• Proceedings of the Korean Nuclear Society Conference
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• 1996.05b
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• pp.637-642
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• 1996

This paper presents the analysis results for the core degradation processes and the fission product release of the PHEBUS FPT0 experiment using MELCOR1.8.3. The objective of this study is to assess models associated with the core damage and fission product behavior in MELCOR. The calculation results were much improved through sensitivity studies. Thermal/hydraulic behavior in the core and the circuit was well predicted under the intact core geometry. In non-eutectic model case. the UO$_2$ dissolution model in the MELCOR always showed such a tendency that the resulting dissolved UO$_2$ mass was small at the highly oxidized condition due to the model logic. Total H$_2$ generation mass was underpredicted because the stiffner was not modeled and the liner in the shroud was not allowed to be oxidized in MELCOR. Some difficulties were found in modeling the activation product were solved by manipulating the RN input associated with the initial fission product inventory. These problem were occurred because there are no control rod model in MELCOR. Generally the fission product release ratio showed a similar trend compared with the measured data except the activation product. which have no model to simulate in MELCOR.

• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.323-329
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• 1997

Ipriflavone is non-hormonal antiosteoporotic drug which inhibits bone resorption by reducing recruitment and/or differentiation of osteoclasts, and stimulates proliferation and differentiation of osteoblast, and also enhances calcitonin secretion in the presence of estrogen. Although some kinds of immediately-released preparation of ipriflavone are available in commercial market, in present study, we tried to formulate sustained-release tablet using coating method with hydrophobic and hydrophilic coating materials. In vitro dissolution test was applied to evaluate sustained-release patterns of several test preparations (Test tablet A, B and C) designed using different preparation method or different compositions. From the results of dissolution test, test tablet A which showed suitable dissolution profile was selected as the candidate of new product. Pharmacokinetic evaluation of test drug, ipriflavone sustained-release tablets, was conducted in 6 beagle dogs weighing $11.5{\pm}0.5\;Kg$ compared with $Theobon^{\circledR}$ tablet, immediately-released tablet (Kukjae Pharm. Co.) as reference drug. Two products were randomly administered to 6 beagle dogs, and after 1 week, cross-over study was conducted. From the present study, AUC and $T_{max}$ of test product were significantly different from those of reference product (p<0.05), respectively$(AUC\;:\;3646.28{\pm}472.56\;vs\;3646.28{\pm}472.56\;ng{\cdot}hr/ml,\;T_{max}\;:\;4.33{\pm}1.03\;vs\;1.42{\pm}0.38\;hr)$. But $C_{max}$ was not significantly different between two products (p>0.05) $(\;512.52{\pm}48.18\;vs\;443.97{\pm}140.53\;ng/ml)$. From the results of pharmacokinetic evaluations, it was noted that absorption amount of test product was increased, but absorption rate was delayed and $C_{max}$ of two products were not changed. And it was concluded that redesign of the sustained-release preparation which has a lower content of iprifavone rather than test tablet A must be considered.

• Journal of Distribution Science
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• v.13 no.8
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• pp.81-90
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• 2015

Purpose - To vitalize a market or develop a new one, companies frequently release new products into the market, often by shortening the time to market, called the release period. This research aims to investigate the purchase intention behavior of consumers in terms of buying new products at the time of product release based on the release speed. Research Design, Data, and Methodology - The research reviews the influence of relative advantage, complexity, and compatibility among innovative attributes of new products, as proposed by Rogers. Moreover, it examines the moderating effect of the innovative new product attributes in terms of speed of obsolescence of old products and how that influences consumer purchase behavior. Additionally, this study tests the research hypotheses using empirical analysis. Results - The analysis demonstrated that the relative predominance (H1) and suitability (H3) of new products had a statistically significant positive influence on new product purchase intention. However, the complexity (H2) of new products had a statistically significant positive influence on new product purchase intention in contrast to its predicted sign (-). The results of the moderating effect of the old product use period were as follows. H4-1 was not supported since the difference between the path coefficients of the group with the low level old product use period and the group with the high level, represented by the relationship of relative predominance and new product purchase intention, was not statistically significant. H5-1 was also not supported since the difference between the path coefficients of the group with the low level of old product use period and the group with the high level, represented by the relationship of complexity and new product purchase intention, was not statistically significant. However, H4-2 was supported since the difference between the path coefficients of the group with the low level of old product use frequency and the group with the high level, represented by the relationship of relative advantage and new product purchase intention was statistically significant. H5-2 was not supported since the difference between the path coefficients of the group with the low level of old product use frequency and the group with the high level, represented by the relationship of complexity and new product purchase intention, was not statistically significant. H6-2 was also not supported since the difference between the path coefficients of the group with the low level of old product use frequency and the group with the high level, represented by the relationship of compatibility and new product purchase intention, was not statistically significant. Conclusion - According to the results, only H4-2 among the hypotheses on the moderating effect of the old product use period and use frequency was statistically significant. Future research should focus on carrying out a detailed review of the hypothesis on the moderating effect of the old product usage period and frequency, find the cause, and connect this to potential new research.

• Journal of the Korean Wood Science and Technology
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• v.51 no.5
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• pp.410-418
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• 2023

In this study, the combustion characteristics of the Tulip tree, which is the representative broad-leaved afforestation tree in Korea, were analyzed. The flame retardant performance of the Tulip tree was analyzed by analyzing combustion characteristics on a total of three test samples; flame retardant treated, both flame retardant and oil stain-treated, and untreated. Then the flame retardance grade was classified for each of them. According to the result, test samples showed the strongest flame retardance were in order of flame retardant treated (C), both flame retardant and oil stain-treated (B), and untreated (A). As a result of analyzing the total heat emission and maximum heat emission rates, which is the evaluation standard for interior materials of Korean domestic buildings, test samples with flame retardant treat or flame retardant and oil stain treat were qualified for the flame-retardant standard. Both flame retardant and oil stain-treated samples showed higher total heat release (THR) and heat release rate compared to flame retardant-treated samples as the oil causes combustion with oxygen. On the other hand, they didn't qualify the THR in Quasi-non-combustible standards. To determine the correlation between the physical and combustion characteristics of wood, the combustion characteristics of other diffuse porous wood species, with which the Tulip tree is affiliated were analyzed, and noticed that the characteristic correlates with the density and quantity of wood. The results of this study are expected to be used as basic information on the combustion characteristics of the Tulip tree.

• Nuclear Engineering and Technology
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• v.49 no.8
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• pp.1575-1588
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• 2017

In order to develop a domestic research roadmap for severe accidents, a special committee was established by the Korean Nuclear Society. One of the subcommittees discussed the characteristics and the relevant technical issues in the stages of fission product release and physical forms of radionuclide release and transport. The group members developed a tree to identify fission product release phenomena by tracing failures of individual defense-in-depth barriers and added possible countermeasures against failure. For each elemental issue, they searched for technical problems by examining the phenomena, accident management actions, and regulatory aspects relevant to the mitigation features for containment, including mitigation strategies against containment bypass accidents. Regulatory concerns, including the source term and the acceptance criteria for radionuclide release, were also considered. They identified further research needs regarding important technical issues based on the degree of the current knowledge level in Korea and in foreign countries, looking at the significance and urgency of issues and the expected research period required to reach an advanced level of knowledge. As a result, the group identified the 12 most important and urgent issues, most of which were expected to require mid-term and long-term research periods.

• Food Science and Industry
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• v.50 no.2
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• pp.27-36
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• 2017

Today, the food packaging industry has a great interest in using active packaging to fresh food product as a solution for the future to positively provide its quality, safety and shelf life. Many researches have extensively studied functional packaging strategies in recently years. Controlled release packaging (CRP) is an innovative packaging technology in the packaging polymer matrix from which can active agents are delivered in a controlled way into the product. CRP technology is well-suited for controlling release of antimicrobial compounds and antioxidants to prevent food degradation reactions such as microbial growth and lipid oxidation. Advances in CRP technology allow food packaging manufacturers to challenge the development of better functional food packaging systems. This overview examines the most recent developments and technologies of active packaging for applying the food industry. The scope of this article has mainly been focused on controlled releasing systems.

• Animal Bioscience
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• v.35 no.2
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• pp.260-271
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• 2022

Objective: We aimed to investigate the effect of the differing amino acid (AA) release dynamics of two protein sources on the growth performance, nitrogen deposition, plasma biochemical parameters, and muscle synthesis and degradation of piglets when included in their diets at normal and low concentrations. Methods: Forty-eight piglets (Duroc×Landrace×Large White) with initial body weight of 7.45±0.58 kg were assigned to six groups and fed one of 6 diets. The 6 dietary treatments were arranged by 3×2 factorial with 3 protein sources and 2 dietary protein levels. They are NCAS (a normal protein content with casein), NBlend (a normal protein content with blend of casein and corn gluten meal), NCGM (a normal protein content with corn gluten meal), LCAS (a low protein content with casein), LBlend (a low protein content with blend of casein and corn gluten meal), LCGM (a low protein content with corn gluten meal). The release dynamics of AA in these diets were determined by in vitro digestion. The digestibility, utilization and biological value of nitrogen in piglets were determined by micro Kjeldahl method. Plasma insulin was measured by enzyme-linked immunosorbent assay kits. The protein expression of mediators of muscle synthesis and degradation was determined by western blotting. Results: Although the consumption of a low-protein diet supplemented with crystalline AA was associated with greater nitrogen digestion and utilization (p<0.05), the final body weight, growth performance, nitrogen deposition, and phosphorylation of ribosomal protein S6 kinase 1 and eIF4E binding protein 1 in the muscle of pigs in the low-protein diet-fed groups were lower than those of the normal-protein diet-fed groups (p<0.05) because of the absence of non-essential AA. Because of the more balanced release of AA, the casein (CAS) and Blend-fed groups showed superior growth performance, final body weight and nitrogen deposition, and lower expression of muscle ring finger 1 and muscle atrophy F-box than the CGM-fed groups (p<0.05). Conclusion: We conclude that the balanced release of AA from CAS containing diets and mixed diets could reduce muscle degradation, favor nitrogen retention, % intake and improve growth performance in pigs consuming either a normal- or low-protein diet.

• Proceedings of the KWS Conference
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• 2002.10a
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• pp.372-377
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• 2002

Residual stress by welding should be reduced because that decreases the reliability on strength of welded structure. The reason is that the total stiffness of structure decreases by non-linear behavior of weldment under external load. The release of residual stress by mechanical loading and unloading is often performed in the fabrication of box structure for steel bridge. The proper degree of loading and unloading is significant at release method of residual stress by mechanical loading because that degree is changed by material and geometric shape of welded structure. Therefore, the simulation model that could exactly analyze the release of residual stress by mechanical loading is to be necessary. This simulation model should be established on the based of variable and accurate measurement data. In this study, the non-linear behavior of weldments under external loading and unloading, such as the decrease and increase of structure stiffness, was investigated by monitoring of nominal stress and strain. Tensile loading and unloading test under variable load was performed and the proper degree of stress relaxation was measured by sectioning technique using strain gauge.

• International Journal of Korean Welding Society
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• v.2 no.1
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• pp.40-44
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• 2002

Residual stress by welding should be reduced because that decreases the reliability on strength of welded structure. The reason is that the total stiffness of structure decreases by non-linear behavior of weldment under external load. The release of residual stress by mechanical loading and unloading is often performed in the fabrication of box structure for steel bridge. The proper degree of loading and unloading is significant at release method of residual stress by mechanical loading because that degree is changed by material and geometric shape of welded structure. Therefore, the simulation model that could exactly analyze the release of residual stress by mechanical loading is to be necessary. This simulation model should be established on the based of variable and accurate measurement data. In this study, the non-linear behavior of weldments under external loading and unloading, such as the decrease and increase of structure stiffness, was investigated by monitoring of nominal stress and strain. Tensile loading and unloading test under variable load was performed and the proper degree of stress relaxation was measured by sectioning technique using strain gauge.

• Journal of Korean Dental Science
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• v.14 no.2
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• pp.51-60
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• 2021

Purpose: Measuring viability of a three-dimensional in vitro organotypic human oral tissue model has been suggested as an alternative test method to the oral mucosa irritation test of oral care products. The aim of this study was to investigate the production of two different cytokines using organotypic human oral tissue model following exposure to chemicals that are commonly used in oral care products. Materials and Methods: The organotypic human oral tissues were exposed to ethanol, sodium lauryl sulphate or hydrogen peroxide for 90 minutes. Following exposure, interleukin (IL)-1α and IL-8 productions were assessed and correlated with cell viability testing as well as histology of the organotypic human oral tissues. Result: High levels of IL-8 were released from organotypic human oral tissues in all of the test and control groups without any significant differences between them. In contrast, differences were found in IL-1α release between the test and control groups. Additionally, the trend of IL-1α release corresponded to the phenotypes observed in histological analysis while different trend existed between IL-1α release and cell viability. Conclusion: The study concluded the non-specific release of IL-8 for the assessment of oral care product chemicals' toxicity, while potential of measuring IL-1α cytokine level as the possible alternative test method.