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http://dx.doi.org/10.14346/JKOSOS.2021.36.3.24

The Risk Assessment of Runway Reaction in the Process of Fridel-Crafts Acylation for Synthesis Reaction  

Lee, Kwangho (Safety & Health Convergence Engineering, Soongsil University)
Kim, Wonsung (Hanmi Fine Chemical.Co.,Ltd)
Jun, Jinwoo (Safety Convergence Graduate school, Soongsil University)
Joo, Youngjong (Safety & Health Convergence Engineering, Soongsil University)
Park, Kyoshik (Safety & Health Convergence Engineering, Soongsil University)
Publication Information
Journal of the Korean Society of Safety / v.36, no.3, 2021 , pp. 24-30 More about this Journal
Abstract
Heat is generated during the synthesis and mixing process of chemical compounds due to a change in activation energy during the reaction. A runaway reaction occurs when sufficient heat is not removed during the heat control process within a reactor, rapidly increasing the temperature, reaction speed, and rate of heat generation inside the reactor. A risk assessment was executed using an RC-1 (Reaction Calorimeter) during Friedel-Crafts acylation. Friedel-Crafts acylation runs the risk of rapid heat generation during Active Pharmaceutical Ingredient (API) manufacturing; it was used to confirm the risk of a runaway reaction at each synthesis stage and during the mixing process. This study used experimental data to develop a safety efficiency improvement plan to control the risks of runaway and other exothermic reactions, which was implemented at the production site of a chemical plant.
Keywords
pharmaceutical ingredient; reaction calorimeter; risk; runaway reaction; risk assessment; raw material medicine;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
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