• The Journal of Korean Physical Therapy
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• 제10권1호
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• pp.1-6
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• 1998

효율적으로 국소마취를 유발시키는 procaine이온도입의 효과적인 농도를 조사하였다. 19세에서 34까지의 자원자 45명을 9명씩 무작위로 5군으로 나누어 배치하고, 각군 대상자의 오른쪽 전완 전면에 각각 $2\% (pH\;5.2H),\;4%(pH\;5.12),\;8\%(pH\;4.98),\;16\%(pH\; 4.72),\;32\%(pH\;4.52)$ 염산 procaine용액 2ml를 적신 $3.5\times3.5 cm$의 면패드를 대고 4mA로 10분간 양극 직류전류를 통전시켰다. 이온도입 직후부터 5분 간격으로 21 G주사침으로 이온도입부위를 1mm함몰되게 눌러 바늘로 찌르는 통증을 느낄 때까지 감각검사를 시행하여 국소마취지속시간을 측정하였다. Procaine의 농도에 따른 축소마취지속시간을 일원분산분석한 결과 유의한 차이를 보였으며 (F=5.83; df=4, 40; p<.001). 이를 사후검정한 결과 농도 $4\%$의 국소마취지속시간이 농도 $2\%,\;8\%,\;16\%,\;32\%$보다 유의하게 길었다 (p<.01). 또한 상관분석 결과 약물의 농도는 국소마취지속시간과 상관관계가 없었다 (r=-0.41, NS). 본 연구 결과 $4\%$ 농도의 염산 procaine 용액의 이온도입이 국소마취지속시간을 가장 길게 유지하여 $4\%$ 염산 procaine 용액이 이온도입에 가장 효과적인 농도였음을 알 수 있었다.

• Biomolecules & Therapeutics
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• 제24권5호
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• pp.489-494
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• 2016

Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its role in modulating NPP has not been reported yet. This study aims at uncovering the role of procaine in NPP. Rats were pretreated with procaine by intrathecal injection. Then NPP rat model was induced by sciatic nerve chronic compression injury (CCI) and behavior tests were performed to analyze the pain behaviors upon mechanical, thermal and cold stimulations. Spinal expression of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) was detected by qRT-PCR and western blot. JAK2 was also overexpressed in procaine treated model rats for behavior tests. Results showed that procaine pretreatment improved the pain behaviors of model rats upon mechanical, thermal and cold stimulations, with the best effect occurring on the $15^{th}$ day post model construction (p<0.05). Procaine also inhibited JAK2 and STAT3 expression in both mRNA (p<0.05) and protein levels. Overexpression of JAK2 increased STAT3 level and reversed the improvement effects of procaine in pain behaviors (p<0.01). These findings indicate that procaine is capable of attenuating NPP, suggesting procaine is a potential therapeutic strategy for treating NPP. Its role may be associated with the inhibition on JAK2/STAT3 signaling.

• The Korean Journal of Pain
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• 제1권1호
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• pp.16-19
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• 1988

Raynaud 증후군 환자 10명에게 procaine과 reserpine을 1~2회 동맥주사하고 성상교감신경절 차단을 주기적으로 장기간 시행하여 통증의 소실, 수지괴사의 치유등 증상이 호전된 10예를 보고하였다.

• 한국동물학회지
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• 제14권2호
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• pp.43-56
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• 1971

筋小胞體의 Ca 吸收能과 ATPase 活性을 各種 濃度의 K, Mg, caffeine, procaine, 및 quinine 존재하에서 측정하였다. ATP不在下에서 Ca吸收能은 K 또는 Mg의 농도가 증가함에 따라 低下된다. 그러나 ATP 존재하에서의 Ca吸收能은 K의 농도에는 거의 영향을 받지 않고, Mg의 농도가 증가함에 따라 현저히 증가한다. Caffeine과 procaine은 ATP 존재하의 Ca吸收能을 阻害하지만 quinine은 阻害하지 않는다. ATPase 活性은 K의 농도에는 영향을 받지 않으나 Mg의 존재에 의하여 증가된다. Caffeine, procaine 및 quinine은 이 活性에 거의 영향을 미치지 않는다.

• 대한물리치료과학회지
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• 제4권2호
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• pp.399-403
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• 1997

The purpose of this study was to determine the efficacy of electrode placement on procaine iontophoresis. Thirty-three healthy students with an age range of 19 to 34 years, were participated in this study. The subjects were randomly assigned into 3 groups. Each subjects received iontophoresis on the proximal 1/3 of volar surface of dominant forearm with soft cotton pad($3.5{\times}3.5cm$) soaked in 2 ml of 4% procaine hydrochloride (pH 5.1) at 4 mA for 10 minutes(total current 40 mA min) of anodal DC. In transversal electrode placement(TEP) group, dispersive electrode was placed on the proximal 1/3 of dorsal surface of the forearm. In longitudinal electrode placement (LEP) group and control group, dispersive electrode were placed on the distal 1/3 of volar surface of the forearm. After procaine iontophoresis, duration of anesthesia were evaluated at five minutes intervals on five random locations in the iontophoretically area using a 21-gauge sterile hypodermic needle pressed with 1 mm invagination until return the sharp pin-pricking pain sensation. The data were ana lysed with one-way ANOVA to determine signific~nt differences between groups. The results showed significantly differences in the local anesthetic duration between the 3 groups(p<0.001). The anesthetic durations of TEP group and LEP group were significantly longer when compared with control group(p<0.05). Anesthetic durations of TEP group and LEP group were not significantly difference, but anesthetic duration of LEP group tends to longer than TEP group. In view of these results, clinicians should consider the electrode placement method when performing the iontophoresis.

• The Korean Journal of Pain
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• 제1권2호
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• pp.211-213
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• 1988

Efforts from many different approaches have been made to cure Raynaud's phenomenon using dosal sympathectomy and topical injection of nitroglycerine, phentolamine or procaine and oral or parenteral administration of various drugs. However, there has been no successful management proven yet. In recent years, it was reported that intra-arterial adminstriation of various drugs in normal subjects as well as patients with Raynaud's syndrome, had emonstrated a significant increase in blood flow to the hands. We used an intermittent stellate ganglion block in conjunction with intra-arterial injection of reserpine and procaine in the patient suffering from finger necrosis caused by accidental intraarterial antibiotic (cephamezine) injection. The stellate ganglion block was performed via a paratracheal approach by injection of 0.5% bupivacaine 6 ml, and 1% lidocaine 6 ml, and followed by administration of reserpine 1 mg and procaine 50 mg through a butterfly needle inserted in the radial artery. The administration of reserpine and procaine was done twice. The stellate ganglion block was performed every day for about 3 days, then once every a 5 days as needed for 15 days. As the procedure was carried out, the discolored tissue improved and the pain was progressively relieved. In conclusion, it was suggested that the intra-arterial administration of reserpine and procaine helped initiate and accelerate the increasing blood flow to the hand and the stellate ganglion block continued to help revascularization by dilating the peripheral beds.

• Journal of Pharmaceutical Investigation
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• 제36권3호
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• pp.185-192
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• 2006

The purpose of this study was to determine the effects of iontophoresis on transdermal delivery of procaine hydrochloride in healthy volunteers, as well as to the synergic effect of high voltage current or ultrasound on the efficacy of transdermal delivery of iontophoresis. Forty healthy volunteers were randomly assigned to four groups topical application group (TA), iontophoresis group (IT), pre-treatment of high voltage current stimulation with iontophoresis (HVS + IT), and pre-treatment of ultrasound application with iontophoresis (US + IT). All subjects received procaine iontophoresis on the forearm using direct current with 4 mA f3r 15 minutes. All subject was measured the duration of local anesthesia, pressure pain threshold, pain perception threshold using rectangular wave at 0.2 ms, 1 ms, 50 ms of rectangular current stimulation after procaine iontophoresis. For comparisons of the sensory characteristics and efficacy of iontophoresis between the groups, an one-way ANOVA and Kruskal-Wallis were used. The significant difference the duration of local anesthesia were found between the groups (p<0.001). The local anesthetic duration of IT, HVS+IT were significantly longer than TA. Meanwhile, the local anesthetic duration of US+IT was significantly longer than HVS+IT, IT and TA group (p<0.05). Also, the pressure pain threshold, pain perception threshold at 0.2 ms, 1 ms, 50 ms were significant difference between the groups (p<0.001). All sensory characteristics including pressure pain threshold, pain perception threshold of IT, HVS+IT was significantly increased than TA, whereas, US+1T was significantly increased HVS+1T, IT and TA (p<0.05). This study showed that the procaine iontophoresis have increase the duration of local anesthesia concomitantly pressure pain threshold and pain perception threshold of sensory nerve fibers such as $A-{\beta}$, $A-{\delta}$ and C fiber. This findings suggest that the iontophoresis enhanced the transdermal delivery of drug ions in vivo. The combination of ultrasound application and iontophoresis synergized the transdermal delivery of drug ions. It is suggests that an electric field, mechanical and heating property of ultrasound may contribute to synergic effect due to temporary changes of structure in the stratum corneum.

• 한국응용과학기술학회지
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• 제13권3호
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• pp.119-125
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• 1996

The excess volumes of mixing of benzyl alcohol, ethyl alcohol, halothane, and procaine in vesicle and suspensions of several lipids have been determined at $25^{\circ}C$ using a excess volume dilatometer. The potency of general anesthetics has long been known to be correlated with lipid solubility. Denaturations of the bacteriorhodopsin, which is a sole membrane protein in the purple membrane of Halobacteriun Halobium, were studied by UV/Vis absorption changes. The excess volumes of mixing of benzyl alcohol and procaine in egg lecithin were all found to be negative and this result was confirmed as Miller's supposition.

• 대한치과의사협회지
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• 제13권2호
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• pp.133-136
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• 1975

The autor studied skin reactions and their incidences among 130 dental students and dentists to 2% Iidocaine HCI, 2% procaine HCI, direct resin, plaster of paris, zinc oxide-eugenol cement, and adhesive plaster by Patch test. The results of the studies are as follows: 1. Eighteen cases out of 130 revealed slight positive reaction toa 1 or 2 allergens. 2. Lidocaine HCL showed 1 case, procaine HCL 4 cases, direct resin 4 cases, Z.O.E. cement 1 case, adhesive plaster 13 case, and plaster of paris showed none. 3. Two delayed reaction were detected after 48 hours, one of which reacted both lidocaine HCL and direct resin, and the other one was a case of adhesive plaster.

• 미생물학회지
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• 제28권4호
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• pp.297-303
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• 1990

Secretion of Serratia marcescens nuclease by E. coli harboring pNUC4 was investigated. 29.2, 54.2 and 16.6% of total nuclease were observed in culture medium, periplasm, and cytoplasm of E. coli, respectively. To investigate the secretion mechanism of Serratia nuclease by E. coli, secretion kinetics of nuclease was examined in the presences of sodium azide, and energy metabolism inhibitor; procaine, an exoprotein processing inhibitor; and chloramphenicol, a protein synthesis inhibitor. In the presence of sodium azide, periplasmic unclease was gradually decreased and the extracellular nyclease was linearly increased according to the incubation time. Similar results were obtained in presences of procaine and chloramphenicol. From these results, we concluded that two transport processes are involved in nuclease secretion: secretion of nuclease through the inner membrane is occurred by an energy-dependent process and probably requiring precusor processing: secretion of nuclease through outer membrane does not require energy, de novo protein synthesis, and precursor processing.