• 생물정신의학
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• 제12권2호
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• pp.207-215
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• 2005

Objectives:This study was to compare verbal memory ability among patients with schizophrenia, bipolar manic patients and unipolar depressive patients, and to understand their charicteristics of memory process. Methods:All subjects were hospitalized patients and had been interviewed by using the Structured Clinical Interview for DSM-IV(SCID). Schizophrenic patients(N=40), bipolar manic patients(N=17), and unipolar depressive patients(N=20) were assessed with K-AVLT for verbal memory and with K-WAIS for verbal IQ. Three groups were compared regarding total immediate recall, delayed recall, delayed recognition, learning curve, memory retention, and retrieval efficiency under controlled verbal IQ. Multiple regression analysis was performed to find which clinical factors have an influence on verbal memory ability. Results:In MANCOVA, differences of verbal memory test scores among the groups were statistically significant(F=1.800, p<.05). In post hoc analysis, Patients with schizophrenia and bipolar mania showed poorer performance in immediate recall, delayed recall, delayed recognition, retrieval efficiency than unipolar depres- sive patients. And schizophrenics performed poorly in delayed recall, delayed recognition, retrieval efficiency than nonpsychotic affective disorder group, but no difference in total immediate recall, delayed recall, delayed recognition, retrieval efficiency between the schizophrenic group and the psychotic affective group. Conclusions:These results partially confirm previous reports of verbal memory ability among major psychiatric disorders. Our results showed that psychotic symptoms were related with verbal memory, and longer duration of illness was related with poorer performance in schizophrenia and unipolar depression.

• 생물정신의학
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• 제21권1호
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• pp.28-35
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• 2014

Objectives This study aimed to identify the relationship between quality of life (QoL) and psychosocial factors of schizophrenia patients registered in a community mental health center. Methods The ninety patients with schizophrenia, diagnosed by Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition-Text Revision, registered in a community mental health center were studied cross-sectionally. Four trained personnels interviewed each subject individually for the assessment of QoL, psychopathology, severity of depressed mood, insight of illness, attitude toward drugs, social function, degree of social supports and conflicts. Results QoL was significantly related to the psychopathology, depressed mood, social conflict, social support; and other aspects of QoL were slightly differently related to depressed mood, social conflict, social support and attitude toward drug by scales. In multiple regression analysis, depressed mood (20.0%) and social conflict (10.3%) were contributed to QoL assessed by Korean version of 4th revision of Schizophrenia Quality of Life. Social support (21.4%), social conflict (20.9%) and depressed mood (3.1%) were contributed to QoL assessed by Korean modification of the Scale to measure Subjective Well-being under Neuroleptic treatment. Conclusions These findings demonstrated that QoL of schizophrenia patients in a community is affected by depressed mood, social support and conflict rather than psychotic symptoms, insight and attitude toward drugs. And this result suggests the necessity of approaching not only to the psychotic symptoms but also to the psychosocial characteristics in caring schizophrenia patients in the community.

• Clinical and Experimental Pediatrics
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• 제53권3호
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• pp.437-441
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• 2010

독성표피괴사용해(TEN)와 스티븐-존슨 증후군(SJS)은 약물이나 감염에 의해 발생하는 피부점막을 침범하는 드물지만 치명적인 질병이다. 스테로이드는 TEN의 치료에 많이 이용되어왔지만, 아직까지도 논쟁중이다. 스테로이드에 의한 정신과적 영향은 두통, 불면증, 우울증, 심리질환 등이 있다. 스테로이드에 의한 정신질환에서 치료는 스테로이드의 감량 또는 중단이고, 항정신성 약물을 투여한다. 신증후군으로 진단된 11세 남아에서 스테로이드 치료 후 관해상태에서 유지치료를 시행하고 있던 중에 TEN이 발생하였다. 저자들은 이 환아에서 치료목적으로 투여한 고용량 스테로이드 정맥주사로 인해 정신질환이 동반되었고, 이후 스테로이드 감량과 항정신성 약물과 면역글로불린으로 증상이 호전되는 것을 경험하여 이를 보고하는 바이다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권2호
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• pp.239-250
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• 2005

목적 : 소아 청소년 정신과 환자에서 비전형 항정신병약물인 risperidone에 대한 효과 및 안전성에 대한 자료를 얻고자 하였다. 방법 : 2001년 1월에서 2002년 6월까지 서울대병원 소아 청소년 정신과 병동에 입원한 환자 중 risperidone이 사용되었던 5.4세에서 17.3세 사이의 환자 31명(남 18, 여 : 13)을 대상으로 후향적인 진료기록지 검토를 시행하였다. 결과 : Risperidone이 사용된 주된 정신과 진단은 정신분열병 및 기타 정신증, 정신병적 증상이 동반된 I형 양극성 장애, 뚜렛장애, 자폐스펙트럼 질환, 혼합형 표현성 및 수용성 언어장애, 주의력결핍 과잉행동장애 및 품행장애, 강박장애 등이었으며 이 중 12명에서 정신지체가 동반되었다. Risperidone사용의 주된 목표 증상은 정신병적 증상(n=13, $41.9\%$), 공격성, 충동성, 과잉행동, 상동증 등과 같은 행동 증상(n=10, $32.3\%$), 만성적이고 심한 틱 증상 (n=8, $25.8\%$)이었다. Risperidone의 효과는 risperidone의 목표 증상에 대한 CGI(Clinical Global Improvement)로 평가되었는데 $67.7\%$에서 중등도 이상의 호전을 보였고 평균 7.5개월 동안 치료효과가 유지되었다. Risperidone의 평균 하루 사용량은 $0.05{\pm}0.1mg/kg$이었으며, 정신병적증상군이 0.07mg/kg로 다른 두 증상군(0.04mg/kg)에 비해 의미 있게 높았다. 부작용으로는 체중증가(n=23)가 가장 흔하였으며 그 외 추체외로계 증상(n=15), 자율신경계증상(n=6), 진정작용(n=5), 고프로락틴혈증(n=2) 등 다양한 부작용이 보고되었다. 그러나 부작용으로 인해 약물을 변경한 경우는 없었으며 외래 마지막 방문 시 $90\%$에서 risperidone을 유지하고 있어 약물내약성은 비교적 우수한 것으로 평가되었다. 결론 : 비전형 항정신병 약물인 risperidone은 정신병적 증상, 공격성, 충동성, 과잉행동, 상동행동을 포함하는 행동증상, 만성적이고 심각한 틱증상 등 다양한 소아 청소년 정신병리의 치료에 비교적 안전하고 효과적인 약물이 될 수 있을 것으로 평가된다. 향후 risepridone의 효과 및 안전성에 대한 보다 장기적이고 체계적인 연구가 필요할 것이다.

• 대한불안의학회지
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• 제12권1호
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• pp.7-12
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• 2016

Objective : This study was conducted to evaluate the relationships between selective attention bias for fear stimuli and hallucination in patients with schizophrenia Method : A total of 66 patients with schizophrenia admitted to psychiatry clinics were included in the study. Selective attention bias was measured by the dot-probe task. Patient symptoms were measured using the Positive and Negative Symptom Scale, Psychotic Symptom Rating Scale (PSYRATS), Korean version of the Scale to Assess Unawareness of Mental Disorder, and Clinical Global Impression-Severity scale. Results : Selective attention bias was correlated with the hallucination subscale of PSYTATS (r=0.268, p=0.029). No correlation was found between selective attention bias and other clinical measures. There was no significant difference, but a statistical trend was found (p=0.092) in hallucination severities between the biased and non-biased groups. Conclusion : The results suggest that selective attention bias for fear stimuli is associated with auditory hallucination. This preliminary study suggests the possibility of correlation between auditory hallucination in the psychotic domain and anxiety of the affective component.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제2권1호
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• pp.125-134
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• 1991

아동기 심리장애의 표현양상에서의 성별차이를 알아보기 위하여 정신과 진료기관에 내원한 환자 834명을 부모설문형식의 CBCL을 통하여 평가한 후, 그 자료를 남녀별로 각각 요인분석하여 행동장애 증후군을 구성하였다. 그 결과 공격, 과잉활동, 비행, 사회적 위축, 정서불안정, 그리고 신체증상의 여섯 개 요인은 남녀 공통으로 얻어졌으나, 강박, 우울 등의 내면성 증후군과 정신병의 임상적 특징을 나타내는 요인은 남녀간에 상당히 다른 양상을 보였다. 공통적으로 얻어진 여섯 요인들의 경우에도, 그 핵심이 되는 문제행동들은 남녀가 공유하고 있었으나, 그 밖에 측면에서는 남아와 여아 집단은 서로 다른 특징을 보였다. 이같은 문제행동 증후군에서 성별차이는 행동양식에 대한 성역할 고정관념과 관련되어 논의 되었다.

• 대한불안의학회지
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• 제10권1호
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• pp.3-10
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• 2014

Reactive disorder is a group of diagnosis with a definitely known etiology and whose etiological factor is essential to the diagnosis. In DSM system, such reactive disorders are listed as adjustment disorder, acute stress disorder, brief psychotic disorder with marked stressor and posttraumatic stress disorder (PTSD). However, a growing number of individuals is suffering from a prolonged feeling of embitterment after exceptional negative life events and this condition could be diagnosed neither PTSD nor adjustment disorder nor depressive disorder in the context of DSM-IV diagnostic system. This clinical condition can be described as 'posttraumatic embitterment disorder' (PTED). PTED is a reactive disorder triggered by exceptional, though normal negative life events such as conflict in the workplace, unemployment, death of a relative, divorce, severe illness, or experience of loss or separation. The common feature of such events is that they are experienced as unjust, as a personal insult, accompanied by psychological violation of basic beliefs and values. The central psychopathological response pattern in PTED is a prolonged feeling of embitterment. In particular, the core emotion of embitterment can lead to the rejection of treatment. Therefore, "wisdom therapy" as a new treatment approach specifically designed for PTED has been developed. It is assumed that many patients suffering from PTED are often misunderstood and misdiagnosed. This review would help to introduce PTED into the clinical field in psychiatry.

• 대한장애인치과학회지
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• 제2권2호
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• pp.156-160
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• 2006

각각의 환자에게 알맞은 장치를 제작하여 장착한 결과 모두 양호한 치유양상을 보였다. 자해를 관리하기 위해서는 고정성, 가철성 장치를 모두 사용할 수 있다. 장치의 선택은 환자의 상태에 따라 결정되어야 한다. 파괴적인 행위가 중단되어 구강 내 상처부위가 회복되어도 아주 높은 빈도로 재발이 일어나므로 이를 방지하기 위해 정기 내원 관리가 필요하다.

• 대한불안의학회지
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• 제11권1호
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• pp.12-18
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• 2015

Objective : The current study investigated the personality characteristics in the victims of sexual violence, by using the Minnesota Multiphasic Personality Inventory (MMPI) test which are commonly used in clinical medicine. Methods : A total of 40 victims of sexual violence (only female) completed the Korean version of the MMPI. 31 (77.5%), and theywere patients with posttraumatic stress disorder. These victims of sexual violence had been admitted to the Dankook University Hospital in Cheonan. Results : The MMPI scores of the sexual victims were significantly higher on Hs, D, Hy, Pd, Pa, Pt, Sc, and Si, than the comparison group by ANCOVA. Conclusion : The victims of sexual violence may have developed the following characteristics: hypochondriasis, depression, hysteria, psychopathic deviate, paranoia, psychasthenia, schizoid and social introversion. The finding suggests psychotic psychopathology rather than neurotic psychopathology. These results suggested that the psychopatholgy in the victims of sexual violence may be different, compared to the control group.

• 대한불안의학회지
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• 제8권2호
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• pp.79-85
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• 2012

Objective : The current study investigated the psychopathology characteristics of the suicide attempter visited in a university hospital for one year using the Minnesota Multiphasic Personality Inventory (MMPI) test commonly used in clinical medicine. Methods : 72 suicide attempter and 115 control group completed the Korean version of the MMPI. Results : The MMPI scores of the suicide attempters were significantly higher on the lie (L), infrequency (F), defensiveness (K), paranoia (Pa), psychasthenia (Pt), schizophrenia (Sc), hypomania (Ma) than the comparison group. Conclusion : We supposed that suicide attempter have more chance of being paranoid, psychasthenic, schizoid or hypomanic than the control group relatively. They seem to have psychotic psychopathology rather than neurotic psychopathology. These results suppoed that the psychopatholgy of suicide attempter may be different from the control group. However the final decision is indefinite, it needs more well designed systemic studies.