• Korean Journal of Pharmacognosy
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• v.42 no.3
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• pp.218-222
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• 2011

The purpose of this research is to study of inhibitory activity of protostane type triterpens against farnesyl-protein transferase (FPTase). The ingredients of Alismatis Rhizoma, alisol B 23-acetate, C 23-acetate, alisols B and A 24-acetate, and thirteen synthetic analogues from alisol B 23-acetate exhibited inhibition activity against FPTase by scintillation proximity assay method. As a result, alisol C 23-acetate, one of the constituents of Alismatis Rhizoma, the synthetic analogues carboxylated and hydroxylated on branch chain of protostane exhibited a significant inhibitory activity. However, the compounds significantly lowered the inhibitory activity, when there is no 3 position keto on protostane skeletone.

• Bulletin of the Korean Chemical Society
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• v.17 no.11
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• pp.1052-1056
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• 1996

The effects of β-CD, Me-β-CD, and biphenyl capped β-CD on 1H NMR spectra of mandelic acid 1, α-methylbenzylamine 2 and 2-phenylpropionic acid 3 were investigated. Enantiomeric recognition was observed for mandelic acid 1 by all the hosts used, for α-methylbenzylamine 2 by β-CD and Me-β-CD, and for 2-phenylpropionic acid 3 by Me-β-CD. In the presence of biphenyl-capped β-CD, ο-, m-, and p-protons of the phenyl groups of the guests are discriminated due to ring current of the capped biphenyl group. The splitting pattern of the phenyl protons indicates that the phenyl group of the guests is inserted into the β-CD cavity from the secondary hydroxyl side and positioned in close proximity to the capped biphenyl ring. The magnitude of the upfield shifts of H3 and H5 protons of β-CD upon binding of guests 1-3 is similar to that caused by ephedrine or pseudoephedrine, suggesting that the substitution at benzylic carbon atom has little effect on the depth of the insertion of the phenyl group into the β-CD cavity and stability of the inclusion complexes.

• Wind and Structures
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• v.4 no.6
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• pp.481-494
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• 2001

Wind tunnel pressure tests were conducted on a 1:100 scale model of a large industrial building with solar panels mounted parallel to the flat roof. The model form was chosen to have the same aspect ratio as the Texas Tech University test building. Pressures were simultaneously measured on the roof, and on the topside and underside of the solar panel, the latter two combining to produce a nett panel pressure. For the configurations tested, varying both the lateral spacing between the panels and the height of the panels above the roof surface had little influence on the measured pressures, except at the leading edge. The orientation of the panels with respect to the wind flow and the proximity of the panels to the leading edge had a greater effect on the measured pressure distributions. The pressure coefficients are compared against the results for the roof with no panels attached. The model results with no panels attached agreed well with full-scale results from the Texas Tech test building.

• International Journal of Air-Conditioning and Refrigeration
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• v.13 no.4
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• pp.206-216
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• 2005

Numerical analysis has been carried out to investigate laminar convective heat transfer at zero gravity in a tube for supercritical water near the thermodynamic critical point. Fluid flow and heat transfer are strongly coupled due to large variation of thermodynamic and transport properties such as density, specific heat, viscosity, and thermal conductivity near the critical point. Heat transfer characteristics in the developing region of the tube show transition behavior between liquid-like and gas-like phases with a peak in heat transfer coefficient distribution near the pseudo critical point. The peak of the heat transfer coefficient depends on pressure and wall heat flux rather than inlet temperature and Reynolds number. Results of the modeling provide convective heat transfer characteristics including velocity vectors, temperature, and the properties as well as the heat transfer coefficient. The effect of proximity on the critical point is considered and a heat transfer correlation is suggested for the peak of Nusselt number in the tube.

• Applied Microscopy
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• v.25 no.2
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• pp.11-19
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• 1995

This research was undertaken to determine the effect of cyclophosphamide(CP) on the Leydig cells and macrophages in the interstitial tissue of the mice(ICR strain). To evaluate how this drug could affect the these cells, during administration(200mg/kg) 1 time to 3 times at intervals of 48hrs. In the Leydig cells of the control and 1 time treated group, a number of microperoxisomes were observed interspersed among the network of smooth endoplasmic reticulum(SER) in cellular regions where the SER predominantes. Microperoxisomes were also founded in close proximity to the cell membrane. The interstitial tissue were exhibited degenerating Leydig cells but macrophages wer containd greatly increased numbers of cytoplasmic inclusion body and secondary lysosomes. In the 1 time treated group. A very small number of Leydig cells were observed, from 2 to 3 time group, but macrophages were more increased than 1 time group in number. CP thus offers a valuable opportunity to study further the interaction between Leydig cells and macrophages in the interstitial tissue. These alteration could be direct mediated by toxic effect of the drug on the interstitial tissue.

• Journal of Power Electronics
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• v.18 no.4
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• pp.1268-1277
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• 2018

A relatively high operating frequency is required for efficient wireless power transfer (WPT). However, the alternating current (AC) resistance of coils increases sharply with operating frequency, which possibly degrades overall efficiency. Hence, the evaluation of coil AC resistance is critical in selecting operating frequency to achieve good efficiency. For a Litz wire coil, AC resistance is attributed to the magnetic field, which leads to the skin effect, the proximity effect, and the corresponding conductive resistance and inductive resistance in the coil. A numerical calculation method based on the Biot-Savart law is proposed to calculate magnetic field strength over strands in Litz wire planar spiral coils to evaluate their AC resistance. An optimized frequency can be found to achieve the maximum efficiency of a WPT system based on the predicted resistance. Sample coils are manufactured to verify the resistance analysis method. A prototype WPT system is set up to conduct the experiments. The experiments show that the proposed method can accurately predict the AC resistance of Litz wire planar spiral coils and the optimized operating frequency for maximum efficiency.

• Ocean and Polar Research
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• v.25 no.1
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• pp.75-87
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• 2003

The water balance calculation in the IRL shows that fresh groundwater discharge is the primary factor, with surface runoff from gaged and ungaged areas as the second freshwater contributor. Precipitation and evaporation are almost in balance fer the entire IRL. Due to high freshwater discharge from ground-water, the annual net flow is outward from the IRL to the continental shelf of the Atlantic Ocean resulting in a relatively short flushing time, denoted as $T_{0.5}$ (50% flushing time) and $T_{0.99}$ (99% flushing time). $T_{0.5}$, and. $T_{0.99}$ without a tidal effect in the Northern IRL are 17 and 114 days, respectively, during the dry season. During the wet season, they are 10 and 65 days, respectively. Tidal flushing effects are considered in central IRL due to the proximity to Sebastian Inlet. In the Northern Central zone during dry season, $T_{0.5}$, and. $T_{0.99}$ are 6 and 43 days, respectively and during the wet season 5 and 33 days. In the Southern Central zone they are 2 and 16 days for the dry season,2 and 15 days for the wet season. High groundwater seepage into the IRL is considered to be a positive effect in maintaining relatively good water quality condition even with few narrow inlets.

• Journal of the Korea Institute of Military Science and Technology
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• v.4 no.2
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• pp.215-224
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• 2001

An experimental investigation was conducted on the interaction of vortices over a delta wing with the leading edge extension for three angles of attack($16^{\circ},\; 24^{\circ} \;and\; 28^{\circ}$) at Reynolds number of $1.76{\times}10^6.$ The experimental data included total pressure contours and velocity vectors using 5-hole probe measurements. Constant total pressure coefficient contours show the LEX vortex moves downward and outboard, while the wing vortex exhibited an inboard and upward migration. At near the trailing edge, these vortices reveal a direct interaction between the wing and LEX vortex, featuring a coiling of vortex cores about each other. The combined effect of the interaction of these two vortices and proximity to the wing surface results in the increase of the suction peak. This is in contrast to the result obtained on the delta wing alone configuration, where the effect of the vortex breakdown was manifested. The interaction of the wing and LEX vortices is more pronounced at higher AOA.

• Journal of the Society of Naval Architects of Korea
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• v.36 no.3
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• pp.60-70
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• 1999

The longitudinal stability characteristics of a Wing-In-Ground Effect Craft are quite different from that of the conventional airplane due to the existence of force and moment derivatives with regard to height. This stability characteristics plays a great role in designing a safe and efficient WIG due to its potential danger in sea surface proximity. The static and dynamic stability criteria are derived from the motion equations of WIG in the framework of small disturbance theory and discussed in the paper. The static and dynamic stability analyses of a 20-passenger WIG are conducted based on the wind tunnel test data and the dynamic motion behaviors are investigated for the change of the design parameters. Finally, the flying quality of the 20-passenger WIG is analysed at the cruising condition according to the military regulations.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5229-5232
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• 2014

Background: While many studies have concluded that local traffic density is positively associated with childhood leukemia, the results are inconsistent. We therefore performed a meta-analysis to assess the relationship between traffic density and the risk of childhood leukemia. Methods: A systematic literature review was carried out using PubMed, EMBASE, and the Cochrane Library from January 1979 to December 2013. We selected and assessed journal articles evaluating the relationship between local traffic density and the risk of leukemia in children. The analysis was carried out using STATA version 12.0. Results: A total of 11 articles, including 12 estimates of effect, were included in our meta-analysis. The summary effect size from the random-effects model, expressed as an odds ratio, was 1.03 (95% CI: 0.98-1.09, p=0.002). No significant association between traffic density and the risk of childhood leukemia was found. Similar conclusions were found on subgroup analysis. Conclusions: The results of our meta-analysis suggested no association between traffic density and the risk of childhood leukemia. This implies that living in close proximity to roads with heavy traffic may not increase the risk of childhood leukemia. However, further high-quality prospective trials are needed to support these results.