• Journal of Korean Society for Quality Management
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• v.49 no.2
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• pp.145-159
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• 2021

Purpose: A statistical similarity evaluation to compare pharmacokinetics(PK) profile data between nonclinical and clinical experiments has become a significant issue on many drug development processes. This study proposes a new similarity index by considering important parameters, such as the area under the curve(AUC) and the time-series profile of various PK data. Methods: In this study, a new profile similarity index(PSI) by using the concept of a process capability index(Cp) is proposed in order to investigate the most similar animal PK profile compared to the target(i.e., Human PK profile). The proposed PSI can be calculated geometric and arithmetic means of all short term similarity indices at all time points on time-series both animal and human PK data. Designed simulation approaches are demonstrated for a verification purpose. Results: Two different simulation studies are conducted by considering three variances(i.e., small, medium, and large variances) as well as three different characteristic types(smaller the better, larger the better, nominal the best). By using the proposed PSI, the most similar animal PK profile compare to the target human PK profile can be obtained in the simulation studies. In addition, a case study represents differentiated results compare to existing simple statistical analysis methods(i.e., root mean squared error and quality loss). Conclusion: The proposed PSI can effectively estimate the level of similarity between animal, human PK profiles. By using these PSI results, we can reduce the number of animal experiments because we only focus on the significant animal representing a high PSI value.

• Korean Journal of Microbiology
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• v.30 no.5
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• pp.339-346
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• 1992

These studies were carried out to identify Bacillus cereus group 1..5-] strain isolated from 5uyeong Bay. This strain was differentiated from B. cereus group using conventional, API system and fatty acid composition analysis. Colony characteristics were opague. mucoid, entire margin. convex. circular and non hemolysis on sheep blood agar plates, and were observed with central spore forming positive bacilli in a Gram stained preparation. and had no motility. The carbohydrates tested; glucose.maltose, and sucrose were assimilated but neither trehalose nor salicin were assimilated. This strain ultilized gelatin and was also inhibited by 6.5% NaCI. The results of biochemical examination were differented from B. cereus group LS-1 compared with others B. cereus group. The fatty acid composition contained major amounts of branched chain acids. iso $C_{15}$ and iso $C_{13}$ and the range of chain length was $C_{12}$ to C"$C_{17}$ and n$C_{15}$, acid was not detected. Automated fatty acid computer profile indicated "B. mycoides GC subgroup B of 0.312 similarity index." The results agreed with other research cases. On the other hand. A TB computer prolile index of API system (API 50 CHB & API 20E) identified" Doubtful profile of 99.7% B. firmus" . These results were presented with considerable discrepancies between API system and fatty acid analysis. With 67 biochemical characters. the similarity matrix of B. mycaides (KCTC 1033). B. thuringiensis (KCTC 1033). B. cereus (5-3) and B. mycoides (S-12) showed 42%. 42%. 59%, and 52%. respectively. Through the key tests and fatty acid analyses. we could notice the appearance of B. mycoides of the B. cereus group and this leads us to suspect the existence of a new biotype B. mycoides.

• Journal of the Korea Society of Computer and Information
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• v.29 no.2
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• pp.109-118
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• 2024

With the increasing number of social media users worldwide, cases of social media being abused to perpetrate various crimes are increasing. Specifically, drug distribution through social media is emerging as a serious social problem. Using social media channels, the curiosity of teenagers regarding drugs is stimulated through clever marketing. Further, social media easily facilitates drug purchases due to the high accessibility of drug sellers and consumers. Among various social media platforms, we focused on Instagram, which is the most used social media platform by young adults aged 19 to 24 years in South Korea. We collected four types of information, including profile photos, introductions, posts in the form of images, and posts in the form of texts on Instagram; then, we analyzed the similarity among each type of collected information. The profile photos and posts in the form of image were analyzed for similarity based on the SSIM(Structural Simplicity Index Measure), while introductions and posts in the form of text were analyzed for similarity using Jaccard and Cosine similarity techniques. Through the similarity analysis, the similarity among various accounts for each collected information type was measured, and accounts with similarity above the significance level were determined as the same drug sales account. By performing logistic regression analysis on the aforementioned information types, we confirmed that except posts in image form, profile photos, introductions, and posts in the text form were valid information for tracking the same drug sales account.

• Journal of the Korean Society for Precision Engineering
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• v.24 no.2 s.191
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• pp.47-57
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• 2007

The vibration environment essentially companied by vehicle operation on the road is determined by the shape of road surface, which is called profile. In general, the profile and severity of unpaved road is an important issue in the reliability of durability test for vehicles. In order to maintain severity of unpaved road, it is necessary to develop profilometer system. We developed profilometer system which is composed of data processing computer, power unit, air compressor and sensors. This paper focuses on the severity management of unpaved test courses using neural networks. This paper presents the maintenance range for cross-country course in CPG(Chang-won Proving Ground) and the evaluation of similarity degree between unpaved roads.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.7
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• pp.629-639
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• 2016

Batch process TRN(Terrain Relative Navigation) using an altimeter is a technique to correct position by correlating a series of periodically measured terrain height profile and terrain height candidate profile of the DEM(Digital Elevation Map). However, it is generally known that the performance of TRN is degraded when measured terrain height profile and terrain height candidate profiles of the DEM are similar at hill or repetitive terrain. In this paper, area based terrain slope roughness index[11] is applied and area based terrain curvature roughness index which can detect similarity of terrain in ROI(Region Of Interest) is proposed to overcome this problem. Applying terrain roughness indexes to terrain relative navigation system of lunar lander, it is shown that TRN using area based terrain roughness results in improved performance compared to conventional trajectory based method through simulation.

• The KIPS Transactions:PartB
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• v.9B no.4
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• pp.399-406
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• 2002

The goal of this research has been to develop an adaptive user agent for web surfing. To achieve this goal, the research has concentrated on three issues: collection of user data, construction and improvement of user profile, and adaptation by applying the user profile. The main outcome from the research is a prototype system that provides the functional definition and componential design scheme for an adaptive user agent for the web environment. Internally, the system achieves its operational goal from the cooperation of two independent agents. They are IIA (Interactive Interface Agent) and UPA (User Profiling Agent). As a tool for providing a user-friendly interface environment, the IIA employs the Keyword Index, which is a list of index terms of a webpage as well as a keyword menu for subsequent queries, and the Suggest Link, which is a hierarchical list of URLs showing the past browsing procedure of the user. The UPA reflects in the User Profile, both the static and the dynamic information obtained from the user's browsing behavior. In particular, a user's interests are represented in the form of Interest Vectors which, based on the similarity of the vectors, is subject to update and creation, thus dynamically profiling the user's ever-shifting interests.

• The KIPS Transactions:PartD
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• v.16D no.5
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• pp.683-690
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• 2009

Social Networks which is composed of network with an individual in the center in a web support mutual-understanding of information by searching user profile and forming new link. Therefore, if we apply the Social Network which consists of web users who have similar immanent information to web search, we can improve efficiency of web search and satisfaction of web user about search results. In this paper, first, we make a Social Network using web users linked directly or indirectly. Next, we calculate Similarity among web users using their immanent information according to topics, and then reconstruct Social Network based on varying Similarity according to topics. Last, we compare Similarity with Search Pattern. As a result of this test, we can confirm a result that among users who have high relationship index, that is, who have strong link strength according to personal attributes have similar search pattern. If such fact is applied to search algorithm, it can be possible to improve search efficiency and reliability in personalized and social search.

• Journal of Technology Innovation
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• v.5 no.1
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• pp.15-43
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• 1997

This paper investigates empirically the relationship between various business portfolio properties (particularly technological properties) and chaebol's performance using data on the 50largest chaebols in Korea. In addition to the traditional indexes to measure diversification such as entropy index, we calculated inter-industry technological similarity using R'||'&'||'D expenditure data by industry and 1990 Input-output Table in korea, and obtained chaebol-level technological relatedness and internal transaction proportion from chaebols' business profile, inter-inustry technological similarity and 1990 input-output table. We applied factor analysis on 13 business portfolio property indexes and showed that they could be grouped into 3 dimensions. diversification scope, inter-business relatedness and degree of vertical integration. In this paper, using 50 largest chaebols' financial data (1989-1994), we analyzed empirically the effect of business portfolio properties on ROS(Return On Sales) which is conventional index for firm performance and on TFP(Total Factor Productivity) growth which is a pure measure of firm performance. To utilize the advantage of panel data, FEM(Fixed Effect Model) and REM(Random Effect Model) were used. The empirical result shows that the entropy index as a measurement of inter-business relatedness in not significant but technological relatedness index is significant. OLS estimates on pooled data were considerably different from FEM or REM estimates on panel data. By introducing interaction effect among the three variables for business portfolio properties, we obtained three findings. First, only VI(Vertical integration) has a significant positive correlation with ROS. Second, when using TFP growth as an dependent variable, both TR(Technological Relatedness) and VI are significant and positively related to the dependent variable. Third, the interaction term between TR and VI is significant and negatively affects TFP growth, meaning that TR and VI are substitutes. These results suggest strategic directions on restructuring business portfolio. As VI is increased, chaebols will get more profit. A higher level of either TR or VI will increase TFP growth rate, but increase in both TR and VI will have a negative effect on TFP growth. To summarize, certain business portfolio properties such as VI and TR can be considered "resources" themselves since they can affect profit rate and productivity growth. VI and TR have a synergy effect of change in profit rate and productivity growth. VI increases ROS and productivity growth, while TR increases productivity growth representing a technological synergy effect.t.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.29 no.3
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• pp.41-63
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• 2018

This study aimed at analyzing journals and index terms, authors of the reformed theology and evangelicalism, neutral theological position by using bibliometrical analyzing methods. The analyzing methods are average linkage and neighbor centralities, profile cosine similarities. Especially, when analyzing the relationship between authors, we interpreted the research topic by finding the key shared index terms between the authors. In the journal analysis results, 9 journals were largely clustered together in the two clusters of the reformed theology and evangelicalism, but Presbyterian Theological Quarterly that is thought to be a reformed journal was clustered in evangelical cluster. In the index terms analysis results of the clusters, the reformed theology and evangelicalism were key words representing the two clusters. In the authors' analysis results, we had 9 clusters and the Presbyterian theologian studying the reformed theology had the four clusters and the non-Presbyterian theologian had the 5 clusters. Therefore, we consistently had the two clusters of the reformed theology and evangelicalism in all the analysis of the journals and the index terms, the authors.

• Proceedings of the Technology Innovation Conference
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• 1996.12a
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• pp.265-295
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• 1996

This paper investigates empirically the relationship between various business portfolio properties (particularly technological properties) and chaebol′s performance using data on the 50 largest chaebols in Korea. In addition to the traditional indexes to measure diversification such as entropy index we calculated inter-industry technological similarity using R&D expenditure data by industry and 1990 Input-output Table in Korea, and obtained chaebol-level technological relatedness and internal transaction proportion from chaebols′business profile, inter-industry technological similarity and 1990 input-output table. We applied factor analysis on 13 business portfolio property indexes and showed that they could be grouped into 3 dimensions, diversification scope, inter-business relatedness and degree of vertical integration. In this paper, using 50 largest chaebols′financial data (1989-1994), we analyzed empirically the effect of business portfolio properties on ROS (Return On Sales) which is conventional index for firm performance and on TFP(Total Factor Productivity) growth which is a pure measure of firm performance. To utilize the advantage of panel data, FEM(Fixed Effect Model) and REM(Random Effect Model) were used. The empirical result shows that the entropy index as a measurement of inter-business relatedness is not significant but technological relatedness index is significant. OLS estimates on pooled data were considerably different from FEM or REM estimates on panel data. By introducing interaction effect among the three variables for business portfolio properties, we obtained three findings. First, only VI (Vertical integration) has a significant positive correlation with ROS. Second, when using TFP growth as an dependent variable, both TR(Technological Relatedness) and f[ are significant and positively related to the deepened variable. Third, the interaction term between TR and VI is significant and negatively affects TFP growth, meaning that TR and VI are substitutes. These results suggest strategic directions on restructuring business portfolio. As VI is increased, chaebols will get more profit. A higher level of either TR or W will increase TFP growth rate. but increase in both TR and VI will have a negative effect on TFP growth. To summarize, certain business portfolio properties such as VI and TR can be considered "resources" themselves since they can affect profit rate and productivity growth. VI and TR have a synergy effect of change in profit rate and productivity growth. VI increases ROS and productivity growth, while TR increases productivity growth representing a technological synergy effect.