• BMB Reports
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• v.56 no.12
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• pp.657-662
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• 2023

Neurodegenerative diseases are characterized by distinct protein aggregates, such as those of α-synuclein and tau. Lysosomal defect is a key contributor to the accumulation and propagation of aberrant protein aggregates in these diseases. The discoveries of common proteinopathies in multiple forms of lysosomal storage diseases (LSDs) and the identification of some LSD genes as susceptible genes for those proteinopathies suggest causative links between LSDs and the proteinopathies. The present study hypothesized that defects in lysosomal genes will differentially affect the propagation of α-synuclein and tau proteins, thereby determining the progression of a specific proteinopathy. We established an imaging-based high-contents screening (HCS) system in Caenorhabditis elegans (C. elegans) model, by which the propagation of α-synuclein or tau is measured by fluorescence intensity. Using this system, we performed RNA interference (RNAi) screening to induce a wide range of lysosomal malfunction through knock down of 79 LSD genes, and to obtain the candidate genes with significant change in protein propagation. While some LSD genes commonly affected both α-synuclein and tau propagation, our study identified the distinct sets of LSD genes that differentially regulate the propagation of either α-synuclein or tau. The specificity and efficacy of these LSD genes were retained in the disease-related phenotypes, such as pharyngeal pumping behavior and life span. This study suggests that distinct lysosomal genes differentially regulate the propagation of α-synuclein and tau, and offer a steppingstone to understanding disease specificity.

• Journal of Advanced Navigation Technology
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• v.3 no.1
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• pp.20-31
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• 1999

In this paper, we have chosen KimPo International Airport as an area for estimating the flutter interference, in order to analyze the flutter interference. The field test at 25 points around KimPo International Airport and the simulation have been performed for estimating the flutter interference. We consider the received power of a direct wave, the height of an antenna, the ERP of a transmitting point, transmit frequency, and the reflection coefficients of an airplane, the transmit/receive point coordinates as estimation functions for the flutter. From the results, we have found that the flutter interference from flights is very serious around the route of flight circumference, and often occurs when the height of an airplane is low, range from 40 to 240 m. Besides, the degree of the flutter interference can be changed according to the distance between an airplane and a transmitting point, elevation angle, and the reflection coefficients of an airplane.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.13 no.7
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• pp.693-701
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• 2002

In this paper, we analyze the coverage of asynchronous IMT(International Mobile Telecommunication)-2000 reverse link with a MUD(Multi-User Detector) system. The MUD system is utilized to increase the coverage of reverse link. Also we have considered a propagation loss model and an interference effect. Because it is very difficult that we have calculated the interference accurately, so a fractional cell loading factor(F) is used in this paper. We make use of a MUD efficiency($\beta$) to analyze the performance; this efficiency is presented the MAI of reduction. A simulation utilizes Hata's model, we calculated the coverage according to voice and data services. In this paper, we have assumed that the frequency of carrier has 800 MHz or 1.9 GHz, and a bandwidth is decided 3.84 MHz. We have predicted the performance of actual system by the analysis of capacity and coverage.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.3B
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• pp.297-304
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• 2011

MIMO wireless communication embedded systems, and for propagation prediction for indoor and outdoor propagation prediction program incorporates an indoor/outdoor propagation through the simulator can be predicted. This analysis technique developed by the interference between multiple transmitters and a maximum transmission distance issues, the frequency utilization efficiency for a variety of issues, including analysis and prediction becomes possible. Development of the prediction of the conventional methods, but I can consider the environmental characteristics of the ray tracing simulation software to develop and implement an efficient ray tracing, ray tracing techniques and are designed to enable tracked beam analysis of propagation characteristics using information technology by combining the theoretical characteristics of an efficient and well-reflected propagation prediction technique was employed. The frequency of domestic embedded systems, ensure the frequency characteristics and frequency of 3-5GHz band for propagation to investigate the development of local wireless communication technology-based skills needed for securing and jeonpaganseopdeung frequency management techniques to ensure the verification and verified through experiments.

• Journal of Advanced Navigation Technology
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• v.11 no.3
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• pp.266-273
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• 2007

In this paper presents the WCDMA(Wideband Code Division Multiple Access) system using the rake receiver over multipath fading and wireless mobile communication environments. The interference between the propagation paths in a multipath fading causes a serious degradation in the wireless mobile communication environments. In order to derive the path interference and reduce the fading effect the rake receiver is used. As a result, the WCDMA system using the rake receiver gives a better performance than the convention WCDMA system over a multipath fading and wireless mobile communication environments.

• Proceedings of the IEEK Conference
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• 2000.06a
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• pp.236-239
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• 2000

OFDM Transmission system can effectively reduce ISI(Inter Symbol Interference) caused by multipath fading, especially in the case of broad band data transmission. Nevertheless, the delayed waves existing in a symbol degrade the transmission Performance at the receiver. Therefore when OFDM transmission system applies to mobile radio communication system, we have to remove the influence without intricacy. This paper proposes and design a new scheme in order to estimate propagation characteristics using the characteristics of distinctive OFDM signal which is inserted pilot signal periodically in frequency axis before IFFT at the transmitter Moreover, we introduce a cancellation scheme of delayed signal on the basis of the proposed estimation technique. Using these schemes, it is possible to estimate and cancel the Interference of the delayed signal before FFT at the receiver.

• Proceedings of the IEEK Conference
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• 2004.06a
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• pp.55-58
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• 2004

This this paper, we propose vertical Bell laboratories layered space time (V-BLAST) system based on variable rate Low-Density Parity Check (LDPC) codes to improve performance of receiver when QR decomposition interference suppression combined with interference cancellation is used over independent Rayleigh fading channel. The different rate LDPC codes can be made by puncturing some rows of a given parity check matrix. This allows to implement a single encoder and decoder for different rate LDPC codes. The performance can be improved by assigning stronger LDPC codes in lower layer than upper layer because the poor SNR of first detected data streams makes error propagation. Keeping the same overall code rates, the V-BLAST system with different rate LDPC codes has the better performance (in terms of Bit Error Rate) than with constant rate LDPC code in fast fading channel.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.8A
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• pp.649-655
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• 2005

We propose a robust channel estimation method against imperfect synchronization in orthogonal frequency division multiple access (OFDMA) downlink systems. We address time and frequency synchronization, and the channel estimation at the same time, and try to minimize the error propagation from the time and frequency synchronization steps into the chailnel estimation. The simulation results show that the proposed channel estimation method outperforms the conventional algorithms by about 3dB, and circumvents the problem of mismatch among the synchronization tasks.

• International journal of advanced smart convergence
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• v.9 no.3
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• pp.141-144
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• 2020

Iterative decision feedback equalizer (IDFE) is a recursive equalization technique that can help to achieve an additional performance gain for the system by combining iterative channel decoding and interference cancellation. In a single carrier-based system, the intersymbol interference (ISI) is a critical problem that must be resolved since it causes frequency selective fading. Based on the idea of sharing the estimated information in the process of iteration, IDFE is considered as an efficient solution to improve the robustness of the system performance on the ISI channel. In this paper, the IDFE is applied on single carrier FDMA (SC-FDMA) system to evaluate the performance under ISI channel. The simulation results illustrate that IDFE helps to improve the performance of the SC-FDMA system, especially with long delay spread channels.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.4
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• pp.1954-1971
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• 2017

In this work, first, a multiuser detection (MUD) algorithm based on component-level soft interference cancellation and linear minimum mean square error (CLSIC-LMMSE) is proposed, which can enhance the bit error ratio (BER) performance of the traditional SIC-LMMSE-based MUD by mitigating error propagation. Second, for non-binary low density parity check (NB-LDPC) coded high-order modulation systems, when the proposed algorithm is integrated with partial mapping, the receiver with iterative detection and decoding (IDD) achieves not only better BER performance but also significantly computational complexity reduction over the traditional SIC-LMMSE-based IDD scheme. Extrinsic information transfer chart (EXIT) analysis and numerical simulations are both used to support the conclusions.