• Title/Summary/Keyword: Public R&D

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Exposure to Cerium Oxide Nanoparticles Is Associated With Activation of Mitogen-activated Protein Kinases Signaling and Apoptosis in Rat Lungs

  • Rice, Kevin M.;Nalabotu, Siva K.;Manne, Nandini D.P.K.;Kolli, Madhukar B.;Nandyala, Geeta;Arvapalli, Ravikumar;Ma, Jane Y.;Blough, Eric R.
    • Journal of Preventive Medicine and Public Health
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    • v.48 no.3
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    • pp.132-141
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    • 2015
  • Objectives: With recent advances in nanoparticle manufacturing and applications, potential exposure to nanoparticles in various settings is becoming increasing likely. No investigation has yet been performed to assess whether respiratory tract exposure to cerium oxide ($CeO_2$) nanoparticles is associated with alterations in protein signaling, inflammation, and apoptosis in rat lungs. Methods: Specific-pathogen-free male Sprague-Dawley rats were instilled with either vehicle (saline) or $CeO_2$ nanoparticles at a dosage of 7.0 mg/kg and euthanized 1, 3, 14, 28, 56, or 90 days after exposure. Lung tissues were collected and evaluated for the expression of proteins associated with inflammation and cellular apoptosis. Results: No change in lung weight was detected over the course of the study; however, cerium accumulation in the lungs, gross histological changes, an increased Bax to Bcl-2 ratio, elevated cleaved caspase-3 protein levels, increased phosphorylation of p38 MAPK, and diminished phosphorylation of ERK-1/2-MAPK were detected after $CeO_2$ instillation (p<0.05). Conclusions: Taken together, these data suggest that high-dose respiratory exposure to $CeO_2$ nanoparticles is associated with lung inflammation, the activation of signaling protein kinases, and cellular apoptosis, which may be indicative of a long-term localized inflammatory response.

Hierarchical Image Segmentation by Binary Split for Region-Based Image Coding (영역기반 영상부호화를 위한 이진 분열에 의한 계층적인 영상분할)

  • Park, Young-Sik;Song, Kun-Woen;Han, Kyu-Phil;Lee, Ho-Young;Nam, Jae-Yeal;Ha, Yeong-Ho
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.35S no.8
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    • pp.68-76
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    • 1998
  • In this paper, a new morphological image segmentation algorithm of hierarchical structure by binary split is proposed. It splits a region with the lowest quality into two regions using only two markers having the highest contrast. Therefore, it improves the quality of image with limited regions and reduces contour information which is not sensitive to human visual system, when compared with the conventional algorithm. It is appropriate to PSTN, LAN, and mobile networks, of which the available transmission bandwidth is very limited, because the number of regions can be controlled. And the proposed algorithm shows very simple structure because it doesn't need post processing to eliminate small regions and reduces much computation by using only structuring element of small size at simplification step of each hierarchical structure when compared with the conventional algorithm.

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Research on Utilizing Method of CCTV System for Crime Prevention and Safety Accident Reduction (범죄예방 및 안전사고 감소를 위한 CCTV시스템의 활용방안에 관한 연구)

  • Kim, Tae-Hwan
    • Journal of the Society of Disaster Information
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    • v.3 no.1
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    • pp.55-68
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    • 2007
  • Recently, people in cities of developed countries are exposed to unfortified damages of crime and disaster due to urbanization, industrialization and information-oriented era caused by congestion of population in terms of hardware and various social pathology phenomena and frequent and large scale of disaster caused by crime and disorder, which occur in the course of going through nuclear family, a gap between rich and poor and aging society in terms of software. In this regard, demand for security upon individual life and property has been increased but the police that are responsible for the public security does not effectively reduce damage in life and property because their activities are mainly oriented in coping with security accidents more than prevention. Shortage of manpower and budget, retarded equipment, and heavy overwork are the reasons. In order to confront with this kind of situation, we should utilize CCTV system with the purpose of declining possible chances of crime, not for eliminating cause of crime as crime prevention activities to predict danger in advance as a way of prevention and we may expect a role of damage prevention by installing CCTV in places where security accident may possibly happen. In conclusion, there are invasion of privacy, misuse of the system, insufficiency of overall monitoring office management, lack of citizens' understanding and economical allotment of the system installation costs in installation of CCTV system. However. it is necessary to install the CCTV system for effective prevention of crime and prevention activities of security accidents and accurate PR of purposes of installing CCTV to local residents, establishing relevant laws about system misuse, allotment of equipment costs and fees by R&D of the system machinery, cost reduction method of storage, management and replacement, saving costs from co-operative attitude of government, and local autonomous entities and local residents should be involved.

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A Study on the Removal of Fluorescent Whitening Agents from Recycled Fibers

  • Lee, Ji-Young;Lee, Hak-Lae;Youn, Hye-Jung;Lim, Hyung-Woo
    • Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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    • 2006.06a
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    • pp.117-121
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    • 2006
  • Virgin bleached kraft pulp, CPO (computer printout) and white ledgers are main raw materials used in tissue mills. The utilization rate of recycled fibers and virgin pulp in South Korea tissue industry are 90% and 10%, respectively. To improve brightness of printing grades the use of 'fluorescent whitening agents (FWAs)' or 'optical brightening agents (OBAs)' has been increased. When recycling these papers for tissue production, it is unavoidable that FWAs contained in recycled papers flow into tissue production lines and remain in the products. And this draws great attention from the public. This study was carried out to develop a technology for the removal of fluorescent whitening agents from recycled fibers. Enzymatic removal of FWAs was evaluated as a method to remove FWAs from the recycled fiber. The ${\alpha}-amylase$ that degrades starched used for surface sizing of fine papers and contained substantial condition is needed to prevent the re-adsorption of FWAs on fibers. The temperature of pulp suspension was another important factor affecting on FWA removal. The higher the temperature, the greater the efficiency of removing FWAs was obtained. Optimum pH and temperature for the effective removal of FWAs were suggested to be pH 8.5 and $65^{\circ}C$, respectively. The enzymatic removal of FWAs showed a great synergistic effect when proper control in pH and temperature was made.

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A Study on Nutrition Intake Related to Food Habit and Family Environmental Factor of High School Girls in Seoul (서울시내 일부 여고생의 食行動 및 家族環境과 관련된 營養攝取樣相 조사연구)

  • Kim, Hyong Ran
    • Journal of Environmental Health Sciences
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    • v.12 no.2
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    • pp.49-66
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    • 1986
  • The purpose of this study was to investigate nutrition intake of high school girls related to food habit, physical status, family environmental factor. The survey of 216 high school girls, aged 15 to 17 years old in Seoul area was conducted from April, 21 to 30, 1986. Food habit and family environmental factor were researched by means of questionnaires and nutrition intake was surveyed. by recording the kinds, amounts and ingredients of foods taken by the girls for two days, and height and weight were also measured during the period. The findings are summarized as follows: 1. Mean value of height and weight of the girls were 157.6cm and 50.9kg. 2. Number of family members per household was 5.2. Mean value of father's age was 47.1 and mean value of mother's age was 43.6. 44.9% of the girls had fathers who graduated the college, 41.6% of the girls had mothers who graduated the high school and 29.2% of the girls had mothers who had the job. 3. Breakfast missing rate was high, most of the reason for breakfast missing was 'have no time to eat' and time for breakfast was short. 64.4% of the girls had meal irregularly. 4. Mean daily intake of all nutrients except vitamin A and riboflavin was higher than Recommended Dietary Allowances. Mean caloric intake was 89.8% of R.D.A.. Breakfast intake of energy and most of nutrients was less than snack. Mean meal balance score was 47.9 and mean food diversity score was 13.4. 5. Mother's education level was related to intake of protein and calcium and height. Breakfast and lunch missing and number of snack intake were related with nutrition intake.

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Reverse-Engineering and Analysis of Performance for Medium-Altitude Long Endurance Unmanned Aerial Vehicle (중고도-장기체공 무인비행을 위한 비행체 성능 분석 및 역설계)

  • Shim, Ho-Joon;Chang, Kyoungsik;Chung, In Jae;Kim, Sun-Tae;Joh, Chang-Yeol
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.44 no.6
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    • pp.520-529
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    • 2016
  • The main purpose of this study was to analyze the performance of a medium-altitude long endurance unmanned aerial vehicle through reverse-engineering method. The external configuration data of the RQ-1 Predator was reverse-engineered from related photos and specification data available on public domains, which also were used to generate the CATIA modeling and weigh distribution data of the UAV. The aerodynamic characteristics of RQ-1 Predator were mainly predicted the vortex lattice method and an empirical method, which the propeller performance was analyzed by the empirical method proposed by Howe. The rate of climb, service ceiling, range, and the loiter endurance of the UAV was analyzed, which showed good agreement with the reference data.

A Study on the Quantitative Risk Assessment of Hydrogen-LPG Combined Refueling Station (수소-LPG 복합충전소 정량적 위험성평가에 관한 연구)

  • Kang, Seung Kyu
    • Journal of Energy Engineering
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    • v.28 no.4
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    • pp.29-34
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    • 2019
  • In this study, a quantitative risk assessment was carried out for a hydrogen complex station. The complex fueling station to be evaluated was hydrogen-LPG, and the components of each station were analyzed and the risk was evaluated. The final risk is assessed by individual and societal risks, taking into account the impact of damage and the frequency of accidents. As a result of individual risk calculation for the hydrogen-LPG fueling station that is the subject of this study, the hydrogen-LPG type fueling station does not show the unacceptable hazardous area (> 1 × 10E-3) proposed by HSE. The level of individual risk for both the public and the worker is within acceptable limits. In societal risk assessment, the model to be interpreted shows the distribution of risks in an acceptable range(ALARP, As Low As Reasonably Practicable). To ensure improved safety, we recommend regular inspections and checks for high-risk hydrogen reservoirs, dispensers, tube trailer leaks, and LPG vapor recovery lines.

The relationship between emotional intelligence in leadership and organizational performance of nurses in general hospitals (종합병원에 근무하는 간호인력의 감성리더십과 조직성과 간의 관계)

  • Lee, Bo-Hye;Choi, Man-Kyu;Moon, Sang-Sik;Jung, Min-Soo;Kim, Jin-Hee
    • Health Policy and Management
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    • v.21 no.2
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    • pp.309-328
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    • 2011
  • In order to effectively attain the objectives of an organization, it is important for the leader to provide an environment where members can co-exist and mutually advance, and also to have an emotional impact on them. This study examines the structural relationship among emotional intelligence in leadership, organizational commitment, job satisfaction, turnover intention, and organizational performance effects of emotional leadership in the nursing profession of a general hospital. A structured questionnaire was sent to 550 nurses in 11 general hospitals in Seoul Metropolitan City, among which 350 responses were used in the analysis. The independent variable, emotional intelligence in leadership, was measured by 18 items, including self-awareness, self-regulation, social awareness and relationship management. The dependent variable, organizational effectiveness, consisted of 46 items, including 15 items regarding organizational commitment, 20 items on job satisfaction, 3 items on turnover intention and 8 items on organizational performance. The structural equation modeling technique was used to identify the impact of emotional intelligence in leadership on organizational effectiveness. The results of the analysis show that the emotional intelligence in leadership of superior nurses has a significant impact on the nurses'organizational commitment and job satisfaction. While the direct effect on turnover intention and organizational performance was not significantly high, organizational commitment and job satisfaction were parameters in low turnover intention and high job performance. In conclusion, emotional intelligence in leadership is critical as nursing services in hospitals are based on interpersonal relationships. Therefore, by developing appropriate programs and training, hospitals can anticipate improved self-awareness, self-regulation, social awareness and relationship management of nurses, and further improve the effectiveness of the nursing profession.

A Study of Noh Moo Hyun Government's Reform of Governance for Science and Technology (우리나라 과학기술 거버넌스 연구 : 참여정부의 개혁을 중심으로)

  • Cho, Hyun-Suk
    • Journal of Science and Technology Studies
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    • v.8 no.1
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    • pp.29-54
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    • 2008
  • This is to review the reform of the governance for science and technology advanced by the Noh Moo Hyun government. The reform mainly included introducing the vice premiership for science and technology, strengthening the coordinative function of the National Science and Technology Committee over the public R&D budget and programs, and establishing the Office of Science and Technology Innovation under the vice premier for science and technology. The reform aims to improve not only the policy coordinative mechanism but policy discourse mechanism over the enhanced science and technology policy. This paper argues that Noh Moo Hyun Government's reform of the governance for science and technology was not successful. The reason is that the reform targeted mainly to improve the policy coordination among government departments concerning science and technology policy. But it was nearly neglected to make effective the policy discourse mechanism linking the state actors and societal actors.

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Priority Setting for Future Core Technologies in Postharvest Agriculture using the AHP (AHP를 이용한 유통분야 미래유망기술의 우선순위 설정)

  • 조영우;양용준;조근태;이종인
    • Food Science and Preservation
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    • v.11 no.2
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    • pp.276-281
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    • 2004
  • The study focused on setting priority among future core technologies that were derived by Delphi in agricultural management & information using AHP. Items for the setting priority were decided as 'technology', 'market', and 'public concerns' by council. The future core technologies were divided as four parts by importance and R&D level. Technologies that are consisted with upper two parts that have high importance were considered in the study. Questionnaires were given to 10 specialists in division of postharvest agriculture. As the results, 'market' was decided as a most important item. The most important technologies number were PⅠ16 in group Ⅰ, and PⅡ12 in group Ⅱ.