• Title/Summary/Keyword: Propensity

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Clinical Outcomes of Antiplatelets Combined with Statins in Patients with Ischemic Heart Disease (허혈성 심장질환 환자에서 스타틴과 병용하는 항혈소판제 종류에 따른 임상결과)

  • Kim, Chungsoo;Lee, Jimin;Park, Rae Woong;Lee, Sukhyang
    • Korean Journal of Clinical Pharmacy
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    • v.29 no.4
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    • pp.254-266
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    • 2019
  • Background: Patients with cardiovascular risks are recommended to use statins and antiplatelet agents to prevent major cerebro-cardiovascular events (MACCE). Antiplatelet agents also possess anti-inflammatory and antioxidant effects, in addition to their inhibitory activity on platelets. The differences in clinical outcomes in ischemic heart disease (IHD) based on the type of antiplatelet therapy combined with statin treatment were investigated in this study. Methods: We conducted a retrospective cohort study using electronic medical records of IHD patients from January 2010 to December 2014 at Ajou University Hospital. Patients on combination therapy of antiplatelet drugs and statins were grouped based on antiplatelet drug types: clopidogrel, cilostazol, or sarpogrelate. Propensity score matching was applied to balance the baseline of the groups of clopidogrel vs. cilostazol and the groups of clopidogrel vs. sarpogrelate. The incidence and risk of MACCE as primary outcomes were assessed between the groups of antiplatelet drugs. Results: Among the approximately 128,500 patients with IHD, 1,049 patients had taken a combination therapy of statin and antiplatelet agents. The cohorts of patients administered clopidogrel, cilostazol, or sarpogrelate were 906, 79, and 64, respectively. The incidence of MACCE was not significantly different among the cohorts (p=0.58), and there were no differences between clopidogrel vs. cilostazol (p=0.72) or clopidogrel vs. sarpogrelate (p=1.00) after propensity score matching. Conclusion: There was no difference in the incidence of MACCE based on the type of antiplatelet drug (clopidogrel, cilostazol, or sarpogrelate) in combination with a statin in patients with IHD.

Effects of the Continuity of Care on Hospital Utilization : Convergence A Propensity Score Matching Analysis (진료지속성이 의료이용에 미치는 영향 : 융복합 성향점수매칭 방법 적용)

  • Ahn, Lee-Su
    • Journal of Digital Convergence
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    • v.13 no.9
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    • pp.323-332
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    • 2015
  • This paper examines the level of the primary care continuity for patients with high blood pressure and the effects of the primary care continuity on their convergence health outcomes. We conducted a retrospective cohort study. A total of 315,791 patients who had received new diagnoses of hypertension. We determined standard indices of continuity of care-MFPC, MMCI, and COC and evaluated their association with study outcomes over three years of follow-up. Outcome measures included hospitalization and emergency room visits. The result of the primary care continuity levels and hazard ratios of health outcome showed that, comparing continuity group, non-continuity group had higher rates of hospitalization by 1.655(95% CI: 1.547-1.771) and emergency room visits by 1.669(95% CI: 1.465-1.903). This paper argues that medical costs of chronic diseases will reduce if low continuity of care turns into high continuity of care.

A Study on a Special Lifestyle and Population of Golf (골프의 대중화에 따른 라이프스타일 특성연구)

  • Lee Sun-Jae;Je Eun-Sook
    • Journal of the Korean Society of Costume
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    • v.55 no.1 s.91
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    • pp.73-85
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    • 2005
  • According to a rise in leisure time thanks to a five-day workweek system, the population of golf tends to rise day by day as exercise not extreme and doing together with nature, and as a sport with high concentration degree, by virtue of people who have an interest in health care and who strive to enjoy a leisure life. This study targeted the whole male and female golfers who reside in the areas of Seoul and Gyeonggi-do and are now playing golf, carried out sampling, and finally used 485 sheets for analyzing data. The study results were as follows; First, as a result of analyzing the whole lifestyle propensity depending on golfers' gender, it was shown that, as a result of making it type by factor, a male golfer was classified into shopping intention, fashion intention, family intention and tradition intention, and a female golfer was divided into shopping intention, fashion intention, family intention and man-and-woman equality intention. Second, as a result of analyzing a characteristic of gender depending on the standard of selecting goods, it showed the difference between genders as for the standard of selecting goods in case of purchasing golfwear, and it showed the difference in style/design, physique fitness, wearing of a famous golfer, convenience of laundry and management, and functionality, and male golfers were shown to select after seeing the clothes which a famous golfer did wear, compared to female golfers. Also, it could be seen that there was difference depending on the standard of selecting goods and the purchasing propensity in case of buying golfwear.

Users' Moving Patterns Analysis for Personalized Product Recommendation in Offline Shopping Malls (오프라인 쇼핑몰에서 개인화된 상품 추천을 위한 사용자의 이동패턴 분석)

  • Choi, Young-Hwan;Lee, Sang-Yong
    • Journal of the Korean Institute of Intelligent Systems
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    • v.16 no.2
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    • pp.185-190
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    • 2006
  • Most systems in ubiquitous computing analyze context information of users which have similar propensity with demographics methods and collaborative filtering to provide personalized recommendation services. The systems have mostly used static context information such as sex, age, job, and purchase history. However the systems have limitation to analyze users' propensity accurately and to provide personalized recommendation services in real-time, because they have difficulty in considering users situation as moving path. In this paper we use users' moving path of dynamic context to consider users situation. For the prediction accuracy we complete with a path completion algorithm to moving path which is inputted to RSOM. We train the moving path to be completed by RSOM, analyze users' moving pattern and predict a future moving path. Then we recommend the nearest product on the prediction path with users' high preference in real-time. As the experimental result, MAE is lower than 0.5 averagely and we confirmed our method can predict users moving path correctly.

Postoperative Radiotherapy Improves Survival in Gastric Signet-Ring Cell Carcinoma: a SEER Database Analysis

  • Wei, Feng;Lyu, Hongwei;Wang, Shuoer;Chu, Yan;Chen, Fengyuan
    • Journal of Gastric Cancer
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    • v.19 no.4
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    • pp.393-407
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    • 2019
  • Purpose: To identify the potential therapeutic role of postoperative radiotherapy (RT) in patients with locally advanced (stage II and stage III) gastric signet ring cell carcinoma (SRC). Materials and methods: Patients with locally advanced gastric SRC from the Surveillance, Epidemiology, and End Results program database between 2004 and 2012 were included in our study. Univariate and multivariate Cox proportional models were performed, and survival curves were generated to evaluate the prognostic effect of postoperative RT and surgery alone on SRC patients. Propensity score matching (PSM) was used to avoid selection bias among the study cohorts. Results: We found that patients with postoperative RT had better probability of survival compared with those who did not receive RT (overall survival [OS], P<0.001; cancer-specific survival [CSS], P<0.001). After PSM, analysis of both overall and CSS showed that patients who underwent postoperative RT had better prognosis than those receiving surgery alone in the matched cohort (OS, P=0.00079; CSS, P=0.0036). Multivariate Cox proportional model indicated that postoperative RT had better effect on prognosis compared with surgery alone with respect to both overall (hazard ratio [HR], 0.716; 95% confidence interval [95% CI], 0.590-0.87; P=0.001) and CSS (HR, 0.713; 95% CI, 0.570-0.890; P=0.003). Conclusions: Postoperative RT had better prognosis compared with surgery alone for both overall and CSS for patients with locally advanced gastric SRC.

Feasibility of No Prophylactic Antibiotics Use in Patients Undergoing Total Laparoscopic Distal Gastrectomy for Gastric Carcinoma: a Propensity Score-Matched Case-Control Study

  • Na, Yongmin;Kang, Ji Hoon;Jung, Mi Ran;Ryu, Seong Yeob;Jeong, Oh
    • Journal of Gastric Cancer
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    • v.19 no.4
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    • pp.451-459
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    • 2019
  • Purpose: Laparoscopic surgery is associated with lower surgical site infection (SSI) rates due to minimal skin incision and non-exposure of visceral organs. Most previous studies have analyzed the efficacy of prophylactic antibiotic use in open surgery. Here, we investigated the feasibility of total laparoscopic distal gastrectomy (TLDG) for gastric carcinoma without prophylactic antibiotic use. Materials and Methods: Seventy-one patients who underwent TLDG without prophylactic antibiotic use were 1:1 propensity score matched with 393 patients who underwent TLDG with antibiotic prophylaxis. The short-term surgical outcomes, including SSI rates, were compared between the groups. Results: After matching, 65 patients were selected in each group. The baseline clinicopathological characteristics were well balanced in the matched sample. In the matched group, there was no significant increase in postoperative morbidity in the non-prophylactic group compared with the prophylactic group (18.5% vs. 15.4%, P=0.640), and there were no grade 3≤ complications (1.4% vs. 0%, respectively; P=1.000). The SSI rates in the non-prophylactic and prophylactic groups were 3.1% and 1.5%, respectively (P=0.559). The time to gas passage, diet initiation, and mean hospital stay were not significantly different between the 2 groups. The SSI rate did not increase in the non-prophylactic group in the different subgroups based on different clinicopathological characteristics. Conclusions: Postoperative morbidity, including SSI rates, did not significantly increase in patients undergoing TLDG without prophylactic antibiotic use. A large prospective randomized trial is warranted to reappraise the efficacy of prophylactic antibiotic use in patients undergoing TLDG.

A study of Drivers' Behaviors using a Driving Simulator(with Special Reference of Driving Anger and Traffic Congestion (차량 시뮬레이터를 이용한 운전행동 연구(운전분노 및 교통정체를 중심으로))

  • Song, Hye-Su;Sin, Yong-Gyun;Gang, Su-Cheol
    • Journal of Korean Society of Transportation
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    • v.23 no.2
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    • pp.61-74
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    • 2005
  • This study is to investigate the effects of driving anger and traffic congestion on drivers' behaviors. Driving anger is the propensity to become angry while driving, and people differ in the tendency to get angry when encountering frustration and provocation on the road. Individual differences of the propensity contribute to anger on the road and aggressive driving leading traffic vaiolations and accidents. In the experiment three traffic conditions (an open road condition, a bumper-to-bumper traffic condition and a being stuck behind a slower driver condition) were simulated and driving behaviors were collected with RTSA-DS(Road Traffic Safety Authority-Driving Simulator). The results were as follows: Most of high anger drives drove at higher speeds in an open road condition, and in the bumper-to-bumper condition they drove faster and had an higher crash rate, which suggests they did aggressive driving, and risky and unsafe behaviors.

Clinical Outcomes of Perioperative Geriatric Intervention in the Elderly Undergoing Hip Fracture Surgery

  • Jang, Il-Young;Lee, Young Soo;Jung, Hee-Won;Chang, Jae-Suk;Kim, Jung Jae;Kim, Hye-Jin;Lee, Eunju
    • Annals of Geriatric Medicine and Research
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    • v.20 no.3
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    • pp.125-130
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    • 2016
  • Background: Conventionally, elderly hip fracture patients are assessed by orthopedists to decide whether they need geriatric intervention. We aimed to evaluate the effect of perioperative geriatric intervention on healthcare outcomes in patients undergoing surgery for hip fractures. Methods: Our care model for hip fracture surgery resembles a combination of a routine geriatric consultation model and a geriatric ward model. We retrospectively reviewed the medical records of patients aged ${\geq}65years$ undergoing surgery for hip fracture at a single tertiary hospital from January 2010 to December 2013. We assessed comorbidity, indwelling status, fracture type, and mode of anesthesia. We also evaluated in-hospital expenditure, duration of admission, disposition at discharge and 1-year mortality as clinical outcomes. We developed a propensity score model using the variables of age, cholesterol, and creatinine and examined the effect of perioperative geriatric intervention on intergroup differences of clinical variables. Results: Among 639 patients, 138 patients received the geriatric intervention and 501 patients received the usual care. Univariate analysis showed that factors such as age; Charlson comorbidity index; and serum levels of cholesterol, albumin, and creatinine differed significantly between these 2 groups. There was no significant difference between the groups in terms of 1-year mortality, disposition at discharge, and in-hospital expenditure in the propensity matched model. However, the duration of hospitalization was shorter in the intervention group ($8.9{\pm}0.8days$) than in the usual care group ($14.2{\pm}3.7days$, p=0.006). Conclusion: This care model of geriatric intervention for patients with hip fracture is associated with reduced hospitalization duration.

A Study on the Style Factors of Office Investment -An Analysis using Appraisal-based Returns- (오피스 투자의 스타일인자에 관한 연구 -평가기반 수익률을 기준으로-)

  • Min, Seonghun;Lee, Young Ho
    • Korea Real Estate Review
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    • v.24 no.1
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    • pp.53-62
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    • 2014
  • A test on the significance of style factors which were revealed to be significant in U.S. and U.K. literature is conducted in this study using appraisal-based returns of offices in Korea. Region, size (appraisal value), value-growth propensity (yield gain gap) and leasing conditions (the number of tenants, the length of average leased period and the proportion of key tenant) are included in the analysis model as style factors. The empirical result suggests that firstly core region and large size are significant but they increase risk as well as return contrary to general belief, secondly value propensity significantly decreases risk as well as return as it does in U.S. and U.K., finally the number of tenants among leasing conditions decreases risk as well as return but the length of average leased period and the proportion of key tenant are not significant.

Retrospective Medical Record Analysis on Frequent Disease of Collaboration: A Pilot Study (다빈도 협진 질환의 후향적 진료기록 분석 연구 : 예비연구)

  • Gong, Na-gyeong;Lee, Hyeon-joo;Lee, Chan;Hwang, Jin-seub;Lee, In
    • The Journal of Internal Korean Medicine
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    • v.42 no.4
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    • pp.563-571
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    • 2021
  • Objectives: This pilot study aimed to confirm the possibility of applying our design to the main study, a retrospective medical record analysis of the diseases which have most frequently been treated with collaborations of Korean and Western medicine, and to identify what corrections and statistical models are needed to conduct the main study. Methods: Data were collected from a case report form developed for patients who received treatment in the medical institutions. Appropriate statistical techniques, like Propensity Score (PS) and Generalized Estimation Equation (GEE) models, were used to compare the indicators of collaboration and non-collaboration groups for patients in comparable diseases. Results: Using PS matching for each M and S disease group, the indicators were compared by balancing the collaboration and non-collaboration group, and the GEE models compared indicators between groups in each disease over follow-up. Through this process we identified two limitations, insufficient samples and a large deviation of the follow-up period. Conclusion: This pilot study confirmed that the study design and case report form are applicable. The main study will be conducted by collecting sufficient samples and reflecting deviation of follow-up period.