• Archives of Pharmacal Research
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• v.21 no.4
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• pp.465-469
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• 1998

The search for platinum (II)-based compounds with improved therapeutic properties was prompted to design and synthesize a new family of water-soluble, third generation cis-diaminedichloroplatinum (II) complexes linked to uracil and uridine. Six heretofore unreported uracil and uridine-platinum (II) complexes are; [N-(uracil-5-yl-methyl)ethane-1,2-di-amine]dichloroplatinum (II) (3a), [N-(uracil-6-yl-methyl)ethane-1,2-diaminel dichloroplatinum (II) (3b), t[N-($2^1$, $3^1$,$5^1$-tri-O-acetyl)uridine-5-yl-methyl] ethane-1,2-diamineldichloroplatinum (II) (6a), {[N-($2^1$,$3^1$, $5^1$-tri-O-acetyl) uridine-6-yl-methyl]ethane-1,2-diamine)dichloroplatinum (II) (6b),[N-(uridine- 5-yl-methyl)ethane-1,2-diamine]dichloroplatinum (II) (7a), [N-(uridine-6-yl- methyl)ethane-1,2-diamine]dichloroplatinum (II) (7b). These analogues were prepared from the key starting materials, 5-chloromethyluracil (1a) and 6-chloromethyluracil (1b) which were reacted with ethylenediamine to afford the respective 5-[(2-aminoethyl)aminol methyluracil (2a) and 6-[(2-aminoethyl)amino]methyluracil (2b). The cis-platin complexes 3a and 3b were obtained through the reaction of the respective 2a and 2b with potassium tetrachloroplatinate (II). The heterocyclic nucleic acid bases 1a and 1b were efficiently introduced on the .betha.-D-ribose ring via a Vorbruggen-type nucleoside coupling procedure with hexamethyldisilazane, trimethylchlorosilane and stannic chloride under anhydrous acetonitrile to yield the stereospecific .betha.-anomeric 5-chloromethyl- $2^1$,$3^1$,$5^1$-tri-O-acetyluridine (4a) and 6-chloromethyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (4b), respectively. The nucleosides 4a and 4b were coupled with ethylenediamine to provide the respective 5-[(amino-ethyl)aminolmethyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (5a) and 6-[(aminoethyl)amino] methyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (5b). The diamino-uridines 5a and 5b were reacted with potassium tetrachloroplatinate (II) to give the novel nucleoside complexes, 6a and 6b, respectively which were deacetylated into the free nucleosides, 7a and 7b by the treatment with CH$_{3}$ONa. The cytotoxic activities were evaluated against three cell lines (FM-3A, P-388 and J-82) and none of the synthesized compounds showed any significant activity.

• Korean Journal of Soil Science and Fertilizer
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• v.39 no.1
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• pp.29-37
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• 2006

In remediation of the contaminated soil, it requires to select at least more than two remediation technologies depending on the fate and transport phenomena through complicated reactions in soil matrix. Therefore, methodologies related to develop the integrated remediation technology were reviewed for agricultural soils contaminated with heavy metals. Pneumatic fracturing is necessary to implement deficiency because soil washing is not effective to remove heavy metals in the subsurface soil. But it needs to evaluate the characteristics such as essential data and factors of designated technology in order to effectively apply them in the site. In the remediation site, the important soil physical and chemical factors to be considered are hydrology, porosity, soil texture and structure, types and concentrations of the contaminants, and fate and its transport properties. However, the integrated technology can be restrictive by advective flux in the area which remediation is highly effective although both soil washing and pneumatic fracturing were applied simultaneously in the site. Therefore, we need to understand flow pathways of the target contaminants in the subsurface soils, that includes kinetic desorption and flux, predictive simulation modeling, and complicated reaction in heterogenous soil.

• The Journal of the Convergence on Culture Technology
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• v.7 no.1
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• pp.58-65
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• 2021

Jewelry Object to adorn a body with has been a very important culture since the primitive age when history of human beings started. Ornaments for social status or wealth's symbolic icon otherwise for private embellishment have been developed with various properties such as decorative, monetary, scarce, historic ones. However, since the latter 20th century, when intellecture concept was more valuable than the tradition laying emphasis on preciousness, with counting of artistic activities and aesthetic values, they have had expressionistic tendency centered on artists. In this manner, modern ornaments have been developed as an artistic genre deviating from traditional way in which material or technology was emphasized. While this expressionistic tendency emphasized artistic value, galleries only for ornaments have been started since 1960s and especially from this period, a lot of experimental and revolutionary ornaments works deviating from traditional way have been exhibited. The appearance of galleries specialized in ornaments as described above had a great influence on the ornaments' development to an artistic genre. This study is the one in respect of two exhibition types through the combination of human body and clothes in displaying ornaments. The first one represents active displaying way for the communication with audience by introducing fashion show to galleries deviating from general exhibition way. The second one plans to run a project collaborating fashion brand for the communication between ornaments and clothes and represents displaying way in the shop of fashion brand for active exhibition publicity.

• Journal of Conservation Science
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• v.37 no.2
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• pp.144-153
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• 2021

Gwanghwadang-Wonsam was designated as National Folklore Cultural Heritage No. 52 in 1979, it is in good condition. However, a problem is the attached a phoenix insignia badge that did not exist when it was designated recently. As it became known as the only purple Wonsam artifact with "phoenix insignia", raising the need for its conservation. In this regard, scientific analysis was required to correct misinformation about designated cultural assets and restore the original designated state by analyzing the history of the Gwanghwadang-Wonsam, other relics of the phoenix insignia and its making design patterns. An X-ray fluorescence analysis was used to confirm that the Phoenix insignia's metal threads were titanium-plated silver. Phoenix insignia using titanium-plated gold thread was not identified in Gwanghwadang-Wonsam photographs in 1986, and the TiN-type membrane plating method was used in various industries in the 1990s, which can be estimated to be attached in the early and mid-1990s. Especially, the scientific analysis results from the X-ray fluorescence analysis in this study provide key evidence for conservation processing. This study demonstrates the importance of investigating relics and similar artifacts in the conservation process of inherited relics and as a precedent for restoration that corrects misinformation about designated cultural properties.

• Journal of Korean Tunnelling and Underground Space Association
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• v.25 no.2
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• pp.65-85
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• 2023

The use of TBM (Tunnel boring machine) has increased worldwide due to its performance together with the benefit of being safely and environmentally friendly compared to conventional tunneling. In particular, EPB (Earth Pressure Balanced) TBM is widely used because it can be applied to various grounds compared to Open TBM. Also EPB TBM has a simple mechanical structure and advantages in cost, requires less ground area than Slurry TBM. EPB TBM has advantages in soft ground, and more importantly, can extend its applicability by use of appropriate soil conditioning, which improves mechanical and hydrological properties of excavated soil and increases the excavation performance of EPB TBM. Various studies suggested the proper mixing ratio and injection ratio, but almost they are limited to laboratory test under atmospheric pressure such as slump test. Actual field conditions may differ depending on the ground and mechanical condition. In this study, first the amount of used soil conditioning used in the field with various grounds from hard rock to soft ground was estimated through laboratory tests and compared with the estimate in design stage. And also it was compared with the amount used during actual excavation. In addition, experience of soil conditioning for the problems of cutter head clogging and groundwater inrush that occurred during excavation is discussed. Finally, lesson learned for the use of soil conditioning in difficult ground condition such as mixed ground are reviewed.

• Journal of KIISE:Computer Systems and Theory
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• v.35 no.5
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• pp.213-222
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• 2008

This paper is related to color image segmentation and textile texture mapping for the 2D virtual wearing system. The proposed system is characterized as virtually wearing a new textile pattern selected by user to the clothing shape section, based on its intensity difference map, segmented from a 2D clothes model image using color image segmentation technique. Regardless of color or intensity of model clothes, the proposed system is possible to virtually change the textile pattern or color with holding the illumination and shading properties of the selected clothing shape section, and also to quickly and easily simulate, compare, and select multiple textile pattern combinations for individual styles or entire outfits. The proposed system can provide higher practicality and easy-to-use interface, as it makes real-time processing possible in various digital environment, and creates comparatively natural and realistic virtual wearing styles, and also makes semi-automatic processing possible to reduce the manual works to a minimum. According to the proposed system, it can motivate the creative activity of the designers with simulation results on the effect of textile pattern design on the appearance of clothes without manufacturing physical clothes and, as it can help the purchasers for decision-making with them, promote B2B or B2C e-commerce.

• The KIPS Transactions:PartD
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• v.8D no.1
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• pp.71-80
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• 2001

Object-Oriented (OO) methodology to use the concept like encapsulation, inheritance, polymorphism, and message passing demands metrics that are different from structured methodology. There are many studies for OO software metrics such as program complexity or design metrics. But the metrics for the analysis class need to decrease the complexity in the analysis phase so that greatly reduce the effort and the cost of system development. In this paper, we propose new metrics to measure the complexity of analysis classes which draw out in the analysis phase based on Unified Process. By the collaboration complexity, is denoted by CC, we mean the maximum number of the collaborations can be achieved with each of the collaborator and detennine the potential complexity. And the interface complexity, is denoted by IC, shows the difficulty related to understand the interface of collaborators each other. We prove mathematically that the suggested metrics satisfy OO characteristics such as class size and inheritance. And we verify it theoretically for Weyuker' s nine properties. Moreover, we show the computation results for analysis classes of the system which automatically respond to questions of the it's user using the text mining technique. As we compared CC and IC to CBO and WMC, the complexity can be represented by CC and IC more than CBO and WMC. We expect to develop the cost-effective OO software by reviewing the complexity of analysis classes in the first stage of SDLC (Software Development Life Cycle).

• Journal of Navigation and Port Research
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• v.33 no.10
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• pp.691-697
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• 2009

Hardware dedicated off-the-shelf maritime differential GPS RSIM lacks the open architecture to meet all the minimum maritime user requirements and to include future GNSS improvements after recapitalization. This paper carries out a study to replace existing hardware dedicated differential GPS RSIM with software differential GPS RSIM in order to make up the weak point of hardware dedicated off-the-shelf maritime differential GPS RSIM. In this paper, the architecture of software RSIM is proposed for maritime DGPS recapitalization. And the feasibility analysis of the proposed software differential GPS RSIM is performed as the first phase to realize the proposed architecture. For the feasibility analysis, the prototype RF module and DSP module are implemented with properties as wide RF bandwidth, high sampling frequency, and high speed transmission interface. This paper shows that the proposed architecture has the possibility of real time operation of software RSIM functionality onto the PC-based platform through the analysis of computation time. Finally, this paper verifies that the L1/L2 dual frequency software differential RSIM designed according to the proposed method satisfies the performance specifications set out in RTCM paper 221-2006-SC104-STD.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.36 no.4
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• pp.329-336
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• 2000

Welding is a important technological method in mechanical engineering. $CO_2$MAG(metal active gas) welding means that metal part in double capstan drum for the inshore and costal vessels are joined by melting(with or without a filler material) or that new material is added to a metal part by melting. The thermal stresses appear due to a non-uniform temperature field, inhomogeneous material properties, external restraint and volume changes during phase transformations. In this study analysis the elasto-plastic thermal stresses distribution of welding part in double capstan drum for the inshore and costal vessels using finite element method (FBM). Therefore it calculates the numerical value that can be applied to the optimum design of welding parts and the shapes. The significant results obtained in this study are summarized as fellows. At early stage of the cooling after welding process, the abrupt thermal stresses gradient has been shown in the vicinity of welding part. In the thermal stresses analysis due to temperature gradient and heat shocking maximum stress was occurred of welding part and stresses were distributed from 54MPa~48MPa.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.581-584
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• 2008

Generally, durability of concrete structures under marine environment is grossly declined by detrimental ions such as chlorides, which penetrate concrete and was diffused to corrode reinforcing rod. Therefore, chloride diffusion properties in concrete are important for durability evaluation and design of concrete structure. For estimation of chloride diffusion coefficient in concrete, both evaluation methods are used for steady state and non-steady state derived from Fick's 1st and 2nd law, respectively. However, as it is very difficult to evaluate diffusion coefficient for non-steady state like service environment where concrete is actually exposed, indirect evaluation method by laboratory accelerated test is generally used. In this study, comparison of chloride diffusion behavior was investigated for fixed mix proportion and age of concrete using four accelerated test methods based on domestic and foreign standards. From test results, only relative comparison between concrete mixtures was possible using ASTM C 1202 test, and diffusion coefficient for steady state was estimated as low as 1/10 of that for non-steady state. In addition, diffusion coefficient estimated by immersion test was similar to result by NT build 492 test.