• Research in Community and Public Health Nursing
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• v.8 no.2
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• pp.277-288
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• 1997

The purpose of this study is to identify the behavioral subsystems of the obese adult and contribute to the utility of Johnson's Behavioral System Model. The subjects were 167 obese adults in out-patients clinics of 2 hospitals and health clinics for 4 companies. These data were collected by a structured questionnaire with 52 items from July 1 to Sep. 30, 1995. The instrument used for this study was modified from the DBSM -self reporting instrument (1983) and Grubbs(1980)'s. The reliability of this method was cronbach's ${\alpha}$=.8476 and the construct validity of it was accepted by using a factor analysis. These data were analyzed by frequency, percentage, mean, standard deviation, factor analysis, pearson's correlation coefficient, Kruskal-Wallis with an SPSS PC+ Program. The results of this study were as follows: 1. The 9 behavioral subsystems of the obese were indentified : sex-related, attachment-affiliative I(social), dependency, ingestive, eliminative, restorative, aggressive-protective, attachment-affiliative and II (familial), an achievement behavioral subsystem. 2. Out of 9 subsystems, the highest significant positive correlation between dependency and acheivement subsystem was found(r=.5357, p<.01), The next, attachment-affiliative I and attachment-affiliative II subsystem was correlated significantly (r=.4526, p<.01). Significant positive correlations among sex-related, achivement, attachment-affiliative I, II, dependency, restorative, and aggressive-protective subsystems were found. But, ingestive and eliminative subsystems were not correlated with the above seven subsystems significantly, only the positive correlation between the ingestive and eliminative subsystems was found. 3. The explained variance of the 9 subsystems was explained as 56.1% out of a total of one. The sex-related subsystem was the first factor explaining 16.3% of the total variance and then the next 8 factors which resulted in 39.8%. According to the results of this study, the suggestions were as follows: 1. In the nursing practice, nursing assessmentand intervention of the obese should be in cluded not only in ingestive and eliminative subsystems but also in sex-related, attachment-affiliative I, dependency, restorative, aggressive-protective, attachment -affiliative II, and achievement behavioral subsystem. 2. Concerning instruments, some items to measure the eliminative, dependency, and aggressive-protective behavioral subsystems with relatively reliability are needed. 3. Johnson's concept of a dependency subsystem should be clarified. 4. Correlation among the 7 subsystems, and the ingestive and eliminative subsystems should be clarified.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.511-516
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• 2001

The flow characteristics in a hot mill reheating furnace is numerically simulated in this study. Navier-Stokes equations for conservation of mass, momentum, energy are solved and the standard $k-\varepsilon$ model, mixture fraction/PDF model are used for the turbulent reacting flow in the furnace. Radiation heat transfer is incorporated by the P-1 method with the absorption coefficient evaluated using WSGGM. First, simulation results are obtained for the total furnace region with existing protective dam, and then the calculations are carried out only for the preheating zone in the furnace. In that zone, additional center darn is built in order to control the flow behavior of the inlet air and the combustion gas.

• Journal of Oriental Neuropsychiatry
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• v.14 no.2
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• pp.61-78
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• 2003

Objective : This study was designed to assess the protective effects of Chengwhabosimtang on the animal model of depression, chronic mild stress(CMS). Method : Male Sprague-Dawley rats were used for this experiment. The subjects were divided into 3 groups ( 1. CMS-drug: Chengwhabosimtang administered during CMS treatment, 2. CMS-vehicle: water administered, 3. normal ). After 4 weeks of CMS treatment, they were executed Forced swimming test(FST) and Elevated plus maze. Tyrosine hydroxylase(TH) in ventral tegmental area(VTA) and c-Fos in paraventricular nucleus(PVN) were measured. Result : 1. In FST, CMS-drug group showed significantly decreased immobility behavior. 2. CMS-drug group showed no significantly lower TH level in VTA than CMS-vehicle group. 3. CMS-drug group showed significantly less c-Fos expressed cell bodies in PVN than CMS-vehicle group. 4. In Elevated plus maze, CMS-drug group showed no significantly anxiety. Conclusion : These results suggest that Chengwhabosimtang may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated stress-copying behaviors which are related with PVN of hypothalamus and dopaminergic neurons in VTA.

• Korean Journal of Medicinal Crop Science
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• v.28 no.2
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• pp.85-94
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• 2020

Background: Alzheimer's disease (AD) is caused by various factors, such as cholinergic dysfunction, regulation of neurotrophic factor expression, and accumulation of amyloid-beta. We investigated whether or not a combination of Carthamus tinctorius L. seed and Taraxacum coreanum (CT) has a protective effect on scopolamine-induced memory impairment in a mouse model. Methods and Results: Mice were orally pretreated with CT (50, 100 and 200 mg/kg/day) for 14 days, and scopolamine (1 mg/kg/day) was injected intraperitoneally before subjecting them to behavior tests. CT-administered mice showed better novel object recognition and working memory ability than scopolamine-treated control mice. In T-maze and Morris water maze tests, CT (100 and 200 mg/kg/day) significantly increased space perceptive ability and occupancy to the target quadrant, respectively. In addition, 100 and 200 mg/kg/day of CT attenuated cholinergic dysfunction through inhibition of butyryl cholinesterase in brain tissue. Furthermore, CT-administered mice showed higher cyclic adenosine monophosphate-response element-binding protein (CREB) levels and lower amyloid precursor protein (APP) levels compared to scopolamine-treated control mice. Conclusions: CT improved scopolamine-induced memory impairment through inhibition of cholinergic dysfunction, up-regulation of CREB, and down-regulation of APP. Therefore, CT could be a useful therapeutic agent for AD with protective effects on cognitive impairment.

• Korean Journal of Social Welfare
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• v.63 no.1
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• pp.317-342
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• 2011

This study aims to find out the determinants of male police officers' investigative behavior(active investigation vs. secondary victimization) of sexual violence. For this purpose, a hypothetical model which explains the relationships among the 5 variables (knowledge of law about the investigative role, perception of the protective & connective role, prejudice against the sexual violence, active investigation, and secondary victimization) was developed. Using the data collected from 354 male police officers of 3 cities in Gyeongnam area, the hypothetical model was tested. For data analysis, a structural equation modeling was used, and the final model was found(CFI=0.947, IFI=0.948, RMSEA=0.048). As a result of analyzing the model, the followings were found: (1) Active investigation was increased by knowledge of law about the investigative role, and perception of the protective & connective role, while decreased by prejudice against the sexual violence. (2) Secondary victimization was decreased by knowledge of law about the investigative role. (3) Prejudice against the sexual violence mediate the effects of knowledge of law about the investigative role, and perception of the protective & connective role on active investigation. (4) Prejudice against the sexual violence was found to have no significant effect on secondary victimization. Based on the findings, multi-educational programs, protocols on investigation of sexual violence, professionalization of the police, and changes in investigation environment as well as a system of collaboration and cooperation between police officer and social worker were suggested as a way to increase active investigation and to decrease secondary victimization.

• Journal of Oriental Neuropsychiatry
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• v.14 no.1
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• pp.1-16
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• 2003

Objective : This study was designed to assess the protective effects of Hwangryeonhaedoktang on the animal model of depression, induced by chronic mild stress(CMS). Method : Male Sprague-Dawley rats were used for this experiment. The subjects were divided into 3 groups ( 1. CMS-drug: Hwangryeonhaedoktang administered during CMS treatment, 2. CMS-vehicle: water administered, 3. normal ). After 4 weeks of CMS treatment, they were executed forced swimming test(FST), open field test and c-Fos in paraventricular nucleus(PVN) were measured. Result : 1. In FST, immobility behavior decreased significantly in CMS-drug group. 2. There was no difference in the open field test between 3 groups 3. c-Fos expressed cell bodies in PVN were significantly less in CMS-drug than in CMS-vehicle group. Conclusion : These results suggest that Hwangryeonhaedoktang may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated stress-copying behaviors which are related with PVN of hypothalamus.

• Journal of Ginseng Research
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• v.44 no.4
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• pp.603-610
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• 2020

Background: Depression is a common neuropsychiatric disease that shows astrocyte pathology. Ginsenoside Rf (G-Rf) is a saponin found in Panax ginseng which has been used to treat neuropsychiatric diseases. We aimed to investigate antidepressant properties of G-Rf when introduced into the L-alphaaminoadipic acid (L-AAA)-infused mice model which is representative of a major depressive disorder that features diminished astrocytes in the brain. Methods: L-AAA was infused into the prefrontal cortex (PFC) of mice to induce decrease of astrocytes. Mice were orally administered G-Rf (20 mg/kg) as well as vehicle only or imipramine (20 mg/kg) as controls. Depression-like behavior of mice was evaluated using forced swimming test (FST) and tail suspension test (TST). We observed recovery of astroglial impairment and increased proliferative cells in the PFC and its accompanied change in the hippocampus by Western blot and immunohistochemistry to assess the effect of G-Rf. Results: After injection of L-AAA into the PFC, mice showed increased immobility time in FST and TST and loss of astrocytes without significant neuronal change in the PFC. G-Rf-treated mice displayed significantly more decreased immobility time in FST and TST than did vehicle-treated mice, and their immobility time almost recovered to those of the sham mice and imipramine-treated mice. G-Rf upregulated glial fibrillary acidic protein (GFAP) expression and Ki-67 expression in the PFC reduced by L-AAA and also alleviated astroglial change in the hippocampus. Conclusion: G-Rf markedly reversed depression-like behavioral changes and exhibited protective effect against the astrocyte ablation in the PFC induced by L-AAA. These protective properties suggest that G-Rf might be a therapeutic agent for major depressive disorders.

• Steel and Composite Structures
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• v.43 no.2
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• pp.257-270
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• 2022

Recycled aggregate concrete (RAC) is rarely used in load-carrying structural members. To widen its structural application, the compressive behavior of a promising type of composite column, steel-fiber reinforced polymer (FRP) double-tube confined RAC column, has been experimentally and analytically investigated in this study. The objectives are the different performance of such columns from their counterparts using natural aggregate concrete (NAC) and the different mechanisms of the double-tube and single-tube confined concrete. The single-tube confined concrete refers to that in concrete-filled steel tubular (CFST) columns and concrete-filled FRP tubular (CFFT) columns. The test results showed that the use of recycled coarse aggregates (RCA) affected the axial load-strain response in terms of deformation capacity but such effect could be eliminated with the increasing confinement. The composite effect can be triggered by the double confinement of the steel and carbon FRP (CFRP) tubes but not by the steel and polyethylene terephthalate (PET) FRP tubes. The proposed analysis-oriented stress-strain model is capable to capture the load-deformation history of such steel-FRP double-tube confined concrete columns under axial compression.

• Journal of Preventive Medicine and Public Health
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• v.50 no.1
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• pp.10-17
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• 2017

Objectives: The purpose of this study was to examine the relationship of meeting the recommended levels of physical activity (PA) with health status and preventive health behavior in adults. Methods: A total of 5630 adults 18 years of age or older were included in this study. PA was assessed using a series of questions that categorized activities based on their metabolic equivalent values and then categorized individuals based on the reported frequency and duration of such activities. Participants reporting 150 minutes or more of moderate-intensity PA per week were considered to have met the PA guidelines. Multiple logistic regression was used to model the relationships between meeting PA guidelines and health status and preventive health behavior, while controlling for confounding variables. Results: Overall, 53.9% (95% confidence interval [CI], 51.9 to 55.9%) of adults reported meeting the recommended levels of PA. Among adults with good general health, 56.9% (95% CI, 54.7 to 59.1%) reported meeting the recommended levels of PA versus 43.1% (95% CI, 40.9 to 45.3%) who did not. Adults who met the PA guidelines were significantly more likely not to report high cholesterol, diabetes, chronic obstructive pulmonary disease, arthritis, asthma, depression, or overweight. Furthermore, adults meeting the PA guidelines were significantly more likely to report having health insurance, consuming fruits daily, consuming vegetables daily, and not being a current cigarette smoker. Conclusions: In this study, we found meeting the current guidelines for PA to have a protective relationship with both health status and health behavior in adults. Health promotion programs should focus on strategies that help individuals meet the current guidelines of at least 150 minutes per week of moderate-intensity PA.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.04a
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• pp.123-135
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• 2006

Alzheimer's disease (AD) is the most common form of dementia in the aging population and is clinically characterized by a progressive loss of cognitive abilities. Pathologically, it is defined by the appearance of senile plaques - extracellular insoluble, congophilic protein aggregates composed of amyloid $\beta$ (A$\beta$) and neurofibrillary tangles (NFTs) - inyracellular lesions consisting of paired helical filaments from hyperphosphorylated cytoskeletal tau protein as described by Alois Alzheimer a century ago. These hallmarks still serve as the major criteria for a definite diagnosis of the disease. Consequently, one of the key strategy for drug development in this disease area focuses on reducing the concentration of cerebral A$\beta$ plaque by using substances that inhibit A$\beta$ fibril formation. We focused on developing inhibitors by synthesizing several kinds of aromatic molecules. The synthetic compounds were initially screened to evaluate the effective compound by tioflavin T fluorescence assay. The selected effective compounds were tested cytotoxicity and protective effect from A$\beta$-induced neuronal toxicity by cell based MTT assay with HT22 hippocampal neurons. The BBB permeability on effectors was also tested in in vitro co-culture model(HUVEC/C6 cell line). The behavior test wea carried out in mutant APP/PS1 transgenic mouse model of Alzheimer's disease. And inhibition of A$\beta$ fibril formation by the effective compound was monitored with transmitted electron microscopic images.