• Geomechanics and Engineering
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• v.14 no.1
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• pp.91-98
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• 2018

Length of a vehicle is an important variation to generate different variants of an automotive platform. This parameter is usually adjusted by embedding dimensional flexibility into different components of the Body in White (BIW) including the floor pan. Due to future uncertainties, it is not necessarily possible to define certain values of wheelbase for the future products of a platform. This work is performed to add flexibility into the design process of a length-variable floor pan. By means of this analysis, the cost and time consuming process of optimization is not necessary to be performed for designing the different variants of a product family. Stiffness and mass of the floor pan are two important functional requirements of this component which directly affect the occupant comfort, dynamic characteristics, fuel economy and environmental protection of the vehicle. A combination of Genetic algorithm, GMDH-type of artificial neural networks and TOPSIS methods is used to optimally design the floor pan associated with arbitrary length of the variant in the defined system range. The correlation between the optimal results shows that for a constant mass of the floor pan, the first natural frequency decreases by increasing the length of this component.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5275-5279
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• 2013

Background: The XRCC1 (X-ray repair cross complimenting group-I) gene in BER (base excision repair) pathway is essential for DNA repair process. Polymorphisms in this gene are associated with variations in the repair efficiency which might predispose individuals to development of various cancers. Two variants of XRCC1gene (at codon 399), Gln/Gln and Arg/Gln, have been shown to be related to lowered DNA repair capacity and increased genomic instability in multiple studies. Hence our investigation focused on genotyping these variants to correlate with other multiple risk factors in lung cancer (NSCLC) patients since we hypothesized that these variants of the XRCC1 gene might influence disease susceptibility. Materials and Methods: We examined the frequency of the polymorphism in one hundred cases and an almost equal number of controls after recording their demographics with a structured questionnaire. Genomic DNA from blood samples was extracted for PCR studies, followed by RFLP to determine the variants. The significance of the data was statistically analyzed. Results: The three genotypes in cases and controls were Arg/Arg (40% and 54.45%); Gln/Gln (19% and 9.90%), and Arg/Gln (41.0% and 35.64%) respectively. Among these 3 genotypes, we found Gln/Gln and Arg/Gln to show association with lung cancer. Correlating these genotypes with several parameters, we also found that these two variants were associated with risk in males (p<0.05) and with smoking habits (p<0.05). In females Arg/Gln genotype showed association with stage of the disease (p=0.04). This is the first report in South Indian scenario where Arg399Gln genotypes were found to be associated with stage of the disease in females. Conclusions: It is concluded that XRCC1 genotypes Gln/Gln and Arg/Gln may influence cancer susceptibility in patients with smoking habits and these functional SNPs in XRCC1 gene may act as attractive candidate biomarkers in lung cancer for diagnosis and prognosis.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.12
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• pp.1716-1721
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• 2003

Steroid hormones and their receptors play an important role in reproductive process. Estrogen is intimately involved with pregnancy and its function is mediated through the estrogen receptor which has been chosen as a candidate gene to study litter size in pigs. In this study, we report that two estrogen receptor variants, designated pER-1 and pER-2 were co-expressed in the uteri of normal cycling Lan-Yu pig (Sus vittatus; a small-ear miniature in Taiwan) with the pER-1 expression level appeared to be several times higher than that of pER-2. These receptor variants were isolated using reverse transcription-PCR from the pig uteri and their sequences were determined. The pER-1 and pER-2 sequences, which are homologous to those found in other mammalian estrogen receptors, encode putative proteins consisting of 574 and 486 amino acids, respectively. A deletion in exon I was identified in both sequences, with deletion lengths of 63 bp in pER-1 and 327 bp in pER-2. The deletion in pER-1 is internal to that in pER-2 and both deletions resulted in a truncation of the B domain, which confers the transactivating activity of estrogen receptor protein. This result describes the existence of estrogen receptor variants with a deletion in exon I and implies the possibility that physiological functioning of an estrogen receptor may not require the presence of an intact B domain.

• YAKHAK HOEJI
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• v.45 no.4
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• pp.426-430
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• 2001

Cells are eliminated in a variety of physiological settings by apoptosis, a genetically encoded process of cellular suicide. Bak, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown mechanism. We have found a novel cDNA encoding a 101 amino acid protein possessing a Bak-like in our full-length cDNA bank. Bak-like shares the conserved domains BHI and 2 with other proapoptotic proteins but lacks the BH3 domain. Bak-like is expressed in a wide variety of tissues. Like Bak, Bak-like gene product primarily enhances apoptotic cell death following an appropriate stimulus.

• Korean Journal of Mathematics
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• v.29 no.3
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• pp.501-510
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• 2021

A uniform study towards normality is provided for topological spaces. Following Császár, 𝛄-normality and 𝛄(𝜃)-normality are introduced and investigated. For 𝛄 ∈ 𝚪₁₃, 𝛄-normality is found to satisfy Urysohn's lemma and provide partition of unity. Several existing variants of normality such as 𝜃-normality, 𝚫-normality etc. are shown to be particular cases of 𝛄(𝜃)-normality. In this process, 𝛄-regularity and 𝛄(𝜃)-regularity are introduced and studied. Several important characterizations of all these notions are provided.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.4
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• pp.680-683
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• 2002

Bovine aortic endothelial cells(BAEC) produce two variant forms of laminin with a subunit composition of AB1B2 and A'B1B2. Analyses of the intracellular assembly of these subunits revealed that the B1B2 dimer formed first, and that A or A' joined to form the AB1B2 or A'B1B2 trimer. Angiostatic steroids shifted the relative size of the A and A' monomer pool in BAEC, and competition between the A and A' subunits in joining the B1B2 dimer produced AB1B2 and A'B1B2 in different ratios. This result suggests that subunit replacement is the general mechanism for producing laminin variants by various cells for tissue morphogenesis. When laminin subunits in BAEC were cross-linked with dithio-bis-succinimidylpropionate(DSP) and immunoprecipitated with anti-Iaminin antiserum, monomeric A,A',B1 and B2 monomers and the B1B2 dimer migrated as extremely large molecules in sodium dodecyl sulfate gel electrophoresis under nonreducing conditions. When the crosslinking disulfide bonds were cleaved under reducing conditions, they migrated as the usual subunits. This result suggests that molecular chaperones were involved in the process of the assembly and replacement of laminin subunits.

• Journal of the Korean Data and Information Science Society
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• v.20 no.1
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• pp.225-235
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• 2009

Lattice process models are used to explain phase transitions in statistical mechanics, a branch of physics. The Ising model, a specific form of lattice process model, was proposed by Ising in 1925. Since then, variants of the Ising model such as the Potts model and the unitary cell model have been proposed. Like the Ising model, it is believed that the more general models exhibit phase transitions on the critical surface, which is based on the mathematical equation. In statistical sense, phase transitions can be simulated through Markov Chain Monte Carlo (MCMC). We applied Swendsen-Wang algorithm, a block Gibbs algorithm, to a general lattice process models and we simulate phase transition phenomena of the unitary cell model.

• Nuclear Engineering and Technology
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• v.54 no.8
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• pp.2755-2770
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• 2022

The need for Dissimilar Welded Joint (DWJ) in the power plant components arises in order to increase the overall efficiency of the plant and to avoid premature failure in the component welds. The Activated-Tungsten Inert Gas (A-TIG) welding process, which is a variant of Tungsten Inert Gas (TIG) welding, is focus of this review work concerning the DWJ of nuclear grade creep-strength enhanced ferritic/martensitic (CSEF/M) steels and austenitic steels. A-TIG DWJs are compared with Multipass-Tungsten Inert Gas (M-TIG) DWJ based on their mechanical and microstructural properties. The limitations of multipass welding have put A-TIG welding in focus as A-TIG provides a weld with increased depth of penetration (DOP) and enhanced mechanical properties. Hence, this review article covers the A-TIG welding principle and working parameters along with detailed analysis of role played by the flux in welding procedure. Further, weld characteristics of martensitic and austenitic steel DWJ developed with the A-TIG welding process and the M-TIG welding process are compared in this study as there are differences in mechanical, microstructural, creep-related, and residual stress obtained in both TIG variants. The mechanics involved in the welding process is deliberated which is revealed by microstructural changes and behavior of base metals and WFZ.

• Toxicological Research
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• v.17
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• pp.17-24
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• 2001

Risk assessment is useful tool making good decisions on the risks of certain hazardous com-pound and suggests safe margin through scientific process using toxicological data, statistical tool, exposure value and relevant variants. The goal of risk management is to protect the public health from hazardous compound based on result of risk assessment having reality. For the suggestion of exact man-aging information, risk assessment must be designed to represent a "plausible estimate" of the exposure to the individuals and to minimize uncertainty. Risk assessment methodology and knowledge are expected to change more rapidly than before and up-to-date methodology should be applied in regulatory aspects through the Agency. For the useful application of risk assessment, the communication between the risk assessor and the risk manager is needed before the initiation of the risk assessment and upon its completion. Generally, the risk assessment itself as a practical tool in the regulatory decision making process would be regarded with social economic impact.ic impact.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.35 no.1
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• pp.115-123
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• 2012

Material flow control mechanism is a kind of operational policy in manufacturing. It is very important because it varies throughput, throughput time, and work-in-process (WIP) under the same manufacturing resources. Many Researchers have developed various material flow control mechanisms and insisted that their mechanism is superior to others. However the experimental environment used in the performance comparison are different and impractical. In this paper, we set various manufacturing environments to fairly compare five previous material flow control mechanism : Push, Pull, CONWIP, Gated MaxWIP, and Critical WIP Loops. The simulation results show that the Push is superior to others in both of throughput and WIP if required demand is less than 80% of capacity. In addition, the performance of CONWIP and its variants are not different statistically.