• 생약학회지
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• 제31권3호
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• pp.259-263
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• 2000

This study was designed to evalulate the biological activity, particularly induction of IgA in primary Peyer's patches cells, of herbal medicines for a long time in Asia. Among fifty four herbal medicines tested, Ephedra sinica, Magnolia officinalis, Lonicera japonica and Lithospermum erythorhizon induced IgA production. The polar and high molecular weight component in Ephedra sinica was capable of inducing IgA in primary Peyer's patches cells. Therefore, we suggest that some herbal medicines could use for the treatment of food allergy.

• 한국약용작물학회지
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• 제18권6호
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• pp.398-404
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• 2010

Complementary and alternative medicines are considered as a promising research field to develop new therapies for various allergic diseases. In this study, we investigated the anti-allergic effect of Agrimonia pilosa Ledeb (AP) by using passive cutaneous anaphylaxis in mice and its mechanism of action in mast cells. The extract of AP reversibly inhibited degranulation in RBL-2H3 cells and bone marrow-derived mast cells (BMMCs). AP also suppressed the passive cutaneous anaphylaxis inducing by IgE and antigen (Ag) in a dose-dependent manner. In the study to find its mechanism of action, AP inhibited the phosphorylation of Syk kinase, a pivotal protein which is regulated by Src-family kinase for activation of mast cells. In addition, AP also suppressed activation of Akt and Erk1/2 that are critical for the production of cytokines in mast cells. The results strongly suggest that AP exerts anti-allergic activity in vitro and in vivo through the inhibition of activation of Syk in mast cells.

• 자원환경지질
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• 제57권2호
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• pp.129-141
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• 2024

본 연구는 지역산업연관표를 이용하여 생산-생산 승수를 도출하고 비금속광물 부문과 콘크리트 제품 부문을 통해 골재의 유발효과를 추정하였다. 유발효과를 파악할 수 있도록 지역산업연관표를 활용하여 분석을 진행하였다. 골재의 유발효과를 도출함에 있어 지역산업연관표를 이용하는 것은 부문분류 문제로 인해 어려움이 있는데, 본 연구는 골재를 포함한 비금속광물 부문을 골재로 간주한 분석과 골재생산의 대부분을 수요하는 콘크리트 제품 부문을 분석함으로써 부문분류 제약으로 인한 난점을 완화하고자 하였다. 산업연관효과를 추정하는 과정에서 골재의 생산감소 상황을 전제해 진행하였으며, 콘크리트 제품 부문을 분석하는 과정에서는 골재 생산감소로 인한 콘크리트 제품 생산감소의 효과, 즉 골재 1단위 생산감소는 콘크리트 제품 부문 0.8511단위의 생산감소를 전제로 분석하였다. 지역산업연관표가 구분하고 있는 17개 광역시도에 대해 자기지역 내 및 지역간 유발효과를 산출하였다. 골재 생산감소로 인해 자기지역에서 발생하는 생산감소 효과는 지역별 평균 1.28의 유발효과를 보였으며, 타지역의 골재 생산감소로 인한 생산감소 효과는 지역별 평균 0.10의 유발효과를 보였다. 취업효과도 산출하였는데, 지역별 골재 및 콘크리트 제품 부문의 규모에 따른 차이를 나타낼 수 있도록 10% 생산감소 상황을 전제하여 취업효과를 산출하였다.

• 한국미생물·생명공학회지
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• 제42권2호
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• pp.207-210
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• 2014

바이러스 감염은 감염된 숙주세포에서 활성산소를 유도할 수 있으며, 항산화제들은 많은 바이러스에 대해서 항바이러스 능을 갖는다고 보고되었다. 본 연구에서 cytopathic effect (CPE) reduction 방법에 의한 항바이러스 활성 평가에서 gallic acid는 현저하게 CPE형성을 감소시키면서 coxsackievirus B3 (CB3)와 coxsackievirus B4 (CB4)에 대해 항바이러스 활성을 나타내었다. 그러나 rabavirin은 CB3와 CB4에 대해 CPE를 막지 못하면서 약한 항바이러스 활성을 나타내었다. 그럼으로 gallic acid의 CB3와 CB4에 대한 항바이러스 활성은 항산화제 효능 때문인 것으로 사료된다.

• 해양환경안전학회지
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• 제22권5호
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• pp.536-546
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• 2016

본 논문에서는 한국은행에서 발표한 4년(2010-2013) 동안의 산업연관표로부터 해양환경산업의 시장규모 및 부가가치액을 추계하여 국민경제적 지위를 따져보고, 산업연관분석을 적용하여 해양환경산업의 경제적 파급효과를 분석하였다. 해양환경산업의 시장규모를 추계한 결과, 총 산출액은 2010년 1조 3,406억원에서 2013년 1조 9,723억원으로 증가하였으며, 총 산출액 전체에서 차지하는 비중 또한 0.04%에서 0.05%로 증가하였다. 부가가치액은 2010년 6,185억원에서 2013년 8,415억원으로 증가하였으며, 국내총생산에서 해양환경산업의 부가가치가 차지하는 비중은 0.05%에서 0.06%로 증가하였다. 또한 수요유도형 모형을 이용하여 경제적 파급효과를 분석한 결과, 해양환경산업에서의 1원 생산 또는 투자가 국민경제 전체에 야기하는 생산유발효과는 2010년 1.8845원에서 2013년 1.8115원으로 소폭 감소하였다. 해양환경산업에서의 1원 생산 또는 투자로 발생하는 부가가치 유발효과는 2010년 0.7680원에서 2013년 0.7063원으로 감소하였다. 해양환경산업에서의 10억원 생산 또는 투자의 취업유발효과는 2010년 10.17명에서 2013년 9.18명으로 감소하였다. 요컨대, 해양환경산업의 산출액 및 부가가치는 증가 추세를 보이고 있지만, 경제적 파급효과의 원단위는 감소 추세를 보였다.

• 한국자원식물학회지
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• 제11권1호
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• pp.80-85
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• 1998

The influence of elevated CO2 and temperature on growth parameters, biomass production and its partitioning of rice (Oryza sativa L.cv. Chukwangbyeo) were investigated in the three experiments (1991-1993). Rice plants were grown from transplanting to harvest at either ambient(350ppm) or elevated CO2 concentrations (690 or 650ppm) in combination with either four or seven temperature regimes ranging form ambient temperature (AT) to AT plus 3$^{\circ}C$.From transplanting to panicle initiation, crop growth rate (CGR) was enhanced by up to 27% with elevated CO2 , primarily due to an an increase in leaf area index. although net assimilatiion rate was also greater at elevated CO2. The effect of elevated CO2 varied with temperature. During the reproductive phase, CGR declined linearly with increased temperature, and was greater at elevated CO2 . Elevated CO2 increased final crop biomass and panicle weight 30% respectively at AT(27.6$^{\circ}C$ : 1991) . However, there was no significant effect of elevated CO2 on panicle weight at AT plus 3$^{\circ}C$, where severe spikelet sterility occurred. There was no significant effect of elevated CO2 on panicle weight at AT plus 3$^{\circ}C$, where severe spikelet sterility occurred. There was also no effect of CO2 on biomass pratitioning into vegetative and reproductive organs (harvest index)) at AT, although higher temperature could affect that by inducing spikelet sterility. These results suggest that elevated CO2 could enhance rice producivity througth promoted growth and biomass production , but its positive effects may be less at higher temperatures.

• IMMUNE NETWORK
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• 제16권1호
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• pp.75-84
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• 2016

Cancer is one of the leading causes of morbidity and mortality worldwide; therefore there is a need to discover new therapeutic modules with improved efficacy and safety. Immune-(cell) therapy is a promising therapeutic strategy for the treatment of intractable cancers. The effectiveness of certain chemotherapeutics in inducing immunogenic tumor cell death thus promoting cancer eradication has been reported. Ginsenoside Rg3 is a ginseng saponin that has antitumor and immunomodulatory activity. In this study, we treated tumor cells with Rg3 to verify the significance of inducing immunogenic tumor cell death in antitumor therapy, especially in DC-based immunotherapy. Rg3 killed the both immunogenic (B16F10 melanoma cells) and non-immunogenic (LLC: Lewis Lung Carcinoma cells) tumor cells by inducing apoptosis. Surface expression of immunogenic death markers including calreticulin and heat shock proteins and the transcription of relevant genes were increased in the Rg3-dying tumor. Increased calreticulin expression was directly related to the uptake of dying tumor cells by dendritic cells (DCs): the proportion of CRT⁺CD11c⁺cells was increased in the Rg3-treated group. Interestingly, tumor cells dying by immunogenic cell death secreted IFN-γ, an effector molecule for antitumor activity in T cells. Along with the Rg3-induced suppression of pro-angiogenic (TNF-α) and immunosuppressive cytokine (TGF-β) secretion, IFN-γ production from the Rg3-treated tumor cells may also indicate Rg3 as an effective anticancer immunotherapeutic strategy. The data clearly suggests that Rg3-induced immunogenic tumor cell death due its cytotoxic effect and its ability to induce DC function. This indicates that Rg3 may be an effective immunotherapeutic strategy.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 2010년도 춘계학술발표대회 초록집
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• pp.57-57
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• 2010

For thin panel welded structure, the various welding distortions were found due to the low resistance against welding deformation. Especially, buckling distortion induced in the thin panel welded structure produce severe problems related to cost in production stage and safety in service life. So, many researches including mechanical and thermal tensioning method for preventing the occurrence of buckling distortion in the production stage have been performed. The purpose of this study is to identify the behavior of longitudinal residual stress at the SA butt weldment with thin plate of 6mm thickness under tension load by 3 dimensional FEA. For it, mesh design for 3D FEA was constructed with 20 nodes brick element for butt weldment and 8 nodes shell element for base metal. According to FEA results, the longitudinal compressive strain inducing tensile residual stress at the butt weldment decreased. It was because the compressive thermal strain in way of weldment was reduced by tension load. The control effect of residual stress increased with an increase in tension load. So, if the amount of tension load applied to the weldment exceeds 1.5 times of longitudinal shrinkage force, the amount of longitudinal residual stress decreased below the critical value inducing the buckling distortion at the SA butt weldment. Its validity was verified by experiment.

• 약학회지
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• 제51권1호
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• pp.44-50
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• 2007

Acute septic shock is one of inflammatory diseases mediated by pro-inflammatory cytokines such as tumor necrosis factor (TNF)-${\alpha}$. In this study, we examined the pathological difference and mechanism of lipopolysaccharides isolated from E. coli (E-LPS) or S. abortus (S-LPS) on inducing acute septic shock in ICR mouse. All mice were died by intraperitoneal treatment of S-LPS with 0.75 mg/kg, whereas E-LPS treated with even 3 mg/kg only showed 30% of mice lethal, indicating that S-LPS may be more feasible in triggering a strong septic shock condition. The secretion pattern of TNF-${\alpha}$, a critical pro-inflammatory cytokine in septic shock condition, was also distinct between E-LPS- and S-LPS-treated groups. Thus, S-LPS strikingly increased serum level of TNF-${\alpha}$ (6 ng/ml) at 1 h, while E-LPS just displayed at 2 ng/ml level. However the interaction of S-LPS with LPS receptor toll like receptor (TLR)-4, was not stronger than that of E-LPS, according to experiments with macrophage cell line RAW264.7 cells. Thus, E-LPS rather than S-LPS strongly enhanced the production of TNF-${\alpha}$. Interestingly, S-LPS more strongly up-regulated splenocyte proliferation, compared to E-LPS group, whereas there was no difference between S- or E-LPS treated groups in proliferation of Balb/c- or C57BL/6-originated splenic lymphocytes. Therefore, our data suggest that S-LPS is a more active endotoxin and that the strong septic shock-inducing effect of S-LPS seems due to the enhancement of early TNF-${\alpha}$ production and S-LPS-sensitive lymphocyte proliferation.

• Journal of Microbiology and Biotechnology
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• 제27권3호
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• pp.480-491
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• 2017

Fluorescent pseudomonads have been isolated from halophytes, mesophytes, and xerophytes of Pakistan. Among these, eight isolates, GS-1, GS-3, GS-4, GS-6, GS-7, FS-2 (cactus), ARS-38 (cotton), and RP-4 (para grass), showed antifungal activity and were selected for detailed study. Based on biochemical tests and 16S rRNA gene sequences, these were identified as strains of P. chlororaphis subsp. chlororaphis and aurantiaca. Secondary metabolites of these strains were analyzed by LC-MS. Phenazine-1-carboxylic acid (PCA), 2-hydroxy-phenazine, Cyclic Lipopeptide (white line-inducing principle (WLIP)), and lahorenoic acid A were detected in variable amounts in these strains. P. aurantiaca PB-St2 was used as a reference as it is known for the production of these compounds. The phzO and PCA genes were amplified to assure that production of these compounds is not an artifact. Indole acetic acid production was confirmed and quantified by HPLC. HCN and siderophore production by all strains was observed by plate assays. These strains did not solubilize phosphate, but five strains were positive for zinc solubilization. Wheat seedlings were inoculated with these strains to observe their effect on plant growth. P. aurantiaca strains PB-St2 and GS-6 and P. chlororaphis RP-4 significantly increased both root and shoot dry weights, as compared with uninoculated plants. However, P. aurantiaca strains FS-2 and ARS-38 significantly increased root and shoot dry weights, respectively. All strains except PB-St2 and ARS-38 significantly increased the root length. This is the first report of the isolation of P. aurantiaca from cotton and cactus, P. chlororaphis from para grass, WLIP and lahorenoic acid A production by P. chlororaphis, and zinc solubilization by P. chlororaphis and P. aurantiaca.