• 한국임상수의학회지
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• 제30권5호
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• pp.387-389
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• 2013

8년령의 중성화하지 않은 암컷 시츄견이 자궁축농증을 치료받기 위해 충남대학교 부속동물병원에 내원하였다. 임상증상으로 질출혈, 외음부출혈, 다식, 다음/다뇨 및 구토 등이 있었다. 혈액검사상으로는 미약한 백혈구감소증이 있었고 혈청화학적으로 ALP 감소 및 GLU 증가가 있었다. 방사선, 초음파 및 복강천자로 이루어졌으며 자궁축농증에 의한 복막염으로 잠정 진단하였다. 수술적 처치로 난소자궁적출술을 실시하였으며 생리식염수로 복강을 세척하였다. 심산 장 괴사가 있었고 자궁축농증에 의한 난소간막에서 농의 복강내로의 유출이 있었다. 이번 보고에서 2차적으로 패혈성 복막염이 발병할 수 있으니 자궁축농증 진단 시 2차성 질병에 대해서도 고려되어야 할 것이다.

• 한국임상수의학회지
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• 제28권3호
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• pp.307-309
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• 2011

1년령 암컷 요크셔테리어가 설사와 활력저하로 충북대학교 동물의료센터에 내원하였다. 혈액, 혈청화학 및 방사선 검사 결과로 환자는 복막염을 동반한 자궁축농증으로 진단하였다. 설사 원인 진단을 위한 분변 검사에서는 다수의 효모 증식이 관찰되었으며, 진균 배양 및 분자생물학적 동정으로 C. parapsilosis를 최종적으로 확인하였다. 이 보고는 개에서 C. albicans외에 C. parapsilosis도 장관 질환을 야기할 수 있음을 보여준다.

• 한국임상수의학회지
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• 제37권6호
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• pp.360-362
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• 2020

A 12-year-old intact female Pomeranian dog was presented with vulvar discharge, lethargy, polyuria, and polydipsia. A complete blood count revealed leukocytosis and anemia. The serum biochemical analyses showed elevated serum alkaline phosphatase activity and blood urea nitrogen. Survey abdominal radiography revealed an enlarged left kidney. Abdominal ultrasonography identified multiple rounded hypoechoic subcapsular lesions in the left kidney. The bilateral uterine horn was enlarged, and contained echogenic fluid. Percutaneous ultrasonographic-guided aspiration of the renal subcapsular lesions was performed on the left kidney. Cytological examination revealed bacterial cocci, degenerated neutrophils, and suppurative inflammation. Bacterial culture produced growth of Escherchia coli. Left nephrectomy and ovariohysterectomy were performed. Dilated uterine fluid was also evaluated for bacterial culture, and showed growth of E. coli. Urine was examined by bacterial culture, and showed negative results. The treatment consisted of antibiotic therapy according to the antibiotic sensitivity test. Based on these findings, the diagnosis was renal subcapsular abscess associated with pyometra. This study suggests that pyometra should be considered as the cause of renal abscess.

• 한국임상수의학회지
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• 제38권1호
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• pp.21-26
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• 2021

Pyometra, a common disorder in intact bitches, can lead to canine sepsis. Identification of biomarkers for sources of infection in the uterus using two-dimensional electrophoresis (2-DE)-mass spectrometry (MS) analysis may enable the discovery of novel diagnostic markers of sepsis. Toward this end, surgically resected uterus samples from four bitches (three pyometra and one healthy) were randomly selected for 2-DE-MS, which identified 32 differentially expressed proteins, including seven inflammatory proteins, five non-inflammatory proteins, and 20 functionally unknown proteins. Despite the limited information on canine uterus proteomics, we suggest the potential use of differentially expressed uterus proteins as candidate biomarkers to discover targets to attenuate inflammation in pyometra. Further identification of the functionally unknown proteins is warranted.

• 한국임상수의학회지
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• 제30권4호
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• pp.305-309
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• 2013

개에서 자궁축농증은 발정휴지기에 주로 발생하는 질병으로서 급성으로 발병하여 만성 질병 경과를 나타낸다. 또한 장막성 낭포는 분만 후 자궁의 퇴축이 급속하게 일어나는 수복기 동안 흔히 발생한다. 10세 암컷 골든 리트리버견이 무기력, 식욕부진, 빈호흡, 복부팽만 및 비정상적인 외음부 분비물의 증상으로 내원하였다. 방사선 검사, 초음파 검사 및 실험실적 검사를 통하여 자궁축농증으로 진단되었고 난소자궁적출술이 시행되었다. 육안으로 관찰한 결과, 자궁은 팽만 되어 있었으며, 부분적으로 복벽과 유착되어있었다. 또한, 자궁 전반에 걸쳐 맑은 액체로 충만해 있는 낭포들이 관찰되었다. 세균배양검사를 통하여 자궁내강에 차있던 농에서 대장균이 감염되어있다는 것을 확인하였으며, enrofloxacin에 감수성이 있었다. 낭포에 대한 조직검사를 실시하여 자궁축농증과 장막성 낭포로 최종 진단하였다.

• 한국임상수의학회지
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• 제17권1호
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• pp.285-288
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• 2000

Nine immature 30-day-old female rats were injected sc at 0800 hr with pregnant mare serum gonadotrophin(PMSG) to induce ovulation and mating. Fifty-six hours later the animals were placed with mature male rats overnight (one female and one male). Five of 9 immature female rats treated with PMSG were pregnant and allowed to maintain the pregnancy to term. Three of 5 pregnant rats were failed to maintain pregnancy to term. Two of 5 pregnant rats seemed to be developed normally and increased abdominal enlargement as pregnancy progresses, but did not occurred parturition on day of 43 or 48 of pregnancy, respectively. On day 44 or 49, pregnant rats were killed and examined uterus and ovaries. There was no fetus but approximately 50∼60ml. of mucopurulent fluids were accumulated in the uterine cavity and 40 or 42 corpora lutea persisted in the ovaries. Pyometra was developed after coitus in PMSG-treated immature female rat.

• 한국임상수의학회지
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• 제16권2호
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• pp.474-477
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• 1999

A four-year old bitch which showed occasional hemomorragic exudate from the vulva for two weeks after the previous estrus 7 months ago was ovariohysterectomied. About 200m1 of sanguineous fluid was flowed out from the uterus and some scattered blood clots were found in both uterine horns. Hematometra of the bitch which was presumed to occur during the proestrus two weeks ago was thought to progress into early pyometra at the time of diagnosis. To diagnose hematometra, vaginal examination using vaginal speculum or vaginoscope and hematological examination were performed. Radiography and ultrasonography were also proved to be of use to diagnose hematometra. Treatment for hematometra was considered to be the same as for the case of pyometra.

• 한국임상수의학회지
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• 제35권5호
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• pp.222-225
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• 2018

The current study describes a case of endometrial polyps accompanied by an open-cervix pyometra in a 15-year-old female Chinchilla Persian cat. The cat was presented with a history of a large mass in the endometrium and purulent discharge from the vulva. Ovariohysterectomy was performed and pedunculated polypoid mass on the endometrium was seen protruded into the uterine cavity. Histologically, the mass was composed of multiple cystically dilated glands surrounded by fibrous stroma. Based on gross and histologic findings, the diagnosis for this case was concluded.

• 한국임상수의학회지
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• 제34권2호
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• pp.98-102
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• 2017

A 7-year-old, intact, female Siberian husky presented with vomiting and diarrhea after a fight with a dog with which it lived. The bitch was diagnosed with pyometra and severe dehydration. The patient received IV fluid therapy for 2 day pre- and post-operatively. Four days post-surgery, the patient had a decreased level of consciousness and suffered a tonic-clonic generalized seizure. On magnetic resonance imaging and histopathological findings, a diagnosis of laminar cortical necrosis caused by fluid overload was made. This case provides important information on the potential for fluid overload in a dehydrated patient giving rise to critical condition and death.

• 대한수의학회지
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• 제40권4호
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• pp.763-767
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• 2000

본 연구는 1998년부터 1999년까지 서울대학교 수의과대학 부속동물병원에 내원한 개중 자 궁축농중으로 진단된 개의 자궁내용물로부터 균을 분리, 동정하고 항생제 감수성 검사를 실시하여 개 자궁축농증 치료를 위한 기초 자료로 사용하고자 하였다. 위 병원에 내원하여 자궁축농증으로 진단된 개는 16두였으며, 이들로부터 자궁적출술을 이용하여 자궁을 적출한 후 원인균을 분리하였고, 분리된 균에 대하여 15종의 항균제에 대하여 감수성 검사를 실시하였다. 16두의 개로부터 분리된 균은 Escherichia coli 11주, Serratia marcescens 2주, Staphylococcus aureus 및 Salmonella spp 각 l주 씩 이었다. 이들 균주들에 대하여 항균제 감수성 검사를 실시한 결과, 대부분의 균주들이 enrofloxacin, norfloxacin, chloramphenicol, nalidixic acid, gentamicin, Trimethprim-sulfamethazole, tetracycline에 대하여는 높은 감수성을 나타내었고, carbenicillin, amikacin, ampicillin, neomycin에 대하여는 중등도의 감수성을 나타내었으나, vancomycin, streptomycin, bacitracin, colistin에 대하여는 저항성을 나타내었다.