• Journal of Sasang Constitutional Medicine
• /
• v.28 no.1
• /
• pp.57-66
• /
• 2016

Objectives The purpose of this study is to report on the collecting status of the prospective clinical data, that is designed to find clinical factors for determining the constitutional prescription.Methods We collected the prospective clinical data of 1208 subjects in the 10 oriental hospitals and 2 oriental clinic, from September 2012 to July 2015. Subjects were diagnosed and prescribed by the Sasang Constitution specialist. We counted the usage frequency of each constitutional herbal formula. Besides we check the main chief complaints on each constitutional herbal formula.Results & Conclusions In TE type, Yeoldahanso-tang, Cheongsimnyeonja-tang were used in high frequency. In SE type, Palmulgunja-tang, Gwakhyangjunggi-san were used in high frequency. In SY type, Hyeongbangjihwang-tang, Yanggyeoksanhwa-tang were used in high frequency. The both of high frequency-prescriptions in TE types were for the Interiorheat disease, expecially liver-heat lung-dry symptomatology. The main chief complaint of high frequency-prescriptions was fatigue in every constitution. We hope that the process of constitutional prescription would be standardized through the subsequent researches.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.26 no.6
• /
• pp.849-854
• /
• 2012

In this research, the status of prospective clinical researches related to Korean Oriental Medicine was identified from the papers published in domestic Korean medicine journals for the past 10 years, and the ethical validity of them were evaluated. Selection of researches and assessment on the ethical validity were made from the evaluation of two independent persons and the adjustment of the third party, and the collected data was analyzed using SPSS 17.0 software. The yearly status of prospective clinical researches related to Korean oriental medicine showed that the average number of them, which was six before 2005, was decreased to only one in 2006, and it started to recover gradually after 2007. The result of ethical validity test of prospective clinical researches related to oriental medicine showed that 5 researches (12.2%) in "unbiased selection of subjects and recruitment", 15 researches (36.6%) in "informed consent", 10 researches (24.4%) in "ethical considerations for vulnerable subjects", and 8 researches (19.5%) in "pre-deliberation and ethical oversight of the IRB" were appropriate to the ethical standards. The interest for clinical researches has been increased, and the ethical aspect of the clinical researches has been emphasized in oriental medicine. The results reported here are expected to provide a help to perform an ethical oriental medicine related clinical researches.

• Journal of Oriental Neuropsychiatry
• /
• v.21 no.4
• /
• pp.151-161
• /
• 2010

Objectives : This study aimed to evaluate any clinical studies regarding the herbal medicine for dementia focusing on Korean literature for future rigorous clinical research. Methods: Every article relevant to dementia was initially obtained from oriental medical related journals by electronic search at journal web sites or manual searches. Journals were limited to those registered with the Korea Research Foundation. From initial findings. two independent reviewers selected clinical articles and these articles were further analyzed separately by predefined criteria according to prospective and retrospective studies. For randomized controlled trial and non randomized controlled trial. quality assessment was also conducted. Results: From ninety seven patients initially obtained articles. twenty three patients were finally analyzed. One article was randomized controlled study. Four articles were prospective whereas eighteen patients were retrospective. In the qualitative evaluation of prospective articles. there was deduction regarding pre-calculated study size and prospective data collecting. Assessment measurement most frequently used was Mini Mental State Examination. The order of frequency of use herbs were identified. Conclusions : According to our study. the herbal medicine for dementia in general showed a positive effect in the cognitive aspects of dementia patients. Further well-designed randomized controlled studies should be conducted.

• Journal of Sasang Constitutional Medicine
• /
• v.29 no.3
• /
• pp.248-261
• /
• 2017

Objectives The purpose of this study is to analyze the decision making process of prescribing Yeoldahanso-tang and Taeeumjowi-tang Choweseuncheng-tang using decision tree. Methods We used collected the prospective clinical data of TE type from September 2012 to July 2015. In this study, we used gender, BMI, blood pressure, pulse and clinical symptoms (digestion, sweat, defecation, urination, sleep, physical status, emotion, heat-coldness, water consumption, facial color) as variables. Decision trees were analyzed using open source R version 3.3.2. Results & Conclusions We found that the decision trees differed among institutions. However, in all institutions, it was found that stool type (ordinary symptom), urine frequency (ordinary and present symptom) and anxiety (ordinary symptom) were important in the decision of prescription. Besides, clinical informations such as sex, Body Mass Index and blood pressure affected the prescription decision.

• Journal of Gastric Cancer
• /
• v.16 no.2
• /
• pp.93-97
• /
• 2016

Several prospective studies on laparoscopy-assisted distal gastrectomy for early gastric cancer have been initiated, but no prospective study evaluating laparoscopy-assisted total gastrectomy or laparoscopy-assisted proximal gastrectomy has been completed to date. A non-randomized confirmatory trial was commenced in April 2015 to evaluate the safety of laparoscopy-assisted total gastrectomy and laparoscopy-assisted proximal gastrectomy for clinical stage I gastric cancer. A total of 245 patients will be accrued from 42 Japanese institutions over 3 years. The primary endpoint is the proportion of patients with anastomotic leakage. The secondary endpoints are overall survival, relapse-free survival, proportion of patients with completed laparoscopy-assisted total gastrectomy or laparoscopy-assisted proximal gastrectomy, proportion of patients with conversion to open surgery, adverse events, and short-term clinical outcomes. The UMIN Clinical Trials Registry number is UMIN000017155.

• The Journal of Korean Academic Society of Nursing Education
• /
• v.24 no.1
• /
• pp.80-88
• /
• 2018

Purpose: This study was designed in order to explore the factors affecting the satisfaction of clinical practice among prospective graduates in nursing colleges and attempt to provide the base data for the quality improvement of clinical practice education. Methods: A total of 205 perspective graduates in nursing who have completed the clinical practice at four colleges of nursing located in Gyeonggi-Do and Chungcheongnam-Do participated in the study. Using structured questionnaires, the data was collected between October 10th, 2016 and November 9th, 2016. Results: The average scores for the image of nurses ($3.86{\pm}0.66$), satisfaction of major ($3.85{\pm}0.55$), self-efficacy ($3.44{\pm}0.51$), nursing professionalism ($3.70{\pm}0.47$), and satisfaction of clinical practice ($3.32{\pm}0.56$) were calculated. The satisfaction of clinical practice was in significant statistical correlation with the image of nurses (r=.59, p<.001), major satisfaction (r=.47, p<.001), self-efficacy (r=.21, p<.001), and professional identity (r=.46, p<.001). The significant predictors of the satisfaction of clinical practice included the image of nurses (${\beta}=.48$, p<.001) and nursing professionalism (${\beta}=.19$, p=.008). The regression model resulted in 36.0% satisfaction of clinical practice. Conclusion: Active development and implementation of programs for establishing positive images of nurses and nursing professionalism are needed in order to improve the satisfaction of clinical practice for nursing students.

• Clinical Endoscopy
• /
• v.57 no.1
• /
• pp.18-23
• /
• 2024

Computer-assisted polyp characterization (computer-aided diagnosis, CADx) facilitates optical diagnosis during colonoscopy. Several studies have demonstrated high sensitivity and specificity of CADx tools in identifying neoplastic changes in colorectal polyps. To implement CADx tools in colonoscopy, there is a need to confirm whether these tools satisfy the threshold levels that are required to introduce optical diagnosis strategies such as "diagnose-and-leave," "resect-and-discard" or "DISCARD-lite." In this article, we review the available data from prospective trials regarding the effect of multiple CADx tools and discuss whether they meet these thresholds.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.25 no.2
• /
• pp.147-162
• /
• 2022

Purpose: To design a prospective study on endovascular closure of congenital portosystemic shunts. The primary endpoint was to assess the safety of endovascular closure. The secondary endpoint was to evaluate the clinical, analytical and imaging outcomes of treatment. Methods: Fifteen patients (age range: 2 days to 21 years; 10 male) were referred to our center due to congenital portosystemic shunts. The following data were collected prior to treatment: age, sex, medical history, clinical and analytical data, urine trimethylaminuria, abdominal-US, and body-CT. The following data were collected at the time of intervention: anatomical and hemodynamic characteristics of the shunts, device used, and closure success. The following data were collected at various post-intervention time points: during hospital stay (to confirm shunt closure and detect complications) and at one year after (for clinical, analytical, and imaging purposes). Results: The treatment was successful in 12 participants, migration of the device was observed in two, while acute splanchnic thrombosis was observed in one. Off-label devices were used in attempting to close the side-to-side shunts, and success was achieved using Amplatzer™ Ductus-Occluder and Amplatzer™ Muscular-Vascular-Septal-Defect-Occluder. The main changes were: increased prothrombin activity (p=0.043); decreased AST, ALT, GGT, and bilirubin (p=0.007, p=0.056, p=0.036, p=0.013); thrombocytopenia resolution (p=0.131); expansion of portal veins (p=0.005); normalization of Doppler portal flow (100%); regression of liver nodules (p=0.001); ammonia normalization (p=0.003); and disappearance of trimethylaminuria (p=0.285). Conclusion: Endovascular closure is effective. Our results support the indication of endovascular closure for side-to-side shunts and for cases of congenital absence of portal vein.

• Nutrition Research and Practice
• /
• v.18 no.2
• /
• pp.165-179
• /
• 2024

BACKGROUND/OBJECTIVES: Mushroom consumption, rich in diverse nutrients and bioactive compounds, is suggested as a potential significant contributor to preventing cardiometabolic diseases (CMDs). This systematic review aimed to explore the association between mushrooms and cardiometabolic health outcomes, utilizing data from prospective cohort studies and clinical trials focusing on the general population, with mushrooms themselves as a major exposure. SUBJECTS/METHODS: All original articles, published in English until July 2023, were identified through searches on PubMed, Ovid-Embase, and google scholar. Of 1,328 studies, we finally selected 5 prospective cohort studies and 4 clinical trials. RESULTS: Existing research is limited, typically consisting of 1 to 2 studies for each CMD and cardiometabolic condition. Examination of articles revealed suggestive associations in some cardiometabolic conditions including blood glucose (both fasting and postprandial), high-density lipoprotein cholesterol related indices, high-sensitivity C-reactive protein, and obesity indices (body weight, body mass index, and waist circumference). However, mushroom consumption showed no association with the mortality and morbidity of cardiovascular diseases, stroke, and type 2 diabetes, although there was a potentially beneficial connection with all cause-mortality, hyperuricemia, and metabolic syndrome. CONCLUSION: Due to the scarcity of available studies, drawing definitive conclusions is premature. Further comprehensive investigations are needed to clarify the precise nature and extent of this relationship before making conclusive recommendations for the general population.

• Journal of TMJ Balancing Medicine
• /
• v.6 no.1
• /
• pp.24-26
• /
• 2016

To investigate the effects of the postural balance of TMJ using intraoral balancing appliance of functional cerebrospinal technique (FCST) combined acupuncture and manual medicine therapeutics in the treatment of congenital muscular torticollis. An idiopathic cervical dystonia case was managed with postural training with intraoral balancing appliance, combined with acupuncture and manual medicine therapeutics. Clinical assessment included radiography, Toronto Western Spasmodic Torticollis Rating Scale, and global clinical impression. Clinical improvement was observed over 5 months of treatment period. Clinical observational data on spasmodic torticollis provide an positive prospective for further investigation on the effect of FCST.