• 한국임상약학회지
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• 제21권1호
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• pp.39-42
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• 2011

Idiopathic thrombocytopenic purpura is a potentially life-threatening condition characterised by thrombocytopenia and mediated by an autoimmune mechanism. Several recent studies have suggested that an association exists between H. pylori eradication and improvement in platelet count in a significant proportion of patients with idiopathic thrombocytopenic purpura. This study confirmed the efficacy of H. pylori eradication in increasing the platelet count in steroid refractory idiopathic thrombocytopenic purpura patients. Eradication therapy is simple and inexpensive, with limited toxicity and the advantage of avoiding long-term immunosuppressive treatment.

• 동의생리병리학회지
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• 제21권5호
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• pp.1303-1306
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• 2007

Idiopathic thrombocytopenic purpura(ITP) is an autoimmune disease which is related to antibodies against platelets. More than 95% of the patients progress into chronic type. Usually, IPT patients suffer form hypodermal bleeding, purpura, decreases in platelet counts. Purpura of legs, nosebleeds and oral ulcer may occur. In this study, herbal medicine, acupuncture and moxibustion in conjunction with cupping were applied to IPT patient based on the oriental medicine principle such as Lihyulyanggangeonbi-tang(理血養肝建脾湯). After the treatment, the patient improved better, and had no more inconvenient symptoms according to the follow-up research. So the result shows the possibility that oriental medical treatment may be applied to the IPT patient clinically.

• Journal of Yeungnam Medical Science
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• 제10권2호
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• pp.512-517
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• 1993

임신전 만성 ITP로 진단되어 prednisolone 경구투여와 vincristine 정맥주사로 치료후에 추적관찰중 환자가 임신하였으나 조기진통으로 질식 둔위분만했으며 증세가 재발하여 prednisolone, 감마글로불린을 투여하였으나 호전이 없이 비장적출술을 시행한 임신과 동반된 특발성 혈소판 감소성 자반증 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Yeungnam Medical Science
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• 제5권1호
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• pp.173-179
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• 1988

Since 1931, sporadic reports have appeared noting an apparent association between hyperthyroidism and idiopathic thrombocytopenic purpura. Recent various studies suggested that these two diseases may share a similar immunologic background, but the the exact mechanism is still a matter of speculation. This 22-year old female patient visisted this hospital because of general weakness and purpura of legs for 2 months. The laboratory findings were compatible with Graves' disease associated with idiopathic thrombocytopenic purpura. The palatclet count was 16000/$mm^3$, hemoglobulin was 10.9g/dl and MCV was 60.1tL. T3 was 490.53ng/dL, T4 was 24ug/dL and free T4 was 5.66ng/dL. Antiplatelet antibody and anti-microsomal antibody were positive. The bone marrow findings were compatible with tron deficiency anemia and idiopathic thrombocytopenic purpura. The thyroid biopsy showed adenomatous goiter. She was administered with propyl thiouracil, Beta-blocker, iron and prednisolon. On the 10th hospital day, platelet count was 184000/$mm^3$, hemoglobulin was 12.0gm/dL and MCV was 67.5fL. On the 20th hospital day, T4 was 10.35ug/dL and free T4 was 2.30ng/dL. Therefore she was discharged and followed up.

• Journal of Acupuncture Research
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• 제23권4호
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• pp.219-224
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• 2006

Idiopathic thrombocytopenic purpura(ITP) is characterized by the development of a specific anti-platelet autoantibody immune response mediating the development of thrombocytopenia. Systemic lupus erythematosus(SLE) is an autoimmune disease characterized by the production of a wide variety of autoantibodies. We experienced SLE patient whose initial symptoms were related to idiopathic thrombocytopenic purpura(ITP). She has a thrombocytopenia after Splenectomy and Steroid therapy on ITP and SLE. After she took Eight constitution Acupuncture treatment, thrombocytopenia has improved. We think Acupuncture will be effective treatment at autoimmune disease.

• Journal of Trauma and Injury
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• 제26권3호
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• pp.238-242
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• 2013

Idiopathic thrombocytopenic purpura (ITP) is the condition of having an abnormally low platelet count with an unknown cause. Acute subdural hematomas (ASDHs) usually develop in trauma patients and often involve a high bleeding tendency. However, ITP patients rarely have a large ASDH, and when a traditional decompressive craniectomy is performed on patients with coagulopathy, the mortality rate is higher because of the greater bleeding risk. We report the case of an ITP patient with a large ASDH who treated with a burr-hole trephination and irrigation and who was discharged without any neurological deficit.

• 대한한방내과학회지
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• 제42권5호
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• pp.1074-1081
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• 2021

Objectives: This study demonstrated the positive effect of herbal medication on a suspected idiopathic thrombocytopenic purpura (ITP) patient-a 57-year-old male with suspected ITP and a decreased platelet count. Methods: The patient was treated with an herbal medicine named Nokyongdaebo-tang, and its effect was measured with periodic platelet blood tests. Results: Before taking the herbal medicine, the patient's blood platelet count was 98 K/μl, but following treatment, the blood platelet count increased to 201 K/μl and maintained a continuously elevated level. Conclusion: The results indicated that herbal medication may improve the blood platelet count of suspected ITP patients.

• Clinical and Experimental Reproductive Medicine
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• 제26권2호
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• pp.265-269
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• 1999

Thrombocytopenic patients without detectable bound antiplatelet antibody should be diagnosed with idiopathic thrombocytopenic purpura (ITP) if no other cause of their decreased platelet count could be found. More recently the term "autoimmune thrombocytopenic purpura (ATP) has supplanted ITP since the disease is related to the production of autoantibodies against one's own platelets. This entity should not be confused with isoimmune thrombocytopenic purpura (also called alloimmune thrombocytopenic purpura). In this cases maternal antiplatelet antibodies directed against the PLA 1 antigen on the fetal platelets causes severe fetal and neonatal thrombocytopenia in a situation analogous to Rheusus disease. Antibodies to the negatively charged phospholipids, lupus anticoagulant, and anticardiolipin have been linked to adverse pregnancy events. Pregnant women possessing these antibodies have an increased risk of spontaneous abortion, stillbirths, intrauterine fetal growth retardation, preterm birth, and arterial and venous thrombosis. Antiphospholipid antibodies decrease or may even disappear between pregnancies only to recur with increased activity in a subsequent pregnancy and lead to loss. We have experienced a case of antiphospholipid syndrome associated with autoimmune thrombocytopenic purpura in patient with recurrent spontaneous abortion. So we report this case with a brief review of literatures.

• Clinical and Experimental Pediatrics
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• 제49권8호
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• pp.833-838
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• 2006

Giant platelet syndrome is a group of unique disorders characterized by the presence of abnormally large platelets, and usually accompanied by thrombocytopenia. Most cases of giant platelets are encountered in idiopathic thrombocytopenic purpura(ITP). In contrast, inherited giant platelet disorders, a group of heterogeneous diseases, are rare. Bernard-Soulier syndrome and its variants, and MYH9 related diseases have been defined at the molecular level. Abnormalities in transcription factors are implicated in a couple of macrothrombocytopenia syndromes. However, the molecular defects are unknown in gray platelet syndrome. It is important to make a proper diagnosis of congenital macrothrombocytopenia to avoid unnecessary medications and potentially dangerous treatment for presumed ITP.

• Childhood Kidney Diseases
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• 제2권2호
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• pp.133-137
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• 1998

목 적 : 1987년 정주용 면역글로불린(Intravenous immunoglobulin: IVIG)에 의한 급성신부전의 첫 증례가 보고된 이후 성인에서는 고용량의 IVIG와 관련된 신손상의 보고들이 다수 있었다. 이에 저자들은 고용량 IVIG의 사용이 보편화되어 있는 가와사끼병과 특발성 혈소판 감소성 자반증 환아에서 IVIG의 신독성 여부를 관찰하고자 하였다. 방 법 : 1996년 1월에서 8월까지 이대 부속 목동 병원에 입원하여 가와사끼병(23례)과 특발성 혈소판 감소성 자반증(7례)으로 고용량의 정주용 면역글로불린(2 g/kg)을 투여받은 환아를 대상으로 하였다. IVIG투여후 1일, 3일에 요량, BUN, 혈청 creatinine, Ccr, FENa, TRP, 24 시간뇨 ${\beta}_2$-microglobulin/cr 비 및 microalbumin/cr 비의 변화를 관찰하였다. 통계는 repeated measurement ANOVA test와 t-test를 사용하여 검정하였다. 결 과 : 고용량의 IVIG 투여후에 요량, BUN, 혈청 creatinine, Ccr, TRP, 24 시간뇨 ${\beta}_2$-microglobulin/cr 비 및 microalbumin/cr비의 유의한 변화는 없었다. IVIG투여후 1일에 일시적으로 증가한 FENa만이 유의한 변화였다. 결 론 : 소아에서 흔히 사용되는 고용량 IVIG는 정상 신기능 상태에서는 유의한 신손상을 일으키지 않았다.