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FPTase Inhibition Effect of Protostanes from Alismatis Rhizoma and Derivatives from Alisol B 23-acetate  

Lee, Sang-Myung (Korea Ginseng Corporation Central Research Institute)
Kwon, Byoung-Mog (Korea Research Institute of Biosience & Biotechnology)
Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu)
Publication Information
Korean Journal of Pharmacognosy / v.42, no.3, 2011 , pp. 218-222 More about this Journal
Abstract
The purpose of this research is to study of inhibitory activity of protostane type triterpens against farnesyl-protein transferase (FPTase). The ingredients of Alismatis Rhizoma, alisol B 23-acetate, C 23-acetate, alisols B and A 24-acetate, and thirteen synthetic analogues from alisol B 23-acetate exhibited inhibition activity against FPTase by scintillation proximity assay method. As a result, alisol C 23-acetate, one of the constituents of Alismatis Rhizoma, the synthetic analogues carboxylated and hydroxylated on branch chain of protostane exhibited a significant inhibitory activity. However, the compounds significantly lowered the inhibitory activity, when there is no 3 position keto on protostane skeletone.
Keywords
Alismatis Rhizoma; Alisol; Farnesyl-protein transferase (FPTase);
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