• 대한화학회지
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• 제56권4호
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• pp.468-472
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• 2012

마이크로웨이브를 이용한 가열 방법과 MeO-PEG-OMe를 용매로 사용하여, benzo-[1,4]-oxazinone의 효율적인 one-pot 합성방법을 개발하였으며, 개발한 합성방법을 이용하여, 8 가지의 benzo-[1,4]-oxazinone 화합물과 1H-pyrido[2,3-b][1,4]-oxazin-2-(3H)-one을 좋은 수율로 합성하였다.

• Bulletin of the Korean Chemical Society
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• 제29권7호
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• pp.1379-1385
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• 2008

Highly efficient synthesis of substituted benzo[1,4]oxazin-3-ones and pyrido[1,4]oxazin-2-ones under microwave irradiation via Smiles rearrangement is reported. Substituted benzo[1,4]oxazin-3-ones and pyrido[1,4]oxazin-2-ones were obtained by treatment of substituted 2-chlorophenols or 2-chloropyridols with N-substituted 2-chloroacetamide in the presence of potassium carbonate in MeCN and subsequent exposure to cesium carbonate in DMF. All the reactions which take 2-10 hours under conventional condition were completed successfully within a few minutes under microwave irradiation giving moderate to excellent yields.