• Genomics & Informatics
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• v.21 no.3
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• pp.30.1-30.13
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• 2023

Ephs belong to the largest family of receptor tyrosine kinase and are highly conserved both sequentially and structurally. The structural organization of Eph is similar to other receptor tyrosine kinases; constituting the extracellular ligand binding domain, a fibronectin domain followed by intracellular juxtamembrane kinase, and SAM domain. Eph binds to respective ephrin ligand, through the ligand binding domain and forms a tetrameric complex to activate the kinase domain. Eph-ephrin regulates many downstream pathways that lead to physiological events such as cell migration, proliferation, and growth. Therefore, considering the importance of Eph-ephrin class of protein in tumorigenesis, 7,620 clinically reported missense mutations belonging to the class of variables of unknown significance were retrieved from cBioPortal and evaluated for pathogenicity. Thirty-two mutations predicted to be pathogenic using SIFT, Polyphen-2, PROVEAN, SNPs&GO, PMut, iSTABLE, and PremPS in-silico tools were found located either in critical functional regions or encompassing interactions at the binding interface of Eph-ephrin. However, seven were reported in nonsmall cell lung cancer (NSCLC). Considering the relevance of receptor tyrosine kinases and Eph in NSCLC, these seven mutations were assessed for change in the folding pattern using molecular dynamic simulation. Structural alterations, stability, flexibility, compactness, and solvent-exposed area was observed in EphA3 Trp790Cys, EphA7 Leu749Phe, EphB1 Gly685Cys, EphB4 Val748Ala, and Ephrin A2 Trp112Cys. Hence, it can be concluded that the evaluated mutations have potential to alter the folding pattern and thus can be further validated by in-vitro, structural and in-vivo studies for clinical management.

• Archives of design research
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• v.2 no.1
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• pp.13-41
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• 1989

The raw materials for plant-stalk-folkcrafts are cultivated in the whole country. Most Korean farmers, to increase their income, have produced mats and containers with various plants as a side line from very long ago. At first, they began from the instruments of life and then made folkart and at last get to manu\ulcornerfacturing of industrial folk craft. The folkcrafts, made of plant-stalk, which could nor conform to changing society, are partly declined and partly handed down as the traditions. The social change today, however, makes living conditions more speedy and multisided, accordingly the characteristics of demand also become in\ulcornerdividual and various. While the demend is various like this, suppliers cannot answer demendants' requirements, and consequently, the demand and profit cannot be increased. According to this, the purpose of this study is set up to give an answer to the situation that is at the traditional standstill, through an examination of the motives. I. The crafts of plant-stalk are made only in an organized relationship between agriculture, industry and art as it is compounded art of gathering raw material, manufacturing, producing, improv\ulcornering design and production conditions. It may be possible that a farmer gathers material and weaves it manually but in others, it is im\ulcornerpossible to refine, bleach and dye because the process requires a professional industrial treatment. It is impossible to make art works to a farmer as every farner does not always have aesthetic sense. Though a farmer or producer has these all abilities, it is not desirable to him from economical view. 2. The development or improvement is essential in many sides but the most important thing seems to he in design. According to reports, it is, howevt!r, fact that the crafts improved in design of existing works have more expanded the sales than newly developed works. Therefore, ir appears advisable to improve designs of existing things positively as they have merit of occupying a position already, but on the other hand, new crafts have to be also developed and the producer should grasp the proper time. 3. Building up an industrial complex to improve design with collecting the producing districts for this works scattered allover the country is very desirable for speedy communication, intensive educa\ulcorner tion or training, and effective guidance. 4. In producing for export abroad, before everything, must know the life environment, custom! and manners, main thought of the country, and then produce according to these. S. The crafts of plant-stalk are the fIrst industry in present but in the futher it should change intc second or third industry. 6. A synethetic organization for supporting side line should be established for effectiveness, and experts have to be secured and also the educational-industrial complex and activation of study should be preceded.

• Genomics & Informatics
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• v.4 no.1
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• pp.33-39
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• 2006

Alternative splicing (AS) is an important mechanism of producing transcriptome diversity and microarray techniques are being used increasingly to monitor the splice variants. There exist three types of microarrays interrogating AS events-junction, exon, and tiling arrays. Junction probes have the advantage of monitoring the splice site directly. Johnson et al., performed a genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays (Science 302:2141-2144, 2003), which monitored splicing at every known exon-exon junctions for more than 10,000 multi-exon human genes in 52 tissues and cell lines. Here, we describe an algorithm to deduce the relative concentration of isoforms from the junction array data. Non-negative Matrix Factorization (NMF) is applied to obtain the transcript structure inferred from the expression data. Then we choose the transcript models consistent with the ECgene model of alternative splicing which is based on mRNA and EST alignment. The probe-transcript matrix is constructed using the NMF-consistent ECgene transcripts, and the isoform abundance is deduced from the non-negative least squares (NNLS) fitting of experimental data. Our method can be easily extended to other types of microarrays with exon or junction probes.

• Journal of KIISE:Computing Practices and Letters
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• v.9 no.2
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• pp.123-132
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• 2003

The quality certification test is usually conducted by a certifying organization to determine and guarantee the quality of software after the software development phase, commonly without the actual source code, but with by going against the product's manual. In this paper, we implement a Manual-based Automatic Test data generating tool: MaT, the test technique based on manual, that automatizes producing the test data from analysis data of software package and manual. The input data of MaT are the result of the analysis of software and manual. We propose 'menu-based test analysis model' in order to generate the input data. We believe that the proposed technique and tool he]p improving quality and reliability of the software.

• Genomics & Informatics
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• v.17 no.4
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• pp.41.1-41.12
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• 2019

Survival analysis mainly deals with the time to event, including death, onset of disease, and bankruptcy. The common characteristic of survival analysis is that it contains "censored" data, in which the time to event cannot be completely observed, but instead represents the lower bound of the time to event. Only the occurrence of either time to event or censoring time is observed. Many traditional statistical methods have been effectively used for analyzing survival data with censored observations. However, with the development of high-throughput technologies for producing "omics" data, more advanced statistical methods, such as regularization, should be required to construct the predictive survival model with high-dimensional genomic data. Furthermore, machine learning approaches have been adapted for survival analysis, to fit nonlinear and complex interaction effects between predictors, and achieve more accurate prediction of individual survival probability. Presently, since most clinicians and medical researchers can easily assess statistical programs for analyzing survival data, a review article is helpful for understanding statistical methods used in survival analysis. We review traditional survival methods and regularization methods, with various penalty functions, for the analysis of high-dimensional genomics, and describe machine learning techniques that have been adapted to survival analysis.

• Journal of the Korean Society of Earth Science Education
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• v.7 no.3
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• pp.347-357
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• 2014

The purpose of this research is to examine the current state of inserting illustrations in science textbooks under the 7th Revised Educational Curriculum which is currently enforced in all grades of elementary schools, and to compare and analyze the external and internal differences in illustrations in science textbooks of elementary schools in Tanzania and Korea to present desirable direction of producing illustrations. There are not only some differences in rate of the kinds and role of the illustrations in grades, but also in both countries. In Korea textbooks, Photographs were mainly used to guide the students into experiments and to train the students in analyzing and interpreting data. In contrast, the Tanzania textbooks place more emphasis on pictures to enhance their interests and curiosity and understand. The Korea textbooks have to place more various illustrations instead of photos but the Tanzania textbooks should place more photos. As a result the addition of more diverse forms of illustrations and the re-organization of illustrations according to the topic should be considersd in future Korea and Tanzania textbooks.

• Korean Institute of Interior Design Journal
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• v.23 no.3
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• pp.204-211
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• 2014

The development of digital culture has brought radical change in the fundamental concept of what workspace is defined by and has also switched the cognition of workspace originally being a place to spend time and do activities regarding tasks into space more than just that. If we take a look at the cases overseas firms have announced after the year 2000, we can find distinguishing facts different from the existing workspace composition, like creative workspace, amusement workspace, workspace for communities, etc. Thereupon, the goal of this research is to look into the domestic characteristics of workspace by investigating and analyzing case by case targeting domestic firms. This research is to first comprehend the theoretical study of workspace, the changing environment, and the characteristics of domestic workspace, going on to utilizing the information achieved above to analyze 8 appointed domestic firms as examples. Contemporary domestic workspace is defined not a place only for activities regarding work tasks but rather a place comfortable and friendly in the concept of a second residence, community node for sharing knowledge and information, mobile space for the digital nomads, and space for coincidental encountering and communication. Based on this the analyzed characteristics of contemporary domestic work places are metaphor, convergence, beyond boundary, and emergence. The characteristics mentioned above are considered elements that increase corporate profits by managing efficient smart-work and producing creative ideas. Therefore, I believe continuous research and development related to this subject is necessary.

• Journal of the Korean Institute of Rural Architecture
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• v.12 no.3
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• pp.1-10
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• 2010

Knowing in a view of legislation, we are able to use modernly the interior of registered cultural property with its preservation and its use freely in the limit of not changing the outer appearance. And on investigation, many building registered as cultural property has been used continuously with the function kept or changed. It means that modern building must keep their function at kept to survive in a change of city construction. Likewise, even Jae cheon leaf tobacco receipt agency lose the original function, there will be great possibilities that the agency may be changed or disappeared if we don't preserve it or give it a new function by making out the meaning of preservation. So, if Jae Cheon leaf tobacco receipt agency is restored as mentioned above in close cooperation with related organization, Jae Cheon area will demonstrate the meaning as a representative producing district of leaf tobacco with its cultural value in Korean modern ages.

• The Journal of Korean Association of Computer Education
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• v.7 no.2
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• pp.11-23
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• 2004

Delivering documents within school itself, has been ignored, since it is not considered as a large organization such as government education agencies. It is necessary to change the procedures in delivering official documents within school's administrative services along with the outside administrative procedure changes. For the above purposes, this study can be practiced toward the actual schools therefore it is to design the framework for Distributable Official XML Document management and to implement official document management system based on JSP component. As a result, this system will reduce the negativity in producing the time critical official documents in educational activities. It is important at the fact that electronic document management procedures will incredibly improve the quality in school's administrative services.

• Journal of Radiation Protection and Research
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• v.26 no.3
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• pp.333-335
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• 2001

The 2 GeV electron linac, the injector of the Pohang Light Source, was used as a photo-neutron source for radiation shielding research. The operational beam parameters are the nominal electron intensity of $0.5\;{\sim}5\;nC/sec$, the repetition rate of 10 Hz, and the beam pulse length of 1.0 nsec. One electron beam line was modified in order to install the target systems for producing pulsed photo-neutrons. The neutron spectrum and intensity were investigated by the time-of-flight technique. The reliable maximum energy of the measured neutrons was about 500 MeV. The number of neutrons above 20 MeV produced by one 1 GeV electron in a thick Pb target was about $6.45{\times}10^{-4}/sr$ at 90 degrees to the beam axis. The status of the photo-neutron source and the application research are presented.