• International Journal of Contents
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• 제8권1호
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• pp.82-87
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• 2012

Organizational improvisation, the convergence of planning and execution, has emerged as an alternative approach to the limitations in strategic planning. Organizational improvisation has a significant impact not only on organizational performance, but also on market orientation, which has emerged as a key issue in the field of technology commercialization. This study investigates both the effect of organizational improvisation on market orientation, as well as the effect of environmental turbulence and time pressure on organizational improvisation. Results show that organizational improvisation has a positive influence on market orientation, with a stronger effect on the diffusion of market information. This is greatly impacted by environmental turbulence and time pressure. As a result, promoting competencies in organizational improvisation at the corporate level is suggested as a significant means to enhance market-oriented organizational innovation.

• Journal of information and communication convergence engineering
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• 제19권4호
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• pp.284-289
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• 2021

This study attempted to identify the service satisfaction with the 119 emergency service and the factors that affect it based on the responses of subjects who used the service. Data collection was conducted from February 11 to March 11, 2021, using convenience sampling. A total of 1842 subjects who used emergency medical services using 119 ambulance in 2020 participated. For the collected data, frequency, percentage, mean, and standard deviation were calculated, and t-test, analysis of variance, and multiple regression analysis were performed using SPSS 23.0. Based on these results, to further enhance the satisfaction of users of the 119 emergency service and the quality of emergency medical services, it is important to improve the quality of paramedics through education and systems. In addition, to increase user satisfaction, efficient and systematic communication education is required. The quality of emergency medical services will increase only when communication skills required for explanations and promoting understanding are improved.

• 전자통신동향분석
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• 제39권3호
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• pp.25-35
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• 2024

As artificial intelligence advances, major countries are actively promoting the use of intelligent robots to improve industrial productivity and enhance the quality of life. As robots become more capable of interacting with humans, they are being increasingly integrated into the human realm. Accordingly, major countries are actively implementing policies to lead intelligent robot technology and secure market leadership. We examine the status of policies related to intelligent robots in five countries: United States, China, Japan, Germany, and South Korea. These countries apply 1) government-led intelligent robot policies, 2) investments to secure core robot technologies and promote the convergence of artificial intelligence and robots, 3) programs for research and development on intelligent robots, 4) strengthened human-centered human-robot interaction and collaboration, and 5) ethics, stability, and reliability in the development and use of robot technologies. For Korea to compete with major countries and promote the intelligent robot industry, high-risk, high-performance innovation projects should be prioritized.

• Journal of Microbiology and Biotechnology
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• 제32권10호
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• pp.1245-1252
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• 2022

Induced pluripotent stem cells (iPSCs) can be generated from somatic cells using Oct4, Sox2, Klf4, and c-Myc (OSKM). Small molecules can enhance reprogramming. Licochalcone D (LCD), a flavonoid compound present mainly in the roots of Glycyrrhiza inflata, acts on known signaling pathways involved in transcriptional activity and signal transduction, including the PGC1-α and MAPK families. In this study, we demonstrated that LCD improved reprogramming efficiency. LCD-treated iPSCs (LCD-iPSCs) expressed pluripotency-related genes Oct4, Sox2, Nanog, and Prdm14. Moreover, LCD-iPSCs differentiated into all three germ layers in vitro and formed chimeras. The mesenchymal-to-epithelial transition (MET) is critical for somatic cell reprogramming. We found that the expression levels of mesenchymal genes (Snail2 and Twist) decreased and those of epithelial genes (DSP, Cldn3, Crb3, and Ocln) dramatically increased in OR-MEF (OG2^+/+/ROSA26^+/+) cells treated with LCD for 3 days, indicating that MET effectively occurred in LCD-treated OR-MEF cells. Thus, LCD enhanced the generation of iPSCs from somatic cells by promoting MET at the early stages of reprogramming.

• 융합보안논문지
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• 제23권4호
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• pp.81-92
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• 2023

현재 우리 군은 다가오는 인구절벽에 대비하기 위해 인공지능(AI) 기반의 과학기술강군 육성을 목표 국방혁신 4.0을 추진중에 있다. 특히 북한의 도발위협이 높아지는 현시점에 우리 군은 첨단기술을 활용한 과학화경계시스템 도입을 통해 병력절감을 도모하고 있다. 하지만 우리 군의 통합 전투능력을 보장하기 위한 핵심 기반통신체계인 전술정보통신체계(TICN)의 경우 전송 대역폭이 좁아 영상정보 송수신이 원활하지 않을뿐더러 보안 및 난청지역 발생 등의 이유로 평시 과학화경계시스템의 기반 네트워크로 활용하기에는 일부 제한적이다. 이러한 문제를 해결하기 위해 본 논문은 2017년부터 국내에서 무료로 활용할 수 있게 된 TVWS 기반의 무선네트워크 구축 기술을 활용해 TVWS 기반 과학화경계시스템 구축방안을 제안한다. 본 논문에서 제안하는 TVWS 기반 과학화경계시스템의 경우 기존의 유선네트워크 기반의 과학화경계시스템과 비교해 작전공백 최소화, 구축비용 절감, 설치 및 운용의 탄력성 측면에서 다양한 장점을 가진다.

• Journal of Microbiology and Biotechnology
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• 제34권2호
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• pp.233-239
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• 2024

N6-methyladenosine (m6A) RNA methylation has recently emerged as a significant co-transcriptional modification involved in regulating various RNA functions. It plays a vital function in numerous biological processes. Enzymes referred to as m6A methyltransferases, such as the methyltransferase-like (METTL) 3-METTL14-Wilms tumor 1 (WT1)-associated protein (WTAP) complex, are responsible for adding m6A modifications, while m6A demethylases, including fat mass and obesity-associated protein (FTO) and alkB homolog 5 (ALKBH5), can remove m6A methylation. The functions of m6A-methylated RNA are regulated through the recognition and interaction of m6A reader proteins. Recent research has shown that m6A methylation takes place at multiple sites within hepatitis B virus (HBV) RNAs, and the location of these modifications can differentially impact the HBV infection. The addition of m6A modifications to HBV RNA can influence its stability and translation, thereby affecting viral replication and pathogenesis. Furthermore, HBV infection can also alter the m6A modification pattern of host RNA, indicating the virus's ability to manipulate host cellular processes, including m6A modification. This manipulation aids in establishing chronic infection, promoting liver disease, and contributing to pathogenesis. A comprehensive understanding of the functional roles of m6A modification during HBV infection is crucial for developing innovative approaches to combat HBV-mediated liver disease. In this review, we explore the functions of m6A modification in HBV replication and its impact on the development of liver disease.

• 한국융합학회논문지
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• 제11권4호
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• pp.95-108
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• 2020

신종 코로나 바이러스(COVID-19)가 세계적으로 대유행하고 있다. 정부는 세계적인 전염병 확산에 대응할 수 있는 국가적 기술 역량 확보에 필요한 연구개발(R&D) 투자를 통해 향후 성장 동력을 확보하고 단기 경기 부양을 추진하고 있다. 따라서 코로나 바이러스에 대한 R&D 투자 및 연구현황을 종합적으로 파악하여 향후 R&D 기획의 방향성을 정립하기 위한 지식정보가 필요한 시점이다. 주요 해외 국가(미국, EU 등) R&D 과제를 기반으로 4개(세부 5개) R&D 영역을 도출하고, 국내 R&D 과제와의 비교분석을 통해 차별화된 2개 R&D 영역을 추가하였다. 제시된 6(세부 7개)개의 R&D 연구영역별 국내외 연구기관-연구과제명-과제규모-과제기간을 제시하였다. 동시에 학제 간 융합적 특징을 나타내는 R&D 과제를 제시하였다. 본 연구는 코로나 바이러스 관련 국내 경쟁 우위 영역과 차별화된 연구영역을 도출하여 현재 세계적으로 조명받고 있는 코로나 바이러스 검출 및 현장진단 역량의 우수성을 입증하고, 향후 집중 투자 영역을 제시하였다.

• 자원환경지질
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• 제53권1호
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• pp.111-120
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• 2020

괄목할만한 과학기술성과는 이종분야간 초융합 또는 융합의 융합에서 주로 나타나고 있으며, 기술경쟁국들은 고위험 고수익 연구생태계를 추진하고 있다. 구글은 실패를 두려워하지 않는 관점에서 수많은 새로운 도전을 수행하고 있고, 미국 고등연구계획국(DARPA)의 혁신적인 연구추진은 지금까지 인터넷, GPS, 반도체, 마우스, 자율주행차, 드론 등과 같은 획기적인 성과물을 만들었다. 중국은 달기지 개척, 세계 최대 규모의 핵융합 에너지와 초대형 입자가속기 프로젝트를 추진 중이며, 일본도 '문샷형 기술개발연구제도'를 착수하여 파괴적 혁신창출을 추진하려 한다. 우리나라도 글로벌 과학난제의 도전과 해결을 위해 신규 연구프로그램을 준비하고 있다. 따라서 지질자원기술 연구자가 중심이 되어 도전하고 해결하며 공감할 수 있는 과학난제의 주제 발굴과 이들 주제에 관한 사전연구 등이 필요하다. 이를 위해서는 신진연구자 중심의 장기 창의연구사업, 우수한 과제책임자 선정, 선행연구나 참고문헌도 없는 획기적 주제 도출, 과제제안절차 간소화, 아이디어 중점 선정시스템 혁신, 컨퍼런스 형태의 집단지성에 의한 결과평가 등이 필요하다고 사료된다.

• Journal of Microbiology and Biotechnology
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• 제33권9호
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• pp.1206-1212
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• 2023

The Wnt/β-catenin pathway plays essential roles in regulating various cellular behaviors, including proliferation, survival, and differentiation [1-3]. The intracellular β-catenin level, which is regulated by a proteasomal degradation pathway, is critical to Wnt/β-catenin pathway control [4]. Normally, casein kinase 1 (CK1) and glycogen synthase kinase-3β (GSK-3β), which form a complex with the scaffolding protein Axin and the tumor suppressor protein adenomatous polyposis coli (APC), phosphorylate β-catenin at Ser45, Thr41, Ser37, and Ser33 [5, 6]. Phosphorylated β-catenin is ubiquitinated by the β-transducin repeat-containing protein (β-TrCP), an F-box E3 ubiquitin ligase complex, and ubiquitinated β-catenin is degraded via a proteasome pathway [7, 8]. Colorectal cancer is a significant cause of cancer-related deaths worldwide. Abnormal up-regulation of the Wnt/β-catenin pathway is a major pathological event in intestinal epithelial cells during human colorectal cancer oncogenesis [9]. Genetic mutations in the APC gene are observed in familial adenomatous polyposis coli (FAP) and sporadic colorectal cancers [10]. In addition, mutations in the N-terminal phosphorylation motif of the β-catenin gene were found in patients with colorectal cancer [11]. These mutations cause β-catenin to accumulate in the nucleus, where it forms complexes with transcription factors of the T-cell factor/lymphocyte enhancer factor (TCF/LEF) family to stimulate the expression of β-catenin responsive genes, such as c-Myc and cyclin D1, which leads to colorectal tumorigenesis [12-14]. Therefore, downregulating β-catenin response transcription (CRT) is a potential strategy for preventing and treating colorectal cancer. Plant cytokinins are N⁶-substituted purine derivatives; they promote cell division in plants and regulate developmental pathways. Natural cytokinins are classified as isoprenoid (isopentenyladenine, zeatin, and dihydrozeatin), aromatic (benzyladenine, topolin, and methoxytopolin), or furfural (kinetin and kinetin riboside), depending on their structure [15, 16]. Kinetin riboside was identified in coconut water and is a naturally produced cytokinin that induces apoptosis and exhibits antiproliferative activity in several human cancer cell lines [17]. However, little attention has been paid to kinetin riboside's mode of action. In this study, we show that kinetin riboside exerts its cytotoxic activity against colon cancer cells by suppressing the Wnt/β-catenin pathway and promoting intracellular β-catenin degradation.

• 한국융합학회논문지
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• 제7권6호
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• pp.49-54
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• 2016

사물 인터넷은 여러 산업분야에 적용되어 새로운 서비스를 창출하는 기술 중 하나로 주목 받고 있다. 사물 인터넷은 기존의 네트워크 기술을 활용하여 사물들 간의 인터넷 연결을 제공하여 서비스를 창출 할 수 있다. 사물 인터넷을 이용하여 다양한 데이터의 수집되면서 사용자 맞춤형 서비스들이 만들어 질 수 있다. 농업 분야에서도 사물 인터넷을 이용하여 지속 가능한 농업 실현과 경쟁력 제고를 추진하고 있고 농업에서의 사물 인터넷 융합은 스마트 농업으로의 확대를 추진하고 있다. 국내에서도 사물 인터넷 기술을 이용한 농업 경쟁력 제고를 위해 농림축산식품부에서는 스마트 팜 확산 대책을 마련하여 추진하고 있다. 그러므로 본 논문에서는 사물 인터넷 기반의 농업 융 복합 사례 연구를 통해 향후 스마트 농업의 발전 모델을 제시한다.