• BMB Reports
• /
• v.33 no.3
• /
• pp.268-275
• /
• 2000

In contrast to the pyrimidine (6-4)pyrimidone photoproduct [(6-4) adduct], its Dewar valence isomer (Dewar product) is low mutagenic and produces a broad range of mutations with a 42 % replicating error frequency. In order to determine the origin of the mutagenic property of the Dewar product, we used experimental NMR restraints and molecular dynamics to determine the solution structure of a Dewar·lesion DNA decamer duplex, which contains a mismatched base pair between the 3'-T residue and an opposed G residue. The 3'-T of the Dewar lesion forms stable hydrogen bonds with the opposite G residue. The helical bending and unwinding angles of the DW/GA duplex, however, are much higher than those of the DW/AA duplex. The stable hydrogen bonding of the G 15 residue does not increase the thermal stability of the overall helix. It also does not restore the distorted backbone conformation of the DNA helix that is caused by the forming of a Dewar lesion. These structural features implicate that no thermal stability, or conformational benefits of G over A opposite the 3'-T of the Dewar lesion, facilitate the preferential incorporation of an A. This is in accordance with the A rule during translesion replication and leads to the low frequent $3'-T{\rightarrow}C$ mutation at this site.

• International Journal of Automotive Technology
• /
• v.3 no.2
• /
• pp.47-52
• /
• 2002

The integration of CAD/CAM/CAE in product development is the key to realize concurrent engineering. Generally, different systems are employed in product development departments. These different systems create a lot of trout)toes such as difficulty in communication, misunderstanding and so on. A new approach to integrate CAD/CAM/CAE in one system based on CATIA thor the end-to-end process in cylinder head development is presented. Hulti Model Technology (MMT) is used to create consistent and associated CAD models for the end-to-end process in cylinder head development. The concept and method to create and organize multi models are discussed. A typical four-layer structure of HHT for mechanical products is defined. The multi level structure of the cylinder head models based on MMT is provided. The CAD models of cylinder head created based on MMT can be used as the consistent model. All models in the downstream of cylinder head development such as structure analysis, CFD, sand core design , casting simulation and so oil are associated with the CAD models. Practice shows the approach in this paper enables the development process to be carried concurrently and can obviously shorten time to the market, reduce product cost and improve product quality.

• The KIPS Transactions:PartA
• /
• v.18A no.3
• /
• pp.81-92
• /
• 2011

There has been a number of attempts to apply 3D CAD data created in the design stage of product life cycle to various applications of the other stages in related industries. But, 3D CAD data requires a large amount of computing resources for data processing, and it is not suitable for post applications such as distributed collaboration, marketing tool, or Interactive Electronic Technical Manual because of the design information security problem and the license cost. Therefore, various lightweight visualization formats and application systems have been suggested to overcome these problems. However, most of these lightweight formats are dependent on the companies or organizations which suggested them and cannot be shared with each other. In addition, product structure information is not represented along with the product geometric information. In this paper, we define a dataset called prod-X3D(Enhanced X3D Dataset for Web-based Visualization of 3D CAD Product Model) based on the international standard graphic format, X3D, which can represent the structure information as well as the geometry information of a product, and propose a translation method from 3D CAD data to an prod-X3D.

• Korean Journal of Computational Design and Engineering
• /
• v.16 no.3
• /
• pp.187-196
• /
• 2011

Generally, BOM (Bill of Material) means a part list which is needed to manufacture or assemble a product or part. During manufacturing processes, BOM is inevitably required for most of enterprise processes such as design, procurement, production planning/control, resource planning, and financial works. Every manufacturing industry uses many kinds of BOM's that are adjusted to the requirement of functions of their work division. Moreover, BOM evolves in different forms according to the product development phases such as conceptual design; function design, detail design, and production design because it is necessary to use different product structures to keep product data generated throughout the lifecycle of a product. This includes all data and information related to the all the product development phases. Shipbuilding works also are processed and controlled based on BOM. However, effective maintenance of ship outfitting BOM data is getting difficult as the amount and complexity of data have increased due to variety and long lifecycle of ship. For the effective management of outfitting BOM data, two aspects must be considered. One is how to classify numerous BOMs type and the others how to display BOMs. So this study suggests a method to classify BOM types and propose two categories - Structure BOM, Display BOM. Base on this result, we propose the integrated ship outfitting BOMs model and analysis outfitting BOMs.

• Proceedings of the Korea Society of Design Studies Conference
• /
• 2004.10a
• /
• pp.20-21
• /
• 2004

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2001.05a
• /
• pp.235-238
• /
• 2001

Milli-structure components are classified as a component group whose size is between macro and micro scales, that is, about less than 20mm and larger than 1mm. The forming of these components has a typical phenomenon of bulk deformation with thin sheets because of the forming size. In this study, milli-structure rectangular cup drawing is analyzed and measured using the finite element method and experiment. Generally, milli-structure containers or cases like cellular phone vibrator consist of rectangular-shaped drawing to save installation space. A systematic approach is established for the design and the experiment of the forming processes for rectangular milli-structure cases. To verify the simulation results, the experimental investigations were also carried out on a real industrial product. The numerical analysis by FEM shows good agreement with the experimental results in view of the deformation shape of the product.

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.18 no.4
• /
• pp.1-9
• /
• 2019

Most product structural components are assembled by various members and castings except casting products. In such cases, a particular structure is required to move and fix each component. In particular, the safety uncertainty of heavy product assemblies can be linked to large accidents. Thus, the safety design and evaluation of additional structures have become more important. In the field and factories, these additional structures are called handling structures, which are designed and manufactured. As the types of products produced become more diverse, the design and manufacture of a handling structure are also diversified. The results of each evaluation should be derived. We develop a logical design and evaluation method, which was previously designed based on empirical data, for the handling structure.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2005.06a
• /
• pp.1155-1158
• /
• 2005

Micro-stereolithography is a newly proposed technology as a means that can fabricate a 3D micro structure of free form. It makes a 3D micro-structure by dividing the shape into many slices of relevant thickness along horizontal surfaces, hardening each layer of slice with a focused laser beam, and stacking them up to a desired shape. However, we do not anticipate the electric conductivity of the final product at the existing micro-stereolithography. The reason is that this technology uses polymer to make the product. Thus the new suspension which was mixed conventional photopolymer with metal powder was developed in this study. The developed suspensions were based on SL5180 which is commercialized resin and IMS03 that is made in our laboratory. And Triton X-100 was added at the suspension for getting the scattering effect and stabilizing effect. The layer recoating device was developed to be flat the mixed high viscosity suspension. A 3D micro structure was manufactured by using recoating system and micro-stereolithography system. The fabricated product was sintered to get the electric conductivity. After sintering, a pure copper product was made. In this study, new process was developed by making metal micro structure having an electric conductivity. This technology broadened the realm of the micro-stereolithography technology. And it will be applied to make the 3D micro structure of free form which has a high hardness and an electric conductivity in the near future.

• Biomedical Science Letters
• /
• v.12 no.3
• /
• pp.281-287
• /
• 2006

Cigarette smoke causes atypical structure of pulmonary and oxidative damage. Therefore, we carried out to determine if exposure to cigarette smoke alters pulmonary structure and anti-oxidant related enzyme in a animal model, when natural product extracts using by Nebulizer. The rat were divided into four groups: $H_2O-treated$ (Control), natural product (Camellia sinensis) extracts-treated (CS), natural product extracts-treated with cigarette smoke-exposed (CS+SM) and cigarette smoke-expose (SM). All groups are similar to Control group in weight, but SM group is lower than the other groups. Microscopic image of the pulmonary structure in SM group showed deleterious alterations in the morphology, but the other groups are maintained in normal structure. In anti-oxidant related enzymes, SOD (superoxide dismutase) and catalase, SM group represents the lowest enzyme activity among all groups. But G6PD (glucose-6-phosphate dehydrogenase) and LPO (lipid peroxidation) is SM group represents the highest enzyme activity among all groups. These result indicate that the natural product extracts is an efficient tissue protective substance against smoke-induced lung injury.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.41 no.4
• /
• pp.279-289
• /
• 2017

This paper presents some of the methods used to incorporate the parts constituting a product. A new relation function concept and its structure are introduced to analyze the relationships of component parts. This relation function has three types of information, which can be used to establish a relation function structure. The relation function structure of the analysis criteria was established to analyze and present the data. The priority components determined by the analysis criteria can be integrated. The analysis criteria were divided based on their number and orientation, as well as their direct or indirect characteristic feature. This paper presents a design algorithm for component integration. This algorithm was applied to actual products, and the components inside the product were integrated. Therefore, the proposed algorithm was used to conduct research to improve the brake discs for bicycles. As a result, an improved product similar to the related function structure was actually created.