• BMB Reports
• /
• v.48 no.9
• /
• pp.525-530
• /
• 2015

Activation of the Wnt/β-catenin pathway plays a pathogenic role in age-related macular degeneration (AMD) and is thus a potential target for the development of therapeutics for this disease. Here, we demonstrated that Wnt5a antagonized β-catenin response transcription (CRT) induced with Wnt3a by promoting β-catenin phosphorylation at Ser33/Ser37/Thr41 and its subsequent degradation in human retinal pigment epithelial (RPE) cells. Wnt5a decreased the levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-α(TNF-α), and nuclear factor-κB (NF-κB), which was up-regulated by Wnt3a. Furthermore, Wnt5a increased E-cadherin expression and decreased cell migration by down-regulating Snail expression, thereby abrogating the Wnt3a-induced epithelial-mesenchymal transition (EMT) in human RPE cells. Our findings suggest that Wnt5a suppresses the pathogenic effects of canonical Wnt signaling in human RPE cells by promoting β-catenin phosphorylation and degradation. Therefore, Wnt5a has significant therapeutic potential for the treatment of AMD. [BMB Reports 2015; 48(9): 525-530]

• Journal of Convergence for Information Technology
• /
• v.11 no.4
• /
• pp.211-219
• /
• 2021

The purpose of this study is to investigate the level of verbal abuse experiences, emotional labor, and health-promoting behaviors of nurses in small and medium hospitals and to identify the relationship between them. Participants were 138 nurses from 2 small-medium sized hospitals. Collected data were analyzed using t-test, ANOVA, and Pearson's correlation coefficients with the SPSS 20.0 for Windows Program. As a result of the study, 82.7% of them experienced verbal abuse, and there were differences in the degree of health- promoting behavior according to gender (p=.032) and department (p=.009). Besides, it was found that emotional labor was related to health-promoting behavior (p=.039), and spiritual growth (p=<.01), and stress management (p=.028) as sub-factors. Accordingly, this study will be used as basic data for developing strategies and customized programs to reduce emotional labor, increase health-promoting activities, and contribute to the stable securing of nursing personnel.

• The Journal of the Convergence on Culture Technology
• /
• v.10 no.2
• /
• pp.439-446
• /
• 2024

The purpose of this study was to investigate relationship among sexual knowledge, sexual attitudes, and reproductive health promoting behaviors of nursing college students. The research tools utilized were sexual knowledge measurement tool by Jeon(2004), sexual attitudes measurement tool by Ho(2009), and reproductive health promoting behaviors measurement tool by Jo(2014). A total of 300 nursing college students were surveyed, and 229 responses were analyzed. Data analysis was performed using descriptive statistics, t-test, ANOVA, Scheffe's post hoc test and pearson's correlation coefficients with IBM SPSS Statistics 21.0. Female students exhibited higher sexual knowledge, and it was evident that reproductive health promoting behavior education is appropriate during lower academic years. Additionally, the indication that higher sexual knowledge corresponds to higher reproductive health promoting behaviors suggests the ongoing necessity for sexual education to enhance reproductive health promoting behaviors. Therefore, this study could serve as foundational data for developing educational materials on reproductive health promoting behaviors for counseling and education aimed at improving nursing college students' reproductive health.

• International journal of advanced smart convergence
• /
• v.10 no.3
• /
• pp.97-104
• /
• 2021

The Industrial Revolution 4.0 has significantly improved labor productivity, upholding the role of people as the creator of core values and the focus of sustainable development. Vietnam is facing an important turning point when GDP growth has gradually slowed down in the context that natural resources are beginning to dry up. This requires Vietnamese businesses to innovate to promote economic growth and improve competitiveness. This paper focuses on clarifying the activity and policy Vietnam's innovation. Thereby to propose the solution for supporting and promoting of innovative startup enterprise in accordance with the conditions and circumstances of Vietnam in the context of Industry 4.0

• Journal of Nutrition and Health
• /
• v.47 no.5
• /
• pp.374-384
• /
• 2014

Purpose: Health professionals and policy makers confront the failure of provider-administered, conventional behavioral interventions in the fight against obesity epidemic. The aim of this study was to develop a tailored, cost-effective delivery system for a child obesity prevention and management program through technology convergence using Web-enabled smart cellular phones. Methods: Assessment of service needs and development of a delivery system for the program were based on a comprehensive literature review and expert reviews, and results from in-depth interviews and a need-assessment survey. Results: The user- and site-centered service delivery system using Web-enabled cellular telephones as the hardware platform for obesity prevention and management has been developed. A tailored informational service and intervention will be provided interactively between stakeholders through the platform. The potential legal issues associated with the service design have also been considered. Conclusion: The user-centered convergence design and platform based on principles of Transtheoretical Model and Stages of Change using the Health Promoting School framework could enable effective intervention and promote acceptance in the long-run.

• Transactions of the Korean hydrogen and new energy society
• /
• v.34 no.5
• /
• pp.398-412
• /
• 2023

The Korean government is actively promoting the hydrogen industry as a key driver of economic growth. This commitment is evident in the 2019 hydrogen economy activation roadmap and the 2021 basic plan for hydrogen economy implementation. This study quantitatively analyzes the economic impact of the hydrogen economy using input-output analysis based on the Bank of Korea's 2019 input-output table, projecting its size by 2050. Four parts dealt with production-inducing, value-added creation, employment-inducing, and wage-inducing based on a demand-driven model. The results reveal that transportation had the most remarkable economic effect throughout the hydrogen economy, and production was the least. The hydrogen economy is projected to reach 71.2 trillion won by 2050.

• Korean Institute of Interior Design Journal
• /
• v.25 no.6
• /
• pp.15-22
• /
• 2016

Recent changes in the Korean education policies are promoting the advances in science and technology and cultivating people of convergence talent. STEAM (science, technology, engineering, art and math) educational program is Korean styled convergence program for creative competent human resources. Therefore, Therefore the aim of this study is developing convergence hand-on educational program coping with climate change for elementary school students. For development of the program, we investigated the curriculum of the elementary school about the climate change, and allocated in the creative learning standard frame. Also, we selected themes related the climate change in the curriculum and learning activity. For more effective program to build the convergence competency, we analyzed the program based on creative problem based learning process and 4 core competency(creativity, communication, convergence, caring) elements. In conclusion, the STEAM program needs to develop by school curriculum and leaner's ability. For elementary school students, the STEAM program consists with creative problem based learning process. And the convergence educational program would analyze by the creative PBL process and convergence competency elements. So, this developing program has brought the promotion of the creative convergence competent talented person for the future global environment.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.15 no.3
• /
• pp.1327-1333
• /
• 2014

IT convergence plays a key role in increasing the value of goods and services in other industry sectors. The government has enhanced the policy and institutional support for convergence technology development and technology commercialization. Some of the leading companies already achieve performance through the strategic IT convergence. However, in order to maximize the benefits and performance of IT convergence, policies should be established from the viewpoint of industrial ecology and many companies can participate in and share benefits of IT convergence business. From an industrial ecology perspective, this study suggests a role of the government, keystone enterprise, and other stakeholder for promoting the IT convergence using analytic hierarchy process(AHP).

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.6 no.1
• /
• pp.133-158
• /
• 2011

In 2030s, as we enter in to the era of BT (Bio-Technology) market opening up, technologies in all areas such as IT, data analysis, IC and biochemistry are necessitated. New development in technology will be based on "Convergence", especially between IT and BT. In order to have synergy effects from the convergence, those related industries and universities should be physically inter-related in an appropriate location. Until 2009, 819 industrial clusters where many Korean industries and firms are concentrated have been constructed in Korea. They have had supports from various institutions and facilities. However, few systems designed to assist "intellectual property (IP) service" for technology convergence are found in Korea. Thus, by analyzing current problems and challenges of the Korean industrial clusters, this paper suggests a possible answer to maximize the synergy from technology convergence through organic cooperation among companies in industrial clusters. This paper finds that the Korean industrial clusters need to establish IP service supporting center while suggesting its function and concept on organization structure, and work flow, which help firms to develop IP strategies. In addition, the paper provides a direction for current IP system and policies implemented by the Korean government to be more effective to small-and-medium-sized companies located in the industrial clusters.

• Journal of Microbiology and Biotechnology
• /
• v.31 no.11
• /
• pp.1559-1567
• /
• 2021

The root bark of Morus alba L. has cytotoxic activity against several types of cancer cells. However, little is known about its chemopreventive mechanisms and bioactive metabolites. In this study, we showed that M. alba L. root bark extracts (MRBE) suppressed β-catenin response transcription (CRT), which is aberrantly activated in various cancers, by promoting the degradation of β-catenin. In addition, MRBE repressed the expression of the β-catenin/T-cell factor (TCF)-dependent genes, c-myc and cyclin D1, thus inhibiting the proliferation of RPMI-8226 multiple myeloma (MM) cells. MRBE induced apoptosis in MM cells, as evidenced by the increase in the population of annexin VFITC-positive cells and caspase-3/7 activity. We identified ursolic acid in MRBE through LC/mass spectrum (MS) and observed that it also decreased intracellular β-catenin, c-myc, and cyclin D1 levels. Furthermore, it suppressed the proliferation of RPMI-8226 cells by stimulating cell cycle arrest and apoptosis. These findings suggest that MRBE and its active ingredient, ursolic acid, exert antiproliferative activity by promoting the degradation of β-catenin and may have significant chemopreventive potential against MM.