• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2014년도 추계학술대회
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• pp.690-692
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• 2014

기존의 학교현장에서의 단방향 주입식 교육은 학습자의 학습 흥미와 몰입감, 학습능률이 매우 떨어지는 단점을 가지고 있고 집단지성, 협력학습에 한계를 드러내고 있다. 학생들의 자발적인 학습참여를 유도하여 자기주도적인 학습을 통한 학습효과를 높일 수 있는 수단으로 근거리 통신을 활용한 교육콘텐츠 서비스 플랫폼이 요구되고 있다. 본 연구는 IoT(Internet of Things) 기반의 근거리 통신기술인 블루투스를 이용해 교사음성과 교수학습이 전자칠판(Interactive White Board)과 통신하고, NFC 기술을 이용해 학생들의 개인 강의노트 콘텐츠를 재생성하여 빅데이터화 되고 학생 간 공유가 가능해짐으로써 질 좋은 교육 콘텐츠를 생성하는 스마트 스쿨에 걸맞는 교육콘텐츠 제작시스템 기술을 연구하였다.

• 대한설비관리학회지
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• 제23권4호
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• pp.5-19
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• 2018

Recently, utilizing the supply chain among companies, major companies support their sub-vendors to establish an environmental management system and transfer the clean production technology(know-how) to them for strengthening of environmental competitiveness. Thus, Green Supply Chain Management(GSCM) became a key successful factor for companies to be environmentally sustainable. This research endeavors to identify the relationship among the inside and outside GSCM implementation activities of Korean manufacturing companies and their financial, operational and environmental performances. Based on a the review of previous research findings, twenty one hypotheses are developed and examined. Total 251 valid responses from 1,634 survey responses are identified and the structural equation models(SEM) are developed and analysed for examining our hypotheses. The result shows that inside GSCM has a positive effect on outside GSCM. Also, it reveals that companies' performances are more positively affected by inside GSCM than by outside GSCM.

• 실천공학교육논문지
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• 제13권3호
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• pp.497-505
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• 2021

재료의 변형률과 진동 측정을 실습하기 위한 외팔보 형태의 실험 장치를 개발하였다. 주변에서 구할 수 있는 재료와 저렴한 제어기를 사용하여 제작하였다. 철재 자로 된 외팔보에 서로 다른 위치에 변형률게이지를 설치하여 외부 하중에 따른 보의 변형률을 측정할 수 있도록 구성하였다. 전자석으로 외팔보를 가진하며, 함수발생기로 원하는 주파수로 외팔보에 진동이 발생하도록 하였다. 장치를 사용하여 수행이 가능한 세 가지 실험을 제시하였으며, 각각 저울 만들기 시험, 외팔보의 공진주파수 측정 실험, 그리고 가진주파수와 측정 주파수의 차이를 구하는 실험이다. 간단하면서도 저렴하게 만들 수 있는 실험 장치와 실험 포트폴리오를 통해 효과적인 하중 및 진동 측정 교육 수행이 가능할 것으로 기대된다.

• International journal of advanced smart convergence
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• 제12권3호
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• pp.149-156
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• 2023

Joint research on software, electronic engineering, computer engineering, and financial engineering and the use of ICT knowledge through network formation play an important role in strengthening science and technology-based innovation capabilities and facilitating the development and production process of products using new technologies. For the purpose of this study, I would like to strategically propose ICT specialized education in the 4th industrial revolution. To this end, the ICT specialization model, ICT specialization strategy analysis, and ICT specialization operation and effect were explored to establish ICT specialization strategies centered on software, electronic engineering, computer engineering, and financial engineering in the era of super-intelligence, hyper-connected, and hyper-convergence. Secondly, a roadmap for detailed promotion tasks related to efficient ICT characterization based on core strategies, detailed promotion tasks, and programs was proposed, focusing on talent related to ICT characterization. Thirdly, we would like to propose a reorganization of the academic structure and organization related to ICT characterization. Finally, we would like to propose the establishment of a future-oriented education system related to ICT specialization based on the advanced education and research environment.

• Journal of Veterinary Science
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• 제24권3호
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• pp.42.1-42.6
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• 2023

Lumpy skin disease (LSD) is one of the most important emerging transboundary diseases. Recently, LSD has emerged in many countries in the northern hemisphere. The LSD virus has a huge genome and is highly resistant to environmental conditions. The virus is also host-specific and large ruminants, such as cattle and domestic water buffalo, are particularly susceptible. In addition, wild ruminants can serve as potential reservoirs for spreading the LSD virus. The emergence might be related to climate change in various regions because LSD is an arthropod-borne infectious disease. This disease causes enormous economic losses, such as leather damage, decreased milk production, abortion, and death in infected ruminants. The economic importance of LSD in the bovine industry has forced countries to develop and implement control strategies against the disease. With the recent global spread and the economic impact, LSD will be discussed intensively. In addition, effective preventive measures are suggested based on the presence or absence of LSD outbreaks.

• Elastomers and Composites
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• 제58권4호
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• pp.208-215
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• 2023

In this study, the properties of polyurethane-polydimethylsiloxane (PU-PDMS) hybrid foams containing different types and contents of physical blowing agents (PBAs) were investigated. Two types of blowing agents, namely physical blowing agents and thermally expandable microspheres (TEM), were applied. The apparent density was measured using precisely cut foam samples, and the pore size was measured using image software. In addition, the microstructure of the foam was confirmed via scanning electron microscopy and transmission electron microscopy. The thermal conductivities related to the microstructures of the different foams were compared. When 0.5 phr of the hydrocarbon-based PBA was added, the apparent density and pore size of the foam were minimal; however, the pore size was larger than that of neat foam. In contrast, the addition of 3 phr of TEM effectively reduced both the apparent density and pore size of the PBAs. The increase in resin viscosity owing to TEM could enhance bubble production stability, leading to the formation of more uniform and smaller pores. These results indicate that TEM is a highly efficient PBA that can be employed to decrease the weight and pore size of PU-PDMS hybrid foams.

• International journal of advanced smart convergence
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• 제12권4호
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• pp.268-276
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• 2023

The representative branch of ICT education is Arduino. However, there are various problems when teaching using Arduino. Arduino requires a complex understanding of hardware and software, and this can be perceived as a difficult course, especially for beginners who are not familiar with programming or electronics. Additionally, the process of connecting the pins of the Arduino board and components must be accurate, and even small mistakes can lead to project failure, which can reduce the learner's concentration and interest in learning Arduino. Existing Arduino learning content consists of text and images in 2D format, which has limitations in increasing student understanding and immersion. Therefore, in this paper analyzes the necessary conditions for sprouting 'growing kidney beans' in the first semester of the fourth grade of elementary school, and builds an automated experimental environment using Arduino. Augmented reality of the pin connection process was designed and produced to solve the difficulties when building an automation system using Arduino. After 3D modeling Arduino and components using 3D Max, animation was set, and augmented reality (AR) content was produced using Unity to provide learners with more intuitive and immersive learning content when learning Arduino. Augmented reality (AR)-based Arduino learning content production is expected to increase educational effects by improving the understanding and immersion of classes in ICT education using Arduino and inducing fun and interest in physical computing coding education.

• Journal of Plant Biotechnology
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• 제50권
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• pp.76-81
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• 2023

As cultured plant cells can grow in high oxidative stress conditions, they form an excellent system to study antioxidant mechanisms and the mass production of antioxidants. Oxidative stress is a major cause of damage in plants exposed to various types of environmental stress, including heavy metals, such as cadmium (Cd). Heavy metal accumulation can interfere with many cell functions and plant growth. To evaluate the contribution of oxidative stress to Cd-induced toxicity, cultured sweetpotato (Ipomoea batatas) cells were treated with increasing concentrations of Cd (0, 10, 25, and 50 μM) and cultured further. Cell growth was significantly inhibited by 25 and 50 μM of Cd, and the total protein content increased with 50 μM of Cd. Additionally, the activity of peroxidase (POD) and ascorbate peroxidase (APX), antioxidant enzymes that remove hydrogen peroxide (a reactive oxygen species), increased in the cells after treatment with 50 μM of Cd. The expression analysis of POD, APX, and peroxiredoxin (PRX) isolated from sweetpotato cultured cells in a previous study revealed the differential expression of POD in response to Cd. In this study, the expression levels of several acidic POD (swpa2, swpa3, and swpa4) and basal POD (swpb1, swpb2, and swpb3) genes were increased in Cd-treated cultured cells. These results indicate that Cd-mediated oxidative stress is closely linked to improved POD-mediated antioxidant defense capacity in sweetpotato suspension-cultured cells.

• Journal of Ginseng Research
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• 제46권6호
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• pp.738-749
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• 2022

Background: Ginseng possesses antitumor effects, and ginsenosides are considered to be one of its main active chemical components. Ginsenosides can further be hydrolyzed to generate secondary saponins, and 20(R)-panaxotriol is an important sapogenin of ginsenosides. We aimed to synthesize a new ginsengenin derivative from 20(R)-panaxotriol and investigate its antitumor activity in vivo and in vitro. Methods: Here, 20(R)-panaxotriol was selected as a precursor and was modified into its derivatives. The new products were characterized by ¹H-NMR, ¹³C-NMR and HR-MS and evaluated by molecular docking, MTT, luciferase reporter assay, western blotting, immunofluorescent staining, colony formation assay, EdU labeling and immunofluorescence, apoptosis assay, cells migration assay, transwell assay and in vivo antitumor activity assay. Results: The derivative with the best antitumor activity was identified as 6,12-dihydroxy-4,4,8,10,14-pentamethyl-17-(2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl(tert-butoxycarbonyl)glycinate (A11). The focus of this research was on the antitumor activity of the derivatives. The efficacy of the derivative A11 (IC₅₀ < 0.3 µM) was more than 100 times higher than that of 20(R)- panaxotriol (IC₅₀ > 30 µM). In addition, A11 inhibited the protein expression and nuclear accumulation of the hypoxia-inducible factor HIF-1α in HeLa cells under hypoxic conditions in a dose-dependent manner. Moreover, A11 dose-dependently inhibited the proliferation, migration, and invasion of HeLa cells, while promoting their apoptosis. Notably, the inhibition by A11 was more significant than that by 20(R)-panaxotriol (p < 0.01) in vivo. Conclusion: To our knowledge, this is the first study to report the production of derivative A11 from 20(R)-panaxotriol and its superior antitumor activity compared to its precursor. Moreover, derivative A11 can be used to further study and develop novel antitumor drugs.

• Asian-Australasian Journal of Animal Sciences
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• 제21권5호
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• pp.745-753
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• 2008

Gene-manipulated mice were discovered for the first time about a quarter century ago. Since then, numerous sophisticated technologies have been developed and applied to answer key questions about the fundamental roles of the genes of interest. Functional genomics can be characterized into gain-of-function and loss-of-function, which are called transgenic and knock-out studies, respectively. To make transgenic mice, the most widely used technique is the microinjection of transgene-containing vectors into the embryonic pronucleus. However, there are critical drawbacks: namely position effects, integration of unknown copies of a foreign gene, and instability of the foreign DNA within the host genome. To overcome these problems, the ROSA26 locus was used for the knock-in site of a transgene. Usage of this locus is discussed for the gain of function study as well as for several brilliant approaches such as conditional/inducible transgenic system, reproducible/inducible knockdown system, specific cell ablation by Cre-mediated expression of DTA, Cre-ERTM mice as a useful tool for temporal gene regulation, MORE mice as a germ line delete and site specific recombinase system. Techniques to make null mutant mice include complicated steps: vector design and construction, colony selection of embryonic stem (ES) cells, production of chimera mice, confirmation of germ line transmission, and so forth. It is tedious and labor intensive work and difficult to approach. Thus, it is not readily accessible by most researchers. In order to overcome such limitations, technical breakthroughs such as reporter knock-in and gene knock-out system, production of homozygous mutant ES cells from a single targeting vector, and production of mutant mice from tetraploid embryos are developed. With these upcoming progresses, it is important to consider how we could develop these systems further and expand to other animal models such as pigs and monkeys that have more physiological similarities to humans.