• Journal of Microbiology and Biotechnology
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• v.18 no.5
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• pp.997-1003
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• 2008

Viral safety is a prerequisite for manufacturing clinical antihemophilic factor VIII concentrates from human plasma. With particular regard to the hepatitis A virus (HAV), a terminal dry-heat treatment ($100^{\circ}C$ for 30 min) process, following lyophilization, was developed to improve the virus safety of a solvent/detergent-treated antihemophilic factor VIII concentrate. The loss of factor VIII activity during dry-heat treatment was of about 5%. No substantial changes were observed in the physical and biochemical characteristics of the dry-heat-treated factor VIII compared with those of the factor VIII before dry-heat treatment. The dry-heat-treated factor VIII was stable for up to 24 months at $4^{\circ}C$. The dry-heat treatment after lyophilization was an effective process for inactivating viruses. The HAV, murine encephalomyocarditis virus (EMCV), and human immunodeficiency virus (HIV) were completely inactivated to below detectable levels within 10 min of the dry-heat treatment. Bovine herpes virus (BHV) and bovine viral diarrhea virus (BVDV) were potentially sensitive to the treatment. However porcine parvovirus (PPV) was slightly resistant to the treatment. The log reduction factors achieved during lyophilization and dry-heat treatment were ${\geq}5.55$ for HAV, ${\geq}5.87$ for EMCV, ${\geq}5.15$ for HIV, 6.13 for BHV, 4.46 for BVDV, and 1.90 for PPV. These results indicate that dry-heat treatment improves the virus safety of factor VIII concentrates, without destroying the activity. Moreover, the treatment represents an effective measure for the inactivation of non-lipid-enveloped viruses, in particular HAV, which is resistant to solvent/detergent treatment.

• The Korea Journal of Herbology
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• v.22 no.4
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• pp.75-80
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• 2007

Objectives : This study was conducted to control microorganisms of deer antler products with ethanol and heat process. Methods : The deer antler of Cervus elaphus was used for this study. The sliced deer antler of market condition were processed with 70% ethanol only (酒洗) and 70% ethanol with heat (酒炙). The microorganisms were isolated and incubated on Luria broth (LB) plates at $37^{\circ}C$ for 24 h. Results : The number of isolated microorganism colony were 201.1, 33.5 and 2.0 ea from each sliced deer antler of market condition, 70% ethanol only and 70% ethanol with heat process, respectively. Conclusions : These results suggested that 70% ethanol with heat processing is effective for reducing microbial contamination of deer antler products.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.9 s.252
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• pp.842-849
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• 2006

An experimental study has been conducted to investigate the effects of a multi air-staged burner on NOx formation and heat transfer in a 15kW large-scale laboratory furnace adopted the reburning process. The reburn fuel as well as burnout air was injected from each nozzle attached at the wall of the cylindrical furnace. Fuel in both main burner and reburn nozzle was LPG (Liquefied Petroleum Gas). The paper reports the influences on NOx reduction of reburn fuel fraction in reburning zone. Temperature distribution inside the overall region as well as total heat flux at the wall of the furnace has been measured to examine the heat transfer characteristics due to the reburning process. For comparison, the reburning effects were examined for a combustor with two types of burner; a regular single staged burner and a multi-air staged burner. A gas analysis was also performed to evaluate an appropriate condition for NOx emission in a primary zone for the excess air ratio of 1.1. As a result, combustion efficiency expected to become more efficient due to the reduction of heat loss in burnout zone decrease when multi air-staged burner in furnace adopted reburning technology was used.

• Journal of Korea Foundry Society
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• v.25 no.6
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• pp.226-232
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• 2005

Contact material is widely used in the field of electrical parts. Ag-CdO material has a good wear resistance and stable contact resistance. In order to establish optimizing heat treatment condition, rolling temperature and oxidation process, we studied the microstructure of Ag-CdO material with various conditions. The experimental procedure were melting using high frequency induction, heat treatment, rolling and internal oxidation. And we experimented on difference process, Post-oxidaion. In this study, we obtained the optimizing heat treatment condition was $700^{\circ}C$ for 15 min. and the optimizing rolling temperature was $730^{\circ}C$. In investigation of the microstructure of oxidized material, coarse oxide and depleted oxidation layer existed. The hardness was average Hv 70. When we used Post-oxidation, oxides were finer than prior process and depleted oxidation layer did not exist. The hardness of Post-oxidation material was average Hv 80. And the optimizing rolling temperature was $800^{\circ}C$.

• Journal of the Korean Society of Safety
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• v.36 no.3
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• pp.24-30
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• 2021

Heat is generated during the synthesis and mixing process of chemical compounds due to a change in activation energy during the reaction. A runaway reaction occurs when sufficient heat is not removed during the heat control process within a reactor, rapidly increasing the temperature, reaction speed, and rate of heat generation inside the reactor. A risk assessment was executed using an RC-1 (Reaction Calorimeter) during Friedel-Crafts acylation. Friedel-Crafts acylation runs the risk of rapid heat generation during Active Pharmaceutical Ingredient (API) manufacturing; it was used to confirm the risk of a runaway reaction at each synthesis stage and during the mixing process. This study used experimental data to develop a safety efficiency improvement plan to control the risks of runaway and other exothermic reactions, which was implemented at the production site of a chemical plant.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.10 no.2
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• pp.227-237
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• 1998

A numerical simulation has been carried out for the automotive air conditioning system. The purpose of this simulation is to present the methods for simulating car air conditioning components, systems and cool-down performance by computerized mathematical model and to analyze the performance of A/C system. In analyzing the heat exchanger(evaporator and condenser), the finite volume model which has a merit in predicting the temperature field in detail because it can consider partial variation of thermal property and heat transfer coefficient is used. In analyzing the compressor, the polytropic approach which regards the actual compression process as a reversible polytropic process is employed. In analyzing vehicle passenger compartment, the thermal network is employed to simulate the car cool down process. This A/C system program can be used for analyzing a component performance when a component is alternated or designed and for analyzing the engine cooling system when A/C system is operated.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2001.04a
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• pp.930-933
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• 2001

Titanium Alloys used in this experiment has an good corrosion resistance and specific strength, and is the new material developed for medical supplies living goods. In this study the rolled titanium alloy is done by annealing, solution heat-treatment and aging and then is worked by wire EDM. With changing the process conditions, the process properties of surface hardness, surface roughness, shape of process surface and the analysis of ingredients are measured through experiment repeating main cut and finish cut. It is confirmed to gain good measure values as increasing the number of processing of wire EDM. In this experiment the phenomena of processing is studied and the appropriate process condition is proposed.

• 제어로봇시스템학회:학술대회논문집
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• 1991.10a
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• pp.252-257
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• 1991

This paper proposed that the eddy-current measurement method can be used a means of in-process measuring the hardening depth in Laser surface treatment process. Also, this paper deal with the numerical analysis of magnetic flux distribution and experimental result of measurement. In Laser heat treatment process of steels, a thin layer of the substrate is rapidly heated to austenitizing temperature and subsequently cooled at a very fast rate due to the self-quenching by heat conduction into the bulk body, to produce a martensite structure which have low magnetic permeability. The eddy-current measurement method depends on the properties of material to be measured such as electric conductivity, magnetic permeability and geometry. In this paper, the hardening depth was measured by detecting relevant magnetic permeability changes caused by heat treatment of steels.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.1283-1288
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• 2003

The friction heat generated by the CMP process hasinfluence on removal rate and WIWNU(Within Wafer Non-Uniformity). Therefore, the object of this study is to find the distribution of temperature on pad surface during CMP process. To do this, the authors analyse the kinematics of CMP equipment to verify the sources of friction heat and compare the analysis result with the experimental results. Through the analysis and experiment conducted in this paper, we can predict the distribution of polishing temperature across the pad surface. Furthermore the result could help to predict the process conditions which could enhance the polishing results, such as WIWNU and removal rate of thin film to achieve more efficient process.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.4
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• pp.16-23
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• 2020

An electric vehicle operates at high currents and requires real-time monitoring of the entire system for ensuring efficiency and safety of the vehicle. Current sensors are applied to drive the motors, inverters, and battery control systems, and are the key components to ensure constant monitoring of the magnitude and waveforms of the operating current. In this study, a heat treatment process condition to influence the performance of Permalloy current sensors was developed; the correlation between the output capacity, low-temperature characteristics, and high-temperature characteristics of the current sensor was studied; and the process was optimized to meet the required output accuracy and temperature characteristics.