• Journal of Korean Ophthalmic Optics Society
• /
• v.14 no.1
• /
• pp.69-80
• /
• 2009

Purpose: We investigated validity of a monitor-based computer eye test program, Test Chart 2000 Pro (developed by Thomson Software Solutions, UK). Methods: We chose ten common eye tests of the Test Chart 2000 Pro and Korean Standard Eye Test, applying them to same subject groups each by each, followed by comparison and analyses of agreement degree of the results. Results: Among the ten eye tests, Snellen Chart, Cross-cyl target, Duochrome test, Fan and Block test, and Random dot stereograms showed statistically significant agreement between both the Korean standard eye test method and Test Chart 2000 Pro. On the other hand, some disagreements were found between the two eye test methods in LogMAR Chart, Single Letter Chart, Phoria Test, Fixation Disparity Test, and Worth 4 Dot Test. Conclusions: Comparing to the Korean Standard Eye Test that consists of Han eye chart and Phoroptor, validity of the Test Chart 2000 Pro is not so high. Further improvements of the Test Chart 2000 Pro in accuracy are required.

• Journal of Korean Society for Quality Management
• /
• v.40 no.2
• /
• pp.166-175
• /
• 2012

Enterprises are continuously trying management innovation activities for survival. Among representative management innovation activities in domestic manufacture enterprise, which are TPS, 6 sigma, Lean 6 sigma etc. Many enterprises through these reform activity have gotten good result. However, these techniques have merits and demerits according to circumstance of enterprise. Specially, there are a lot of difficulties in medium and small size enterprises. In this research, We introduce Lean-SMAIS Method for medium and small size enterprises that is consists of the merit of lean 6 sigma and software(which is called ProEye). We prove Lean-SMAIS method is useful by applying medium and small size enterprise A company.

• The Journal of the Korea Contents Association
• /
• v.19 no.7
• /
• pp.91-98
• /
• 2019

The purpose of this study was to develop and test an eye tracker focusing on early childhood participants, based on the characteristics of early childhood eye tracking studies. Eye tracking collects eye movement data of the subject, which provides scientific evidence of human cognition and thinking. The researcher built a Do It Yourself eye tracker camera module from general electronic components, and used Viewpoint analysis software from Arrington Research. The researcher compared the eye tracking data between the DIY eye tracker group and Tobii Pro eye tracker group, which provides a professional eye tracking system. Eye tracking data was collected from 52 five-year old children. The average proportion of valid trials between the two groups was compared with t test, and no significant difference was found. This result indicates that the DIY eye tracker can be used to collect valid eye tracking data from young children under certain research environment.

• Nutrition Research and Practice
• /
• v.14 no.3
• /
• pp.203-217
• /
• 2020

BACKGROUND/OBJECTIVE: Centella asiatica, also known as Gotu kola, is a tropical medicinal plant native to Madagascar, Southeast Asia, and South Africa. It is well known to have biological activities, including wound healing, anti-inflammatory, antidiabetic, cytotoxic, and antioxidant effects. The purpose of this study was to determine the efficacy of extracts of C. asiatica against age-related eye degeneration and to examine their physiological activities. MATERIALS/METHODS: To determine the effects of CA-HE50 (C. asiatica 50% EtOH extract) on retinal pigment cells, we assessed the cytotoxicity of CoCl₂ and oxidized-A2E in ARPE-19 cells and observed the protective effects of CA-HE50 against N-methyl-N-nitrosourea (MNU)-induced retinal damage in C57BL/6 mice. In particular, we measured factors related to apoptosis and anti-oxidation and the protein levels of rhodopsin/opsin. We also measured glucose uptake to characterize glucose metabolism, a major factor in cell protection. RESULTS: Induction of cytotoxicity with CoCl₂ and oxidized-A2E inhibited decreases in the viability of ARPE-19 cells when CA-HE50 was administered, and promoted glucose uptake under normal conditions (P < 0.05). In addition, CA-HE50 inhibited degeneration/apoptosis of the retina in the context of MNU-induced toxicity (P < 0.05). In particular, CA-HE50 at 200 mg/kg inhibited the cleavage of pro-caspase-3 and pro-poly (ADP-ribose)-polymerase and maintained the expressions of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 similar to normal control levels. Rhodopsin/opsin expression was maintained at a higher level than in normal controls. CONCLUSION: A series of experiments confirmed that CA-HE50 was effective for inhibiting or preventing age-related eye damage/degeneration. Based on these results, we believe it is worthwhile to develop drugs or functional foods related to age-related eye degeneration using CA-HE50.

• Fashion & Textile Research Journal
• /
• v.19 no.2
• /
• pp.230-239
• /
• 2017

In the clothes industry, there are lack of experts including technical designers who can analyze the fit of clothes. This study is to provide practical data available for fit analysis education by distinguishing the differences in standards and aspects of garment fit between experts and novices, through the eye-tracking technology to quantify the sense of fit. For this study, two groups were organized; one composed of 7 experts with over 15 year-experience including technical designers and patternmakers, and the other composed of 7 novices who are students majoring in clothing. Wearing the goggle type eye-tracker Tobii Pro Glasses 2, the participants in the experiments were required to conduct fit analyses for a pair of pants on a live model. After those experiments, they were required to check the items for fit analysis and assess the importance level of them on a questionnaire. The differences between the two groups in the ratios of total visit count and total visit duration by each AIO(Area of Interest) of clothes were analyzed through non-parametric statistical test. The results of eye tracking experiments showed that experts focused on center front and back line, crotch area, and side seam, while novice's fixation points were dispersed around the pants. The survey results showed that the experts put importance on the center line position and its verticality, front-back proportion of side seam line, and front-back proportion of waist line, 71.4~100% of whom checked them, while 14.3% of the novices checked them.

• Toxicological Research
• /
• v.26 no.1
• /
• pp.9-14
• /
• 2010

The evaluation of eye and skin irritation potential is essential to ensuring the safety of human in contact with a wide variety of substances. Despite this importance of irritation test, little is known with respect to the irritation potency of lomefloxacin, a fluoroquinolone antibiotic, which has been known to cause phototoxicity with an abnormal reaction of the skin. Thus, to investigate the tendency of lomefloxacin to cause eye and skin irritation, we carried out in vitro eye irritation test using Balb/c 3T3, and in vitro skin irritation test using $KeraSkin^{TM}$ human skin model system. 3T3 neutral red uptake assay has been proposed as a potential replacement alternative for the Draize Eye irritation test. In this study, the $IC_{50}$ value obtained for lomefloxacin was 375 ${\mu}g$. According to the classification model used for determining in vitro categories, lomefloxacin was classified as moderately irritant. For evaluation of skin irritation, engineered epidermal equivalents ($KeraSkin^{TM}$) were subjected to 10 and 25 mg of lomefloxacin for 15 minutes. Tissue damage was assessed by tissue viability evaluation, and by the release of a pro-inflammatory mediator, interleukin- 1${\alpha}$. Lomefloxacin increased the interleukin-1${\alpha}$ release after 15 minutes of exposure and 42 hours of post incubation, although no decrease in viability was observed. Therefore, lomefloxacin is considered to be moderately irritant to skin and eye.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.11 no.11
• /
• pp.4145-4150
• /
• 2010

This research aims to design on an automatic machine vision system to replace eye inspection of alternator spool which is one of the key automotive parts. The alternator spool, plastic extrusion part would have various defects like unfinished, crack and burr. Through the design failure examples the optimized fast machine vision system will be designed to inspect all spools also focuses on the low cost machine for the middle sized company as 2'nd automotive supplier. 3-dimensional design softwares of Pro-Engineer & CATIA were used and the system were built based on the design. The system will contribute to satisfy the cycle time and can inspect each part in an absolutely accurate method, which is sufficient for industrial applications.

• Toxicological Research
• /
• v.31 no.1
• /
• pp.49-59
• /
• 2015

Eye is a highly vascularised organ. There are chances that a foreign substance can enter the systemic circulation through the eye and cause oxidative stress and evoke immune response. Here the eyes of rabbits were exposed, for a period of 7 days, to 5 known ocular irritants: Cetyl pyridinium chloride (CPC), sodium salicylate (SS), imidazole (IMI), acetaminophen (ACT) and nicotinamide (NIC). The eyes were scored according to the draize scoring. Blood collected from the treated rabbit were analyzed for haematological and biochemical parameters. After sacrifice, histological analysis of the eye and analysis of pro-inflammatory biomarkers ($IL-1{\alpha}$, $IL-1{\beta}$, IL-8 and $TNF-{\alpha}$) in the cornea using ELISA was carried out. Spleen was collected and the proliferation capacities of spleenocytes were analyzed. Liver and brain were collected and assessed for oxidative stress. The eye irritation potential of the chemicals was evident from the redness and swelling of the conjunctiva and cornea. Histopathological analysis and ELISA assay showed signs of inflammation in the eye. However, the haematological and biochemical parameters showed no change. Spleenocyte proliferations showed only slight alterations which were not significant. Also oxidative stress in the brain and liver were negligible. In conclusion, chemicals which cause ocular irritation and inflammation did not show any systemic side-effects in the present scenario.

• Progress in Medical Physics
• /
• v.8 no.1
• /
• pp.17-24
• /
• 1997

We developed PC-based planning system for linear accelerator based stereotactic radiosurgery. The system was developed under Windows 95 on Pentium Pro$\^$(R) 200 ㎒ IBM PC with 128 MB RAM. It was programed using IDL$\^$(R)/ of Research Systems, Inc. as a programing tool. CT image data obtained with BRW stereotactic frame is transferred to PC through magnetoptical disk. As loading the image, the system automatically recognizes the location of rods and establishes stereotactic coordinates. It accurately calculates and corrects the coordinates, degree of tilting, and magnification rate of axial images. After the coordinates is defined we can delineate and edit the contours of target and organs of interest on axial images. Upon delineating contours of target, isocenter is determined automatically and we can set up the beam configuration for radiosurgery. The system provides beam's eye view and room's eye view for efficient confuguring of beams. The system calculates dose distribution 3-dimensionally. It takes 1 to 2 minutes to calculate dose distribution for 5 arcs. We can verify the dose distribution on serial axial images. We can analyze the dose distribution quantitatively by evaluation of dose-volume histogram of target and organ of interest. This system, PC-based radiosurgery planning system, includes the basic features for radiosurgery planning and calculates dose distribution within reasonable time for clinical application.

• BMB Reports
• /
• v.46 no.2
• /
• pp.124-129
• /
• 2013

FK506 binding protein 12 (FK506BP) belongs to a family of immunophilins, and is involved in multiple biological processes. However, the function of FK506BP in corneal disease remains unclear. In this study, we examined the protective effects on dry eye disease in a Botulinum toxin A (BTX-A) induced mouse model, using a cell-permeable PEP-1-FK506BP protein. PEP-1-FK506BP efficiently transduced into human corneal epithelial cells in a time- and dose-dependent manner, and remained stable in the cells for 48 h. In addition, we demonstrated that topical application of PEP-1-FK506BP was transduced into mouse cornea and conjunctiva by immunohistochemistry. Furthermore, topical application of PEP-1-FK506BP to BTX-A-induced mouse model markedly inhibited expression levels of pro-inflammatory cytokines such as interleukin-$1{\beta}$ (IL-$1{\beta}$), tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and macrophage inhibitory factor (MIF) in corneal and conjunctival epithelium. These results suggest PEP-1-FK506BP as a potential therapeutic agent for dry eye diseases.