• ETRI Journal
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• v.33 no.2
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• pp.210-218
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• 2011

Battiti's mutual information feature selector (MIFS) and its variant algorithms are used for many classification applications. Since they ignore feature synergy, MIFS and its variants may cause a big bias when features are combined to cooperate together. Besides, MIFS and its variants estimate feature redundancy regardless of the corresponding classification task. In this paper, we propose an automated greedy feature selection algorithm called conditional mutual information-based feature selection (CMIFS). Based on the link between interaction information and conditional mutual information, CMIFS takes account of both redundancy and synergy interactions of features and identifies discriminative features. In addition, CMIFS combines feature redundancy evaluation with classification tasks. It can decrease the probability of mistaking important features as redundant features in searching process. The experimental results show that CMIFS can achieve higher best-classification-accuracy than MIFS and its variants, with the same or less (nearly 50%) number of features.

• Childhood Kidney Diseases
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• v.28 no.1
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• pp.8-15
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• 2024

With the rapid evolution of diagnostic tools, particularly next-generation sequencing, the identification of genetic diseases, predominantly those with pediatric-onset, has significantly advanced. However, this progress presents challenges that span from selecting appropriate tests to the final interpretation of results. This review examines various genetic testing methodologies, each with specific indications and characteristics, emphasizing the importance of selecting the appropriate genetic test in clinical practice, taking into account factors like detection range, cost, turnaround time, and specificity of the clinical diagnosis. Interpretation of variants has become more challenging, often requiring further validation and significant resource allocation. Laboratories primarily classify variants based on the American College of Medical Genetics and Genomics and the Association for Clinical Genomic Science guidelines, however, this process has limitations. This review underscores the critical role of clinicians in matching patient phenotypes with reported genes/variants and considering additional factors such as variable expressivity, disease pleiotropy, and incomplete penetrance. These considerations should be aligned with specific gene-disease characteristics and segregation results based on an extended pedigree. In conclusion, this review aims to enhance understanding of the complexities of clinical genetic testing, advocating for a multidisciplinary approach to ensure accurate diagnosis and effective management of rare genetic diseases.

• Industrial Engineering and Management Systems
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• v.11 no.3
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• pp.233-240
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• 2012

The implementation of business process management (BPM) systems in large number of business organizations transforms BPM system into such a level of maturity and tends to collect large repositories of business process (BP) models. This issue encourages BP flexibility that leads to a large number of process variants derived from the same model, but differing in structure, to be stored in the large repositories of BP models. Therefore, the repositories may include thousands of activities and related business objects with variation of requirements and quality of service. It is a common practice to customize processes from reference processes or templates in order to reduce the time and effort required to design and deploy processes on all levels. In order to address redundancy and underutilization problems, a generic process model, called as reference BP, is absolutely necessary to cover the best of process variants. This study aims to develop multiple-objective business process genetic algorithm (MOBPGA) to find a set of non-dominated (Pareto) solutions of business reference model to enhance conventional approach which considered only a single objective on creating BP reference model by using proximity score measurement. A mixed-integer linear program is constructed to evaluate performance of the proposed MOBPGA on small-scale problems by using standard measures for multiple-objective techniques. The results will show the viability of applying MOBPGA in terms of simultaneously maximizing proximity score measurement, minimizing total duration, and total costs of the selected reference model.

• Journal of Ginseng Research
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• v.17 no.2
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• pp.153-158
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• 1993

The study was carried out for comparison of variants and development of genetic markers using Randomly Amplified Polymorphic D사A (RAPD) analysis method. The ginseng variants used were as follows: Chungkyung-Chong, Hwangskoog-Chong, KG101 selected by the pureline selection method, and 6 kinds of Jakyung-Chong strains Uinjakyung, Jakyung-Chong 81783, Jakyung-Chong 847913, Jaky tong-Chong 79742, Jinjakyung of USSR, and Mimaki of Japan). Four of 10 RAPD primers showed the distinctive polymorphism among 9 ginseng variants and lines, and were selected for more detailed polymorphic analysis. The sequences of 4 selected primers were TGCCGAGCTG (Primer#2), AATCGGGCTG (#4), GAAACGGGTG (U7), and GTGACGTAGG (#8). All primers produced several common bands among the strains. However, when primer # 2 was applied, the electrophoregram showed the specific band at 1.8 kb region in Chungkyung-Chong, Hwangskoog- chong, and KG101, and 1 kb in the Jakyung-Chong 847913. In primer #4, 1.1 kb band was shown in Chungkyung-Chong, Hwangskoog-Chong, KG101, and Jakyung-Chong 79742. In primer # 7, 700 bp band was appeared in Jakyung-Chong 81783 and Jinjakyung of USSR In primer # 8, 800 bp band was observed only in Mimaki, comparing to another strains. When Similarity Index (SI) was calculated, Chungkyung-Chong and Hwngskoog-Chong, and Jakyung- chong 81783 and Jinjakyung of USSR showed the most close SI, 0.11 and 0.08, respectively. The data of KG101, which showed the SI of 0.13 with the group of Chungkyung-Chong and Hwangskoog-Chong, coincided with the fact that it was released from Hwangskoog-Chong by breeding process. The data of Jakyung strains indicated the significant variation among the strains. From these results, RAPD analysis method could be succesively applied to the classification and genetic analysis for breeding of Korean ginseng.

• Proceedings of the Korean Society for Applied Microbiology Conference
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• 2001.06a
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• pp.77-80
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• 2001

A variety of different methods to generate diverse proteins, including random mutagenesis and recombination, are currently available, and most of them accumulate the mutations on the target gene of a protein, whose sequence space remains unchanged. On the other hand, a pool of diverse genes, which is generated by random insertions, deletions, and exchange of the homologous domains with different lengths in the target gene, would present the protein lineages resulting in new fitness landscapes. Here we report a method to generate a pool of protein variants with different sequence spaces by employing green fluorescent protein (GFP) as a model protein. This process, designated functional salvage screen (FSS), comprises the following procedures： a defective GFP template expressing no fluorescence is firstly constructed by genetically disrupting a predetermined region(s) of the protein, and a library of GFP variants is generated from the defective template by incorporating the randomly fragmented genomic DNA from E. coli into the defined region(s) of the target gene, followed by screening of the functionally salvaged, fluorescence-emitting GFPs. Two approaches, sequence-directed and PCR-coupled methods, were attempted to generate the library of GFP variants with new sequences derived from the genomic segments of E. coli. The functionally salvaged GFPs were selected and analyzed in terms of the sequence space and functional property. The results demonstrate that the functional salvage process not only can be a simple and effective method to create protein lineages with new sequence spaces, but also can be useful in elucidating the involvement of a specific region(s) or domain(s) in the structure and function of protein.

• Journal of KIISE:Software and Applications
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• v.33 no.2
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• pp.154-166
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• 2006

Product Line Engineering(PLE) is a software reuse paradigm that core assets are defined using common features in a domain and are instantiated in various applications. To apply the core asset effectively, variants which satisfy application requirements are extracted and the core asset should be also instantiated based on the variants. For the work, variability on architecture and components should be extracted exactly and an instantiation process and guidelines should be defined based on this variability In this paper, we define variability types depending on core assets elements and describe artifact templates related to tile variability. We also propose a systematic process which uses defined core assets including variability and verify practicability of the proposed process and variability expression through doing ease study. If utilizing with the proposed process in PLE, it can be feasible to model concrete core asset and variability and to utilize practical application engineering.

• The Pure and Applied Mathematics
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• v.22 no.2
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• pp.127-138
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• 2015

The object of this paper is to emphasize the role of 'common limit range property' and utilize the same with variants of R-weakly commuting mappings for the existence of common fixed point under strict contractive conditions in metric spaces. We also furnish some interesting examples to validate our main result. Our results improve a host of previously known results including the ones contained in Pant [Contractive conditions and common fixed points, Acta Math. Acad. Paedagog. Nyhàzi. (N.S.) 24(2) (2008), 257-266 MR2461637 (2009h:54061)]. In the process, we also derive a fixed point result satisfying $\phi$-contractive condition.

• Korean Journal of Cognitive Science
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• v.3 no.1
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• pp.25-39
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• 1991

When an ending which begins with 'a/a'combines to a stem,'a/a'can be deleted.Especially when ot combines to an h-irregular verb,it is represented as a variant like '-a-','-e-','-ia-',or'-ie-'.In order to analyze the variants of 'a/a',we suggest the format of a grammatical morpheme dictionary which is represented as a binary tree and several procedures which process the variants so that the unexpected errors can be removed which occur frequently when we analyze Korean worl phrase.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.230.3-231
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• 2003

The therapeutic use of protein pharmaceuticals produced by recombinant DNA technology is increasing in recent decades. In order to investigate the quality of recombinant proteins, it is important to identify and assign the impurities produced in the process of recombination or in storage conditions. Capillary Electrophoresis is emerging technology exhibiting high sensitivity, selectivity and speed and may be most powerful tools for this application. In this study, human growth hormone (hGH) has been analyzed by various mode of capillary electrophoresis such as capillary zone electrophoresis (CZE), capillary gel electrophoresis (CGE), and capillary isoelectric focusing (cIEF) to indicate the chemically or biologically oriented variants and the degraded fragments. (omitted)

• Journal of Electrical Engineering and Technology
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• v.12 no.1
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• pp.378-384
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• 2017

In this paper, an efficient short-time Fourier analysis method for the quasi-periodic signals is proposed via an optimal fixed-lag finite impulse response (FIR) smoother approach using a receding horizon scheme. In order to deal with time-varying Fourier coefficients (FCs) of quasi-periodic signals, a state space model including FCs as state variables is augmented with the variants of FCs. Through an optimal fixed-lag FIR smoother, FCs and their increments are estimated simultaneously and combined to produce final estimates. A lag size of the optimal fixed-lag FIR smoother is chosen to minimize the estimation error. Since the proposed estimation scheme carries out the correction process with the estimated variants of FCs, it is highly probable that the smaller estimation error is achieved compared with existing approaches not making use of such a process. It is shown through numerical simulation that the proposed scheme has better tracking ability for estimating time-varying FCs compared with existing ones.