• Title/Summary/Keyword: Pulse injection

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Laser Induced Microjet Drug Delivery System: Drug Permeation Depending on Laser Wavelength and Pulse Duration (레이저 유도 마이크로젯을 활용한 약물 전달 방식: 레이저 파장 및 펄스길이에 따른 약물 침투 분석)

  • Jang, Hun jae;Ham, Hwi chan;Yoh, Jai ick
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.41 no.7
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    • pp.463-468
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    • 2017
  • For transdermal drug delivery, needless injection system is composed of laser and microjet injector. Main mechanism of microjet injector is the laser-induced bubble. Nd:YAG and Er:YAG laser are used as a power source. Laser parameters such as pulse duration and wavelength are considered, which are core parameters to control the bubble motion. The Nd:YAG laser, pulse duration is short than bubble life time making cavitation like bubble while in Er:YAG laser, long pulse duration and high absorption in water drive bubble as a boiling bubble. Detailed motion of bubble and microjet is captured by the high speed camera. So it is observed that microjet characteristics are determined by the bubble behavior. The performance of drug delivery system is evaluated by fluorescent staining of guinea pig skin.

Spray Structure and Cross-section Characteristics of Pulsed Liquid Jet Injected into a Cross-flow (횡단 유동장으로 펄스 분사된 액체 제트의 분무 구조 및 단면 분포 특성)

  • Lee, In-Chul;Koo, Ja-Ye
    • Journal of the Korean Society of Propulsion Engineers
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    • v.13 no.2
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    • pp.1-8
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    • 2009
  • Present studies of these experiments was conducted to using water, over a range of cross-flow velocities from 42 to 136 m/s, with injection frequencies from 35.7 to 166.2 Hz. In cross-flow field, main parameters of liquid jet for secondary breakup were cross-flow drag rather than pressure pulse frequency. As oscillation of the periodic pressure, liquid jet was moved up and down. Also, a bulk of liquid jet puff was detected at upper field of liquid surface. Because of pressure pulsation frequency, an inclination of SMD for the structured layer was evanescent. Cross-sectional characteristics of SMD at downstream area were non-structured distributions. The tendency of volume flux value for various frequency of pressure pulse was same distribution. And volume flux was decreased when the frequency of pressure pulse increasing.

Non-thermal Plasma Process for simultaneous removal of SO2/NOx from a Sintering Plant of Steel Works

  • Nam, Chang-Mo;Mok, Young-Sun;Kwon, Gi-Hong;Suh, You-Duck;Cho, Byeung-Rak
    • Journal of the Korean Society of Industry Convergence
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    • v.6 no.1
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    • pp.81-86
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    • 2003
  • For the simultaneous removal of $SO_2$/NOx from an iron-ore sintering plant, industrial plasma experiments have been conducted with a flue gas flow rate of $5,000Nm^3/hr$. The maximum 40kW power using the magnetic pulse compression (MPC) system generates a peak value of 100-150kV pulse voltage with its risetime of 200nsec and full width at half maximum (FWHM) of 500nsec, and with a frequency <300Hz. The plasma reactor module adopts a wire-plate structure with a gap of 200-400mm ID between plates. Initial concentrations of $SO_2$ and NOx were around 100-150ppm, respectively in the presence of 15% $O_2$ and <10% $H_2O$. Various reaction parameters such as specific energy ($Whr/Nm^3$), $NH_3$ injection with corona discharge, flow rate and injection of hydrocarbons were investigated for $SO_2$/NOx removal characteristics. About 90/65% of $SO_2$/NOx were simultaneously removed with a specific energy of $3.0Whr/Nm^3$ when both $NH_3$ and hydrocarbons were injected. Practical implications that the pilot-scale plasma results provide are further discussed.

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Development of Fast Side-impact Sensing Algorithm (고속 측면 충돌 감지 알고리즘의 개발)

  • 박서욱;김현태
    • Transactions of the Korean Society of Automotive Engineers
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    • v.8 no.3
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    • pp.163-170
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    • 2000
  • Accident statistics shows that the portion of fatal occupant injuries due to side impacts is considerably high. The side impact usually leads to a severe intrusion of side structure into the passenger compartment. Furthermore, the safety zone for the side impact is relatively small compared to the front impact. Those kinds of physics for side impact frequently result in a fatal injury for the occupant. Therefore, NHTSA and EEVC are trying to intensify the regulation for the occupant protection against side impact. Both the regulation and recent market trends are asking for an installation of side airbag. There are several types of system configuration for side impact sensing. In this paper, we adopt the acceleration-based remote sensing method for the side airbag control system. We mainly focus on the development of hardware and crash discrimination algorithm of remote sensing unit. The crash discrimination algorithm needs fast decision of airbag firing especially for high-speed side impact such as FMVSS 214 and EEVC tests. It is also required to distinguish between low-speed fire and no-fire events. The algorithm should have a sufficient safety margin against any misuse situation such as hammer blow, door slam, etc. This paper introduces several firing criteria such as acceleration. velocity and energy criteria that use physical value proportional to crash severity. We have made a simulation program by using Matlab/Simulink to implement the proposed algorithm. We have conducted an algorithm calibration by using real crash data for 2,500cc vehicle. The crash performance obtained by the simulation was verified through a pulse injection method. It turned out that the results satisfied the system requirements well.

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Development of RF Ion Source for Neutral Beam Injector in Fusion Devices

  • Jang, Du-Hui;Park, Min;Kim, Seon-Ho;Jeong, Seung-Ho
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.02a
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    • pp.550-551
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    • 2013
  • Large-area RF-driven ion source is being developed at Germany for the heating and current drive of ITER plasmas. Negative hydrogen (deuterium) ion sources are major components of neutral beam injection systems in future large-scale fusion experiments such as ITER and DEMO. RF ion sources for the production of positive hydrogen ions have been successfully developed at IPP (Max-Planck- Institute for Plasma Physics, Garching) for ASDEX-U and W7-AS neutral beam injection (NBI) systems. In recent, the first NBI system (NBI-1) has been developed successfully for the KSTAR. The first and second long-pulse ion sources (LPIS-1 and LPIS-2) of NBI-1 system consist of a magnetic bucket plasma generator with multi-pole cusp fields, filament heating structure, and a set of tetrode accelerators with circular apertures. There is a development plan of large-area RF ion source at KAERI to extract the positive ions, which can be used for the second NBI (NBI-2) system of KSTAR, and to extract the negative ions for future fusion devices such as ITER and K-DEMO. The large-area RF ion source consists of a driver region, including a helical antenna (6-turn copper tube with an outer diameter of 6 mm) and a discharge chamber (ceramic and/or quartz tubes with an inner diameter of 200 mm, a height of 150 mm, and a thickness of 8 mm), and an expansion region (magnetic bucket of prototype LPIS in the KAERI). RF power can be transferred up to 10 kW with a fixed frequency of 2 MHz through a matching circuit (auto- and manual-matching apparatus). Argon gas is commonly injected to the initial ignition of RF plasma discharge, and then hydrogen gas instead of argon gas is finally injected for the RF plasma sustainment. The uniformities of plasma density and electron temperature at the lowest area of expansion region (a distance of 300 mm from the driver region) are measured by using two electrostatic probes in the directions of short- and long-dimension of expansion region.

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Development of an Optical Tissue Clearing Laser Probe System

  • Yeo, Changmin;Kang, Heesung;Bae, Yunjin;Park, Jihoon;Nelson, J. Stuart;Lee, Kyoung-Joung;Jung, Byungjo
    • Journal of the Optical Society of Korea
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    • v.17 no.4
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    • pp.289-295
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    • 2013
  • Although low-level laser therapy (LLLT) has been a valuable therapeutic technology in the clinic, its efficacy may be reduced in deep tissue layers due to strong light scattering which limits the photon density. In order to enhance the photon density in deep tissue layers, this study developed an optical tissue clearing (OTC) laser probe (OTCLP) system which can utilize four different OTC methods: 1) tissue temperature control from 40 to $10^{\circ}C$; 2) laser pulse frequency from 5 to 30 Hz; 3) glycerol injection at a local region; and 4) a combination of the aforementioned three methods. The efficacy of the OTC methods was evaluated and compared by investigating laser beam profiles in ex-vivo porcine skin samples. Results demonstrated that total (peak) intensity at full width at half maximum of laser beam profile when compared to control data was increased: 1) 1.21(1.39)-fold at $10^{\circ}C$; 2) 1.22 (1.49)-fold at a laser pulse frequency of 5 Hz; 3) 1.64 (2.41)-fold with 95% glycerol injection; 4) 1.86 (3.4)-fold with the combination method. In conclusion, the OTCLP system successfully improved the laser photon density in deep tissue layers and may be utilized as a useful tool in LLLT by increasing laser photon density.

Effect of vibration during local anesthesia administration on pain, anxiety, and behavior of pediatric patients aged 6-11 years: A crossover split-mouth study

  • Hegde, Kuthpady Manasa;Neeraja, R;Srinivasan, Ila;Murali Krishna, DR;Melwani, Anjana;Radhakrishna, Sreeraksha
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.19 no.3
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    • pp.143-149
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    • 2019
  • Background: Uncooperative behavior of children due to dental anxiety may interfere with the effective delivery of dental care and compromise the quality of treatment provided. Injection of local anesthesia is one of the most anxiety-inducing stimuli in pediatric dentistry. This study aimed to compare the efficacy of a child-friendly device, having a combined effect of vibration and distraction, with the conventional method of injection on pain, anxiety, and behavior of pediatric patients aged 6-11 years. Methods: This randomized, crossover, split-mouth study included 30 children requiring a bilateral inferior alveolar nerve block. The children were equally divided into two groups: group 1, aged 6-8 and group 2, aged 9-11 years. All children were injected with anesthesia using the conventional and device method in two separate sessions. They were assessed for anxiety by measuring the pulse rate before and during the administration of local anesthesia. Behavior was assessed using Faces, Legs, Activity, Cry, Consolability (FLACC) scale, and the child's experience while receiving anesthesia was assessed using the Wong Bakers Pain Rating Scale. Results: Results showed that the children who received local anesthesia using the device method had a lower mean pulse rate, FLACC scores, and pain rating scores than those who received local anesthesia using the conventional method. Conclusion: The device method was more effective than the conventional method in managing pain, anxiety, and behavior of patients aged 6-11 years. The device is a cost effective, simple, and child-friendly product for administrating local anesthesia in pediatric patients.

Effects of Sperm Membrane Disruption and Electrical Activation of Oocytes on In vitro Development and Transgenesis of Porcine Embryos Produced by Intracytoplasmic Sperm Injection

  • Shim, Sang Woo;Kim, Young Ha;Lee, Hoon Taek;Shim, Hosup
    • Asian-Australasian Journal of Animal Sciences
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    • v.21 no.3
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    • pp.358-363
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    • 2008
  • The intracytoplasmic sperm injection (ICSI) procedure has recently been utilized to produce transgenic animals and may serve as an alternative to the conventional pronuclear microinjection in species such as pigs whose ooplasm is opaque and pronuclei are often invisible. In this study, the effects of sperm membrane disruption and electrical activation of oocytes on in vitro development and expression of transgene green fluorescent protein (GFP) in ICSI embryos were tested to refine this recently developed procedure. Prior to ICSI, sperm heads were treated with Triton X-100+NaCl or Triton X-100+NaCl+NaOH, to disrupt membrane to be permeable to exogenous DNA, and incubated with linearized pEGFP-N1 vector. To induce activation of oocytes, a single DC pulse of 1.3 kV/cm was applied to oocytes for $30{\mu}sec$. After ICSI was performed with the aid of a micromanipulator, in vitro development of embryos and GFP expression were monitored. The chemical treatment to disrupt sperm membrane did not affect the developmental competence of embryos. 40 to 60% of oocytes were cleaved after injection of sperm heads with disrupted membrane, whereas 48.6% (34/70) were cleaved without chemical treatment. Regardless of electrical stimulation to induce activation, oocytes were cleaved after ICSI, reflecting that, despite sperm membrane disruption, the perinuclear soluble sperm factor known to mediate oocyte activation remained intact. After development to the 4-cell stage, 11.8 (2/17, Triton X-100+NaCl+NaOH) to 58.8% (10/17, Triton X-100+NaCl) of embryos expressed GFP. The expression of GFP beyond the stage of embryonic genome activation (4-cell stage in the pig) indicates that the exogenous DNA might have been integrated into the porcine genome. When sperm heads were co-incubated with exogenous DNA following the treatment of Triton X-100+NaCl, GFP expression was observed in high percentage (58.8%) of embryos, suggesting that transgenic pigs may efficiently be produced using ICSI.

An Experimental Study on Variations of Exhaust Gas Temperature and Concentration with Synthetic Gas Combustion in Exhaust Manifold (배기관에서의 합성가스 연소에 따른 배기가스 온도 및 농도 변화에 관한 실험적 연구)

  • Cho, Yong-Seok;Lee, Seang-Wock;Yang, Seung-Il;Song, Chun-Sub;Park, Young-Joon
    • Transactions of the Korean Society of Automotive Engineers
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    • v.16 no.4
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    • pp.56-62
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    • 2008
  • A synthetic gas reformed from hydrocarbon-based fuels consists of $H_2$, CO and $N_2$. Hydrogen contained in the synthetic gas is a very useful species in chemical processes, due to its wide flammability range and fast burning speed. The ESGI (Exhaust Synthetic Gas Injection) technology is developed to shorten the light-off time of three way catalysts through combustion of the synthetic gas in the exhaust manifold during the cold start period of SI engines. Before the ESGI technology is applied to the test engine, the authors set a test rig that consists of gas temperature and composition controllers, an exhaust pulse generator and an exhaust manifold with a visualization window, in order to optimize the point and conditions of injection of the synthetic gas. Through measuring burned gas temperatures and taking photographs of synthetic gas combustion at the outlet of the exhaust manifold, the authors tried to find the optimal injection point and conditions. Analysis of burned gas composition has been performed for various $O_2$ concentrations. As a result, when the synthetic gas is injected at the port outlet of the cylinder No. 4 and $O_2$ concentration exceeds 4%, combustion of the synthetic gas is strong and effective in the exhaust manifold.

Effect of Submucosal Midazolam on Percutaneous Saturation Percentage of Oxygen ($SpO_2$), End-tidal Carbon Dioxide ($EtCO_2$) and Physiologic Response When Combined with Chloral Hydrate, Hydroxyzine and Nitrous Oxide Sedation (구강 점막 하 주입 Midazolam과 경구 투여한 Chloral Hydrate의 용량에 따른 산소 포화도 및 생징후 변화에 대한 비교 연구)

  • Yu, Ji-Hye;Kim, Yun-Hee;Jung, Sang-Hyuk;Baek, Kwang-Woo
    • Journal of The Korean Dental Society of Anesthesiology
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    • v.6 no.2 s.11
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    • pp.89-97
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    • 2006
  • Background: The aim of this study was to examine the difference of $SpO_2$, PR, $EtCO_2$, RR with submucosal injection of midazolam to oral chloral hydrate and hydroxyzine for pediatric patients Methods: Thirty two sedation cases were performed in this study. Patients were randomly classified into one group taking oral CH (60 mg/kg). hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.1 mg/kg) and the other group recieving oral CH (50 mg/kg), hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.2 mg/kg). For evaluating the depth of sedation. data including saturation percentage of oxygen ($SpO_2$), pulse rate (PR), end-tidal carbon dioxide ($EtCO_2$), respiratory rate (RR) and the behavior scale were checked every 2 minutes and were collected for only 40 minutes from the beginning of treatment and were analyzed using Two independent sample T-test. Results: Analysis showed no significant difference in the mean $SpO_2$, PR, $EtCO_2$, RR during sedation between two groups (P > 0.05). The values of $SpO_2$, PR, $EtCO_2$ and RR for both groups remained within the normal values. Conclusions: The results of this present study indicate that combination of oral CH, hydroxyzine, nitrous oxide gas inhalation and submucosal injection of midazolam improved the sedation quality without compromising safety.

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