Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Efficient Synthesis and in vitro PDT Effect of Purpurin-18-N-Aminoimides

  • Cui, Bing Cun (PDT Research Institute, School of Nano System Engineering, Inje University) ;
  • Cha, Min-Uk (PDT Research Institute, School of Nano System Engineering, Inje University) ;
  • Li, Jia Zhu (PDT Research Institute, School of Nano System Engineering, Inje University) ;
  • Park, Ho-Sung (PDT Research Institute, School of Nano System Engineering, Inje University) ;
  • Yoon, Il (PDT Research Institute, School of Nano System Engineering, Inje University) ;
  • Shim, Young-Key (PDT Research Institute, School of Nano System Engineering, Inje University)
  • Received : 2010.05.10
  • Accepted : 2010.09.15
  • Published : 2010.11.20
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Abstract

A simple and efficient synthetic route for making purpurin-18-N-aminoimides is described. The purpurin-18-Naminoimides are obtained by treatment of purpurin-18 methyl ester with various amines. These new compounds have long wavelength absorptions in the range of 706 - 711 nm. In preliminary screening, the purpurin-18-N-aminoimides have shown promising photosensitizing activity for the cancer cell by in vitro study in photodynamic therapy.

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References

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