• Title/Summary/Keyword: Purpurin-18-N-aminoimide

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Efficient Synthesis and in vitro PDT Effect of Purpurin-18-N-Aminoimides

  • Cui, Bing Cun;Cha, Min-Uk;Li, Jia Zhu;Park, Ho-Sung;Yoon, Il;Shim, Young-Key
    • Bulletin of the Korean Chemical Society
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    • v.31 no.11
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    • pp.3313-3317
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    • 2010
  • A simple and efficient synthetic route for making purpurin-18-N-aminoimides is described. The purpurin-18-Naminoimides are obtained by treatment of purpurin-18 methyl ester with various amines. These new compounds have long wavelength absorptions in the range of 706 - 711 nm. In preliminary screening, the purpurin-18-N-aminoimides have shown promising photosensitizing activity for the cancer cell by in vitro study in photodynamic therapy.