• Allergy, Asthma & Respiratory Disease
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• v.6 no.6
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• pp.310-314
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• 2018

Purpose: Conventional serum IgE assay was costly, required the skills of expert, and relied heavily on expensive equipment. Quantitative measurement of total IgE using Point of Care Test (POCT) device can be the solution for these limitations. This study evaluated and validated the reproducibility of ImmuneCheck IgE. Methods: This study included 120 patients of allergic diseases such as allergic rhinitis, asthma, drug allergy, food allergy, atopic dermatitis, or anaphylaxis. The reliability of POCT ImmuneCheck IgE was evaluated by comparing results from the naked eye and from the Q-Reader. Intratest reproducibility and intertest correlation were analyzed using intraclass correlation coefficient (ICC). Results: Of the 120 enrolled patients, 51 were males and 69 were females. The ages ranged from 19 to 84 years, with an average age of 51.5 years. The concentration of serum total IgE measured by Phadia ImmunoCAP IgE ranged from 5.95 to 5,000 IU/mL. ICC for Intratest reproducibility of ImmuneCheck IgE by naked eye and by Q-Reader were 0.991 (P< 0.001) and 0.989 (P< 0.001), respectively. In addition, intertest correlation between ImmuneCheck IgE and Phadia ImmunoCAP IgE results of naked eye and Q-Reader were 0.968 (P< 0.001) and 0.948 (P< 0.001), respectively. Conclusion: The ImmuneCheck IgE was reproducible and highly correlated with conventional Phadia ImmunoCAP IgE assay. This result suggests that ImmuneCheck IgE can be a useful tool for rapid and precise detection of total IgE.

• The Journal of Korean Society for Radiation Therapy
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• v.28 no.1
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• pp.35-46
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• 2016

Purpose : BoS(Base of Skull) Frame, the fixation tool which is used for the proton of brain cancer increases the lateral penumbra by increasing the airgap (the distance between patient and beam jet), due to the collision of the beam of the posterior oblique direction. Thus, we manufactured the fixation tool per se for improving the limits of BoS frame, and we'd like to evaluate the utility of the manufactured fixation tool throughout this study. Materials and Methods : We've selected the 3 patients of brain cancer who have received the proton therapy from our hospital, and also selected the 6 beam angles; for this, we've selected the beam angle of the posterior oblique direction. We' ve measured the planned BoS frame and the distance of Snout for each beam which are planned for the treatment of the patient using the BoS frame. After this, we've proceeded with the set-up that is above the location which was recommended by the manufacturer of the BoS frame, at the same beam angle of the same patient, by using our in-house Bos frame fixation tool. The set-up was above 21 cm toward the superior direction, compared to the situation when the BoS frame was only used with the basic couch. After that, we've stacked the snout to the BoS frame as much as possible, and measured the distance of snout. We've also measured the airgap, based on the gap of that snout distance; and we've proceeded the normalization based on each dose (100% of each dose), after that, we've conducted the comparative analysis of lateral penumbra. Moreover, we've established the treatment plan according to the changed airgap which has been transformed to the Raystation 5.0 proton therapy planning system, and we've conducted the comparative analysis of DVH(Dose Volume Histogram). Results : When comparing the result before using the in-house Bos frame fixation tool which was manufactured for each beam angle with the result after using the fixation tool, we could figure out that airgap than when not used in accordance with the use of the in-house Bos frame fixation tool was reduced by 5.4 cm ~ 15.4 cm, respectively angle. The reduced snout distance means the airgap. Lateral Penumbra could reduce left, right, 0.1 cm ~ 0.4 cm by an angle in accordance with decreasing the airgap while using each beam angle in-house Bos frame fixation tool. Due to the reduced lateral penumbra, Lt.eyeball, Lt.lens, Lt. hippocampus, Lt. cochlea, Rt. eyeball, Rt. lens, Rt. cochlea, Rt. hippocampus, stem that can be seen that the dose is decreased by 0 CGE ~ 4.4 CGE. Conclusion : It was possible to reduced the airgap by using our in-house Bos frame fixation tool for the proton therapy; as a result, it was possible to figure out that the lateral penumbra reduced. Moreover, it was also possible to check through the comparative analysis of the treatment plan that when we reduce the lateral penumbra, the reduction of the unnecessary irradiation for the normal tissues. Therefore, Using the posterior oblique the Brain cancer proton therapy should be preceded by decreasing the airgap, by using our in-house Bos frame fixation tool; also, the continuous efforts for reducing the airgap as much as possible for the proton therapy of other area will be necessary as well.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.830-835
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• 2011

DMT Freight is judged that economic performance is good because can increase cargoes than existing freight. However, the existing freight cars, each with a different balance to the body structure is bogie because the vibrations may occur. Thus, by minimizing vibration over the existing freight securing the safety of the driving if you will not have major problems in cargoes. In this study, multi-body dynamic analysis tool, VI-Rail using the actually Gyeongbu Railroad line and an empty, full freight condition include curve radius, track irregularity, cent. DMT freight of the derailed wagons were assessed for safety analysis. Full and empty freight conditions for parity in the Gyeongbu Railroad line(Dongdaegoo ${\leftrightarrow}$Gyungsan) derailment safety analysis, such as derailment safety coefficient and the radius wheel road decrement, echoing the curve and the orbit is affected by the irregularity was found. Full freight condition than the empty conditions showed a significant derailment safety. Overall, the limits of derailment coefficient (Q/P=0.8) and wheel road decrement limits (${\Delta}P/P=0.6$) is less safe with me confirmed that the derailment safety.

• Journal of Integrative Natural Science
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• v.9 no.2
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• pp.128-135
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• 2016

5-hydroxytryptamine (serotonin) receptor ($5-HT_7R$) 7 is one of G-Protein coupled receptors, which is activated by the neurotransmitter Serotonin. After activation by serotonin, $5-HT_7$ activates the production of the intracellular signaling molecule cyclic AMP. $5-HT_7$ receptor has been found to be involved in the pathophysiology of various disorders. It is reported that $5-HT_7$ receptor antagonists can be used as antidepressant agents. In this study, we report the important structural and chemical parameters for 2-methoxyphenylpiperazinylakanamides as $5-HT_7R$ inhibitors. A 3D QSAR study based on comparative molecular field analysis (CoMFA) was performed. The best predictions were obtained for the best CoMFA model with $q^2$ of 0.594 with 6 components, $r^2$ of 0.986, Fisher value as 60.607, and an estimated standard error of 0.043. The predictive ability of the test set was 0.602. Results obtained the CoMFA models suggest that the data are well fitted and have high predictive ability. The contour maps are generated and studied. The contour analyses may serve as tool in the future for designing of novel and more potent $5-HT_7R$ derivatives.

• Journal of Environmental Impact Assessment
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• v.4 no.2
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• pp.71-91
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• 1995

In order to develop an appropriate set of criteria applicable for environmental impact assessment (EIA) of natural forest 8 items are proposed. The criteria are vegetation distribution area (DA), distribution pattern (DP), size (S), diameter of breast height of tree (DBH), humus (H), sustainment (ST), successional stage (SS) and impact of adjacent ecosystem (IAE), Each criterion has an interval which minimum 1 score to maximum 5 score Forest Evaluation Index (FEI) was obtained as the sum of 8 criteria value. Above 70% is considered to be absolutely conservative and from 50% to 70% range of total score is to be considered conservative. In the case of the Sancho˘ng Pumping-up Power Plant of Mt. Chiri, 8 criteria were applied base on actual vegetation map. Pinus densiflora community got 73%(29 scores) and Quercus variabilis - Q. serrata community got 60%(24 scores). This may be said that this local vegetation has high ecological potentiality. These criteria cannot always be absolutely evaluation tool. So it is expected to take the more time to be developed further, and holistically added by the other field such as fauna, geological feature etc.

• Environmental Analysis Health and Toxicology
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• v.31
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• pp.18.1-18.8
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• 2016

Objectives This study aimed to evaluate the risk factors associated with depression and suicidal ideation in a rural population. Methods A survey was conducted with 543 farmers from Chungcheongnam-do Province using the Center for Epidemiologic Studies Depression Scale (CES-D) for depression, Lubben Social Network Scale (LSNS) for social support, Swedish Q16 for neurotoxicity symptoms and a survey tool for farmer's syndrome. Results After adjusting for socioeconomic factors using logistic regression analysis, poor self-rated health, low social support and neurotoxicity were positively associated with the risk of depression (odds ratio [OR], 15.96; 95% confidence interval [CI], 3.11 to 81.97; OR, 3.14; 95% CI, 1.26 to 7.82; and OR, 3.68; 95% CI, 1.08 to 12.57, respectively). The risk of suicidal ideation significantly increased with low social support, neurotoxicity and farmer's syndrome (OR, 2.28; 95% CI, 1.18 to 4.40; OR, 6.17; 95% CI, 2.85 to 13.34; and OR, 3.70; 95% CI, 1.51 to 9.07, respectively). Conclusions Given the overall results of this study, there is a need to establish programs which can improve the health and social relationships of farmers. Also, when farmers have neurological symptoms from pesticide exposure and characteristic symptoms of farmer's syndrome, a monitoring system for depression and suicide must be made available.

• Journal of Korean Public Health Nursing
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• v.15 no.1
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• pp.1-12
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• 2001

This study. aimed to categorize attitude of smoking behaviors among female student smokers and to provide useful data for development of anti-smoking programs was conducted from Aug. 22 to Nov. 1. using the Q-method. After reviewing the literature the researcher proceeded to interview 10 female students, then developed a statement form consisting of 40 items, and then 30 female student smokers were sampled. The collected data were coded after having been scaled from 1 to 9 points, and analyzed using the PC QUANL program. Three types were identified; The first type focused on the right of the individual to smoke. the second type of students used smoking as a way to relieve their stress, and the third type of students wanted to use smoking as a tool to relate with their peer group. They smoked in closed areas, i.e. rest rooms. coffee shops - places that are not well ventilated and deep inhalation occurs. most subjects of the study started smocking at early ages(the average age was 17). Smoking at this age is especially harmful. It is suggested that the results of the study may be useful for designing anti-smoking health programs including health promotion.

• Transactions of the Korean hydrogen and new energy society
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• v.20 no.3
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• pp.179-187
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• 2009

This paper presents a static and dynamic characteristics of the relief valve which is a kind of direct operated pressure control valve for hydrogen compressor. The valve is consisted of a main poppet, a spring, an adjuster and a valve body. The purpose of this study is development of the simulation model for relief valve by using commercial AMESlM$^{(R)}$ tool. Poppet with sharp edge seat type and ball poppet with sharp edge seat type compare for P-Q characteristic. The dynamic simulation results are presented the operating pressure characteristics of relief valve. High pressure power unit of which maximum pressure control range is 100MPa was manufactured, and the pressure control valve was experimented using the above-mentioned power unit. The new model of pressure control valve from this results was suggested. It was confirmed that the suggested valve has a good control performance from experimental setup.

• Wind and Structures
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• v.11 no.2
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• pp.153-178
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• 2008

Based on the empirical formulas for power spectra of generalized modal forces and local fluctuating wind forces in across-wind and torsional directions, the wind-induced lateral-torsional coupled response analysis of a representative rectangular tall building was conducted by setting various parameters such as eccentricities in centers of mass and/or rigidity and considering different torsional to lateral stiffness ratios. The eccentricity effects on the lateral-torsional coupled responses of the tall building were studied comprehensively by structural dynamic analysis. Extensive computational results indicated that the torsional responses at the geometric center of the building may be significantly affected by the eccentricities in the centers of mass and/or rigidity. Covariance responses were found to be in the same order of magnitude as the along-wind or across-wind responses in many eccentricity cases, suggesting that the lateral-torsional coupled effects on the overall wind-induced responses can not be neglected for such situations. The calculated results also demonstrated that the torsional motion contributed significantly to the total responses of rectangular tall buildings with mass and/or rigidity eccentricities. It was shown through this study that the framework presented in this paper provides a useful tool to evaluate the wind-induced lateral-torsional coupled responses of rectangular buildings, which will enable structural engineers in the preliminary design stages to assess the serviceability of tall buildings, potential structural vibration problems and the need for a detailed wind tunnel test.

• Journal of Multimedia Information System
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• v.2 no.3
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• pp.255-262
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• 2015

The modern manufacturing systems and technologies produce products that are more accurate day by day. This can be reached mainly by improvement the manufacturing process with at the same time restricting more and more the quality specifications and reducing the uncertainty in part. The main objective an industry becomes to lower the part's variability, since the less variability - the better is product. One of the part of this task is measuring the object's uncertainty. The main purpose of this study is to understand the application of bootstrap method for uncertainty evaluation. Bootstrap method is a collection of sample re-use techniques designed to estimate standard errors and confidence intervals. In the case study a surface of an automobile engine block - (Top view side) is measured by Coordinate Measuring Machine (CMM) and analyzed for uncertainty using Geometric Least Squares in complex with bootstrap method. The designed experiment is composed by three similar measurements (the same features in unique reference system), but with different points (5, 10, 20) concentration at each level. Then each cloud of points was independently analyzed by means of non-linear Least Squares, after estimated results have been reported. A MatLAB software tool used to generate new samples using bootstrap function. The results of the designed experiment are summarized and show that the bootstrap method provides the possibility to evaluate the uncertainty without repeating the Coordinate Measuring Machine (CMM) measurements many times, i.e. potentially can reduce the measuring time.