• Journal of Chest Surgery
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• 제37권3호
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• pp.201-209
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• 2004

생명구조장치(ECLS)는 호흡부전 및 심부전에 적용하는 장치로 세계적으로 많은 연구개발과 임상시도가 계속되고 있다. 현재까지 생명구조장치의 혈류펌프로는 비박동형 구동장치가 표준으로 사용되고 있으며, 박동형 구동장치는 생리적인 측면에서 유리하지만 급격한 회로압 상승과 그에 따른 혈구손상에 대한 우려가 있고 특히 막형산화기를 사용하는 인공폐 회로에서 기피되어 왔다. 본 연구는 인공폐 실험모델에서 단일 박동형 구동펌프와 막형 산화기 사이에 압력완충장치를 설치함으로써 언급한 부작용을 최소화시키면서 생리적인 박동혈류를 유도할 수 있을 것이라는 가능성을 검증하였다. 실험대상은 올레익산으로 급성 호흡부전증이 유발된 잡견(N=16)을 사용하였다. 실험군은 사용된 구동펌프의 종류와 압력완충장치의 유무에 따라 3개 군으로 분류하였다. 제1군(n=6)은 대조군으로 원심펌프를 이용하였고, 제2군(n=4)은 단일 박동형 구동펌프를 사용하였으며, 제3군(n=6)은 단일 박동형 구동펌프에 압력완충장치를 설치하였다. 실험모델은 흉강 절개 후 우심방-대동맥을 우회시키는 부분 체외순환 형태로, 1.8～2 L/min의 펌프박출량에서 2시간을 구동하였다. 관찰지표는 주로 혈역학 변화, 회로압, 혈액검사 및 혈구세포에 미치는 영향 등에 한정하였다. 맥동압(pulse pressure)은 박동형 구동펌프를 이용한 2군(47$\pm$10 mmHg)과 3군(41$\pm$9 mmHg)에서 비박동형 원심펌프를 이용한 1군(17$\pm$7 mmHg)에 비해 유의하게 높았다(p<0.001). 막형산화기에 걸리는 회로압은 1 군의 경우 222$\pm$8mmHg, 2군의 경우 739 $\pm$ 35 mmHg, 3군의 경우 470$\pm$ 17 mmHg였다(p<0.001). 순환 2시간째의 동맥혈 산소분압은 1군에 비해 박동혈류를 사용하는 2군과 3군에서 현저하게 높았다(77$\pm$41, 96$\pm$48, 97$\pm$25 mmHg; p<0.05). 혈구손상지표인 혈장 유리 헤모글로빈치는 1군에서 가장 낮았고, 2군에서 가장 높았으며, 3군에서 유의하게 감소하였다(55.7$\pm$43.3, 162.8$\pm$113.6, 82.5$\pm$25.1 mg%; p<0.05). 기타 혈액검사치는 특별한 차이가 없었다. 이상의 결과에서 단일 박동형 구동펌프는 비박동형 원심펌프에 비해 막형산화기의 산소교환에 유리한 반면, 회로압과 혈구세포 손상 측면에서 불리하다는 것을 알 수 있었다. 그러나 단일 박동형 구동펌프와 막형 산화기 사이에 압력완충장치를 설치하는 경우, 회로압 상승과 혈구세포손상을 유의하게 감소시킬 수 있었다.

• 대한기계학회논문집
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• 제18권4호
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• pp.1031-1038
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• 1994

Characteristics of pulsatile flow and heat transfer have been studied numerically in the constant heat flux curved tube with periodic pressure gradient. As the Womersley number increases, the phase difference between the pressure gradient and the cross section averaged axial velocity becomes larger. In case of the Womersley number $\beta = 2$, when cross section averaged axial velocity reaches periodic state with time, the reverse and the natural flow coexist at phase angle, $\lambda = 1.44\pi$ and $\lambda =1.96\pi$. For all the Womersley numbers of present investigation, the time variation of wall temperature near inner wall is higher than that of near outer wall, independent of phase angle.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1484-1486
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• 2008

Characteristics of pulsatile flow in 3-dimensional elastic vessel wall should be investigated in order to understand the physiological blood flow in human body. In this study, the modelling of the physiological blood flow in the elastic blood vessel is proposed. Variation of the pressure and the velocity wavefroms are obtained using the FSI method

• 대한기계학회논문집
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• 제17권9호
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• pp.2294-2303
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• 1993

This paper investigated the characteristics of the turbulent incompressible flow past the orifice ring in an axi-symmetric pipe. The flow field was the turbulent pulsatile flow for Reynolds number of $2{\times}10^{5}$ which was defined based on the maximum velocity and the pipe diameter at the inlet, with oscillating frequence $(f_{os})=1/4{\pi}$ which was considered as quasi-steady state frequence. In the present investigation, finite analytic method was used to solve the governing equations in Navier Stokes and turbulent transport formulations. Particularly at high Reynolds number and low oscillation frequency, the effects of orifice ring on the flow were numerically investigated. The separation zone behind the orifice ring during the acceleration phase was found to be decreased. However, during the deceleration phase, the separation behind the orifice ring for pulsatile flow continuously grow to a size even larger than that in steady flow. The pressure drop in steady flow was found to be constant and always positive while for pulsatile flow the pressure drop change with time. And large turbulent kinetic energy, dissipation rate were found to be located in the region where the flow passes through the orifics ring. The maximum turbulent kinetic energy, generally occurs along the shear layer where the velocity gradient is large.

• Journal of Advanced Marine Engineering and Technology
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• 제38권2호
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• pp.140-146
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• 2014

Stenosis is the drastic reduction in the cross-sectional area of blood vessel caused by accumulations of cholesterol. It affects the blood flow property and structure from the fluid dynamic point of view. To understand the flow phenomenon more clearly, a particle image velocimetry method is used and the fluid dynamic characteristics in a circular channel containing stenosis structure is investigated experimentally in this study. Different stenotic-structured models made of acrylic material are subjected to a pulsatile flow generated by an in-house designed pulsatile pump. The inner diameter of the tube inlet is 20 mm and the length of reduced area for stenosis ranges between 35mm and 40mm. It is circulated continuously through a circular channel by the pump system. Pressure is measured at four different sections during systolic and diastolic phase changes. The phase-averaged velocity field distribution shows a recirculation regime after the stenotic structure. The effects of the stenotic obstructions are found to be more severe when the aspect ratio is varied.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 춘계학술대회논문집B
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• pp.535-540
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• 2000

The objective of the present study is to visualize the pulsatile flow fields by using three-dimensional computer simulation and the PIV system. A closed flow loop system was built for the steady and unsteady experiments. The Harvard pulsatile pump was used to generate the pulsatile pressure and velocity waveforms. Conifer powder as the tracing particles was added to water to visualize the flow field. Two consecutive particle images were captured by a CCD camera for the image processing. The cross-correlation method in combination with the moving searching area algorithm was applied for the image processing of the flow visualization. The pulsatile flow fields were visualized effectively by the PIV system in conjunction with the applied algorithm. The range validation and the area interpolation methods were used to obtain the final velocity vectors with high accuracy. The finite volume predictions were used to analyze three-dimensional flow patterns in the bifurcation model. The results of the PIV experiment and the computer simulation are in good agreement and the results show the recirculation zones and formation of the paired secondary flow distal to the apex of the bifurcated model. The results also show that the branch flow is pushed strongly to the inner wall due to the inertial force effect and helical motions are generated as the flow proceeds toward the outer wall.

• 대한의용생체공학회:의공학회지
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• 제28권3호
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• pp.387-391
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• 2007

An oxygenator is a very important artificial organ and widely used for patients with lung failure or during open heart surgery. Although an oxygenator has been widely studied worldwide to enhance its efficiency, studies on oxygenators, in particular when using a pulsatile blood flow, are domestically limited. Therefore, a new oxygenator was developed in the lab and animal experimental results are described in the paper. The oxygenator is composed of polycarbonate housing and polypropylene hollow fibers. It has a total length of 400 mm and a surface area of $1.7 m^2$. The animal experiment lasted for 4 hours. The blood flow rate was set to 2 L/min and a pulsatile blood pump, T-PLS (Twin-Pulse Life Support), was used. Samples were drawn at the oxygenator's inlet and outlet. The total hemoglobin (Hb), saturation oxygen ($sO_2$), and partial oxygen pressure ($pO_2$), partial $CO_2$ pressure ($pCO_2$), and plasma bicarbonate ion concentration ($HCO_3^-$) were measured. The oxygen and carbon dioxide transfer rates were also calculated based on the experimental data in order to estimate the oxygenator's gas transfer efficiency. The oxygen and carbon dioxide transfer rates were $16.4{\pm}1.58$ and $165.7{\pm}10.96 mL/min$, respectively. The results showed a higher carbon dioxide transfer rate was achieved with the oxygenator. Also, the mean inlet and outlet blood pressures were 162.79 and 137.92 mmHg, respectively. The oxygenator has a low pressure drop between its inlet and outlet. The aim of own preliminary study was to make a new oxygenator and review its performance when applying a pulsatile blood pump thus, confirming the possibility of a new oxygenator suitable for pulsatile flow.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집E
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• pp.748-753
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• 2001

The objective of the present study is to visualize the pulsatile flow fields by using three-dimensional computer simulation and the PIV system. A closed flow loop system was built for the steady and unsteady experiments. The Harvard pulsatile pump was used to generate the pulsatile pressure and velocity waveforms. Conifer powder as the tracing particles was added to water to visualize the flow field. Two consecutive particle images were captured by a CCO camera for the image processing at several cross section. The range validation and the area interpolation methods were used to obtain the final velocity vectors with high accuracy. The finite volume predictions were used to analyze three-dimensional flow patterns in the bifurcation model. The results of the PIV experiment and the computer simulation are in good agreement and the results show the recirculation zones and formation of the paired secondary flow distal to the apex of the bifurcated model. The results also show that the branch flow is pushed strongly to the inner wall due to the inertial force effect and helical motions are generated as the flow proceeds toward the outer wall.

• 대한의용생체공학회:의공학회지
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• 제27권2호
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• pp.78-82
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• 2006

The ventricular assist device(VAD) helps to reduce the overload against the patient's native heart(NH). The pulsatile VAD pumps out the ventricular blood to the aorta with pulsatile flow. If the VAD pulsates simultaneously with the NH, the ventricle of the NH could confronts abnormally elevated aortic pressure, and this could deteriorate the ventricle rather than assist to recover it. Thus counterpulsation algorithms to avoid copulsation have been adopted by many VADs, but these methods utilize electrocardiography or arterial pressure signals, which may have difficulties to acquire consistently for a long period. In this study, the copulsation estimation algorithm for the counterpulsation is developed using the VAD outlet pressure signal. The VAD outlet pressure signal is good to maintain for a long time and the sensor part could be integrated to the VAD as a built-in module. From the VAD outlet pressure signal and its pump rate information calculated with Fast Fourier Transform, pulse peaks by the VAD and the NH were extracted and the next copulsation time at which the VAD and the NH would pulsate simultaneously was estimated. This estimation algorithm was implemented by using PC MATLAB software and tested for various pump rate conditions with mock circulation system. For each condition, the copulsation time was estimated successfully. Consequently, the results showed the possibility to use the outlet cannula pressure signal in the copulsation estimation.

• 대한의용생체공학회:의공학회지
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• 제35권5호
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• pp.119-124
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• 2014

A Ventricular assist device (VAD) is one of the most efficient treatments to raise the survivability of the end stage heart failure patient. However, some of LVAD patients have died for the failures and improper control of LVAD. To detect critical dangers in LVAD, the monitoring methods of LVAD outflow have been requested, because it can be affected by patient's hemodynamic states and abnormal conditions of LVAD. In the case of an external pulsatile LVAD, the air movement through the air line can be used to estimate LVAD outflow. In this study, the air movement in the air-line of the extracorporeal pulsatile LVAD was measured with a differential pressure sensor between different points. The precise estimation of air movement could be achieved by additional measurement of air pressure. In a series of in-vitro experiments, the LVAD outflow were changed according to the afterload of LVAD and the differential pressure of LVAD didn't have close correlation with the LVAD outflow that were measured with an ultrasonic flowmeter at the same time. However, new precise estimation with the data from differential pressure and one point pressure in the air-line showed higher correlations with LVAD outflow.