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http://dx.doi.org/10.4014/kjmb.1404.04004

Antiviral Activity of Gallic Acid against Coxsackievirus B3 and Coxsackievirus B4  

Choi, Hwa-Jung (Department of Beauty Science, Kwangju Women's University)
Publication Information
Microbiology and Biotechnology Letters / v.42, no.2, 2014 , pp. 207-210 More about this Journal
Abstract
Viral infections are capable of inducing reactive oxygen species (ROS) production in the infected cells and antioxidants have been reported to have antiviral activities against many viruses. In this study, an antiviral assay using the cytopathic effect (CPE) reduction method revealed that gallic acid possesses good anti-coxsackievirus B3 (CB3) and coxsackievirus B4 (CB4) activities, reducing the formation of visible CPE. However, ribavirin did exhibit weak anti-CB3 and CB4 activities and was unable to prevent CPE. Therefore, we conclude that the inhibition of CB3 or CB4 production by gallic acid may be due to its general action as an antioxidant.
Keywords
Antioxidants; antiviral; coxsackievirus; gallic acid;
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1 Choi HJ, Kim JH, Lee CH, Ahn YJ, Song JH, Baek SH, et al. 2008. Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus. Antiviral Res. 81: 77-81.
2 Agol VI, Belov GA, Bienz K, Egger D, Kolesnikova MS, Raikhlin NT, et al. 1998. Two types of death of poliovirus-infected cells: caspase involvement in the apoptosis but not cytopathic effect. Virol. 252: 343-353.   DOI
3 Bhatt LR, Yook CN, Choi HJ, Baek SH. 2008. Radical scavenging activity of gallic acid from Woodfordia Fruticosa flowers. Korean J. Oriental Physiol. Pathol. 22: 903-906.
4 Gaudernak E, Seipelt J, Triendl A, Grassauer A, Kuechler E. 2002. Antiviral effects of pyrrolidine dithiocarbamate on human rhinoviruses. J. Virol. 76: 6004-6015.   DOI
5 Jason DG, Craig EC. 2006. Mechanisms of action of ribavirin against distinct viruses. Rev. Med. Virol. 16: 37-48.   DOI   ScienceOn
6 Kaul P, Biagioli MC, SinghI, Turner RB. 2000. Rhinovirus induced oxidative stress and interleukin-8 elaboration involves p47-phox but is independent of attachment to intercellular adhesion molecule-1 and viral replication. J. Infect. Dis. 181: 1885-1890.   DOI   ScienceOn
7 Kratz JM, Andrighetti-Fröhner CR, Kolling DJ, Leal PC, Cirne- Santos CC, Yunes RA, et al. 2008. Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate. Mem. Inst. Oswaldo Cruz 103: 437-442.   DOI
8 Weiss L, Hildt E, Hofschneider PH. 1996. Anti-hepatitis B virus activity of N-acetyl-L-cysteine (NAC): new aspects of a wellestablished drug. Antiviral Res. 32: 43-53.   DOI