• Title/Summary/Keyword: Pv92

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Characterization of Pv92, a Novel Merozoite Surface Protein of Plasmodium vivax

  • Lee, Seong-Kyun;Wang, Bo;Han, Jin-Hee;Nyunt, Myat Htut;Muh, Fauzi;Chootong, Patchanee;Ha, Kwon-Soo;Park, Won Sun;Hong, Seok-Ho;Park, Jeong-Hyun;Han, Eun-Taek
    • Parasites, Hosts and Diseases
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    • v.54 no.4
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    • pp.385-391
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    • 2016
  • The discovery and understanding of antigenic proteins are essential for development of a vaccine against malaria. In Plasmodium falciparum, Pf92 have been characterized as a merozoite surface protein, and this protein is expressed at the late schizont stage, but no study of Pv92, the orthologue of Pf92 in P. vivax, has been reported. Thus, the protein structure of Pv92 was analyzed, and the gene sequence was aligned with that of other Plasmodium spp. using bioinformatics tools. The recombinant Pv92 protein was expressed and purified using bacterial expression system and used for immunization of mice to gain the polyclonal antibody and for evaluation of antigenicity by protein array. Also, the antibody against Pv92 was used for subcellular analysis by immunofluorescence assay. The Pv92 protein has a signal peptide and a sexual stage s48/45 domain, and the cysteine residues at the N-terminal of Pv92 were completely conserved. The N-terminal of Pv92 was successfully expressed as soluble form using a bacterial expression system. The antibody raised against Pv92 recognized the parasites and completely merged with PvMSP1-19, indicating that Pv92 was localized on the merozoite surface. Evaluation of the human humoral immune response to Pv92 indicated moderate antigenicity, with 65% sensitivity and 95% specificity by protein array. Taken together, the merozoite surface localization and antigenicity of Pv92 implicate that it might be involved in attachment and invasion of a merozoite to a new host cell or immune evasion during invasion process.

Economic Analysis on VLS-PV System from Sunbelt Region (Sunbelt 지역의 태양광발전 경제성분석)

  • Choi, Bong-Ha;Park, Soo-Uk;Lee, Deok-Ki;Kim, Seok-Ki;Song, Jin-Soo
    • New & Renewable Energy
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    • v.2 no.4 s.8
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    • pp.86-92
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    • 2006
  • This paper analyses the economics of 50kW PV system installed in Tibet and using domestic technology. We show that this system can be expanded to very large-scale photovoltaic power generation [VLS-PV] system successfully. Based on this result, we conduct the economic analysis of 100MW VLS-PV system designed assuming that it will be installed from 2008 to 2017 in Tibet. In this analysis, future price of PV module and system are estimated based on the methodology of experience curve. In 50kW PV system, the generation cost is calculated at 567.2 won/kWh and this is lower than the one of domestic PV system. In future 100MW VLS-PV system. the generation cost is calculated at 305.4 won/kWh by declining system price. If the lifetime and efficiency of the system goes up, due to future technological improvements, the generation cost can be lowered. Moreover, under the environmental and political effect, VLS-PV system can be as competitive as the conventional energy within 20 years.

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Comparision for Islanding Method of Grid-connected PV System (태양광발전 시스템의 단독운전법 비교)

  • Eun Seog-Jun;Choi Jong-Woo;Kim Heung-Geun
    • Proceedings of the KIPE Conference
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    • 2004.07a
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    • pp.92-96
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    • 2004
  • Islanding of PV systems can cause a variety of problems and must be prevented. However, if the real and active powers of RLC load and PV system are closely matched, islanding detection by passive methods becomes difficult. Active methods enables islanding detection by forcing the frequency of the voltage in the island to drift up/down. This paper shows the simulation and comparision by Matlab for the active methods.

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Computed tomographic evaluation of portal vein indices in cats with the extrahepatic portosystemic shunts

  • Eunji Jeong;Jin-Young Chung;Jin-Ok Ahn;Hojung Choi;Youngwon Lee;Kija Lee;Sooyoung Choi
    • Journal of Veterinary Science
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    • v.25 no.3
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    • pp.37.1-37.10
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    • 2024
  • Importance: The portal vein to aorta (PV/Ao) ratio is used to assess the clinical significance of extrahepatic portosystemic shunt (EHPSS). Previous studies using computed tomography (CT) were conducted in dogs but not in cats. Objective: This study aimed to establish normal reference values for PV indices (PV/Ao ratio and PV diameter) in cats and determine the usefulness of these for predicting symptomatic EHPSS. Methods: This study included 95 dogs and 114 cats that underwent abdominal CT. The canine normal (CN) group included dogs without EHPSS. The cats were classified into feline normal (FN, 88/114), feline asymptomatic (FA, 16/114), and feline symptomatic (FS, 10/114) groups. The PV and Ao diameters were measured in axial cross-sections. Results: The group FN had a higher PV/Ao ratio than the group CN (p < 0.001). Within the feline groups, the PV indices were in the order FN > FA > FS (both p < 0.001). The mean PV diameter and PV/Ao ratio for group FN were 5.23±0.77 mm and 1.46±0.19, respectively. The cutoff values between groups FN and FS were 4.115 mm for PV diameter (sensitivity, 100%; specificity, 97.7%) and 1.170 for PV/Ao ratio (90%, 92.1%). The cutoff values between group FA and FS were 3.835 mm (90%, 93.8%) and 1.010 (70%, 100%), respectively. Conclusions and Relevance: The results demonstrated significant differences in PV indices between dogs and cats. In cats, the PV/Ao ratio demonstrated high diagnostic performance for symptomatic EHPSS. The PV diameter also performed well, in contrast to dogs.

Modeling of Grid-Connected Photovoltaic Generation using Matlab/Simulink (Matlab/Simulink를 이용한 계통연계형 태양광발전 모델링)

  • Seo, H.C.;Yoon, Y.M.;Kim, S.R.;Lee, S.B.
    • Proceedings of the KIEE Conference
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    • 2008.11a
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    • pp.92-94
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    • 2008
  • This paper introduces the modeling of grid-connected photovoltaic(PV) generation using Matiab/Simulink. The model is based on the equivalent circuit of the PV solar cell including the effects of solar irradiation and temperature changes. The PV arrays are modeled to be built up with the series/parallel combination of PV solar cell and are connected to the distribution system via an inverter. The simulation results show that the typical characteristics and outputs of the PV arrays are accurate.

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An analysis on the operating characteristics of 50kW Photovoltaic Power System (50 kW급 계통연계형 태양광 발전시스템 장기 실증 운전)

  • Kim, Y.S.;Ahn, K.S.;Lim, H.C.;Oh, J.M.
    • Proceedings of the KIEE Conference
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    • 2005.07b
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    • pp.1788-1790
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    • 2005
  • In this paper, an operating characteristics of a 50 kW gird-connected photovoltaic(PV) power system was analysed from 2000 to 2004. The construction of the PV system includes a 3-phase inverter for grid connection, PV module, distribution box, and data monitoring system. The major results of the demonstration test of the 50 kW class gird-connected PV system showed that efficiency of PV system was 11.13%, and the conversion efficiency of the inverter was 92% at a 50% load.

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Movable BIPV Shading Device Design for Apartment Building Balcony (발코니 설치식 가동형 차양겸용 BIPV 디자인과 성능연구)

  • Chin, Kyung-Il;Yoon, Jong-Ho
    • Journal of the Korean Solar Energy Society
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    • v.30 no.5
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    • pp.85-92
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    • 2010
  • At the beginning the 21st century, we are interested in renewable energy especially photovoltaic. So, we have been installed PV at the building roofs so that we call it building integrated photovoltaic. But strictly speaking, installing the PV on the roof is not building integrated. There are few BIPV designs especially for balcony. In the apartment building, roof is good installing place for PV, but its area was limited. Now a day, built apartment building's heights are more and more increased so that the performance of installed PV on the roof cannot be enough to use even the public use. Thereby, we need the new space in the building to install the PV except the building roof. This study suggests the building facade balcony as a new space to install the PV with building integrated PV design. Hence, in this study, we are designed the movable BIPV shading device for apartment building balcony, and verified its performance with computer simulation. Developed device in this study can works as an electronic generation device and an overhang on the side balcony. As a result, the electronic generation performance of device contributes 15~30% to each apartment unit. The more unit width increase, the better contributed device generates.

The Experimental Performance of Rectangular Tube Absorber PV/Thermal Combined Collector Module (사각튜브부착형 흡열판을 적용한 Unglazed PVT 복합모듈의 열적 전기적 성능분석)

  • Jeong, Seon-Ok;Chun, Jin-Aha;Kim, Jin-Hee;Kim, Jun-Tae;Cho, In-Soo;Nam, Seung-Baeg
    • 한국태양에너지학회:학술대회논문집
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    • 2011.11a
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    • pp.87-92
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    • 2011
  • The heat from PV modules should be removed for better electrical performance, and can be converted into useful thermal energy. A photovoltaic-thermal(PVT)module is a combination of PV module with a solar thermal collector which forms one device that converts solar radiation into electricity and heat simultaneously. The performance of the PV/Thermal combined collector module is directly influenced by solar radiation that also has an effect on PV module temperature. It is also has believe that the energy performance of PV/T collector is related to absorber design as well as PV module temperature. The existing study has been paid to the PV/Thermal combined collector module with circle tube absorbers. The aim of this study is to analyze the experimental performance of the PV/Thermal combined collector rectangular tube absorbers according to solar radiation. The experimental result show that the average thermal and electrical efficiencies of the PVT collector were 43% and14.81% respectively. Solar radiation is one of the most influential factors to determine the energy performance of PVT collector, but from a certain level of solar radiation the PVT collector receives on, its efficiencies began to decrease.

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Somatic JAK-2 V617F Mutational Analysis in Polycythemia Rubra Vera: a Tertiary Care Center Experience

  • Sultan, Sadia;Irfan, Syed Mohammed;Khan, Sadia Rashid
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.3
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    • pp.1053-1055
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    • 2016
  • Background: Polycythemia rubra vera (PV), being a primary polycythemia, is caused by neoplastic proliferation of erythroid, megakaryocytic and granulocytic lineages which result in panmyelosis. PV patients have a somatic acquired mutation in the Janus kinase (JAK2) pathway, rendering cell proliferation independent of the normal regulatory mechanisms that regulate erythropoiesis. The rational of this study was to determine the prevalence of the JAK-2 V617F mutation in Pakistani patients with PV. Materials and Methods: In this cross sectional study, 26 patients with PV were enrolled from January 2010 to December 2014. Patients were diagnosed based on WHO criteria for PV. All were screened for G-T point mutation (V617F) in the JAK2 gene on chromosome 9 by an allele specific PCR. Results: The mean age was $53.4{\pm}9.31years$ (range 36-72) and the male to female ratio was 2:1. The frequency of JAK2 V617F positivity in our PV patients was found to be 92.3%. Overall 30.7% of patients were asymptomatic and remaining 69.3% presented with symptomatic disease. The mean hemoglobin was $18.1{\pm}1.9g/dl$ with the mean hematocrit of $55.6{\pm}8.3%$. The mean total leukocyte count was $12.8{\pm}7.1{\times}10^9/l$ and the platelet count was $511{\pm}341.9{\times}10^9/l$. A positive correlation of JAK2 V617F mutation was established with high TLC count (P=0.01). No correlation of JAK2 V617F could be established with age or gender (P>0.05). Conclusions: The JAK2 V617F mutation frequency in our PV patients was similar to those reported internationally. Screening for the mutation in all suspected PV cases could be beneficial in differentiating patients with reactive and clonal erythrocytosis.

Genetic Differentiation of Strains of Xanthomonas campestris pv. vesicatoria by Random Amplified Polymorphic DNA (RAPD) (Random Amplified Polymorphic DNA (RAPD)를 이용한 고추 더뎅이병균 균주의 유전적 분류)

  • 정희정;김가영;고영진;노일섭;황병국
    • Korean Journal Plant Pathology
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    • v.13 no.1
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    • pp.5-12
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    • 1997
  • Genetic diversity of forty-four strains of Xanthomonas campestris pv. vesicatoria from diverse geographic origins was investigated using random amplified polymorphic DNA (RAPD) of genomic DNA. One hundred and thirty-seven amplified fragments were produced by polymerase chain reaction with a set of 14 random primers, and the sizes of amplified DNA fragments ranged approximately from 0.3 to 3.2 kb. Cluster analysis of genetic similarity among the strains generated the dendrogram that clearly separated all strains from each other. The 44 strains of X. campestris pv. vesicatoria were classified into 4 major genomic DNA RAPD groups and 15 subgroups at the genetic similarity of 0.60 and 0.92, respectively. The strains from foreign countries formed discrete subgroups, but the United States strain 87-77 clustered closely with some of Korean strains together. Thirty-nine Korean strains were classified into 11 subgroups, and especially Masan strain Ms93-1 clustered distinctly far from the other Korean strains. RAPD polymorphism suggests strongly the occurrence of genetic differentiation of X. campestris pv. vesicatoria and the existence of genetically distinctive subgroups among the populations in Korea.

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