• 제목/요약/키워드: Production Line

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ISO 9001:2015 인증을 위한 리스크 기반 사고의 개념과 리스크 관리 (A Fundamental Concept of Risk-Based Thinking and Risk Management for ISO 9001:2015 Certification)

  • 김호균;강병환;박동준
    • 산업경영시스템학회지
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    • 제40권3호
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    • pp.38-48
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    • 2017
  • ISO 9001 Quality Management Systems-Requirements has been revised in 2015. It has been updated four times since its publication in 1987. It is the most widely used International Standard in the world. There are over one million companies and organizations in over 170 countries certified to ISO 9001 from an ISO survey. Organizations are supposed to be certified to this new version by late 2018. The key changes in ISO 9001:2015 are to establish a High Level Structure (HLS) and focus on Risk-Based Thinking (RBT). Risk-Based Thinking means the process approach to decide how risk is addressed in establishing the processes to improve process outputs and prevent undesirable results. It pursues process planning and controls based on risks so that organizations can improve the effectiveness of the quality management system. It maintains and manages a Quality Management System that inherently addresses risks and meets objectives. In this article we firstly attempt to explain how to understand the fundamental concept of Risk-Based Thinking which is a systematic approach to consider risks rather than treating prevention as a separate component of a Quality Management System. We comment on the detailed requirements that contain risks in ISO 9001:2015 clauses. We also summarize recent advances on the risk assessment and management in line with ISO 31000:2009 Risk Management-Principles and Guidelines. We finally propose the practical risk management procedures for implementing ISO 9001:2015 with an emphasis on RBT. This article would contribute to help quality managers and practitioners convert to ISO 9001:2015.

Anti-inflammatory Effects of Ponciri Fructus Extracts on Raw 264.7 Cells

  • Lee, Jin Wook;Jung, Hyuk-Sang;Sohn, Youngjoo;Kang, Yoon Joong
    • 한국자원식물학회:학술대회논문집
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    • 한국자원식물학회 2018년도 춘계학술발표회
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    • pp.91-91
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    • 2018
  • Poncirus Fructus (PF) is obtained by drying the trifoliate orange fruit belonging to the Rutaceae family. In our country of medicine, PF has been used as a treatment of indigestion, allergy and inflammation. But Mechanism and medical data for PF is insignificant. Recently, the effect of the study PF of biological activity was reported, such as anti- thrombosis, anti-bacteria, anti-virus, anti- allergic. We investigated that the effect of PF on anti-inflammatory in murine macrophage-like cell line Raw264.7 cells. Our results show that the expression level of Nitric Oxide (NO) and Matrix-metallopeptidase-9 (MMP-9) significantly decreased. Moreover, to determine the expression level of pro-inflammatory cytokines such as Tumor Necrosis Factor ($TNF-{\alpha}$) and Interleukin-6 (IL-6) and the phosphorylation pattern of signaling molecules of mitogen-activated protein kinase (MAPK) family, we performed ELISA and westren blot in Raw264.7 cells. In addition, nuclear factor-kappa B ($NF-{\kappa}B$) pathway was confirmed. PF extract inhibited the production of $TNF-{\alpha}$ and IL-6. The extract suppressed the phosphorylation of ERK1/2, JNK, and p38 MAPK, and the nuclear translocation of $NF-{\kappa}B$ p65 in activated cells. Our results suggest that PF can be used as a potential therapeutic agent or functional food to relieve inflammation.

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Temperature Regulates Melanin Synthesis in Melanocytes

  • Kim, Dong-Seok;Park, Seo-Hyoung;Kwon, Sun-Bang;Joo, Young-Hyun;Youn, Sang-Woong;Sohn, Uy-Dong;Park, Kyoung-Chan
    • Archives of Pharmacal Research
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    • 제26권10호
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    • pp.840-845
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    • 2003
  • Temperature change is one of the major environmental factors that influence the human skin. However, the relationship between temperature and melanogenesis has received little attention. In the present study, we investigated the effects of temperature change on melanogenesis in a mouse melanocyte cell line (Mel-Ab), and primary cultured human melanocytes. We found that Mel-Ab cells cultured at low temperatures (31 and 34$^{\circ}C$) produce less melanin than cells at 37$^{\circ}C$. These results were confirmed by experiments upon human melanocytes, demonstrating that the hypopigmenting effect of low temperatures is not cell type dependent. The observed melanin production was found to be accompanied by tyrosinase activity at each temperature, indicating that tyrosinase activity is regulated by temperature. We further examined whether the incubation period at low temperatures plays an important role in the regulation of melanogenesis. Short exposures to 27$^{\circ}C$ for 1 h or 3 h did not affect tyrosinase activity or melanin synthesis, whereas long exposures to 31$^{\circ}C$ for 2 days or 6 days significantly reduced tyrosinase activity and melanin synthesis in a duration-dependent manner. Our results suggest that exposure to low temperature and the duration of this exposure are important regulators of melanogenesis.

In vitro assay for osteoinductive activity of different demineralized freeze-dried bone allograft

  • Vaziri, Shahram;Vahabi, Surena;Torshabi, Maryam;Hematzadeh, Somayeh
    • Journal of Periodontal and Implant Science
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    • 제42권6호
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    • pp.224-230
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    • 2012
  • Purpose: Various bone graft materials have been used for periodontal tissue regeneration. Demineralized freeze-dried bone allograft (DFDBA) is a widely used bone substitute. The current widespread use of DFDBA is based on its potential osteoinductive ability. Due to the lack of verifiable data, the purpose of this study was to assess the osteoinductive activity of different DFDBAs in vitro. Methods: Sarcoma osteogenic (SaOS-2) cells (human osteoblast-like cells) were exposed to 8 mg/mL and 16 mg/mL concentrations of three commercial types of DFDBA: Osseo+, AlloOss, and Cenobone. The effect of these materials on cell proliferation was determined using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay. The osteoinductive ability was evaluated using alizarin red staining, and the results were confirmed by evaluating osteogenic gene expression using reverse transcription polymerase chain reaction (RT-PCR). Results: In the SaOS-2 cells, an 8 mg/mL concentration of Osseo+ and Cenobone significantly increased cell proliferation in 48 hours after exposure (P<0.001); however, in these two bone materials, the proliferation of cells was significantly decreased after 48 hours of exposure with a 16 mg/mL concentration (P<0.001). The alizarin red staining results demonstrated that the 16 mg/mL concentration of all three tested DFDBA induced complete morphologic differentiation and mineralized nodule production of the SaOS-2 cells. The RT-PCR results revealed osteopontin gene expression at a 16 mg/mL concentration of all three test groups, but not at an 8 mg/mL concentration. Conclusions: These commercial types of DFDBA are capable of decreasing proliferation and increasing osteogenic differentiation of the SaOS-2 cell line and have osteoinductive activity in vitro.

터렛 위치에 따른 FPSO 거동 및 계류시스템 특성에 대한 실험 연구 (Experimental Study on Motion of FPSO and Characteristics of Mooring System according to Turret Position)

  • 이동엽;홍장표;조석규;김윤호;성홍근;서장훈;김대웅;김병우;서용석
    • 한국해양공학회지
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    • 제29권2호
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    • pp.143-153
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    • 2015
  • This paper presents the results of an experimental study on the motion of an FPSO (Floating production storage and off-loading) and the characteristics of the mooring systejavascript:confirm_mark('abe', '1');m according to the turret position. Model tests of a turret-moored FPSO were carried out in the Ocean Engineering basin of KRISO. The FPSO was moored using an internal turret and catenary mooring. The models (1/60 scale) that were prepared included the FPSO, turret, and mooring lines. The experiments were conducted in irregular waves and combined environments, with waves, currents, and winds. A time-domain simulation was performed using OrcaFlex. The motion response and mooring line tension from the present calculations were compared with the results of experiments, and the agreement was fairly good. In addition, the results showed that the weathervaning stability was improved when the position of the turret was moved in the bow direction.

진공에서 소성 가능한 프릿을 이용한 평판디스플레이 진공실장기술 (Vacuum Sealing Technology of the Flat Panel Display by using the Frit Glass Heatable in Vacuum)

  • 권상직;유인상
    • 한국전기전자재료학회논문지
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    • 제29권3호
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    • pp.181-185
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    • 2016
  • One of the important issues for fabricating the microelectronic display devices such as FED, PDP, and VFD is to obtain a high vacuum level inside the panel. In addition, sustaining the initial high vacuum level permanently is also very important. In the conventional packing technology using a tabulation method, it is not possible to obtain a satisfiable vacuum level for a proper operation. In case of FED, the poor vacuum level results in the increase of operating voltage for electron emission from field emitter tips and an arcing problem, resultantly shortening a life time. Furthermore, the reduction of a sealing process time in the PDP production is very important in respect of commercial product. The most probable method for obtaining the initial high vacuum level inside the space with such a miniature and complex geometry is a vacuum in-line sealing which seals two glass plates within a high vacuum chamber. The critical solution for the vacuum sealing is to develop a frit glass to avoid the bubbling or crack problems during the sealing process at high temperature of about $400^{\circ}C$ under the vacuum environment. In this study, the suitable frit power was developed using a mixture of vitreous and crystalline type frit powders, and a vacuum sealed CNT FED with 2 inch diagonal size was fabricated and successfully operated.

애견복 원형 개발에 관한 연구 (A study on the Development on the Basic Pattern for Pet Dog's Wear)

  • 정화숙;문명옥
    • 한국의류산업학회지
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    • 제8권1호
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    • pp.99-106
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    • 2006
  • With the growing interest in pet dogs and pet dog's wear I used this study to compare and analyze the pattern used by each supplier and developed a new pattern for pet dogs' wear which is appropriate for pet dogs' body lines and movement. Test subjects were 91 pet dogs in Busan and after comparing 3 patterns from different suppliers, I developed the pattern reflecting pet dogs' body shapes and movement. Results are as follows; 1) As a result of analyzing measurements, it was found that pet dogs motion in walking on four feet, is different from that of people on two feet. For center measurements, their waist to bust length is longer than their waist to back length. The result of analysis shows that bust circumference impacts most other measurement results and it seems that better results are achieved if the bust line is taken into consideration when measuring bust back length, bust front length, neck base circumference, front leg arc, the length between lateral shoulder etc. 2) As a result of comparing suppliers' patterns, it was discovered that each supplier has different sizes for the same patterns and those sizes are not standardized across the board. Even if the same size of pattern was actually used in the production of pet dogs' wear by the individual companies, there were many variations in size for each item. 3) To develop a more standard pattern of pet dogs' wear, I collected and analyzed 3 patterns from each supplier and designed a new pattern, revising it three times. After test-wearing of the experimental pattern and the studied patterns, and comparing and analyzing the results, the studied pattern had similarly better estimation than the experimental one.

건설산업에서의 Supply Chain Management 교육 프로그램 개발 방안 연구 (Development of Supply Chain Management Education Programs for the Construction Industry)

  • 이태식;박은수;이동욱
    • 대한토목학회논문집
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    • 제31권2D호
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    • pp.275-284
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    • 2011
  • Supply Chain Management는 제조업에서 부가가치의 60~70%가 제조과정 외부의 Supply Chain(공급체인망) 상에서 발생하는 특성을 가지고 있다. 여기에 기업 간의 경쟁이 치열해짐에 따라 효율적인 프로세스 형성을 위해 비용 및 공정 개선을 위한 노력이 선행되고 있으며, 고객지향, 고객만족, 시장요구에 대한 적응을 위해 공급체인의 혁신을 위한 중요성이 강조되고 있다. 그러나 현 건설산업에서는 협력업체와의 계급적인 구조 문제와 협력업체와의 관계 개선을 위한 의식부족 등으로 인해 SCM의 적용에 많은 어려움이 있다. 건설산업에서도 제조업과 마찬가지로 일부특성상의 상이점이 있지만, SCM의 적용을 통해 건설산업에서의 효율적인 업무 프로세스 개선을 위한 다양한 SCM 연계활동이 가능할 것으로 판단된다. 따라서 본 연구를 통해 건설산업 분야에서의 SCM 전문 교육 프로그램의 개발을 통해 건설 SCM 전문가의 육성과 함께 건설 SCM의 적용을 위한 활성화가 이루어질 수 있는 기틀을 마련하고자 한다.

자동차 ALC에 대응하는 Job Shop의 동기화 생산시스템에 관한 연구

  • 권보식;김경섭
    • 한국시뮬레이션학회:학술대회논문집
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    • 한국시뮬레이션학회 1997년도 춘계 학술대회 발표집
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    • pp.100-100
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    • 1997
  • 본 연구에서는 우리 자동차산업이 직면한 총체적인 위기상황을 극복하기 위한 방 안으로, 자동차 생산방식의 변혁, 인적자원관리의 혁신을 통한 생산성 제고, 독자 기술개발 능력의 조기확보, 효율적인 부품조달체제의 형성 등 산업전반에 걸친 혁신으로, 내적인 경 쟁력을 축적함과 동시에, 지역주의화의 진전에 따른 수출 여건의 악화를 극복하기 위해 선 진권 및 개발도상국으로의 현지화 노력이 적극적으로 추진되지 않으면 안될, 중대한 시점에 와 있다고 진단하면서, 본 연구의 목적을, 생산현장을 중심으로 한 내적 경쟁력 확보로 정 의하고, 그 실현방안으로서, 급변하는 시장환경에 적극 대응하기 위한 생산방식의 도입과, 이를 지원하는 생산정보시스템의 구축 모델을 제시하고자 한다. 첫 번째는, 변화가 급격한 시장환경에 적극 대응하는 생산방식의 도입으로, 철저한 낭비 배제 사상 - 생산현장의 낭비 소요를 배제(개선)하는 것만이 아니라 배제하고 바로 체계를 바꾸어 (개혁) 원래의 상태로 되돌아가지 않도록 하는 -을 기본으로, 정보, 관리, 생산, 제품, 물류 등에 관련된 손실 비 용을 감축시킴으로서 원가를 낮추고, 고객이 요구하는 다양하고, 좋은 품질이 제품을 신속 히 공급할 수 있는 체계를 갖추는 것이다. 이러한 낭비 배제 사상은 생산현장에서 필요한 것을, 필요한 때에, 필요한 만큼 만들고 운반하며 전달하는 관리 개선 등을 의미하며, 이것 을 적은 인원 및 설비로 최대한 빨리 (리드 타임의 단축), 계획대로 수행하도록 하는 것이 동기화 생산방식이다. 따라서, 본 연구에서는 자동차 생산공정 중 주 조립공정의 ALC(Assembly Line Control)에 대응하여, 선행 공정으로서 부품을 공급하는 Job Shop의 동기화 생산방식을 실제 적용한 사례 중심으로 전개하고자 한다. 두 번째의 접근방식은, 동 기화 생산방식에 컴퓨터 통합생산 (CIM, Computer Integrated Manufacturing)의 기술을 구 현, 적용하는 것이다. 즉, 동기화 생산 시스템 (SPS, Syncronized Production Sytem)을 구 축하는 것인데, 이것은 최신의 컴퓨터 기술을 생산현장에 적용함으로써 새로운 생산방식의 혁신에 버금가는 기술혁신이라 할 수 있을 것이다. 따라서, 이러한 접근은 컴퓨터 및 통신 기술의 눈부신 발전을 기초로 가능해진 것인데, 제조업에서의 심각한 고비용, 저효율 문제 를 해결하기 위해 필수적으로 도입해야만 하는 실정이다. 또한 소비자의 다양한 요구로 인 하여 제품의 종류와 사양면에서 심한 변동을 보이는 시장 수요에, 신속한 정보처리로 대응 하는데도 크게 기여하고 있다. 이에 본 연구에서는, 자동차 Job Shop의 동기화 생산방식을 지원하는 동기화 생산시스템의 구축 모델을 제시하고자 한다.

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사출성형 공정에서의 통합정비방법에 관한 연구 (An Integrated Maintenance in Injection Molding Processes)

  • 박철순;문덕희;성홍석;송준엽;정종윤
    • 산업경영시스템학회지
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    • 제38권3호
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    • pp.100-107
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    • 2015
  • Recently as the manufacturers want competitiveness in dynamically changing environment, they are trying a lot of efforts to be efficient with their production systems, which may be achieved by diminishing unplanned operation stops. The operation stops and maintenance cost are known to be significantly decreased by adopting proper maintenance strategy. Therefore, the manufacturers were more getting interested in scheduling of exact maintenance scheduling to keep smooth operation and prevent unexpected stops. In this paper, we proposedan integrated maintenance approach in injection molding manufacturing line. It consists of predictive and preventive maintenance approach. The predictive maintenance uses the statistical process control technique with the real-time data and the preventive maintenance is based on the checking period of machine components or equipment. For the predictive maintenance approach, firstly, we identified components or equipment that are required maintenance, and then machine parameters that are related with the identified components or equipment. Second, we performed regression analysis to select the machine parameters that affect the quality of the manufactured products and are significant to the quality of the products. By this analysis, we can exclude the insignificant parameters from monitoring parameters and focus on the significant parameters. Third, we developed the statistical prediction models for the selected machine parameters. Current models include regression, exponential smoothing and so on. We used these models to decide abnormal patternand to schedule maintenance. Finally, for other components or equipment which is not covered by predictive approach, we adoptedpreventive maintenance approach. To show feasibility we developed an integrated maintenance support system in LabView Watchdog Agent and SQL Server environment and validated our proposed methodology with experimental data.