• Bulletin of the Korean Chemical Society
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• 제32권4호
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• pp.1146-1152
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• 2011

The discovery of 2'-spirocyclopropyl-ribocytidine (J. Med. Chem. 2010, 53, 8150-8160) as a potent inhibitor of RNA synthesis by NS5B ($IC_{50}=7.3{\mu}M$), the RNA polymerase encoded by hepatitis C Virus (HCV), has led to the synthesis and biological evaluation of several carbocyclic versions of 2'-spiropropyl-nucleosides. The cyclopentenol intermediate 7 was successfully constructed via ring-closing metathesis (RCM) from divinyl 6. Spirocyclopropanation of enone 8 was effected by using (2-chloroethyl)-dimethylsulfonium iodide and potassium tert-butoxide to form the desired intermediate 9. The synthesized nucleoside analogues 21-24 were assayed for their ability to inhibit HCV RNA replication in a subgenomic replicon Huh7 cell line. Among them, the cytosine nucleoside analogue 22 exhibited significant anti-HCV activity ($EC_{50}= 8.2{\mu}M$).

• 국제학술발표논문집
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• The 4th International Conference on Construction Engineering and Project Management Organized by the University of New South Wales
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• pp.350-356
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• 2011

Early neutral evaluation (ENE) is a fairly recent form of alternative dispute resolution procedure used in the construction industry. In the UK, ENE is usually carried out on an entirely without prejudice basis, however the parties may agree that any or part of it may be referred to at trial or any subsequent hearing. The early neutral evaluation consists of a preliminary assessment of the issues in dispute for use as a basis for negotiations which may result in a settlement of the dispute. An independent person is appointed by the parties who reviews the case and provides an opinion, in written form and in some detail, with reasons on the merits of the matters in dispute. The opinion is non-binding but provides the parties with what in the opinion of the independent person a formal tribunal may decide whether a court or an arbitrator, if the dispute is not resolved. However, ENE has yet to take off in the construction industry in the UK. This paper will explain this procedure and explore the use of it in the UK and internationally, considering the benefits and drawbacks of its use. It will consider whether or not it is more effective than other early resolution forms such as mediation and adjudication. It will argue and conclude that it is a very useful cost effective procedure, particularly in the resolution of complex disputes, whether local or international.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2007년도 정기학술발표대회 논문집
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• pp.917-920
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• 2007

우리나라의 민간투자 사업은 잦은 제도변경으로 많은 혼란을 격고 있지만, 2005년 1월 사회기반시설의 민간투자법 개정으로 공공서비스시설을 대중에게 제공할 수 있는 새로운 민간투자방식은 BTL(Build Transfer Lease)이 국내건설시장에 도입되었다. BTL사업은 계획에서 유지관리까지 사업의 수명주기 전 과정을 대상으로 포괄적 형태의 사업을 수행하는 것으로 사업자의 역할과 수행능력에 따라 사업의 성패가 좌우 된다. 따라서, 본 연구에서는 효율적인 BTL사업의 추진에 필요한 명확한 시스템 기준을 분석하여 사업수행의 정확성을 검증할 수 있는데 그 목적이 있다.

• 교육시설
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• 제8권2호
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• pp.13-26
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• 2001

The study is a Post-Occupancy-Evaluation on newly constructed steel framed school buildings sponsored by POSCO, and presents alternative tactics for planning and programming for the kind of project. The schools in concern are Seowha Primary School(Incheon city) and Galma Primary School(Daejeon city) which were completed in February 1999 and since occupied. The POE-2000 study results had to be compared to the POE-1999 which dealt on Jigog Primary School(Pohang city) and Iwol Primary School(Jincheon township) to develop an improved project tactics. In this reason we had to use the same questionnaire forms envisaged by the former study, ie. POE-1999. To begin with the same study format, it might be appropriate to differentiate whether a 'satisfaction' comes from the 'steel framed construction' or from the 'newly built environment'. However it was difficult with the POE-1999. As the intention to compare the 4 school building were the firstly achieved objective of this study that we had to continue to apply the same format and the analysis procedure. Except this condition, everything the POE-1999 conducted were valuable to this POE-2000. The satisfaction survey form includes 36 questions for individual items and 2 questions for general items.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2006년도 춘계공동학술대회 논문집
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• pp.373-378
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• 2006

Recently the technical advances and complexities have generated much of the difficulties in managing the project resources, for both scheduling and costing to accomplish the project in the most efficient manner. The project manager is frequently required to render judgments concerning the schedule and resource adjustments. This research develops an analytical model for a schedule-cost and risk analysis based on visual PERT/CPM. We used a three-step approach: 1) in the first step, a deterministic PERT/CPM model for the critical path and estimating the project time schedule and related resource planning and we developed a heuristic model for crash and stretch out analysis based upon a time-cost trade-off associated with the crash and stretch out of the project. 2) In second step, we developed web-based risk evaluation model for project analysis. Major technologies used for this step are AHP (analytic hierarchy process, fuzzy-AHP, multi-attribute analysis, stochastic network simulation, and web based decision support system. Also we have developed computer programs and have shown the results of sample runs for an R&D project risk analysis. 3) We developed an optimization model for project resource allocation. We used AHP weighted values and optimization methods. Computer implementation for this model is provided based on GUI-Type objective-oriented programming for the users and provided displays of all the inputs and outputs in the form of GUI-Type. The results of this research will provide the project managers with efficient management tools.

• 한국건설관리학회논문집
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• 제9권3호
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• pp.146-152
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• 2008

2000년대 후반 들어 플랜트산업은 초유의 호황기를 누리고 있으나, 시장 확대에 따라 사업주의 품질, 기술요구가 점차 강화되고 있어 이러한 국내 플랜트 산업이 대외경쟁력을 구비하고 지속적으로 성장 가능한 산업으로 거듭나기 위해서는 우수한 설계능력의 확보를 통한 고부가가치 기술집약산업으로 변화가 요구되고 있다. 이를 위해서 우수설계를 위한 체크리스트의 도출과 그 측정이 가능하도록 하는 객관적인 사례평가모델의 개발이 필수적이다. 본 연구에서는 플랜트사업의 설계사례의 체크리스트기반 평가모델 개발을 위해 우선 국내외 플랜트 EPC 산업현황과 체크리스트 관련 선행연구에 대한 문헌고찰을 수행하였다. 이를 기반으로 전문가 설문을 통해 각 설계분야의 업무항목별 중요도와 업무별 체크리스트 항목의 중요도를 도출하여 체크리스트 평가에 따른 정량적 평가모델을 개발하였다. 또한 개발된 모델의 사례평가의 적용성 검토를 위해 플랜트 설계사례를 정량적으로 평가하고 분석하였다. 현재 국내에서는 우수사례의 도입 초기 단계로 본 연구에서 개발된 건설사업 단계별 업무 체크리스트를 향후 산업계와 학계, 연구계의 상호 협동을 통해 지속적인 연구와 적용을 통해 발전시켜 나간다면 국내 EPC업체의 우수설계능력 확보에 기여할 것으로 기대된다.

• 산업경영시스템학회지
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• 제42권4호
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• pp.165-172
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• 2019

Innovation activities represented by Six Sigma (6σ) led to improvements not only in manufacturing industries but also in various business fields. In the aviation industry, Six Sigma has been used as a tool of innovation since the beginning of 2000, and it has developed into a comprehensive form of innovation activity that includes various improvement tools. In this study, the innovation activities in K company that is a representative company of aviation industry are summarized in the last 10 years, and the effectiveness of the innovation tools and the performance of the tasks are also analyzed. The results of 2,091 projects over the past decade have been analyzed from various perspectives. First, we found out the tools that were used frequently at each DMAIC step, showed their frequency, and analyzed the evaluation results for the project. The project was evaluated from grade 1 (highest level) to grade 7 (lowest level) with an average grade of 4.1 for the overall project. The evaluation grades of the projects were compared and analyzed in terms of the qualifications of the leader, the roadmap for the implementation of the project, the financial effect, the size of the financial effect, the business classification, and the project execution period. These results may suggest new perspectives for companies considering or adopting innovation programs.

• 지역사회간호학회지
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• 제15권4호
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• pp.539-550
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• 2004

Purpose: The purpose of this study was to evaluate the achievements of the project, and also to find out its strengths and weaknesses. Method: This evaluative study employed system theory and analytic techniques by using criteria which were relevance, appropriateness, adequacy, progress, effectiveness and satisfaction for input, process, output, and outcome of program. Study subjects were participants in the home health care program implemented in G public health center in Inchon metropolitan city in 2003. Results: Input factors including recruitment personnel, and support organization development were not adequately met for the program. However. the goal and objectives of the project were really appropriate for the community needs as well as government's policy. For the Process evaluation, home health care record form and computer data base had not progressed as scheduled, but overall program activities were finished on time. However, cooperation between organizations in the health center during service activity were not supportive. Managerial ability of program charged personnel about coordination and integration of team members was not affirmative. Output and outcome evaluation showed that people improved self care ability were 221 (17.5%). and 71 (5.62%) of subjects were moved into category of possible self-care. Client's satisfaction for this project showed a high degree. Conclusions: Based on the above results support organization and staff personnel for this program should be developed. Also, a community network of resources should be established and case management services should be focused continuously in community based home health care.

• Industrial Engineering and Management Systems
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• 제13권2호
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• pp.221-230
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• 2014

With the progress and prosperity of commerce and industry, time and money increasingly form an equal partnership. Using air carriers to shorten the round-trip time has become an important choice for many people in the tourism process. Faced with increasing competition within the aviation service environment, airline evaluation criteria and the requirements of customers are gradually dominating the evaluation mechanism for air transport service quality. Over the past few years, attention on the transport quality of service has been primarily focused more on land-based transport, and less on the relevant evaluation criteria of airlines. Many studies have shown that quality of service will directly affect customer satisfaction, resulting in the fact that good quality aviation services have become increasingly important. Therefore, in practical industrial operations with limited resources, there is an urgent need to delve into the assessment guidelines that have an impact on customers when they choose an airline, which can be used as a basis for improving customer satisfaction. Through a literature review and a reliability and validity analysis, this study summarized 19 evaluation criteria, using the purposive sampling method and the decision laboratory method (DEMATEL). In addition, this study viewed the causal relationship between the evaluation criteria and the degree of association as a continuing project for airlines. This study selected appropriate empirical samples from two domestic airlines. The conclusions may provide recommendations for all airlines.

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2008년도 추계학술대회
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• pp.157-160
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• 2008

The recent successes of systems like Google, Wikipedia and InnoCentive suggest that the time is now ripe for more such systems. Thus, we want to explore these systems and exploit them from a viewpoint of social psychology prior to technological progress. First of all, we examine the difference between 'wisdom of crowds' and 'crowd psychology'. There are two classes, which are for senior management major students. Conditions of two are same, except a class time. Forty five students in one class are tested for this experiment. They form a group with five people and are divided into 9 groups. In a case of a morning class, peer-to-peer evaluations are given to individuals in a class when a group presentation for a final project is given. On the other hand, in a case of afternoon class, peer-to-peer evaluations are given to each group in a class. The result is quite fruitful. The first is that an expert's evaluation for a project agrees with students, who are beginners in this field in the degree of more than 95%. However, in the case of afternoon class, students' group evaluation turns out to agree with an expert's one less than 53%. Morning class experiment result proves the truth of collective intelligence again. It tunrs out independent and confidential opinions are more cost effective and give right answers to questions than group opinions.