Acknowledgement
This work was supported by research fund of Chungnam National University.
References
- Seeger C, Mason WS. 2015. Molecular biology of hepatitis B virus infection. Virology 479-480: 672-686.
- Hu J, Protzer U, Siddiqui A. 2019. Revisiting Hepatitis B Virus: challenges of curative therapies. J. Virol. 93: e01032-19.
- Yan H, Zhong GC, Xu GW, He WH, Jing ZY, Gao ZC, et al. 2012. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife 1: e00049.
- Iwamoto M, Saso W, Sugiyama R, Ishii K, Ohki M, Nagamori S, et al. 2019. Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization. Proc. Natl. Acad. Sci. USA 116: 8487-8492.
- Seeger C, Mason WS. 2000. Hepatitis B virus biology. Microbiol. Mol. Biol. Rev. 64: 51-68.
- Roundtree IA, Evans ME, Pan T, He C. 2017. Dynamic RNA modifications in gene expression regulation. Cell 169: 1187-1200.
- Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, et al. 2012. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485: 201-206.
- Yue Y, Liu J, He C. 2015. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev. 29: 1343-1355.
- Wang X, Feng J, Xue Y, Guan ZY, Zhang DL, Liu Z, et al. 2017. Structural basis of N6-adenosine methylation by the METTL3- METTL14 complex (vol 534, pg 575, 2016). Nature 542: 260-260.
- Fu Y, Jia GF, Pang XQ, Wang RN, Wang X, Li CJ, et al. 2013. FTO-mediated formation of N-6-hydroxymethyladenosine and N-6- formyladenosine in mammalian RNA. Nat. Commun. 4: 1798.
- Zheng GQ, Dahl JA, Niu YM, Fedorcsak P, Huang CM, Li CJ, et al. 2013. ALKBH5 is a mammalian RNA demethylase that Impacts RNA metabolism and mouse fertility. Mol. Cell 49: 18-29.
- Patil DP, Pickering BF, Jaffrey SR. 2018. Reading m(6)A in the transcriptome: m(6)A-binding proteins. Trends Cell Biol. 28: 113-127.
- Shi HL, Wang X, Lu ZK, Zhao BXS, Ma HH, Hsu PJ, et al. 2017. YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. Cell Res. 27: 315-328.
- Wang X, Zhao BS, Roundtree IA, Lu ZK, Han DL, Ma HH, et al. 2015. N-6-methyladenosine modulates messenger RNA translation efficiency. Cell 161: 1388-1399.
- Du H, Zhao Y, He JQ, Zhang Y, Xi HR, Liu MF, et al. 2016. YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex. Nat. Commun. 7: 12626.
- Xiao W, Adhikari S, Dahal U, Chen YS, Hao YJ, Sun BF, et al. 2016. Nuclear m(6)A reader YTHDC1 regulates mRNA splicing. Mol. Cell 61: 507-519.
- Kretschmer J, Rao H, Hackert P, Sloan KE, Hobartner C, Bohnsack MT. 2018. The m(6)A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1. RNA 24: 1339-1350.
- Mao YH, Dong LM, Liu XM, Guo JY, Ma HH, Shen B, et al. 2019. m(6)A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2. Nat. Commun. 10: 5332.
- Kim GW, Siddiqui A. 2021. The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses. Exp. Mol. Med. 53: 339-345.
- Imam H, Kim GW, Siddiqui A. 2020. Epitranscriptomic(N6-methyladenosine) modification of viral RNA and virus-host interactions. Front. Cell. Infect. Microbiol. 10: 584283.
- Gonzales-van Horn SR, Sarnow P. 2017. Making the Mark: The role of adenosine modifications in the life cycle of RNA viruses. Cell Host Microbe 21: 661-669.
- Courtney DG, Tsai K, Bogerd HP, Kennedy EM, Law BA, Emery A, et al. 2019. Epitranscriptomic addition of m(5)C to HIV-1 transcripts regulates viral gene expression. Cell Host Microbe 26: 217-227 e216.
- Gokhale NS, McIntyre ABR, McFadden MJ, Roder AE, Kennedy EM, Gandara JA, et al. 2016. N6-methyladenosine in flaviviridae viral RNA genomes regulates infection. Cell Host Microbe 20: 654-665.
- Kennedy EM, Bogerd HP, Kornepati AV, Kang D, Ghoshal D, Marshall JB, et al. 2016. Posttranscriptional m(6)A editing of HIV-1 mRNAs enhances viral gene expression. Cell Host Microbe 19: 675-685.
- Tan B, Gao SJ. 2018. The RNA epitranscriptome of DNA viruses. J. Virol. 92: e00696-18.
- Kane SE, Beemon K. 1985. Precise localization of m6A in Rous sarcoma virus RNA reveals clustering of methylation sites: implications for RNA processing. Mol. Cell. Biol. 5: 2298-2306.
- Hesser CR, Karijolich J, Dominissini D, He C, Glaunsinger BA. 2018. N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection. PLoS Pathog. 14: e1006995.
- Kim GW, Moon JS, Gudima SO, Siddiqui A. 2022. N6-methyladenine modification of hepatitis delta virus regulates its virion assembly by recruiting YTHDF1. J. Virol. 96: e0112422.
- Imam H, Khan M, Gokhale NS, McIntyre ABR, Kim GW, Jang JY, et al. 2018. N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle. Proc. Natl. Acad. Sci. USA 115: 8829-8834.
- Kim GW, Moon JS, Siddiqui A. 2022. N6-methyladenosine modification of the 5' epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein. Proc. Natl. Acad. Sci. USA 119: e2120485119.
- Kim GW, Imam H, Siddiqui A. 2021. The RNA binding proteins YTHDC1 and FMRP regulate the nuclear export of N6 - methyladenosine-modified Hepatitis B virus transcripts and affect the viral life cycle. J. Virol. 95: e0009721.
- Kim GW, Siddiqui A. 2022. Hepatitis B virus X protein expression is tightly regulated by N6-methyladenosine modification of its mRNA. J. Virol. 96: e0165521.
- Imam H, Kim GW, Mir SA, Khan M, Siddiqui A. 2020. Interferon-stimulated gene 20 (ISG20) selectively degrades N6- methyladenosine modified Hepatitis B Virus transcripts. PLoS Pathog. 16: e1008338.
- Kim GW, Siddiqui A. 2021. Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs. Proc. Natl. Acad. Sci. USA 118: e201945118.
- Zheng YY, Chen WL, Louie SG, Yen TSB, Ou JHJ. 2007. Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology 45: 16-21.
- Kariko K, Buckstein M, Ni H, Weissman D. 2005. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23: 165-175.
- Durbin AF, Wang C, Marcotrigiano J, Gehrke L. 2016. RNAs Containing modified nucleotides fail to trigger RIG-I conformational changes for innate immune signaling. mBio 7: e00833-16.
- Sioud M, Furset G, Cekaite L. 2007. Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs. Biochem. Biophys. Res. Commun. 361: 122-126.
- Uzri D, Gehrke L. 2009. Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities. J. Virol. 83: 4174-4184.
- Takeuchi O, Akira S. 2009. Innate immunity to virus infection. Immunol. Rev. 227: 75-86.
- Schlee M, Hartmann G. 2016. Discriminating self from non-self in nucleic acid sensing. Nat. Rev. Immunol. 16: 566-580.
- Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, et al. 2015. The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for Hepatitis B virus. Immunity 42: 123-132.
- Saito T, Owen DM, Jiang F, Marcotrigiano J, Gale M, Jr. 2008. Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature 454: 523-527.
- Khan M, Syed GH, Kim SJ, Siddiqui A. 2016. Hepatitis B virus-induced Parkin-dependent recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to mitochondria and attenuation of innate immunity. PLoS Pathog. 12: e1005693.
- Kim GW, Imam H, Khan M, Siddiqui A. 2020. N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling. J. Biol. Chem. 295: 13123-13133.
- Li N, Hui H, Bray B, Gonzalez GM, Zeller M, Anderson KG, et al. 2021. METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection. Cell Rep. 35: 109091.
- Lu M, Zhang Z, Xue M, Zhao BS, Harder O, Li A, et al. 2020. N6 -methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I. Nat. Microbiol. 5: 584-598.
- Kim GW, Imam H, Khan M, Mir SA, Kim SJ, Yoon SK, et al. 2020. HBV-induced increased N6-methyladenosine modification of PTEN RNA affects innate immunity and contributes to HCC. Hepatology 73: 533-547.
- Chen CY, Chen J, He L, Stiles BL. 2018. PTEN: Tumor suppressor and metabolic regulator. Front. Endocrinol. (Lausanne) 9: 338.
- Li S, Zhu M, Pan R, Fang T, Cao YY, Chen S, et al. 2016. The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nat. Immunol. 17: 241-249.
- Zhao T, Qi J, Liu T, Wu H, Zhu Q. 2022. N6-methyladenosine modification participates in the progression of Hepatitis B virus-related liver fibrosis by regulating immune cell infiltration. Front. Med. (Lausanne) 9: 821710.
- Rao X, Lai L, Li X, Wang L, Li A, Yang Q. 2021. N6 -methyladenosine modification of circular RNA circ-ARL3 facilitates Hepatitis B virus-associated hepatocellular carcinoma via sponging miR-1305. IUBMB Life 73: 408-417.
- Song MS, Salmena L, Pandolfi PP. 2012. The functions and regulation of the PTEN tumour suppressor. Nat. Rev. Mol. Cell Biol. 13: 283-296.
- Wang C, Yang W, Yan HX, Luo T, Zhang J, Tang L, et al. 2012. Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice. Hepatology 55: 108-120.
- Tirumuru N, Zhao BS, Lu W, Lu Z, He C, Wu L. 2016. N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression. Elife 5: e15528.
- Lichinchi G, Zhao BS, Wu Y, Lu Z, Qin Y, He C, et al. 2016. Dynamics of human and viral RNA methylation during Zika virus infection. Cell Host Microbe 20: 666-673.
- Guo G, Pan K, Fang S, Ye L, Tong X, Wang Z, et al. 2021. Advances in mRNA 5-methylcytosine modifications: Detection, effectors, biological functions, and clinical relevance. Mol. Ther. Nucleic Acids 26: 575-593.
- Dimitrova DG, Teysset L, Carre C. 2019. RNA 2'-O-methylation (Nm) modification in human diseases. Genes (Basel) 10: 117.