• 한국어류학회지
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• 제24권4호
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• pp.253-262
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• 2012

섬진강과 만경강에 서식하는 쉬리의 전골격계를 기재하고 도해하였다. 본 종은 신장된 안전골, 8개의 뒷지느러미 근담기골 수, 제1기새골의 호리병박 같은 모양, 인두치의 2가지 형태, 삽입골에 측돌기가 없고 제4늑골의 폭이 넓은 형태를 가지는 등의 특징을 가지고 있었다. 한편, 사출골의 수와 내측돌기와 외측돌기의 길이는 개체마다 변이가 있었다. 이러한 특징은 두 집단 모두에서 나타났다. 그러나 미골의 상미골에 모양이 두가지 형태를 가지고 있었는데 오직 만경강 집단에서만 확인되었다.

• 대한두개안면성형외과학회지
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• 제13권2호
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• pp.143-146
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• 2012

Purpose: The typical reconstructive option for the nasal tip is paramedian forehead flap. However, the forehead flap is too bulky for nasal tip reconstruction and does not look natural, and therefore, secondary operations for debulking are required. Methods: We treated a 46-year-old woman who suffered from a nose tip soft tissue defect using a modified paramedian forehead flap. The flap was elevated from the hair line of the forehead and had 3-layered structure. The distal part included skin and subcutaneous tissue, the middle part included frontalis muscle, and the proximal part had periosteum. Results: The nasal tip was not bulky and looked natural in terms of height, shape, and had 3-dimensional structure without debulking procedure. The patient was satisfied with the outcome. Conclusion: The authors' modified paramedian forehead flap may be a useful option for the treatment of nasal tip, columella, and alar defects. With these modifications, the paramedian forehead flap can provide an aesthetically acceptable nasal tip appearance without debulking.

• Applied Microscopy
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• 제44권1호
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• pp.15-20
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• 2014

Cytokeratin 19 (CK19) expressed in epidermis of skin, bulge region of hair follicle, outermost layer of outer root sheath and proximal and distal to bulge. Vimentin is a fibrous protein that localized in cytoplasm of fibroblast and forms cytoskeleton to maintain shape of cell and nucleus. In this study, CK19 and vimentin in skin were confirmed with light, fluorescence and transmission electron microscope. As a result, CK19 was localized epidermis, hair follicles, outer root sheath and nucleus of Merkel's cell. However, vimentin was localized some epidermis, dermis, hypodermis and nucleus of Merkel's cell. The role of CK19 is self-renewal and homeostasis in skin. Also, hair follicle regeneration and hair growth is known to be related. It is supposed that required of structural proteins that make up cytoskeleton is increased. Thereby, expression of CK19 is increased. It is considered that vimentin localized in order to stabilize structure of cell and cytoskeleton of fibroblasts. Also, CK19 and vimentin present in nuclei of Merkel's cell, and to act as a fibrous protein that make up end of a nerve fiber present in Merkel's cell and paracrine function of Merkel's cell.

• 한국자기공명학회:학술대회논문집
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• 한국자기공명학회 2002년도 International Symposium on Magnetic Resonance
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• pp.90-90
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• 2002

Syndecans, transmembrane heparan sulfate proteoglycans, are coreceptors with integrin in cell adhesion process. It forms a ternary signaling complex with protein kinase C and phosphatidylinositol 4,5 bisphosphate (PIP2) for integrin signaling. NMR data indicates that cytoplasmic domain of syndecan-4 (4L) undergoes a conformational transition in the presence of PIP2, forming oligomeric conformation. The structure based on NMR data demonstrated that syndecan-4L itself forms a compact intertwined symmetric dimer with an unusual clamp shape for residues Leu$^{186}$ -Ala$^{195}$ . The molecular surface of the syndecan-4L dimer is highly positively charged. In addition, no inter-subunit NOEs in membrane proximal amino acid resides (Cl region) has been observed, demonstrating that the Cl region is mostly unstructured in syndecan-4L dimmer. However, the complex structure in the presence of PIP2 induced a high order multimeric conformation in solution. In addition, phosphorylation of cytoplasmic domain induces conformational change of syndecan-4, resulting inhibition of PKC signaling. The NMR structural data strongly suggest that PIP2 promotes oligomerization of syndecan-4 cytoplasmic domain for PKC activation and further induces structural reorganization of syndecan for mediating signaling network in cell adhesion procedure.

• 대한골관절종양학회지
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• 제14권2호
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• pp.140-145
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• 2008

사지 구제술이 보편화된 후 슬 관절 주위 골육종 환자의 재건 방법은 술자의 선호도에따라 차이가 있을 수 있으나 비교적 표준화 되어 있다. 현재 주로 시행되는 사지 구제술 방법으로는 크게 인공관절 치환술, 동종골 이식술이 있다. 인공관절 치환술의 경우 매우 안정적이며 술후 기능적으로도 양호한 방법으로 알려져 있으나, 궁극적으로 파손에 의한 제거술 시행이 필수적인 단점이 있다. 장기적인 관점에서 볼때 이식골을 이용한 재건술은 큰 장점을 갖고 있다. 하지만, 동종골의 사용은 요구되는 크기와 모양을 쉽게 구하기 어렵다는 단점이 있으며, 자가골 이식술은 수술 절제연이 안전하고, 그 적응증이 확립된 경우에만 사용해야 한다는 단점을 갖고 있다. 사지 구제술에 있어 분절 절제법은 골간의 병변에 있어 그 유용성이 확립되어 있으나, 골간단의 병변에 있어서는 시행 적응증이 널리 알려져 있지 않다. 저자들은 17세 환자의 근위 경골 내측과에 국한적으로 발생한 골육종의 증례에서 내측과 절제만으로도 안전한 절제연을 얻을 수 있을 것으로 사료되어 내측과 절제술 및 저온 열처리 자가골 이식술을 시행하였다. 본 술식은 추가적인 성장이 예상되는 소아환자에게 시행하였을 경우, 추후 파손 발생시에도 반측 치환술로 치환 가능한 방법으로 생각되어 보고하는 바이다.

• 대한소아치과학회지
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• 제33권4호
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• pp.686-692
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• 2006

본 연구는 1998년부터 2004년까지 조선대 소아치과에 내원한 환자 중 상악 중절치와 상악 견치의 편측성 매복으로 진단되어 closed-eruption technique을 이용한 외과적 노출 후 교정 적 견인을 시행하고 치료가 끝난 24명 (상악 중절치 10명, 상악 견치 14명)의 환자를 대상으로 하여 정상적으로 맹출한 인접 및 반대측 치아와 매복치의 치주적인 상태를 비교 분석하여 다음과 같은 결과를 얻었다. 1. 치주적인 평가에서 gingival index와 plaque index, pocket depth와 부착 치은의 비교시 견인을 시행한 상악 중절치, 견치 모두 대조군과 비교하여 유의할 만한 차이가 나타나지 않았다(P>0.05). 2. 상악 중절치의 골지지도 평가에서 근심부간과 윈심부간에 인접 중절치와 비교하여 유의할 만한 차이가 나타났다(P<0.05). 3. 상악 견치의 골지지도 평가시 견인치와 정상 맹출 치아간에 유의차를 보이지 않았다(P>0.05). 이상의 결과를 종합하여 볼 때 임상에서 closed-eruption technique을 이용한 외과적 노출 후 교정적인 견인을 이용한 매복치의 치료가 치은조직의 재생에 긍정적인 영향을 주고, 심미적으로 보다 안정적임을 알 수 있었으며, 상악 중절치 치료 시 견인의 방향과 힘 적용에 있어 정상 치조골의 양상을 유지하는지 관찰하여야 할 것으로 사료된다.

• 한국자원식물학회지
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• 제27권1호
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• pp.51-59
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• 2014

수박에서 과형, 과피, 과육 색이 서로 다른 중소과종인 3가지 계통의 재분화 조건을 확립하고자 각 계통의 유묘의 자엽절편을 배양하여 캘러스 및 신초 형성에 미치는 생장조절물질의 효과를 조사한 결과는 다음과 같다. 각 발아된 유묘 자엽의 캘러스 형성은 모든 계통에서 유묘의 자엽 부위 중 기부(proximal)의 끝부분에서 가장 높은 효율을 나타내었다. 또한 캘러스 형성에 미치는 생장조절제의 영향은 'B02'의 경우 1.0 mg/L BAP와 0.5 mg/L IAA를 혼합한 처리구에서, 'B05'의 경우 1.0 mg/L BAP 단독 처리구에서, 'D04'의 경우 3.0 mg/L BAP와 0.1 mg/L IAA를 혼합한 처리구에서 가장 높게 나타나 계통에 따라 생장조절제의 조건이 달라짐을 확인하였다. 신초 형성율은 'B02'와 'B05'의 경우 1.0 mg/L BAP와 0.5 ㎎/L IAA를 혼합한 처리구에서 'D04'의 경우 1.0 mg/L BAP 단독 처리구에서 가장 효과적인 것으로 확인되었다. 재분화된 식물체의 길이신장은 MS 기본 배지에 생장조절제로 1 mg/L BAP가 첨가된 배지에서 가장 효과적이었으며, 이들 식물체의 최적 발근은 'B02' 경우 0.5 mg/L IBA, 'B05' 경우 0.1 mg/L NAA, 'D04' 경우 0.5 mg/L IAA를 첨가된 배지 조건에서 이루어졌다.

• Archives of Reconstructive Microsurgery
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• 제21권1호
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• pp.14-20
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• 2012

Purpose: Defect after ablation of hypopharyngeal cancer often requires reconstruction by free tissue transfer. Since neo-hypopharynx is totally buried, various methods have been suggested for monitoring. We propose a modified design of anterolateral thigh (ALT) free flap for reconstruction of pharyngolaryngectomy defect, which has an exteriorized part for clinical monitoring and allows for primary closure. Materials and Methods: Three consecutive patients with hypopharyngeal cancer were reconstructed with ALT flap with modified design: 1) distal part of flap was elongated into fusiform shape and used as exteriorized monitoring segment with a deepithelized bridge and 2) proximal part was designed as curve so the maximum width of the flap was reduced to less than 10 cm. Results: Patient 1, 2 had uneventful postoperative course with healthy skin color and fresh pin prick bleeding. In patient 3, defect after cancer ablation was shorter than usual and deepithelized bridge was longer. When the general hemodynamic status of the patient was aggravated in postoperative course, the color of monitoring skin was changed. Viability of the whole flap was confirmed by endoscopy. However, leakage developed after 3 weeks and repair was necessary. In all patients the donor sites were closed primarily. Conclusion: By the modified design of ALT flap, clinical monitoring can be possible by examining exteriorized monitoring flap and also donor site can be closed primarily. However possibility of false positive exists and technical caution and patient selection is needed because of danger of leakage.

• Advances in pediatric surgery
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• 제2권2호
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• pp.143-147
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• 1996

Spontaneous perforation of the bile duct in children is a very rare disorder. We experienced a 6 year-old girl with spontaneous perforation of the right hepatic duct. The patient was initially misdiagnosed as hepatitis because of elevation of liver enzyme and then as appendicitis because of fluid collection in the pelvic cavity demonstrated by ultrasonogram. A laparoscopic exploration was done and no abnormal findings were detected except bile-stained ascites. Peritoneal drainage was performed and the patients seemed to improve clinically. Abdominal pain, distention and high fever developed after removal of the drains. DISIDA scan showed a possible of bile leak into the peritoneal cavity. ERCP demonstrated free spill of dye from the right hepatic duct. At laparotomy, the leak was seen in the anterior wall of the right hepatic duct 2cm above the junction of the cystic duct and common hepatic duct. The perforation was linear in shape and 0.8cm in size. The patient underwent cholecystectomy, primary closure of the perforation and T-tube choedochostomy. We could not identify the cause of the perforation; however, the T-tube cholangiography taken on the 42nd postoperative day showed a little more dilatation of the proximal common bile duct compared with the cholangiography taken on the 14th day. Long-term follow-up of the patient will be necessary because of the possibility for further change of the duct.

• 한국CDE학회논문집
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• 제17권3호
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• pp.149-155
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• 2012

The ankle over-pronation causes the mechanical overloading transferred to proximal areas (i.e. knees or hips) over time. Thus, the over-pronation is recognized as a contributory factor in a wide variety of musculo-skeletal pathologies in lower extremities. Commonly, over-pronated ankles are treated using specially designed insoles that support medial heels and correct the posture of lower limbs. However, the biomechanical effects of the insoles are not yet fully understood, so there still are controversies whether such insoles really have clinical significance. In this study, in order to verify the effects of insoles and determine the best shape of the insoles, we examined how the medio-lateral knee joint reaction force changes due to insole conditions through a case study about a subject. As a result, it is revealed that the medial heel post, which drastically reduced the peak medio-lateral knee joint reaction force, has significant effects on the gait of the over-pronated patients. However, in case that the arch support is combined together, the positive effect of the medial heel post may rather decrease.