• 한국산학기술학회논문지
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• 제8권6호
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• pp.1491-1495
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• 2007

디지털카메라와 고속 인쇄기의 보급으로 디지털 사진을 촬영하고 인화하는 서비스는 누구나 손쉽게 가능해졌지만, 졸업이나 결혼 그리고 백일을 기념하기 위한 앨범제작은 이미지파일의 용량이 많이 필요하고 고품질을 요하는 관계로 사진관에서 전담으로 작업을 하고 있다. 본 논문에서는 이렇게 사진관에서 전문가에 의해 편집 출판되는 앨범제작을 고품질의 템플릿과 다양한 라이브러리를 이용하여 빠르고 정확하게 생산하기 위한 앨범 전체 프로세스를 나타내고, 이를 사진관 업무와 현상소 및 인쇄소로 역할을 분리하여 작업공정에 혁신을 꾀하는 앨범제작을 위한 컴퓨터조판시스템의 모델을 제시한다.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2003년도 춘계학술대회
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• pp.319-328
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• 2003

With the proliferation of WWW, providing more intelligence to Web sites has become a major concern in e-business industry. In recent days, this trend is more accelerated by prosperity of CRM (Customer Relationship Management) in terms of various aspects such as product recommendation, self after service, etc. To accomplish this goal, many e-companies are eager to embed web enabled rule-based system, that is, expert systems into their Web sites and several well-known commercial tools are already available in the market. Most of those tools are developed based on CGI so far but CGI based systems inherently suffer over-burden problem when there are too many service demands at the same time due to the nature of CGI. To overcome this limitation of the existing CGI based expert systems, we propose a new form of Web-enabled expert system using hyperlink-based inference mechanism. In terms of burden to Web server, our approach is proven to outperform CGI based approach theoretically and also empirically. For practical purpose, our this approach is implemented in a software system, WeBIS and a graphic rule editing methodology, Expert Diagram is incorporated into the system to facilitates rule generation and maintenance. WeBIS is now successfully operated for financial consulting in the web site of a leading financial consulting company in Korea.

• Natural Product Sciences
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• 제13권2호
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• pp.128-131
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• 2007

Tumor angiogenesis is a critical step f3r the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on the surface of endothelial cells. This study was carried out to investigate inhibitory effect of extracts from root cortex of Paeonia suffruticosa Andrews on VEGF binding to VEGF receptor. The MeOH extract from P. suffrutiocosa Andr. inhibited the binding of KDR/Flk-1-Fc to immobilized VEGF$_{165}$ more than 45% at the concentration of 100 ${\mu}$g/mL. The MeOH extract was further fractionated into n-hexane, ethyl acetate, n-BuOH, and aqueous fractions. Among the four fractions, the ethyl acetate fraction from the root cortex of P. suffruticosa Andr. exhibited highly effective inhibition (${\approx}$ 79% inhibition) and then n-BuOH fraction (${\approx}$ 45% inhibition) on the binding of KDR/Flk-1-Fc to immobilized VEGF$_{165}$ at the concentration of 100 ${\mu}$g/mL. The ethyl acetate fraction from the root cortex of P. suffruticosa Andr. more efficiently blocked VEGF-induced human umbilical vein endothelial cell proliferation, than the growth of HT1080 human fibrosarcoma. Our results suggest that P. suffruticosa Andr. may be used as a candidate fur developing anti-angiogenic agent.

• Natural Product Sciences
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• 제8권4호
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• pp.155-161
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• 2002

The mistletoe lectins are major active components in the extract of European mistletoe (Viscum album L) that have been widely used in adjuvant chemotherapy of cancer. This study was performed to investigate the antitumor activity of extract of Korean mistletoe (Viscum album var. coloratum) modified with Korean mistletoe lectin (Viscum album var. coloratum agglutinin, VCA). Compared with the results of VCA, survival rate was increased and experimental lung metastasis was reduced by treatment of modified extract (VCM). In addition, the treatment of VCM reduced angiogenesis and VCA-induced toxicity measured by a CAM assay. And VCM inhibited proliferation and induced apoptosis in vitro in tumor cells originated from tissues which are possible to apply topically without surgery. Taken together, the antitumor activities of VCM-treated group outperformed the activities of the VCA-treated group.

• Natural Product Sciences
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• 제27권1호
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• pp.1-9
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• 2021

Methicillin-resistant Staphylococcus aureus (MRSA) infection often complicates burn wounds. Mupirocin is the antibiotic of choice for superficial MRSA infection, and its resistance is on the rise due to its frequent and widespread use. This study aimed to develop and evaluate Curcuma xanthorriza extract (CXE)-containing gel as a topical agent against MRSA-infected second-degree burn wound in rats. CXE was obtained using maceration with 96% ethanol. Xanthorrhizol level, antibacterial, and antioxidant activity were evaluated using a standardized method. In vivo, the wound's healing and bacterial load were evaluated every three days, whereas the histopathology of the wound was examined on day 12 of treatment. One-Way ANOVA and Kruskal-Wallis test were used to analyze the data. In this study, 27.0% and 7.10% of the obtained CXE were xanthorrhizol and curcumin, respectively. Additionally, an IC50 of 64.27 ppm was shown in antioxidant activity measurement, and MIC against MRSA was 5 mg/ml. Treatment with CXE-containing gels showed a significant reduction in bacterial load and proliferation of connective tissue in a dose-dependent manner. In conclusion, CXE-containing gel showed a greater reduction of bacterial load and more advanced wound healing phase than mupirocin.

• Genomics & Informatics
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• 제20권1호
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• pp.6.1-6.15
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• 2022

Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and function of the biologically important hypothetical protein EMK97_00595 (QBG34344.1) using several bioinformatics tools. The functional annotation exposed that the hypothetical protein is an extracellular secretory soluble signal peptide and contains the von Hippel-Lindau (VHL; VHL beta) domain that has a significant role in tumor suppression. This domain is conserved throughout evolution, as its homologs are available in various types of the organism like mammals, insects, and nematode. The gene product of VHL has a critical regulatory activity in the ubiquitous oxygen-sensing pathway. This domain has a significant role in inhibiting cell proliferation, angiogenesis progression, kidney cancer, breast cancer, and colon cancer. At last, the current study depicts that the annotated hypothetical protein is linked with tumor suppressor activity which might be of great interest to future research in the higher organism.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권11호
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• pp.3723-3737
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• 2022

Google Play is one of the largest Android phone app markets and it contains both free and paid apps. It provides a variety of categories for every target user who has different needs and purposes. The customer's rate every product based on their experience of apps and based on the average rating the position of an app in these arch varies. Fraudulent behaviors emerge in those apps which incorporate search rank maltreatment and malware proliferation. To distinguish the fraudulent behavior, a novel framework is structured that finds and uses follows left behind by fraudsters, to identify both malware and applications exposed to the search rank fraud method. This strategy correlates survey exercises and remarkably joins identified review relations with semantic and behavioral signals produced from Google Play application information, to distinguish dubious applications. The proposed model accomplishes 90% precision in grouping gathered informational indexes of malware, fakes, and authentic apps. It finds many fraudulent applications that right now avoid Google Bouncers recognition technology. It also helped the discovery of fake reviews using the reviewer relationship amount of reviews which are forced as positive reviews for each reviewed Google play the android app.

• BMB Reports
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• 제56권5호
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• pp.302-307
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• 2023

Lyn, a tyrosine kinase that is activated by double-stranded DNA-damaging agents, is involved in various signaling pathways, such as proliferation, apoptosis, and DNA repair. Ribosomal protein S3 (RpS3) is involved in protein biosynthesis as a component of the ribosome complex and possesses endonuclease activity to repair damaged DNA. Herein, we demonstrated that rpS3 and Lyn interact with each other, and the phosphorylation of rpS3 by Lyn, causing ribosome heterogeneity, upregulates the translation of p-glycoprotein, which is a gene product of multidrug resistance gene 1. In addition, we found that two different regions of the rpS3 protein are associated with the SH1 and SH3 domains of Lyn. An in vitro immunocomplex kinase assay indicated that the rpS3 protein acts as a substrate for Lyn, which phosphorylates the Y167 residue of rpS3. Furthermore, by adding various kinase inhibitors, we confirmed that the phosphorylation status of rpS3 was regulated by both Lyn and doxorubicin, and the phosphorylation of rpS3 by Lyn increased drug resistance in cells by upregulating p-glycoprotein translation.

• 분석과학
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• 제36권1호
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• pp.53-58
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• 2023

2'-Hydroxy-3',4'-methylenedioxy-3,4,5-trimethoxychalcone (HMTC) is a newly synthesized chalcone that affects proliferation, cytotoxic potential and apoptosis in human leukemia cells. However, no validated determination method has been described so far for HMTC in biological samples. Thus, we developed a liquid chromatographic method using a tandem mass spectrometry to determine HMTC in rat plasma. Liquid-liquid extraction with ethyl acetate was used for the clean-up procedure. The analyte was separated on a reversedphase column with mobile phase of distilled water and acetonitrile (2:8, v/v, including 0.1 % formic acid). The ion transition of the precursor to the product ion was principally deprotonated ions [M-H]^- at m/z 356.8 → 327.2 for HMTC. This analytical method was successfully applied in pharmacokinetic study of HMTC after intravenous administration in rats.

• 감성과학
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• 제20권1호
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• pp.3-16
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• 2017

삼차원(3D) 프린터의 개발과 보급에 따라 현대의 소비자들은 자신이 원하는 제품을 집에서 3D프린팅 할 수 있는 시대에 살고 있다. 3D프린팅을 통해 소비자 맞춤형 제작이 활성화되기 위해서는 3D프린터와 호환되는 디지털 설계도를 소비자 스스로 제작할 수 있어야 한다. 또한 최적의 프린팅 재질과 온도를 설정할 수 있어야 하고 3D프린터의 유지보수에 비용을 감당해야 한다. 더하여 혹시 있을지 모르는 디자인에 대한 지식재산권 문제에 대응할 수 있어야 한다. 그러나 실상 소비자가 이러한 문제들에 대응하기는 어렵기 때문에 소비자가 원하는 방향으로 3D프린팅을 대행해 줄 수 있는 서비스가 개발될 필요가 있다. 이런 동기에서 출발한 본 연구는 소비자가 원하는 3D프린팅 서비스 방식이 무엇인지에 통찰을 얻기 위해 세계적인 온라인 3D프린팅 제품판매 업체인 Shapeways (www.shapeways.com)에 대한 사용자 경험을 다양한 측면에서 탐색하였다. 그 결과 Shapeways의 사용성, 검색과정, 가격 적절성, 재방문의도, 디자인의 다양성, 디자인 만족도에 대한 양적 평가에서 전반적으로 낮은 평가를 받았다. 또한 다양한 언어지원, 제품 제작과정 공개 및 온-오프라인 사이트 동시운영, 디자이너 중심의 소비자 맞춤형 제작 서비스, 배송 안전성과 제품 내구성에 대한 확신을 줄 수 있는 서비스, 표면의 마감처리 서비스가 필요하다는 건설적인 의견을 통해 소비자 맞춤형 3D프린팅 서비스에 대한 통찰을 획득하였다. 본 연구가 3D프린팅 서비스 플랫폼 개발뿐 아니라, 관련된 산업 및 연구에도 폭넓은 시사점을 줄 것으로 기대한다.