Gastric Cancer
• /
• v.21 no.4
• /
• pp.335-351
• /
• 2021

Purpose: An underlying factor for the failure of several clinical trials of anti-epidermal growth factor receptor (EGFR) therapies is the lack of an effective method to identify patients who overexpress EGFR protein. The quantitative dot blot method (QDB) was used to measure EGFR protein levels objectively, absolutely, and quantitatively. Its feasibility was evaluated for the prognosis of overall survival (OS) of patients with gastric cancer. Materials and Methods: Slices of 2×5 ㎛ from formalin-fixed paraffin-embedded gastric cancer specimens were used to extract total tissue lysates for QDB measurement. Absolutely quantitated EGFR protein levels were used for the Kaplan-Meier OS analysis. Results: EGFR protein levels ranged from 0 to 772.6 pmol/g (n=246) for all gastric cancer patients. A poor correlation was observed between quantitated EGFR levels and immunohistochemistry scores with ρ=0.024 and P=0.717 in Spearman's correlation analysis. EGFR was identified as an independent negative prognostic biomarker for gastric cancer patients only through absolute quantitation, with a hazard ratio of 1.92 (95% confidence interval, 1.05-3.53; P=0.034) in multivariate Cox regression OS analysis. A cutoff of 208 pmol/g was proposed to stratify patients with a 3-year survival probability of 44% for patients with EGFR levels above the cutoff versus 68% for those below the cutoff based on Kaplan-Meier OS analysis (log rank test, P=0.002). Conclusions: A QDB-based assay was developed for gastric cancer specimens to measure EGFR protein levels absolutely, quantitatively, and objectively. This assay should facilitate clinical trials aimed at evaluation of anti-EGFR therapies retrospectively and prospectively for gastric cancer.

• Analytical Science and Technology
• /
• v.27 no.3
• /
• pp.121-139
• /
• 2014

In this review, we will discuss aptamer technologies including in vitro selection, signal transduction mechanisms, and designing aptamers and aptazyme for label-free biosensors and catalysts. Dye-displacement, a typical label-less method, is described here which allows avoiding relatively complex labeling steps and extending this application to any aptamers without specific conformational changes, in a more simple, sensitive and cost effective way. We will also describe most recent and advanced technologies of signaling aptamer and aptazyme for the various analytical and clinical applications. Quantum dot biosensor (QDB) is explained in detail covering designing and adaptations for multiplexed protein detection. Application to aptamer array utilizing self-assembled signaling aptamer DNA tile and the novel methods that can directly select smart aptamer or aptazyme experimentally and computationally will also be finally discussed, respectively.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2012.11a
• /
• pp.1198-1199
• /
• 2012

국내에서는 수량산출정보의 전자적인 교환, 납품 등의 활용을 위한 자료구조 및 파일포맷 등을 규격화 하여 디지털 수량산출정보 교환표준을 개발하였다. 국외에서는 IFC 국제표준을 통해 BIM 발주시 데이터 납품 포맷으로 IFC를 활용하고 있으며 건축분야를 중심으로 공사비 정보의 표준 개발이 이루어 지고 있다. 이에 본 논문에서는 디지털 수량산출정보 교환표준의 Type 및 Element와 IFC 국제표준의 공사비 정보 Entity를 비교분석하여 국내 토목분야 실정에 부합하는 공사비 분야 정보모델 표준개발의 기반자료로 활용하고자 한다.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2012.04a
• /
• pp.1428-1429
• /
• 2012

건설분야 수량산출정보의 연계 및 교환을 위한 디지털 수량산출정보 교환표준과 지방국토관리청의 도로관리관점에 따라 구성된 작업분류체계를 바탕으로 도로분야 수량산출정보를 지원도구를 통해 생성한다. 건설사는 지원도구에서 작성한 도로공사 수량산출정보를 건설사업관리시스템에 등록함으로써 공정 공사비 관리에 활용하고 있다. 본 연구는 공정 공사비의 통합관리를 통해 실질적인 사업관리가 가능하도록 10개 도로건설공사 시범사업을 선정하여 문제점과 개선방안을 도출하였다.