• Maxillofacial Plastic and Reconstructive Surgery
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• v.23 no.4
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• pp.306-323
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• 2001

종양발생에서 유전자 발현을 확인하고 profile 변화를 monitor하는 것은 병리학적 변화의 원인뿐 아니라 질병탐지와 진료의 새로운 목표를 확인하기 위한 새로운 기회를 제공해준다. cDNA microarray는 수천개의 유전자 발현을 동시에 연구할 수 있는 최신의 방법으로 피부, 유방, 간을 비롯한 다른 인체장기에서는 일부 이루어졌으나 array를 이용해 타액선 종양 연구에서는 전혀 이루어지지 않았다. 인간의 타액선 세포의 악성형질전환을 조절하는 분자적 상태를 연구하기 위해 본 연구는 약 2,000개의 유전자가 print된 cDNA microarray를 이용하여 인간 타액선 도관상피세포주(HSG)와 악하선에서 기원한 미분화 선암종(SGT)간에 비교연구를 하였다. Cy3와 Cy5 dye로 각각의 세포주에서 얻은 RNA와 reciprocal hybridize시키고 GenePix 4000 scanner로 스캔하고 GenePix Pro로 분석한 후 log2로 평균발현비율을 전환시켜 최소 2배이상의 발현을 보이는 유전자를 분석대상으로 하였다. 90%이상의 유전자가 비슷한 발현을 보였으며 2배이상의 발현을 보이는 경우 HSG가 SGT에 비해 72개 유전자가, SGT가 HSG에 비해 111개의 유전자 발현이 up-regulation되어 총 10%미만의 발현차이를 보였고 반복된 hybridization 으로부터 얻은 선택된 spot의 Pearson 상관계수는 -0.85이였다. HSG에서는 6번 p 염색체에서 과발현되는 유전자가 가장 많았고, SGT에서는 11번 q 염색체에서 가장 많았는데 HSG에서는 SGT에 비해 9, 13, 17, 18, 20, 21, 22염색체에서 과발현 되는 유전자 수가 많았고, SGT에서는 HSG에 비해 2, 7, 10, 15 염색체에서 유전자 발현 증가가 관찰되었다. HSG와 SGT간의 유전 발현을 기능별로 분석한 결과 몇 가지 주요 경로가 세포악성에 관련됨을 발견하였고, 타액선 도관상피세포에서 선암종을 구별하는데 기여하는 관련된 몇종의 과다 발현된 유전자를 찾았는데 전사인자, 성장인자 및 수용기, 세포골격 및 세포외기질 단백, 세포내 신호전달조절자 및 인자, 세포표면 항원등의 그룹으로 분류할 수 있었다. 따라서 이러한 microarray를 이용한 분자학적 표지자 연구가 악성 타액선 종양 발생과정에서 큰 도움을 줄 수 있을 뿐 아니라 유전자 조절에 의한 진단, 예후, 치료에서의 정확성을 개선시킬 수 있으리라 여겨진다.

• Journal of Korean Society of Forest Science
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• v.101 no.2
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• pp.226-235
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• 2012

Floristic composition and phytosociological studies in Mt. Gwaebyung and Galmi-Bong were investigated to classify forest vegetation and distribution of vascular plants. We investigated two study sites from April to September, 2011. Total 477 taxa with 93 families, 279 genera, 408 species, 4 subspecies, 56 varieties and 9 forms were distributed in Mt. Gwaebyung and Galmi-Bong. Korean endemic species were composed of 8 families with 11 genera and 11 species. The plant species which is designated as protected species by the Ministry of Environment, Korea was 2 families, 2 genera and 2 species. Also plant species which is designated by the Korea National Arboretum was 16 taxa with 13 families, 14 genera, 15 species and 1 variety. A naturalized plants were 17 taxa. The Naturalization index and Urbanization index were 3.6% and 5.3% respectively. Pteridophyta-calculation (Pte-Q) was 1.00. Life form spectra was $H-D_4-R_5-e$ type and the highest percentage of useful plant resources were medicinal plant (77.5%). The forest vegetation in Mt. Gwaebyung and Galmi-bong was classified into 1 order, 1 alliance and 4 communities; Rhododendro - Quercetalia mongoliaceae, Lindero-Quercion mongolicae, Quercus mongolica Typical Community, Pinus densiflora-Quercus mongolica Community, Larix kaempferi Community and Sasa borealis-Quercus mongolica Community.

• Journal of IKEEE
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• v.11 no.4
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• pp.145-151
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• 2007

In this work, small-size, high-performance solenoid-type RF chip inductors utilizing a low-loss ${Al_2}{O_3}$ core material were investigated. The size of the chip inductors fabricated in this work were $0.86{\times}0.46{\times}0.45m^3$, $1.5{\times}1.0{\times}0.7m^3$, $2.1{\times}1.5{\times}1.0m^3$, and $2.4{\times}2.0{\times}1.4m^3$ and copper (Cu) wire with $27{\sim}40{\mu}m$ diameter was used as the coils. High frequency characteristics of the inductance, quality factor, and impedance of developed inductors were measured using an RF Impedance/Material Analyzer (HP4291B with HP16193A test fixture). It was observed that the developed inductors with the number of turns of 7 have the inductance of 13 to 100nH and exhibit the self-resonant frequency (SRF) of 6.4 to 1.1GHz. The SRF of inductors decreases with increasing the inductance and the inductors have the quality factor of 50 to 80 in the frequency range of 300MHz to 1.3GHz. In this study, small-size solenoid-type RF chip inductors with high inductance and high quality factor were fabricated successfully.

• Korean Journal of Optics and Photonics
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• v.5 no.1
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• pp.74-79
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• 1994

The characteristics of the type I and type II SHG in LiB305 crystals grown by TSSG method have been investigated using 1064 nm beam from a Q-switched Nd:YAG laser. The measured phase matching angles and angular acceptance bandwidths were $\theta_m=90^{\circ}, \phi_m=11.6^{\circ}$, <$\delta\theta_{int}L_{1/2}=3.3^{\circ}-cm^{1/2}, \theta\phi_{int}L=0.27^{\circ}-cm^{1/2}$ for type I SHG and $\theta_m=20^{\circ}, \phi_m=90^{\circ}$, TEX>$\delta\theta_{int}L_=0.65^{\circ}-cm, \theta\phi_{int}L^{1/2}=3.5^{\circ}-cm^{1/2}$ for type II SHG, respectively. Thp. type I NCPM temperature of 1064 nm beam was found to be $149^{\circ}C$ with the temperature bandwidth $\DeltaTL$of $4.8^{\circ}C-cm$. An energy conversion efficiency of about 1.8% with 2.6 mm thick LBO crystal at an incident power of TEX>$171 MW/\textrm{cm}^2$ was demonstrated. The measured $d_{32} was 0.74\pm0.05 pm/V$..

• Journal of Soil and Groundwater Environment
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• v.17 no.3
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• pp.21-31
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• 2012

This paper presents the short-term and long-term measures to determine the fugitive dust concentration in a contaminated site, which is a crucial step for the determination of particulate emission factor (PEF) for risk assessment. As a long-term measure, USEPA method employing Q/C value (inverse of the ratio of the geometric mean air concentration to the emission flux at center of a 0.5-acre square source) seems to be suitable as it reflects regional-specific meteorological conditions. However, it requires nation-wide database collection and interpretation. Use of ASTM method is an alternative as a short-term measure. The method is readily field-applicable as PEF calculation equation is simple and input parameters can be easily derived at the site of interest as well without the nation-wide efforts. Using ASTM method, PEF at the Former Janghang Smelter Site was determined. According to various mode of aggregate size distribution and fractions of vegetative cover, which are the most important factors in PEF calculation, PEF values at the Former Janghang Smelter Site varied greatly. When the mode of aggregate size distribution was set at 0.25 mm, PEF values at the Former Janghang Smelter Site was 5~20 times higher than the default PEF value (i.e., 35 ${\mu}g/m^3$) shown in the current Korean Soil Contamination Risk Assessment Guidance. On contrast, when the mode was set at 2 mm, PEF values at the Former Janghang Smelter Site was 160~640 times lower than the default PEF value in the Korean Guidance.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.25 no.11
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• pp.1128-1134
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• 2014

In this paper, the effects of a metamaterial slab with negative permeability in a magnetically coupled wireless power transfer system (WPT) in the overall performance are analyzed quantitatively in terms of the effective quality factors of the loop resonators and coupling coefficient considering the slab losses, based on an equivalent circuit. Using the ideal metamaterial slab(lossless slab), the WPT efficiency is improved considerably by the magnetic flux focusing. However, the practical lossy slab made of RRs or SRRs limits the significant enhancement of WPT efficiency due to the relatively high losses in the slab consisting of RRs or SRRs near the resonant frequency. For the practical loop resonator, other than a point magnetic charge, using the practical lossy metamaterial slab in order to improve the transfer efficiency, the width of the slab needs to be optimized somewhat less than the half of the distance between two loop resonators. For the low-loss slab with its loss tangent of 0.001, the WPT efficiency is maximized at 93 % when the ratio of the slab width and the distance between the two resonators is approximately 0.35, compared with 53 % for the case without the slab. The efficiency in case of employing the high-low slab(loss tangent: 0.2) is maximized at 61 % when the slab ratio is 0.25.

• Journal of Biosystems Engineering
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• v.29 no.3
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• pp.267-274
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• 2004

Using geo-statistical method, yield data of different fields were analyzed to examine their field variability according to examining year, analysis method. Semivariogram and Kriged maps of geo-statistical analysis were used to examine their spatial dependence within a filed. The results obtained were as follows. 1) Descriptive statistical results of the yield showed that the yield and the difference of yield ranged from 100 to 946kg/10a and from 272 to 653kg/10a, respectively within a field. The coefficient of variation also ranged from 5.9 to 22.4 %. 2) More than 90% of yield data were placed between 350 to 850kg/10a. e results indicated that the gram mass flow sensor should have the measuring range from 0.34 to 0.82kg/s considering the yields when 4 rows head-feeding combine with 0.8 m/s of working speed was utilized. 3) A high spatial dependence was found within paddy field. The Q values ranged from 0.20 to 0.97, and the range of spatial dependence was from 6.9 to 53.3m. From this result, the rational sampling interval for yield investigation was estimated 6.9m. 4) Yields within a field between observation years showed considerable variability even if the field was evenly cultivated and managed. To apply precision agriculture in a paddy field, the field test should be continued to build a solid data-base including meteorological data, blight damage and insect damage.

• The Journal of Engineering Geology
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• v.30 no.2
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• pp.161-173
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• 2020

This study is to examine the engineering characteristics of colunmar joints in Mudeugsan National Park, a global geopark. For these purposes, physical and mechanical properties of Mudeungsan Tuff, evaluation for the weathering degree of columnar joints, and crack behavior monitoring in columnar joints were conducted. The physical properties of Mudeungsan tuff were 1.02% for the average porosity, 0.38% for the average absorption, 2.69 g/㎤ for the average specific gravity, and 4,948 m/s for the average elastic wave velocity. Its mechanical properties were 337 MPa for the average uniaxial compressive strength, 68 GPa for the average elastic modulus, 0.29 for the average Poisson's ratio, 41.3 MPa for the average cohesion strength, and 62.8° for the average friction angle. the average rebound Q-value of the silver Schmidt hammer for the three columnar joint blocks at the Ipseok-dae was shown as 49.3. when this value is converted into uniaxial compressive strength, it becomes 70.5 MPa, which is about 21% of the uniaxial compression strength of Mudeungsan tuff. In addition, according to the results of crack monitoring measurements for the three columnar joint blocks at the Ipseok-dae, the crack behavior is less than 1 mm, so it is believed that its behavior in Ipseak-dae columnar joints has hardly occured to date.

• The Korean Journal of Pesticide Science
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• v.7 no.2
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• pp.108-116
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• 2003

A series of new quinclorac family, herbicidal 3-phenyl-5-(3,7-dichloro-8-quinolinyl)-1,2,4-oxadiazole derivatives as substrate were synthesized and their growth inhibition activity $(pI_{50})$ against root and shoot of rice plant (Oryza sativa L.) and barnyard grass (Echinochloa crus-galli) were determined. And then comparative molecular field analysis (CoMFA) and molecular holographic quantitative structure- activity relationship (HQSAR) were compared in terms of their potential for predictiability. The statistical results were suggested that HQSAR based model had better predictability than CoMFA model. The selective factors to remove barnyard grass take electron withdrawing groups which can be created positive charge and steric bulky on the phenyl ring. Results revealed that the unknown 2,6-dichloro-substituent, U5 and 2,4,6-trichloro-substituent, U6(${\Delta}pI_{50}$=CoMFA: 1.18 & HQSAR: 1.82) were predicted as compound with higher activity and selectivity.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.44 no.9
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• pp.18-24
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• 2007

We report broadband cascode amplifiers of a single-ended and a balanced amplifier for the millimeter-wave applications. The amplifiers were fabricated using 0.1 ${\mu}m\;{\Gamma}-gate$ PHEMT technology on GaAs substrate. The single-ended cascode amplifier was designed and fabricated by using shunt peaking technology. The fabricated single-ended cascode amplifier shows 3 dB bandwidth of 37 GHz($18.5{\sim}55.5$ GHz) and the maximum $S_{21}$ gain of 9.38 dB. The balanced cascode amplifier using tandem couplers achieves 3 dB bandwidth and the maximum $S_{21}$ gain of 44.5 GHz($21{\sim}65.5$ GHz) and 10.4 dB at 60 GHz, respectively. The 3 dB bandwidth of the balanced cascode amplifier shows 20% lager than the single-ended cascode amplifier.