• 인터넷정보학회논문지
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• 제18권5호
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• pp.55-60
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• 2017

The pulmonary function test (PFT) is an essential data source for evaluating the effect of drugs on the lungs or the status of lung function. However, the numeric values of PFT cannot be easily used for clinical studies without labor-intensive manual efforts, because PFTs are usually recorded as image files. This study was aimed at constructing a de-identified, open-access PFT database with various clinical information. For constructing the PFT database, optical character recognition (OCR), regular expression, and the parsing technique were used to extract alphanumeric data from the PFT images in a Korean tertiary teaching hospital. This longitudinal observational database contains 413,000 measurements of PFT from 183,000 patients.

• Physical Therapy Rehabilitation Science
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• 제9권2호
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• pp.120-130
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• 2020

Objective: This study was conducted to identify the clinical usefulness, validity, and reliability of the Spirokit, a device that combines the pulmonary function test (PFT) and respiratory muscle strength (RMS) test. Design: Cross-sectional study. Methods: Forty young adults (male: 23, female: 17) participated in a PFT and a RMS test. The concurrent validity for pulmonary function was assessed by comparing data obtained from MicroQuark and the Spirokit and the agreements between the MicroRPM and the Spirokit for RMS were compared. The test-retest reliability of the Spirokit was determined by comparing data obtained from the first and second sessions. The test and retest were performed at the same time after one day for the PFT and RMS test. Validity was estimated using intraclass correlation coefficients (ICCs), and by calculating 95% limits of agreement (LoA). To estimate interrater reliability, ICCs were calculated. Results: The Spirokit showed a high agreement intra class coefficient (ICC [2, 1]): 0.978-0.999, 95% limits of agreements (95% LOA): -0.798 to 0.847 with MicroQuark. It also showed a high level of concordance ICC (2, 1): 0.992 to 0.993, 95% LOA: -9.313 to 11.169 with MicroRPM. The test-retest reliability of the Spirokit was analyzed using ICC (2, 1), and showed a high level of reliability (ICC [2,1]=0.960 to 0.998). Standard error of measurement % (SEM%) was 0.12% to 3.39%, and minimum detectable change% (MDC%) was 0.02% to 3.79%, indicating high level of reliability. Conclusions: The Spirokit is a device with high validity and reliability that can be used to simultaneously measure PFT and RMS tests.

• Korean Journal of Radiology
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• 제20권4호
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• pp.683-692
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• 2019

Objective: We aimed to evaluate correlations between computed tomography (CT) parameters and pulmonary function test (PFT) parameters according to disease severity in patients with chronic obstructive pulmonary disease (COPD), and to determine whether CT parameters can be used to predict PFT indices. Materials and Methods: A total of 370 patients with COPD were grouped based on disease severity according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) I-IV criteria. Emphysema index (EI), air-trapping index, and airway parameters such as the square root of wall area of a hypothetical airway with an internal perimeter of 10 mm (Pi10) were measured using automatic segmentation software. Clinical characteristics including PFT results and quantitative CT parameters according to GOLD criteria were compared using ANOVA. The correlations between CT parameters and PFT indices, including the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) and FEV₁, were assessed. To evaluate whether CT parameters can be used to predict PFT indices, multiple linear regression analyses were performed for all patients, Group 1 (GOLD I and II), and Group 2 (GOLD III and IV). Results: Pulmonary function deteriorated with increase in disease severity according to the GOLD criteria (p < 0.001). Parenchymal attenuation parameters were significantly worse in patients with higher GOLD stages (P < 0.001), and Pi10 was highest for patients with GOLD III (4.41 ± 0.94 mm). Airway parameters were nonlinearly correlated with PFT results, and Pi10 demonstrated mild correlation with FEV1/FVC in patients with GOLD II and III (r = 0.16, p = 0.06 and r = 0.21, p = 0.04, respectively). Parenchymal attenuation parameters, airway parameters, EI, and Pi10 were identified as predictors of FEV₁/FVC for the entire study sample and for Group 1 (R² = 0.38 and 0.22, respectively; p < 0.001). However, only parenchymal attenuation parameter, EI, was identified as a predictor of FEV₁/FVC for Group 2 (R² = 0.37, p < 0.001). Similar results were obtained for FEV₁. Conclusion: Airway and parenchymal attenuation parameters are independent predictors of pulmonary function in patients with mild COPD, whereas parenchymal attenuation parameters are dominant independent predictors of pulmonary function in patients with severe COPD.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2003년도 Challenges and Achievements in Environmental Health
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• pp.192-195
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• 2003

To identify the difference between Korean-Chinese and Korean children's variation of pulmonary function with personal factors (suck as age, height, and weight), we performed pulmonary function test (PFT) and measured personal factors of 200 Korean-Chinese children participants from two elementary schools of Beijing and Melons city in China. Regression analysis was utilized to determine which personal factors were significantly correlated with PFT measure (FVC and FEV$_1$). We compared the regression model from this study with those of other studies of Korean children. Similar to other studies, we found that the most important variable, influencing PFT measure, was height, whereas addition of either age or weight in the regression virtually did not increase the accuracy. As the result of comparison of the regression model from this study with those of other studies of Korean children, variation in FVC or FEV$_1$ with height were similar.

• The Journal of Korean Physical Therapy
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• 제25권6호
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• pp.374-378
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• 2013

Purpose: Human body have biological rhythmic pattern in a day, which is affected by internal and external environmental factors. We investigated whether respiratory function was fluctuated according to the influence of time-of-day (around at 9 am, 1 pm, and 6 pm) in health subjects, using pulmonary function test (PFT). Methods: Eighteen healthy volunteers (8 men, mean ages; $22.4{\pm}1.6$, mean heights; $166.61{\pm}9.60$, mean weight; $59.3{\pm}10.3$) were recruited. Pulmonary function test (PFT) was measured at three time points in day, around 9 am, 1 pm, and 6 pm in calm research room with condition of under 55dB noise level, using a spirometer (Vmax 229, SensorMecis, USA). Forced vital capacity (FVC), forced expiratory volume at one second (FEV1), FVC/FEV1, and peak expiratory flow (PEF) were acquired. Results: In comparison of raw value of PFT among three time points, subjects showed generally better respiratory function at 9 am, than at other points, although no significance was found. In comparison of distribution of ranking for respiratory function in each individual, only PEF showed significant difference. In general, distributional ratio of subjects who showed best performance of respiratory function in a day was high. Conclusion: These findings showed that circadian rhythm by diurnal pattern was not detected on respiratory function throughout all day. But, best performance on respiratory function was observed mostly in the morning, although statistical significance did not exist.

• 대한임상검사과학회지
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• 제37권3호
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• pp.207-211
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• 2005

Body index is known as it affects pulmonary function tests (PFT), so it has been used with predictive formula and nomogram in terms of sex, age, height, etc. Body indices as body weight, body mass index (BMI), and body surface area (BSA) might also affect PFT, so that we have analyzed the correlations between body indices and forced expiratory volume in one second ($FEV_1$), and have done multiple regression analysis to see how body indices affect $FEV_1$. We confirmed that $FEV_1$ had positive correlations with height (r=0.49, p<0.01), body weight (r=0.37, p<0.01), and BSA (r=0.47, p<0.01), inverse correlation with age (r=-0.45, p<0.01), but no correlation with BMI. We found that the 41.9% of $FEV_1$ was diverged from height, age and BSA. Therefore, BSA definitely needs to be considered with predictive formula and nomogram in PFT.

• Clinical and Experimental Pediatrics
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• 제51권5호
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• pp.506-511
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• 2008

목 적 : 폐기능 검사는 폐질환의 평가에 매우 중요하여 반복해서 검사를 시행하여 질병의 경과와 치료에 대한 반응을 객관적으로 평가할 수 있다. 소아에서는 협조와 이해 정도에 따라 수치의 변동이 크므로 풍선을 이용한 연습과 검사에 대한 이해가 결과에 어떤 영향을 미치는지 분석하고자 한다. 방 법 : 2006년 6월부터 10월까지 천식으로 순천향대학교병원 소아과 알레르기호흡기센터를 방문하여 폐기능 검사를 실시한 106명을 대상으로 하였다. 첫 검사 시행 후 풍선불기 연습을 시킨 후 다시 검사한 군, 연습과 검사의 필요성에 대한 교육을 시킨 후 다시 검사한 군, 교육만 시킨 후 다시 검사한 군, 그대로 다시 검사를 시행한 군 등 4군으로 나누어 검사 수치를 비교하였다. 결 과 : 연습 전후의 검사 결과는 통계학적으로 유의한 차이는 없었다. 연습과 교육을 시행하여 전후의 검사 결과를 비교했을 시에도 유의한 차이는 없었다. 교육만 시행하였을 경우 $FEV_1$, $FEV_1/FVC$, $FEF_{25-75%}$, PEFR의 평균치가 전반적으로 상승하였으며 $FEV_1$, $FEF_{25-75%}$, PEFR은 통계학적으로 의미가 있는 상승을 보였다. 교육이나 연습을 시행하지 않고 2회 검사 시행시 유의한 차이는 없었다. 결 론 : 폐기능 검사 시행시 풍선 등을 이용하여 연습을 시키거나 여러차례 반복하여 검사를 시행하게 될 경우 오히려 검사 결과에 나쁜 영향을 줄 수 있고 검사의 필요성에 대해 잘 이해를 시킨 후 검사를 하는 것이 정확한 결과에 더 큰 영향을 미치는 것으로 보여지며 이를 바탕으로 향후 폐기능 검사 시행시 체계적으로 검사에 대한 설명을 하여 환아가 충분한 이해를 하도록 하는 것이 필요하다고 할 수 있겠다.

• 대한한방내과학회지
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• 제37권5호
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• pp.839-846
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• 2016

Objective: To examine the effects of Hyeongbangdojeok-san-gami (荊防導赤散加味方) which has been used in asthmatic patients in Korean Medicine. Methods: Five asthmatic patients were enrolled who had visited Semyung University Korean Medical Hospital from July 1, 2015 to June 30, 2016. They were examined by a pulmonary function test and completed the Quality of Life Questionnaire for adult Korean Asthmatics (QLQAKA) before and after taking Hyeongbangdojeok-san-gami for 3 weeks. All data were analyzed by paired t-tests. Results: After treatment with Hyeongbangdojeok-san-gami for 3 weeks, Forced Expiratory Volume 1 sec (FEV 1.0) improved significantly (p=0.01) and Peak Expiratory Flow (PEF) showed an increase of 20% in results examined by Pulmonary Function Test (PFT). The results of the QLQAKA indicated that the main improvements occurred in theitems associated with theactivity domain. Conclusions: This study suggests that Hyeongbangdojeok-san-gami is effective in improving pulmonary function and quality of life in patients with asthma. More extensive study is needed in the future.

• 대한한의학회지
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• 제22권4호
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• pp.131-141
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• 2001

Objectives : Asthma is a chronic inflammatory disorder in which the airway smooth muscle undergoes exaggerated constriction and is abnormally responsive to external stimuli and clinically manifests dyspnea, cough, and wheezing. Recently in Korea, the number of asthma patients has tended to increase as air pollution increases and new allergens appear. This study aimed to identify the therapeutic effects of Sochongryong-tang, which has been used on asthmatic patients in Oriental Medicine for a long time. Methods : We studied 10 asthmatic patients who had visited the Division of Respiratory System, Department of Internal Medicine of Kyunghee Oriental Medical Center from February 1, 2001 to June 30, 2001, which examined the patients by the pulmonary function test (PFT) and Quality of Life Questionnaire for adult Korean Asthmatics (QLQAKA) before and after taking Sochongryong-tang for two weeks. The data was analyzed using paired t-test. Results : After treatment with Sochongryong-tang for two weeks, FEV 1.0 showed a significant increase of 14.2%, FVC a significant increase of 9.3% and PEFR a significant increase of 16.2% in results of patients examined asthmatic by PFT. In the results of QLQAKA, the mean of scores increased significantly over 0.5 points in total score, symptom domain, emotion domain, and environmental domain. Conclusions : This study shows that Sochongryong-tang has the effect of improvements of pulmonary function and quality of life in asthmatic patients.

• Radiation Oncology Journal
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• 제31권1호
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• pp.34-40
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• 2013

Purpose: To evaluate the predictive factors of radiation pneumonitis (RP) and associated changes in pulmonary function after definitive concurrent chemoradiotherapy (CCRT) in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Medical records of 60 patients with NSCLC who received definitive CCRT were retrospectively reviewed. Dose volumetric (DV) parameters, clinical factors, and pulmonary function test (PFT) data were analyzed. RP was graded according to the CTCAE ver. 4.0. Percentage of lung volume that received a dose of threshold (Vdose) and mean lung dose (MLD) were analyzed for potential DV predictors. PFT changes were calculated as the difference between pre-RT and post-RT values at 3, 6, and 12 months after RT. Results: Twenty-two patients (37%) developed grade ${\geq}2$ RP. Among clinical factors, tumor location in lower lobe was associated with RP. Among the DV parameters, only MLD >15 Gy was associated with grade ${\geq}2$ RP. There were statistically significant decreases in PFT at all points compared with pre-RT values in grade ${\geq}2$ RP group. MLD was associated with forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) changes at 6 and 12 months. V10 was associated with FVC changes at 12 months. V20 and V30 were associated with FEV1 changes at 6 months and FVC changes at 12 months. Conclusion: After definitive CCRT in patients with NSCLC, MLD >15 Gy and lower lobe tumor location were predictors of grade ${\geq}2$ RP. Pulmonary functions were decreased after CCRT and the magnitude of changes was associated with DV parameters.