• Journal of the Korea Safety Management & Science
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• v.6 no.3
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• pp.65-75
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• 2004

Product liability is the law of the manufacturer's responsibilities for the consumers' personal injuries or the losses of property resulted from defective products. In today's many countries, the product liability law are being enacted because of the safety of product use and the protection of consumer's right. In korea, the product liability is going to enforce on July 1, 2002. Though the construction of product liability response system is urgent situation, domestic manufacture company's PL response system is not nearly prepared in present. Consequently, the purpose of this study is to discuss the Quality Management's importance and the PL countermeasures by presenting the difference of PL response system construction degree by the Quality Management Maturity degree

• Journal of the Korea Safety Management & Science
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• v.22 no.3
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• pp.9-14
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• 2020

A forklift accident occurs in the logisitcs center. there are many kinds of accidents such as a casualty accident or a minor accident, etc. there are many other causes of accident, including poor visibility and habitual operational mistakes The result of the accident is the phenomenon of cutting, falling, scratching of the product. In the case of minor accidents, workers do not report accidents, so the occurrence of accidents is unknown. The customer receives the goods and then notifies them that they are defective product. After the product is returned, we can see that the forklift accident caused the problem of the product The result of the late response affects the image of the enterprise. In this study, we recognized the need for safety education to prevent accidents and found out which of the education items could raise awareness of safety. As result of the study, disinfection and forklift maneuverability regarding speed were mentioned as the most important items in education.

• Journal of the Korea Safety Management & Science
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• v.21 no.3
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• pp.11-16
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• 2019

The latest issue is the smart factory. In order to implement this smart factory, the most fundamental element is to establish product specifications for factors affecting the product, obtain useful data to analyzed and predicted, and maintain safety. But most manufacturers have many errors. Therefore, the purpose of this study is to verify factors of product through statistical techniques and to study the process control and safety.

• IE interfaces
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• v.15 no.2
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• pp.133-146
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• 2002

In July 2002, law of product liability will be established in Korea. Therefore, prevention for product liability(PL) will be immediately needed for many companies. So, in this paper, following topics will be discussed: 1) what are product liability and product safety, 2) why they are needed, 3) why important, 4) what's the difference between considering PL and not considering PL for companies, 5 ) what are risk management methods and risk evaluation system, 6) what is SASA(Systematic Approach to Accident Scenario Analysis) method for applying PL, 7) providing a final conclusion and discussion for future PL law.

• Journal of the Korea Safety Management & Science
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• v.5 no.2
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• pp.111-127
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• 2003

In this paper, a new method of product function analysis is presented to categorize various design information generated in product development processes. In order to improve product functions, designers must understand unit functions and modified parts of products. The product function analysis (PFA) is based on the designer's understanding of product functions. The proposed PFA provides the methodology to classify the various functions systematically and understand the relation between functions easily. Using this approach, efficient design support system can be developed and used for designers to support decision-making with design knowledge.

• Journal of Korean Society for Quality Management
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• v.37 no.3
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• pp.83-93
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• 2009

This study proposes a stepwise approach to product safety management(PSM), of which roadmap consists of five phases. ISO 9001 QM model is assumed as the first-phase model and each higher-phase model is built by adding a corresponding module to the lower one. In the phase order, those modules are CCMS, a failure to warn, manufacturing defect and design defect. The progress in PSM of a domestic food company is discussed.

• Journal of the Korea Safety Management & Science
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• v.15 no.4
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• pp.179-184
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• 2013

An accident from machine work is often fatal to the worker. This accident is mostly preventable through perfect process jig. In case of this machine work, however, the disaster frequently occurred because of the design which is not considered the beginning of product design, post-process and mass process of production. As for sand casting method, this has the merits of the production; the product is easily produced by manual labor. On the other hand, this method has the demerits of a bigger dimensional error contrary to other mass process of production. When the sand casting product is in machine work, there are various problems such as unsafe fix and excessive cutting, product desorption and rapid life depreciation of equipment and tools. Considering the characteristics of sand casting method, it is accepted as difficulty to improve the problems. In this study, it suggests shell mold method for mold instead of the machine work after the sand casting of the circle shape container product. And the surface accomplishes the following average of surface roughness Ra$9.94{\mu}m$ of machine work with the casting of flask mold by shell mold method. In accordance with the simplification of processing process and reducing the average thickness variation by mass production of product with detailed appearance, it has a good influence on safety accident prevention caused by production and damaged product. It is confirmed that making higher degree of size precision of all machine work product is possible to increase the safety and productivity, reduce the processing process and improve environment.

• Journal of Microbiology and Biotechnology
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• v.29 no.1
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• pp.160-170
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• 2019

The lactic acid bacteria species Lactobacillus plantarum (L. plantarum) has been used extensively for vaccine delivery. Considering to the critical role of dendritic cells in stimulating host immune response, in this study, we constructed a novel CD11c-targeting L. plantarum strain with surface-displayed variable fragments of anti-CD11c, single-chain antibody (scFv-CD11c). The newly designed L. plantarum strain, named 409-aCD11c, could adhere and invade more efficiently to bone marrow-derived DCs (BMDCs) in vitro due to the specific interaction between scFv-CD11c and CD11c located on the surface of BMDCs. After incubation with BMDCs, the 409-aCD11c strain harboring a eukaryotic vector pValac-GFP could lead to more efficient expression of GFP compared with wild-type strains shown by flow cytometry analysis, indicating the enhanced translocation of pValac-GFP from L. plantarum to BMDCs. Similar results were also observed in an in vivo study, which showed that oral administration resulted in efficient expression of GFP in both Peyer's patches (PP) and mesenteric lymph nodes (MLNs) within 7 days after the last administration. In addition, the CD11c-targeting strain significantly promoted the differentiation and maturation of DCs, the differentiation of $IL-4^+$ and $IL-17A^+$ T helper (Th) cells in MLNs, as well as production of $B220^+$ $IgA^+$ B cells in the PP. In conclusion, this study developed a novel DC-targeting L. plantarum strain which could increase the ability to deliver eukaryotic expression plasmid to host cells, indicating a promising approach for vaccine study.

• Proceedings of the Safety Management and Science Conference
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• 2004.05a
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• pp.153-159
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• 2004

There are various types of PLM(product liability management) according to corporation management level. It is necessary to develop diagnostic methods and application systems for PLM as well as to establish an efficient PLM system. This paper aims to propose a PLM system which can be applied to product with high-reliability and high-safety, and diagnostic methods for PLM based on AHP, and also show an empirical application of the proposed PL management system for Auto Test Robot System of the Mobile Phone (EVT 4320).

• International Journal of Stem Cells
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• v.16 no.3
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• pp.281-292
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• 2023

Background and Objectives: Human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte (CM) hold great promise as a cellular source of CM for cardiac function restoration in ischemic heart disease. However, the use of animal-derived xenogeneic substances during the biomanufacturing of hiPSC-CM can induce inadvertent immune responses or chronic inflammation, followed by tumorigenicity. In this study, we aimed to reveal the effects of xenogeneic substances on the functional properties and potential immunogenicity of hiPSC-CM during differentiation, demonstrating the quality and safety of hiPSC-based cell therapy. Methods and Results: We successfully generated hiPSC-CM in the presence and absence of xenogeneic substances (xeno-containing (XC) and xeno-free (XF) conditions, respectively), and compared their characteristics, including the contractile functions and glycan profiles. Compared to XC-hiPSC-CM, XF-hiPSC-CM showed early onset of myocyte contractile beating and maturation, with a high expression of cardiac lineage-specific genes (ACTC1, TNNT2, and RYR2) by using MEA and RT-qPCR. We quantified N-glycolylneuraminic acid (Neu5Gc), a xenogeneic sialic acid, in hiPSC-CM using an indirect enzyme-linked immunosorbent assay and liquid chromatography-multiple reaction monitoring-mass spectrometry. Neu5Gc was incorporated into the glycans of hiPSC-CM during xeno-containing differentiation, whereas it was barely detected in XF-hiPSC-CM. Conclusions: To the best of our knowledge, this is the first study to show that the electrophysiological function and glycan profiles of hiPSC-CM can be affected by the presence of xenogeneic substances during their differentiation and maturation. To ensure quality control and safety in hiPSC-based cell therapy, xenogeneic substances should be excluded from the biomanufacturing process.