• 정신신체의학
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• 제1권1호
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• pp.35-44
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• 1993

This study was aimed at investigating the relationship of stress perception and psychopathology with biological variables such as systolic and diastolic blood pressure. serum total cholesterol high density lipoprotein and triglyceride in 50 adult patients with essential hypertension and 50 normotensive individuals. Both of the groups were matched to each other regarding age, sex, the level of education and BMI(body mass index). Stress perception and psychopathology between the two groups were compared using GARS and SCL-90-R scales. Biological variables such as blood pressure(systolic. diastolic), serum total cholesterol, high density lipoprotein and triglyceride were measured in all the subjects. The results were as follows ; 1) Hypertensive patients scored significantly higher than normotensive individuals in stress perception related to unusual happenings, change or no change in routine and overall global area, respectively. 2) Regarding psychopathology, hypertensive patients scored significantly higher than normotensive individuals in depression. hostility and interpersonal sensitivity. respectively. 3) Systolic blood pressure had a significantly positive correlation with scores of stress perception related to sickness and injury, and change or no change in routine, respectively. Diastolic blood pressure had a significantly positive correlation with scores of stress perception related to change or no change in routine. 4) In hypertensive patients. the level of serum total cholesterol had a significantly positive correlation with scores of stress perception related to unusual happenings. However, the level of serum triglyceride had a significantly negative correlation with scores of stress perception related to changes in relationships, sickness or injury, and change or no chang in routine. 5) There were no significant correlations between scores of stress perception and biological factors in the normotensive group. 6) The level of serum triglyceride correlated negatively with phobic anxiety in hypertensive group. whereas it correlated positively with PSDI in normotensive group. In conclusion, these results suggest that hypertensive patients have higher level of stress perception and psychopathology than normal individuals. In hypertensive patients, their stress perception is suggested to be correlated with serum cholesterol.

• 정신신체의학
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• 제5권1호
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• pp.12-30
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• 1997

The psychiatric interview is not a random or arbitrary meeting between doctor and patient. It is a systematic attempt to understand the relationship of psychopathology to emotional conflicts in patient, and interviewing is an in rather than a science, a skill that can be acquired but probably not taught. The faculty of the Seoul National University Hospital, Department of Psychiatry, have been providing 12 sessions of seminar on Psychiatric Interview and Psychopathology every year for the first year residents for the past 15 years. The authors presented three cases materials with their understandings of psychopathology and psychodynamics, each of which the authors had performed live interviews for 50 minutes in front of the residents. Those are a young male with conversion disorder whose chief complaints was motor aphasia, a young college girl with paranoid schizophrenia whose chief complaints were persecutory and erotic delusions with auditory hallucination, and a climacteric female in delusional disorder who had a delusion of infidelity. The most frequent questions the residents raised after the presentations were on the significances of the first interview, danger of making the diagnoses with short interviews, and methodology of questionings and not-questionings. In reply the authors discussed the importance of understandings of psychopathology and psychodynamics, the flexibility of the techniques of interviewing, and priority-related matters in which the understanding of psychodynamics proceed to the diagnoses.

• 정신신체의학
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• 제3권1호
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• pp.3-10
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• 1995

A comparison was made between the effect of subjective stress and that of objective stress on immune function in male medical college students. Interaction between perceived stress, psychopathology and natural killer-cell(NK) activity was assessed during an exam period, non-exam period, and vacation. No significant difference was found in NK activity among these three periods, but scores of perceived stress related to unusual happenings during an exam period and related to interpersonal relationship during vacation were found to have significantly positive correlation with NK activity, respectively. In psychopathology, only scores of anxiety during an exam period had significantly positive correlation with NK activity. These results suggest that immune function is more likely to be affected by subjective stress than objective stress and that subjective stress such as some perceived stress and subclinical level of anxiety may positively affect immune function.

• Safety and Health at Work
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• 제7권1호
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• pp.55-62
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• 2016

Background: This study aims to: (1) examine rates of obesity and physical health complaints among 911 telecommunicators; and (2) document the role of emotion dysregulation, psychological inflexibility, duty-related distress and dissociation, and psychopathology in predicting obesity and physical health complaints in this population. Methods: The sample consisted of 911 telecommunicators from across the country (N = 758). Participants completed an online survey assessing their mental and physical health functioning. Results: A total of 82.5% of the sample reported a body mass index that fell within the overweight or obese category and an average of 17 physical health complaints within the past month. Peritraumatic reactions (distress and dissociation), emotion dysregulation, and psychological inflexibility had effects on physical health largely through psychopathology (alcohol abuse, post-traumatic stress disorder, and depression). Conclusion: Development of adapted prevention and intervention efforts with this population is needed.

• 정신신체의학
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• 제7권2호
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• pp.203-212
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• 1999

연구목적 : Alexithymia(감정표현불능증)는 내면적 감정을 올바로 인식하거나 언어적으로 표현하기 어려운 상태를 뜻하는 용어이다. 최근에는 말로 표현하는데 장애가 있는 것만이 아니라 인지과정에서의 결함도 강조하고 있다. 그리고 감정은 신체증상과 전반적인 건강상태에 영향을 준다는 점에서 정신신체연구에 매우 중심적인 역할을 하고 있다. 이에 본 연구는 신체형 장애 환자와 정신신체장애의 하나로 알려져 있는 당뇨병 환자를 대상으로 alexithymia의 척도를 비교하고 이 환자들에서의 정신병리와 성격특성을 알아 보고자하였다. 방법 : 본 연구는 만 18세 이상의 신체형장애 환자 20명, 당뇨병 환자 20명 그리고 정상 대조군 20명을 대상으로 세 군의 alexithymia의 정도, 정신병리 및 성격특성을 알아보기 위하여 각각 Toronto Alexithymia Scale(TAS), 한국판 Symptoms Check List 9G-R(SCL-90-R) 및 Sixteen Personality Factor Questionnaire(16-PF)를 이용하여 세 군간의 차이를 분석하고 TAS와 SCL-90-R 및 TAS와 16-PF와의 상관관계를 분석하였다. 결과 : 1) TAS에 따른 세 군간의 비교에서는 신체형장애 환자군이 당뇨병 환자군과 정상 대조군보다 유의하게 높은 수치를 나타냈다. 2) SCV90-R에 의한 비교에서는 신체화증상과 불안증상 척도에서 신체형장애 환자군이 당뇨병 환자군과 정상 대조군보다 유의하게 높게 나타났다. 강박증상, 우울증상, 공포증상 및 정신증상 척도에서는 선체형장애 환자군이 정상 대조군보다 유의하게 높게 나타났다. 전체지표 중 전체심도지수는 신체형장애 환자군과 당뇨병 환자군이 정상 대조군보다 높았고, 표출증상심도지수는 신체형장애 환자군과 당뇨병 환자군이 정상 대조군보다 높았으며 표출증상합계에서는 신체형장애 환자군이 정상 대조군보다 유의하게 높은 결과를 보였다. 3) 16-PF에 의한 비교에서는 지능요인에서만 정상 대조군이 신체형장애 환자군보다 높게 나타났고 다른 요인에서는 차이가 없었다. 4) TAS와 SCL-90-R과의 상관관계분석에서는 신체형장애 환자군에서 표출증상심도지수를 제외한 모든 척도에서 정적 상관관계를 보였다. 그러나 다른 두 군에서는 유의한 상관관계를 보이지 않았다. 5) TAS와 16-PF와의 상관관계분석에서는 모든 대상군에서 유의한 상관관계를 보이지 않았다. 결론 : 신체형장애 환자군이 당뇨병 환자군이나 정상 대조군에 비하여 높은 alexithymia 척도와 많은 정신병리를 보였다. 그리고 신체형 환자군에서의 높은 alexithymia 척도는 정신병리와 유의한 정적 상관관계를 보이고 있었다. 당뇨병환자들은 정상 대조군과 유의한 차이를 보이지 않았다. 그러므로 신체형장애 환자들에게는 감정을 표현하고 그들의 정신병리를 완화하거나 해소할 수 있는 치료적 접근이 도움이 되겠고, 당뇨병환자들에게는 우선적으로 신체질환의 상태를 호전시킬 수 있는 치료가 더욱 필요로 하겠다.

• 생물정신의학
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• 제3권2호
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• pp.262-268
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• 1996

It has been known that clozapine is more selective mesolimbic dopamin $D_2$ receptor antagonist and related to 5-HT receptor. In this study, we wxamined the plasma homovanillic acid(HVA), serotonin(5-HT), and 5-hydroxyindoleacetic acid(5-HIM) levels in refractory schizophrenics during clozapine treatment. And we assessed the effects of clozapine on these plasma monoamine metabolites and their association with psychopathology and treatment response. Eight refractory schizophrenic patients(DSM-IV) have entered the study for 3 months during clozapine treatment. Patients were admitted to the inpatient sevice and withdrawn from all neuroleptics for 7-14 days but exceptionally occasional doses of lorazepam was given if needed for behavioral control. The dose of clozapine was titrated as tolerated to 800mg/day. The plasma HVA. 5-HIM and 5-HT levels were measured before treatment and following 2nd week, 4th week, 8th week, and 12th during treatment. Psychopathology was assessed with Brief Psychiatric Rating Scale (BPRS) and Positive and Negative Synrome Scale(PANSS) before and during clozapine treatment. During clozapine treatment, no statistically significant changes were found in plasma HVA, 5-HIM, 5-HT levels, and HVA/5-HIM ratio between baseline and following 2nd week, 4th week, 8th week, 12th week. However, the change in plasma 5-HIAA/5-HT ratio from baseline to 4th week was statistically significant. Generally, changes of plasma HVA, 5-HIAA, 5-HT levels and HVA/5-HIAA ratio were not associated with psychopathology but 5-HIAA was associated with in positive symptoms and general psychopathology of PANSS. These results suggest that clozapine has been found to have relatively weak dopaminergic blokade and stronger serotonergic antagonism.

• 생물정신의학
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• 제22권4호
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• pp.163-172
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• 2015

Objectives This study was aimed to examine the multidimensional relationship between auditory verbal hallucinations (AVHs) and Positive and Negative Syndrome Scale (PANSS) factors of psychopathology in the patients with schizophrenia. And we explored the differences between assessments to hallucination by the clinicians and patients. Methods 82 patients with schizophrenia who were assessed by the Hamilton Program for Schizophrenia Voices Questionnaire (HPSVQ), Psychotic Symptom Rating Scale-Auditory Hallucination (PSYRATS-AHS), and the PANSS were recruited. Hwang's five-factor model of PANSS, items and total scores of hallucination scales, Kim's and Haddock's factor models of hallucination were applied to examine the correlations between psychopathology and AVHs. AVH-positive patients was 50 in PANSS-HPSVQ group and 24 in PANSS-PSYRATS-AHS. These two groups were separately analyzed. Results Among the five factors of the PANSS, negative and depression/anxiety factors were correlated with the total scores of HPSVQ and PSYRATS-AHS, and positive and autistic preoccupation factors were correlated only with the total score of PSYRATS-AHS. The activation factor was correlated with none of the total scores of HPSVQ/PSYRATS-AHS. These correlation patterns of a total score of HPSVQ/PSYRATS-AHS were same in the emotional factor of HPSVQ and physical factor of PSYRATS-AHS respectively. In the items which showed significant correlations, correlation coefficients of PANSS-PSYRATS-AHS group ranged between 0.406-0.755 and those of PANSS-HPSVQ ranged between 0.283-0.420. Conclusions This study suggested that the psychopathological domains of schizophrenia were differentially correlated with AVHs and the assessment of AVHs by clinicians and patients showed substantial differences which should be integrated into the therapeutic interventions.

• 동의신경정신과학회지
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• 제29권1호
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• pp.21-34
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• 2018

Objectives: The purpose of this study is to understand the theories about the psychophysiology and psychopathology of Korean Medicine. Methods: The concepts and functions of spirit (神), soul (魂魄), five spirits (五神), and seven emotions (七情) occurring in the Huangdineijing have been interpreted, and the correlation between thought and emotion considered. Results and Conclusions: (1) Spirit (神) refers to the source and discipline of vital activity and mental activity. (2) With soul (魂魄), ethereal soul (魂) manifests itself as the mental process, and corporeal soul (魄) as the physical sensory interaction, such as the nervous system. (3) In the five spirits, ethereal soul (魂) is the recognition process of drawing out memories. Spirit (神) is the process of creative thought. Cognition (意) is the ability to recognize and integrate information. Corporeal soul (魄) is the process of selecting what is important and choosing it. Will (志) is the process of storing memories. Ethereal soul (魂) and corporeal soul (魄) of the five spirits (五神) and soul (魂魄) use the same characters, but the meaning differs. Also, spirit (神) and the spirit (神) in five spirits (五神) are the same character, but, because the meaning is different, they need to be interpreted according to the context. (4) Heart (心), Cognition (意), Will (志), Thought (思), Consideration (慮), and Wisdom(智) are all cognitive processes, like perception, recognition, and thinking. (5) Psychopathology is when excessive emotion affects the five viscera, harming the Energy (氣) and Blood (血) and eventually affecting the five spirits, which causes problems in thinking. Therefore, for healthy mental functioning, not only must the emotions be regulated so that they do not become excessive, but the five viscera also need to be kept healthy.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제25권4호
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• pp.217-223
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• 2014

Objectives : This study was conducted in order to investigate the influence of sexual trauma on the psychopathology and quality of life of children and adolescents in Korea. Methods : Twenty-seven children and adolescents and their caretakers who visited the Kangwon Sunflower Center participated in a cross-sectional study. Participants completed the Korean version of Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version, Child Behavior Checklist (CBCL), and Child Health Questionnaire-Parent Form-50 (CHQ-PF-50). Their scores were compared with those of a age and sex-matched control group of 27 healthy children and adolescents. Results : Victims of sexual violence showed higher t score in Withdrawn, Social problems, Delinquent behavior, Externalizing problems, and Total problems in CBCL, compared with control group. In CHQ-PF-50, there were lower scores on Bodily pain/discomfort, Behavior, Mental health, Time impact in parents, and Family activities subscales in victims of sexual violence. While Behavior and Family activities subscale showed negative correlations with Delinquent behavior, Externalizing problems, and Total problems in CBCL. Mental health subscale showed negative correlations with Social problems, Delinquent behavior, Externalizing problems, and Total problems. In addition, Time impact on parent subscale showed a negative association with Delinquent behavior in CBCL. Conclusion : The current study provided evidence suggesting that victims of sexual violence had a higher level of psychopathology and lower level of quality of life.

• 대한조현병학회지
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• 제23권1호
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• pp.8-14
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• 2020

Objectives: This study aimed to investigate suicidal behaviors and the related psychopathology across the different stages of schizophrenia. Methods: We recruited 131 patients with schizophrenia and categorized them into two groups, according to the duration of illness (DI) as follows: ≤10 years (n=39) and >10 years (n=92). Psychopathology and suicidality were assessed using the 18-item Brief Psychiatric Rating Scale (BPRS-18) and the suicidality module from the Mini-International Neuropsychiatric Interview, respectively. Results: One-quarter of the patients with a DI ≤10 years and nearly one-sixth of the patients with a DI >10 years experienced suicidal behaviors in the previous month. Suicidality scores were significantly associated with the "affect" factor scores of the BPRS-18 in patients with a DI ≤10 years (β=0.55, p=0.003) and with the "resistance" factor scores in patients with a DI of >10 years (β=0.29, p=0.006). Conclusion: The present study demonstrated that psychopathological factors were differentially associated with suicidality in patients with schizophrenia according to the illness stage. Our findings suggest that for effective suicide prevention, different approaches are required for the management of each stage of schizophrenia.